EA003322B1 - Применение кетолидов для профилактики тромботических артериальных осложнений, связанных с атеросклерозом - Google Patents
Применение кетолидов для профилактики тромботических артериальных осложнений, связанных с атеросклерозом Download PDFInfo
- Publication number
- EA003322B1 EA003322B1 EA200000531A EA200000531A EA003322B1 EA 003322 B1 EA003322 B1 EA 003322B1 EA 200000531 A EA200000531 A EA 200000531A EA 200000531 A EA200000531 A EA 200000531A EA 003322 B1 EA003322 B1 EA 003322B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methyl
- dideoxy
- radical
- use according
- ketolide
- Prior art date
Links
- 239000003835 ketolide antibiotic agent Substances 0.000 title claims abstract 12
- 201000001320 Atherosclerosis Diseases 0.000 title claims abstract 3
- 230000001732 thrombotic effect Effects 0.000 title claims 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims abstract 16
- 229960003276 erythromycin Drugs 0.000 claims abstract 8
- 125000001841 imino group Chemical group [H]N=* 0.000 claims abstract 6
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 4
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- -1 4-(3- (3-pyridyl)-1H-1,2,4-triazol-1-yl)butyl Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9714358A FR2771008B1 (fr) | 1997-11-17 | 1997-11-17 | Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
| PCT/FR1998/002436 WO1999025365A1 (fr) | 1997-11-17 | 1998-11-16 | Utilisation des ketolides pour prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200000531A1 EA200000531A1 (ru) | 2000-10-30 |
| EA003322B1 true EA003322B1 (ru) | 2003-04-24 |
Family
ID=9513423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000531A EA003322B1 (ru) | 1997-11-17 | 1998-11-16 | Применение кетолидов для профилактики тромботических артериальных осложнений, связанных с атеросклерозом |
Country Status (35)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2777282B1 (fr) * | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
| ATE344269T1 (de) * | 1998-12-10 | 2006-11-15 | Pfizer Prod Inc | Carbamat und carbazat ketolid antibiotika |
| EP1147121B1 (en) * | 1999-01-27 | 2003-12-17 | Pfizer Products Inc. | Ketolide antibiotics |
| EP1114826A3 (en) * | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
| MXPA02009816A (es) | 2000-04-04 | 2003-03-27 | Smithkline Beecham Plc | Derivados de carbamato de 2-hidroxi-multilina para uso antibacteriano. |
| JP2004323414A (ja) * | 2003-04-24 | 2004-11-18 | Japan Science & Technology Agency | １４員環マクロライド化合物を利用した、血管平滑筋の増殖に起因する疾患治療剤 |
| GB0402578D0 (en) * | 2004-02-05 | 2004-03-10 | Cambridge Theranostics Ltd | Methods of treatment of atherosclerosis |
| KR20130120458A (ko) * | 2010-09-10 | 2013-11-04 | 셈프라 파마슈티컬스, 인크. | 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0676409A1 (fr) * | 1994-04-08 | 1995-10-11 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments |
| EP0680967A1 (fr) * | 1994-05-03 | 1995-11-08 | Roussel-Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424187A (en) * | 1991-06-14 | 1995-06-13 | Board Of Regents Of The University Of Washington | Method of screening for arterial chlamydial granuloma |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US6271255B1 (en) * | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
| GB9621771D0 (en) * | 1996-10-18 | 1996-12-11 | St George S Enterprises Ltd | Method of treatment of heart disease |
| FR2757168B1 (fr) * | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| EP0895999A1 (en) * | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
-
1997
- 1997-11-17 FR FR9714358A patent/FR2771008B1/fr not_active Expired - Fee Related
-
1998
- 1998-11-12 ZA ZA9810357A patent/ZA9810357B/xx unknown
- 1998-11-13 TW TW087118866A patent/TW472061B/zh not_active IP Right Cessation
- 1998-11-16 AP APAP/P/2000/001825A patent/AP1196A/en active
- 1998-11-16 KR KR1020007005317A patent/KR20010032130A/ko not_active Ceased
- 1998-11-16 CA CA002312021A patent/CA2312021C/fr not_active Expired - Fee Related
- 1998-11-16 DZ DZ980264A patent/DZ2654A1/xx active
- 1998-11-16 CN CN98813159A patent/CN1286633A/zh active Pending
- 1998-11-16 AU AU12425/99A patent/AU744419B2/en not_active Ceased
- 1998-11-16 TR TR2000/01384T patent/TR200001384T2/xx unknown
- 1998-11-16 ID IDW20000930A patent/ID24940A/id unknown
- 1998-11-16 DE DE69825308T patent/DE69825308T2/de not_active Expired - Lifetime
- 1998-11-16 GE GEAP19985410A patent/GEP20032968B/en unknown
- 1998-11-16 IL IL13614998A patent/IL136149A0/xx unknown
- 1998-11-16 JP JP2000520798A patent/JP4550273B2/ja not_active Expired - Fee Related
- 1998-11-16 EP EP98955662A patent/EP1030673B1/fr not_active Expired - Lifetime
- 1998-11-16 NZ NZ504305A patent/NZ504305A/xx unknown
- 1998-11-16 HU HU0004507A patent/HUP0004507A3/hu unknown
- 1998-11-16 SK SK704-2000A patent/SK7042000A3/sk unknown
- 1998-11-16 BR BR9814199-6A patent/BR9814199A/pt not_active Application Discontinuation
- 1998-11-16 PL PL98340373A patent/PL340373A1/xx unknown
- 1998-11-16 EA EA200000531A patent/EA003322B1/ru not_active IP Right Cessation
- 1998-11-16 ES ES98955662T patent/ES2224446T3/es not_active Expired - Lifetime
- 1998-11-16 TN TNTNSN98206A patent/TNSN98206A1/fr unknown
- 1998-11-16 YU YU29600A patent/YU29600A/sh unknown
- 1998-11-16 WO PCT/FR1998/002436 patent/WO1999025365A1/fr not_active Ceased
- 1998-11-16 EE EEP200000244A patent/EE04095B1/xx not_active IP Right Cessation
- 1998-11-16 HR HR20000314A patent/HRP20000314A2/hr not_active Application Discontinuation
- 1998-11-16 AT AT98955662T patent/ATE271875T1/de not_active IP Right Cessation
- 1998-11-16 MA MA25348A patent/MA26566A1/fr unknown
- 1998-11-17 AR ARP980105823A patent/AR014119A1/es not_active Application Discontinuation
-
2000
- 2000-05-11 NO NO20002435A patent/NO20002435L/no unknown
- 2000-05-11 BG BG104427A patent/BG104427A/xx unknown
- 2000-05-17 OA OA1200000144A patent/OA11411A/fr unknown
-
2007
- 2007-09-28 US US11/863,329 patent/US20080139489A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0676409A1 (fr) * | 1994-04-08 | 1995-10-11 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments |
| EP0680967A1 (fr) * | 1994-05-03 | 1995-11-08 | Roussel-Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments |
Non-Patent Citations (2)
| Title |
|---|
| H. JOHNSSON ET AL.: "Effects of some antibiotics on plateletbfunction in vitro and in vivo." THROMB. RES., vol. 11, no. 2, 1977, pages 237-252, XP002068932 * |
| S. CRONBERG ET AL.: "Investigations on the effect of antimicrobial drugs on platelet aggregation in vitro and ex vivo." FOLIA HAEMATOL., vol. 111, no. 6, 1984, pages 725-734, XP002068933 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |