JP2001527642A - ビーズを配列するための装置および方法 - Google Patents

ビーズを配列するための装置および方法

Info

Publication number
JP2001527642A
JP2001527642A JP53448998A JP53448998A JP2001527642A JP 2001527642 A JP2001527642 A JP 2001527642A JP 53448998 A JP53448998 A JP 53448998A JP 53448998 A JP53448998 A JP 53448998A JP 2001527642 A JP2001527642 A JP 2001527642A
Authority
JP
Japan
Prior art keywords
beads
opening
liquid
needle
movable element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP53448998A
Other languages
English (en)
Japanese (ja)
Inventor
エリオット，ジョン・ダンカン
グリーソン，ジョン・ジェラルド
レーバー，ジャック・デイル
シモライク，ジェラルド・クレイグ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JP2001527642A publication Critical patent/JP2001527642A/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/405—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles having guiding conduits therein, e.g. for feeding the gas to the bottom of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00564—Handling or washing solid phase elements, e.g. beads
    • G01N2035/00574—Means for distributing beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP53448998A 1997-01-17 1998-01-15 ビーズを配列するための装置および方法 Pending JP2001527642A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78507297A 1997-01-17 1997-01-17
US08/785,072 1997-01-17
PCT/US1998/000685 WO1998032000A1 (en) 1997-01-17 1998-01-15 Apparatus and process for arraying beads

Publications (1)

Publication Number Publication Date
JP2001527642A true JP2001527642A (ja) 2001-12-25

Family

ID=25134371

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53448998A Pending JP2001527642A (ja) 1997-01-17 1998-01-15 ビーズを配列するための装置および方法

Country Status (5)

Country Link
US (1) US5935859A (de)
EP (1) EP1024893A1 (de)
JP (1) JP2001527642A (de)
CA (1) CA2278146A1 (de)
WO (1) WO1998032000A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074609A (en) * 1996-04-24 2000-06-13 Glaxo Wellcome Inc. Systems for arraying beads
AU4081297A (en) * 1996-08-21 1998-03-06 Smithkline Beecham Corporation Rapid process for arraying and synthesizing bead-based combinatorial libraries
US20010039020A1 (en) * 1998-05-08 2001-11-08 Ronald Zuckermann Method and device for nonsynthetic deconvolution
US6255116B1 (en) * 1998-12-17 2001-07-03 Smithkline Beecham Corporation Apparatus and process for arraying beads
US6151973A (en) * 1999-01-29 2000-11-28 Glaxo Wellcome Inc. Bead picking apparatus and method
US6497155B1 (en) * 1999-02-09 2002-12-24 Pharmacopeia, Inc. Article comprising a particle retrieval device
US7101510B2 (en) 1999-02-16 2006-09-05 Applera Corporation Matrix storage and dispensing system
US6432719B1 (en) * 1999-02-16 2002-08-13 Pe Corporation (Ny) Matrix storage and dispensing system
ATE341002T1 (de) 1999-02-16 2006-10-15 Applera Corp Vorrichtung zur handhabung von kügelchen
DE19941661B4 (de) * 1999-09-01 2004-06-17 Graffinity Pharmaceuticals Ag Vorrichtung und Verfahren zum Aufnehmen und Plazieren
US6464943B1 (en) * 1999-09-07 2002-10-15 Felix H. Yiu Solid phase evaporator device
WO2001059432A2 (en) * 2000-02-10 2001-08-16 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6447723B1 (en) 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US6756232B1 (en) * 2000-03-20 2004-06-29 Perkinelmer Las, Inc. Method and apparatus for producing compact microarrays
US6878554B1 (en) 2000-03-20 2005-04-12 Perkinelmer Las, Inc. Method and apparatus for automatic pin detection in microarray spotting instruments
US6471917B1 (en) * 2000-04-11 2002-10-29 Affymax, Inc. System and method for single or multiple bead distribution with an adjustable capillary
US6387330B1 (en) * 2000-04-12 2002-05-14 George Steven Bova Method and apparatus for storing and dispensing reagents
US6363801B1 (en) * 2000-04-26 2002-04-02 General Electric Company Apparatus and process for selecting and positioning particles
US7521245B1 (en) 2000-06-05 2009-04-21 Perkinelmer Las, Inc. Method for washing and drying pins in microarray spotting instruments
US6902702B1 (en) * 2000-08-16 2005-06-07 University Health Network Devices and methods for producing microarrays of biological samples
US6406670B1 (en) * 2000-08-25 2002-06-18 Albany Molecular Research, Inc. Multiple well microtiter plate loading assembly and method
US6911181B1 (en) * 2000-10-03 2005-06-28 Isis Pharmaceuticals, Inc. Self-dispensing storage device
US20020117013A1 (en) * 2000-10-25 2002-08-29 Dna Sciences, Inc. Variable geometry fluid sample loader
US6416719B1 (en) * 2001-01-19 2002-07-09 Gilson, Inc. Plate locator for precision liquid handler
US6474181B2 (en) * 2001-01-24 2002-11-05 Gilson, Inc. Probe tip alignment for precision liquid handler
DE10135963B4 (de) 2001-07-24 2005-09-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zum Pipettieren einer Flüssigkeit
JP2005507074A (ja) * 2001-10-26 2005-03-10 セクエノム， インコーポレイテッド ハイスループットのサンプル取り扱いプロセスラインのための方法および装置
JP3593525B2 (ja) * 2002-04-19 2004-11-24 株式会社日立製作所 微粒子アレー作製方法およびその装置
US7364907B2 (en) * 2002-11-08 2008-04-29 Irm Llc Systems and methods for sorting samples
JP2005077284A (ja) * 2003-09-01 2005-03-24 Seiko Epson Corp 粒子アレイの製造装置及び製造方法と標的物質の検出方法
US20120122103A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US7442339B2 (en) * 2004-03-31 2008-10-28 Intel Corporation Microfluidic apparatus, Raman spectroscopy systems, and methods for performing molecular reactions
JP4520359B2 (ja) * 2005-05-13 2010-08-04 日立ソフトウエアエンジニアリング株式会社 粒子捕捉装置、並びに粒子配列方法及び粒子配列装置
EP1949070A4 (de) 2005-11-01 2009-11-18 Symyx Technologies Inc Flüssigkeitsabgabe bei experimenten mit hohem durchsatz
US8192698B2 (en) * 2006-01-27 2012-06-05 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
US20070258862A1 (en) * 2006-05-02 2007-11-08 Applera Corporation Variable volume dispenser and method
US8545757B2 (en) * 2009-01-30 2013-10-01 Hitachi High-Technologies Corporation Automatic analyzer and sample treatment apparatus
JP5846773B2 (ja) * 2010-06-29 2016-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ サンプルの分配
US9029163B2 (en) 2010-08-23 2015-05-12 Avia Biosystems, Inc. Method for generation of automated denaturation graphs
US20130025690A1 (en) * 2011-07-29 2013-01-31 Intermolecular, Inc. No-Contact Wet Processing Tool with Liquid Barrier
FR2978064B1 (fr) * 2011-07-18 2016-02-19 Interlab Procede et dispositif de distribution gravimetrique et en serie de solution.
FR3017706B1 (fr) 2014-02-18 2017-11-03 Interscience Dispositif de distribution gravimetrique

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401456A (en) * 1980-01-09 1983-08-30 The United States Of America As Represented By The Secretary Of Agriculture Controlled release of bioactive materials using alginate gel beads
US4937048A (en) * 1983-01-31 1990-06-26 Olympus Optical Company Limited Carrier transporting apparatus and carrier container for use in an immunological analysis
IT1174039B (it) * 1984-06-19 1987-06-24 Finbiomedica Srl Metodo ed apparecchiatura per analisi chimico-cliniche automatiche ad alta velocita'
US4681742A (en) * 1984-10-01 1987-07-21 Cetus Corporation Assay tray
US4754771A (en) * 1985-07-17 1988-07-05 Hybritech Incorporated Apparatus for washing beads
US4685480A (en) * 1985-08-30 1987-08-11 Abbott Laboratories Combined washer and aspirator
JPS63128259A (ja) * 1986-11-18 1988-05-31 Yasunobu Tsukioka 血液等の検査における反応ビ−ズの洗滌方法と洗滌装置
DE3800379A1 (de) * 1988-01-08 1989-07-20 Boehringer Mannheim Gmbh Vorrichtung zum abwaschen der innenflaeche eines reaktionsgefaesses und/oder der aussenflaeche eines reagenzkugelkoerpers
US5183638A (en) * 1989-12-04 1993-02-02 Kabushiki Kaisha Nittec Automatic immunity analysis apparatus with magnetic particle separation
US5185269A (en) * 1990-02-13 1993-02-09 Source Scientific Systems, Inc. Immunobead aspirator and method of use
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
GB9310557D0 (en) * 1993-05-21 1993-07-07 Smithkline Beecham Plc Novel process and apparatus
DE4329791C2 (de) * 1993-09-03 1996-02-15 Teja Lichtenberg Verfahren zur automatischen Verteilung und zum Transport von Mikrofilterscheiben
JP3351615B2 (ja) * 1994-03-17 2002-12-03 ソニー株式会社 液の境界検出方法と液分離方法
DE19533171A1 (de) * 1994-09-13 1996-03-14 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Applikation von Verbindungsmaterial auf einer Substratanschlußfläche
CA2218366A1 (en) * 1995-04-17 1996-10-31 Romaine R. Maiefski Pipetting needle and rinse station therefor for fluid transfer under inert atmosphere operations
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
US6074609A (en) * 1996-04-24 2000-06-13 Glaxo Wellcome Inc. Systems for arraying beads

Also Published As

Publication number Publication date
CA2278146A1 (en) 1998-07-23
EP1024893A4 (de) 2000-08-09
US5935859A (en) 1999-08-10
EP1024893A1 (de) 2000-08-09
WO1998032000A1 (en) 1998-07-23

Similar Documents

Publication Publication Date Title
JP2001527642A (ja) ビーズを配列するための装置および方法
WO1998032000A9 (en) Apparatus and process for arraying beads
US6074609A (en) Systems for arraying beads
US7488451B2 (en) Systems for particle manipulation
CA2483445A1 (en) Structure and method for handling magnetic particles in biological assays
JP3115501B2 (ja) 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置
JP4695503B2 (ja) 液面検出及び／又は気泡検出を統合したピペット装置
JP2002001092A (ja) 排液装置
JP4335460B2 (ja) 界面パッチクランプ
JPH06221976A (ja) 検体処理方法並びに装置
EP1588766A1 (de) System und Verfahren zur Kontrolle der Integrität und der Operation von Pipettiervorrichtungen zur Manipulation flüssiger Proben
JPH05504412A (ja) 血液学分析装置における吸引方法
JPWO2018193718A1 (ja) 細胞ハンドリング装置
KR20170039288A (ko) 시약운반부, 어댑터 및 시약운반부 취급방법
JP2002535134A (ja) ビーズ採取装置および方法
JP6450476B2 (ja) 対象物移動方法及び装置
US5195657A (en) Manifold liquid handling device with backsip function
JP5090908B2 (ja) 血液試料を自動的に調査する装置と方法
EP1295114B1 (de) Vorrichtung und verfahren zur entnahme von gelscheiben
AU2001283904A1 (en) Spot picker device and method for picking gel plugs
US5264042A (en) Method for washing magnetic particles in a vessel with a bottom pull
CN114459824A (zh) 一种环境质量检测用区域性水质取样器及检测方法
JP7486160B2 (ja) 細胞培養装置および細胞培養方法
EP1187680B1 (de) Universelle waschvorrichtung für mikrotiterplatten und dergleichen
US5105842A (en) Apparatus for washing magnetic particles in a vessel with a bottom pull