JP2001523644A5 - - Google Patents
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- Publication number
- JP2001523644A5 JP2001523644A5 JP2000520798A JP2000520798A JP2001523644A5 JP 2001523644 A5 JP2001523644 A5 JP 2001523644A5 JP 2000520798 A JP2000520798 A JP 2000520798A JP 2000520798 A JP2000520798 A JP 2000520798A JP 2001523644 A5 JP2001523644 A5 JP 2001523644A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- dideoxy
- ketolide
- ribohexopyranosyl
- oxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 239000003835 ketolide antibiotic agent Substances 0.000 description 7
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 229960003276 erythromycin Drugs 0.000 description 4
- 125000001841 imino group Chemical group [H]N=* 0.000 description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 0 CC[C@]([C@@](C)(C1)[C@]([C@@](C)C([C@](C)C2)=O)N2C1=O)OC([C@@](C)(*)C([C@](C)[C@](C(C)(C)OC)OC[C@@]([C@]1O)O[C@](C)C[C@@]1N(C)C)=O)=O Chemical compound CC[C@]([C@@](C)(C1)[C@]([C@@](C)C([C@](C)C2)=O)N2C1=O)OC([C@@](C)(*)C([C@](C)[C@](C(C)(C)OC)OC[C@@]([C@]1O)O[C@](C)C[C@@]1N(C)C)=O)=O 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR97/14358 | 1997-11-17 | ||
| FR9714358A FR2771008B1 (fr) | 1997-11-17 | 1997-11-17 | Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
| PCT/FR1998/002436 WO1999025365A1 (fr) | 1997-11-17 | 1998-11-16 | Utilisation des ketolides pour prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001523644A JP2001523644A (ja) | 2001-11-27 |
| JP2001523644A5 true JP2001523644A5 (enExample) | 2006-01-12 |
| JP4550273B2 JP4550273B2 (ja) | 2010-09-22 |
Family
ID=9513423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000520798A Expired - Fee Related JP4550273B2 (ja) | 1997-11-17 | 1998-11-16 | アテローム性動脈硬化症と結びついた動脈血栓合併症を予防するための製薬組成物の製造のためのケトリドの使用 |
Country Status (35)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2777282B1 (fr) * | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
| ES2273964T3 (es) * | 1998-12-10 | 2007-05-16 | Pfizer Products Inc. | Antibioticos de carbamato y carbazato cetolida. |
| IL144178A0 (en) * | 1999-01-27 | 2002-05-23 | Pfizer Prod Inc | Ketolide antibiotics |
| EP1114826A3 (en) * | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
| IL151887A0 (en) | 2000-04-04 | 2003-04-10 | Smithkline Beecham Plc | 2-hydroxy-mutilin carbamate derivatives for antibacterial use |
| JP2004323414A (ja) * | 2003-04-24 | 2004-11-18 | Japan Science & Technology Agency | １４員環マクロライド化合物を利用した、血管平滑筋の増殖に起因する疾患治療剤 |
| GB0402578D0 (en) * | 2004-02-05 | 2004-03-10 | Cambridge Theranostics Ltd | Methods of treatment of atherosclerosis |
| US9815863B2 (en) * | 2010-09-10 | 2017-11-14 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2249892A (en) * | 1991-06-14 | 1993-01-12 | Board Of Regents Of The University Of Washington, The | Diagnosis and treatment of arterial chlamydial granuloma |
| FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US6271255B1 (en) * | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
| GB9621771D0 (en) * | 1996-10-18 | 1996-12-11 | St George S Enterprises Ltd | Method of treatment of heart disease |
| FR2757168B1 (fr) * | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| EP0895999A1 (en) * | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
-
1997
- 1997-11-17 FR FR9714358A patent/FR2771008B1/fr not_active Expired - Fee Related
-
1998
- 1998-11-12 ZA ZA9810357A patent/ZA9810357B/xx unknown
- 1998-11-13 TW TW087118866A patent/TW472061B/zh not_active IP Right Cessation
- 1998-11-16 BR BR9814199-6A patent/BR9814199A/pt not_active Application Discontinuation
- 1998-11-16 TR TR2000/01384T patent/TR200001384T2/xx unknown
- 1998-11-16 HR HR20000314A patent/HRP20000314A2/hr not_active Application Discontinuation
- 1998-11-16 CN CN98813159A patent/CN1286633A/zh active Pending
- 1998-11-16 AT AT98955662T patent/ATE271875T1/de not_active IP Right Cessation
- 1998-11-16 AU AU12425/99A patent/AU744419B2/en not_active Ceased
- 1998-11-16 MA MA25348A patent/MA26566A1/fr unknown
- 1998-11-16 EP EP98955662A patent/EP1030673B1/fr not_active Expired - Lifetime
- 1998-11-16 KR KR1020007005317A patent/KR20010032130A/ko not_active Ceased
- 1998-11-16 AP APAP/P/2000/001825A patent/AP1196A/en active
- 1998-11-16 DZ DZ980264A patent/DZ2654A1/xx active
- 1998-11-16 CA CA002312021A patent/CA2312021C/fr not_active Expired - Fee Related
- 1998-11-16 ES ES98955662T patent/ES2224446T3/es not_active Expired - Lifetime
- 1998-11-16 NZ NZ504305A patent/NZ504305A/xx unknown
- 1998-11-16 EA EA200000531A patent/EA003322B1/ru not_active IP Right Cessation
- 1998-11-16 TN TNTNSN98206A patent/TNSN98206A1/fr unknown
- 1998-11-16 GE GEAP19985410A patent/GEP20032968B/en unknown
- 1998-11-16 PL PL98340373A patent/PL340373A1/xx unknown
- 1998-11-16 DE DE69825308T patent/DE69825308T2/de not_active Expired - Lifetime
- 1998-11-16 YU YU29600A patent/YU29600A/sh unknown
- 1998-11-16 HU HU0004507A patent/HUP0004507A3/hu unknown
- 1998-11-16 JP JP2000520798A patent/JP4550273B2/ja not_active Expired - Fee Related
- 1998-11-16 ID IDW20000930A patent/ID24940A/id unknown
- 1998-11-16 EE EEP200000244A patent/EE04095B1/xx not_active IP Right Cessation
- 1998-11-16 WO PCT/FR1998/002436 patent/WO1999025365A1/fr not_active Ceased
- 1998-11-16 SK SK704-2000A patent/SK7042000A3/sk unknown
- 1998-11-16 IL IL13614998A patent/IL136149A0/xx unknown
- 1998-11-17 AR ARP980105823A patent/AR014119A1/es not_active Application Discontinuation
-
2000
- 2000-05-11 BG BG104427A patent/BG104427A/xx unknown
- 2000-05-11 NO NO20002435A patent/NO20002435L/no unknown
- 2000-05-17 OA OA1200000144A patent/OA11411A/fr unknown
-
2007
- 2007-09-28 US US11/863,329 patent/US20080139489A1/en not_active Abandoned
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