JP2002145837A5 - - Google Patents
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- Publication number
- JP2002145837A5 JP2002145837A5 JP2000335352A JP2000335352A JP2002145837A5 JP 2002145837 A5 JP2002145837 A5 JP 2002145837A5 JP 2000335352 A JP2000335352 A JP 2000335352A JP 2000335352 A JP2000335352 A JP 2000335352A JP 2002145837 A5 JP2002145837 A5 JP 2002145837A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optical
- complex
- amino acid
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000003287 optical effect Effects 0.000 description 21
- -1 n-propoxycarbonyl group Chemical group 0.000 description 13
- 238000000926 separation method Methods 0.000 description 8
- 230000002209 hydrophobic effect Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 150000002433 hydrophilic molecules Chemical class 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 150000003862 amino acid derivatives Chemical class 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 description 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 125000005929 isobutyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])OC(*)=O 0.000 description 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000011426 transformation method Methods 0.000 description 1
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000335352A JP4783496B2 (ja) | 2000-11-02 | 2000-11-02 | アミノ酸誘導体の光学異性体の分離方法 |
| US10/415,559 US7199264B2 (en) | 2000-11-02 | 2001-10-25 | Method of resolving optical isomers of amino acid derivative |
| AT01980906T ATE374175T1 (de) | 2000-11-02 | 2001-10-25 | Verfahren zur racemattrennung von aminosäurederivaten |
| KR1020037004754A KR100790507B1 (ko) | 2000-11-02 | 2001-10-25 | 아미노산 유도체의 광학 이성체의 분리 방법 |
| DE60130674T DE60130674T2 (de) | 2000-11-02 | 2001-10-25 | Verfahren zur racemattrennung von aminosäurederivaten |
| EP01980906A EP1338588B1 (en) | 2000-11-02 | 2001-10-25 | Method of resolving optical isomers of amino acid derivative |
| CNA018184987A CN1473145A (zh) | 2000-11-02 | 2001-10-25 | 氨基酸衍生物的光学异构体的分离方法 |
| PCT/JP2001/009384 WO2002036544A1 (en) | 2000-11-02 | 2001-10-25 | Method of resolving optical isomers of amino acid derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000335352A JP4783496B2 (ja) | 2000-11-02 | 2000-11-02 | アミノ酸誘導体の光学異性体の分離方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002145837A JP2002145837A (ja) | 2002-05-22 |
| JP2002145837A5 true JP2002145837A5 (enExample) | 2007-03-15 |
| JP4783496B2 JP4783496B2 (ja) | 2011-09-28 |
Family
ID=18811110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000335352A Expired - Fee Related JP4783496B2 (ja) | 2000-11-02 | 2000-11-02 | アミノ酸誘導体の光学異性体の分離方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7199264B2 (enExample) |
| EP (1) | EP1338588B1 (enExample) |
| JP (1) | JP4783496B2 (enExample) |
| KR (1) | KR100790507B1 (enExample) |
| CN (1) | CN1473145A (enExample) |
| AT (1) | ATE374175T1 (enExample) |
| DE (1) | DE60130674T2 (enExample) |
| WO (1) | WO2002036544A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4916064B2 (ja) * | 2001-08-23 | 2012-04-11 | 株式会社トクヤマ | 光学異性体の分離方法 |
| US7019169B2 (en) * | 2003-09-23 | 2006-03-28 | Basf Aktiengesellschaft | Preparation of (meth)acrylic acid |
| DE102004008141A1 (de) * | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
| US7927779B2 (en) * | 2005-06-30 | 2011-04-19 | Taiwan Semiconductor Manufacturing Companym, Ltd. | Water mark defect prevention for immersion lithography |
| JP5122871B2 (ja) * | 2007-06-01 | 2013-01-16 | 大東化学株式会社 | 光学活性ｎ−ベンジルオキシカルボニルアミノ酸の製造方法およびジアステレオマー塩 |
| DE102008013500A1 (de) * | 2008-03-10 | 2009-09-17 | Evonik Degussa Gmbh | Neue chirale Selektoren und stationäre Phasen zur Trennung von Enantiomerengemischen |
| SG11201707908UA (en) * | 2015-05-11 | 2017-10-30 | Shiseido Co Ltd | Chiral analysis method of bound amino acid and chiral analysis system |
| CN108181414B (zh) * | 2017-12-25 | 2020-03-31 | 齐齐哈尔大学 | 手性键合毛细管电色谱开管柱的制备方法及其应用 |
| CN111323497B (zh) * | 2018-12-17 | 2022-07-12 | 武汉武药科技有限公司 | 一种帕瑞肽起始原料的光学纯度分析方法 |
| CN112578031A (zh) * | 2019-09-30 | 2021-03-30 | 天津药业研究院股份有限公司 | 色氨酸杂质的检测方法及应用 |
| CN111100051B (zh) | 2019-12-31 | 2022-01-28 | 山东新和成氨基酸有限公司 | 在甲硫氨酸制备过程中使用的添加剂及甲硫氨酸的制备方法 |
| CN114957024B (zh) * | 2022-05-30 | 2023-08-15 | 厦门理工学院 | 一种dl-苯丙氨酸对映体的手性拆分方法 |
| CN116429927A (zh) * | 2023-03-22 | 2023-07-14 | 大邦(湖南)生物制药有限公司 | 一种n-甲酰基-l-亮氨酸中对映异构体的含量分析方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254258A (en) * | 1991-09-17 | 1993-10-19 | Research Corporation Technologies, Inc. | Chiral selector useful for separation of enantiomers of β-amino alcohol compounds |
-
2000
- 2000-11-02 JP JP2000335352A patent/JP4783496B2/ja not_active Expired - Fee Related
-
2001
- 2001-10-25 US US10/415,559 patent/US7199264B2/en not_active Expired - Fee Related
- 2001-10-25 KR KR1020037004754A patent/KR100790507B1/ko not_active Expired - Fee Related
- 2001-10-25 CN CNA018184987A patent/CN1473145A/zh active Pending
- 2001-10-25 DE DE60130674T patent/DE60130674T2/de not_active Expired - Lifetime
- 2001-10-25 AT AT01980906T patent/ATE374175T1/de active
- 2001-10-25 WO PCT/JP2001/009384 patent/WO2002036544A1/ja not_active Ceased
- 2001-10-25 EP EP01980906A patent/EP1338588B1/en not_active Expired - Lifetime
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