JP2001523465A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2001523465A5 JP2001523465A5 JP2000521213A JP2000521213A JP2001523465A5 JP 2001523465 A5 JP2001523465 A5 JP 2001523465A5 JP 2000521213 A JP2000521213 A JP 2000521213A JP 2000521213 A JP2000521213 A JP 2000521213A JP 2001523465 A5 JP2001523465 A5 JP 2001523465A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- linker
- variant
- subunit
- expression system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 description 20
- 102000004169 proteins and genes Human genes 0.000 description 20
- 125000005647 linker group Chemical group 0.000 description 10
- 102000003886 Glycoproteins Human genes 0.000 description 6
- 108090000288 Glycoproteins Proteins 0.000 description 6
- 239000005556 hormone Substances 0.000 description 6
- 229940088597 hormone Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 239000000556 agonist Substances 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000000540 fraction c Anatomy 0.000 description 1
- 102000035122 glycosylated proteins Human genes 0.000 description 1
- 108091005608 glycosylated proteins Proteins 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/971,439 US6103501A (en) | 1997-11-17 | 1997-11-17 | Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof |
| US08/971,439 | 1997-11-17 | ||
| PCT/US1998/023744 WO1999025849A1 (en) | 1997-11-17 | 1998-11-09 | Single-chain bifunctional glycoprotein hormones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001523465A JP2001523465A (ja) | 2001-11-27 |
| JP2001523465A5 true JP2001523465A5 (enExample) | 2006-01-05 |
| JP4255618B2 JP4255618B2 (ja) | 2009-04-15 |
Family
ID=25518394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000521213A Expired - Fee Related JP4255618B2 (ja) | 1997-11-17 | 1998-11-09 | 単鎖二官能性糖タンパク質ホルモン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6103501A (enExample) |
| EP (1) | EP1032688B1 (enExample) |
| JP (1) | JP4255618B2 (enExample) |
| KR (1) | KR20010032147A (enExample) |
| CN (1) | CN1173037C (enExample) |
| AU (1) | AU754296B2 (enExample) |
| BR (1) | BR9814880A (enExample) |
| CA (1) | CA2308571C (enExample) |
| CZ (1) | CZ299742B6 (enExample) |
| DE (1) | DE69839779D1 (enExample) |
| HU (1) | HUP0004394A3 (enExample) |
| IL (2) | IL135995A0 (enExample) |
| NO (1) | NO20002527L (enExample) |
| PL (1) | PL342853A1 (enExample) |
| TR (1) | TR200001406T2 (enExample) |
| WO (1) | WO1999025849A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319504B1 (en) | 1996-06-24 | 2001-11-20 | University Of Maryland Biotechnology Institute | Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin |
| US6583109B1 (en) | 1997-06-24 | 2003-06-24 | Robert C. Gallo | Therapeutic polypeptides from β-hCG and derivatives |
| US6635256B1 (en) | 1998-10-19 | 2003-10-21 | Washington University | Glycoprotein hormone compositions comprising two β subunits and methods of use thereof |
| US7994278B1 (en) * | 1999-08-06 | 2011-08-09 | Nobel Biosciences Llc | Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) |
| EP1224301A2 (en) * | 1999-10-08 | 2002-07-24 | Biofocus Discovery Limited | Methods and compositions for targeting a cell |
| GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| EP1276765B1 (en) * | 2000-04-25 | 2011-06-08 | Washington University | Single-chain fertility hormones with variable lh activity |
| JP2001333772A (ja) * | 2000-04-25 | 2001-12-04 | Washington Univ | 可変性の活性を有する単鎖稔性ホルモン |
| US6987172B2 (en) * | 2001-03-05 | 2006-01-17 | Washington University In St. Louis | Multifunctional single chain glycoprotein hormones comprising three or more β subunits |
| US7081446B2 (en) * | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
| US10105417B2 (en) | 2003-03-04 | 2018-10-23 | Aspenbio Pharma, Inc. | Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone |
| JP4412989B2 (ja) * | 2003-12-15 | 2010-02-10 | 株式会社日立製作所 | 複数の記憶システムを有するデータ処理システム |
| US20080039372A1 (en) * | 2005-07-21 | 2008-02-14 | The Trustees Of Columbia University In The City Of New York | Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation |
| CA2628725A1 (en) | 2005-11-15 | 2007-05-31 | Glycofi, Inc. | Production of glycoproteins with reduced o-glycosylation |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| WO2007092252A2 (en) * | 2006-02-03 | 2007-08-16 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US8048848B2 (en) | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| AU2009249314A1 (en) | 2008-05-20 | 2009-11-26 | Merck Sharp & Dohme Corp. | Efficient production of heterologous proteins using mannosyl transferase inhibitors |
| EP2324121B1 (en) | 2008-08-12 | 2012-11-07 | GlycoFi, Inc. | Improved vectors and yeast strains for protein production: ca2+ atpase overexpression |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| BR112014001274A2 (pt) | 2011-07-18 | 2017-04-18 | Arts Biologics As | composto de hormônio luteinizante, e, composição farmacêutica |
| PE20142405A1 (es) | 2012-04-19 | 2015-01-25 | Opko Biolog Ltd | Variantes de oxintomodulina de accion prolongada y metodos de produccion de las mismas |
| EP2922867B1 (en) | 2012-11-20 | 2021-07-21 | OPKO Biologics Ltd. | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| PH12017501089B1 (en) | 2014-12-10 | 2022-06-22 | Opko Biologics Ltd | Methods of producing long acting ctp-modified growth hormone polypeptides |
| AU2016280867B2 (en) | 2015-06-19 | 2020-02-27 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| KR102618424B1 (ko) | 2016-07-11 | 2023-12-26 | 옵코 바이오로직스 리미티드 | 지속성 응고 인자 vii 및 그 제조 방법 |
| CN106317226B (zh) * | 2016-08-19 | 2017-09-05 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| CN106279436B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 活化的人凝血因子vii融合蛋白及其制备方法与用途 |
| EP3502143A4 (en) | 2016-08-19 | 2020-07-15 | Ampsource Biopharma Shanghai Inc. | BINDING PEPTIDE FOR THE CONSTRUCTION OF A FUSION PROTEIN |
| CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CN106256835A (zh) * | 2016-08-19 | 2016-12-28 | 安源医药科技（上海）有限公司 | 高糖基化人生长激素融合蛋白及其制备方法与用途 |
| CN107827987B (zh) * | 2017-01-04 | 2021-04-27 | 华侨大学 | 一种促黄体激素类似物及其制备方法 |
| CN110950964B (zh) * | 2018-09-26 | 2021-06-18 | 安源医药科技（上海）有限公司 | 突变型单链人凝血因子viii融合蛋白及其制备方法与用途 |
| BR102019004147A2 (pt) | 2019-02-28 | 2020-10-06 | Ouro Fino Saude Animal Participacoes S.A. | Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso |
| CA3140267A1 (en) | 2019-05-16 | 2020-11-19 | Ceva Sante Animale | Compositions and methods for increasing reproduction performance in non-human mammals using recombinant luteinizing hormone |
| EP4021930A1 (en) * | 2019-08-30 | 2022-07-06 | Syntex S.A. | Recombinant chorionic gonadotropin, procedure for preparation, pharmaceutical compositions and uses of the same |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE169334T1 (de) * | 1983-11-02 | 1998-08-15 | Applied Research Systems | Herstellung heterodimirer menschlicher fruchtbarkeitshormone |
| CA1213537A (en) * | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Polypeptide expression method |
| DK0461200T3 (da) * | 1989-02-21 | 1997-03-10 | Univ Washington | Modificerede former af reproduktionshormoner |
| EP0531407B1 (en) * | 1990-05-08 | 2000-02-09 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity |
| FI932477L (fi) * | 1990-12-13 | 1993-06-11 | Immunex Corp | Receptorer foer leukemi-inhiberande faktor |
| ZA942206B (en) * | 1993-04-01 | 1994-10-31 | Amgen Inc | Biologically active polypeptide fusion dimers |
| ATE314392T1 (de) * | 1994-02-18 | 2006-01-15 | Univ Washington | Einzelketten-gonadotropin |
| CA2173750C (en) * | 1994-08-12 | 2011-03-22 | Irving Boime | Single-chain forms of the glycoprotein hormone quartet |
-
1997
- 1997-11-17 US US08/971,439 patent/US6103501A/en not_active Expired - Lifetime
-
1998
- 1998-11-09 CA CA2308571A patent/CA2308571C/en not_active Expired - Fee Related
- 1998-11-09 AU AU13131/99A patent/AU754296B2/en not_active Ceased
- 1998-11-09 CZ CZ20001774A patent/CZ299742B6/cs not_active IP Right Cessation
- 1998-11-09 HU HU0004394A patent/HUP0004394A3/hu unknown
- 1998-11-09 BR BR9814880-0A patent/BR9814880A/pt not_active Application Discontinuation
- 1998-11-09 TR TR2000/01406T patent/TR200001406T2/xx unknown
- 1998-11-09 KR KR1020007005334A patent/KR20010032147A/ko not_active Abandoned
- 1998-11-09 PL PL98342853A patent/PL342853A1/xx not_active IP Right Cessation
- 1998-11-09 DE DE69839779T patent/DE69839779D1/de not_active Expired - Lifetime
- 1998-11-09 IL IL13599598A patent/IL135995A0/xx active IP Right Grant
- 1998-11-09 JP JP2000521213A patent/JP4255618B2/ja not_active Expired - Fee Related
- 1998-11-09 CN CNB988112353A patent/CN1173037C/zh not_active Expired - Fee Related
- 1998-11-09 EP EP98956662A patent/EP1032688B1/en not_active Expired - Lifetime
- 1998-11-09 WO PCT/US1998/023744 patent/WO1999025849A1/en not_active Ceased
-
2000
- 2000-05-05 IL IL135995A patent/IL135995A/en not_active IP Right Cessation
- 2000-05-16 NO NO20002527A patent/NO20002527L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001523465A5 (enExample) | ||
| JP7316905B2 (ja) | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ | |
| US7081446B2 (en) | Long-acting follicle stimulating hormone analogues and uses thereof | |
| TWI388570B (zh) | 包含具有三個官能端的非肽醯聚合物的多肽複合物 | |
| EP2532674B1 (en) | Long-acting polypeptides and methods of producing and administering same | |
| JP4156024B2 (ja) | 修飾されたタンパク質及びペプチド医薬品 | |
| JP2002513556A5 (enExample) | ||
| JP6580104B2 (ja) | 医薬製剤 | |
| WO2015062350A1 (zh) | 一种长效重组促卵泡激素及其应用 | |
| KR101058467B1 (ko) | 부신피질 자극 호르몬 유사체 및 관련 방법 | |
| CA2173750A1 (en) | Single-chain forms of the glycoprotein hormone quartet | |
| JPH074249B2 (ja) | インシユリン受容体 | |
| AU2017431494B2 (en) | Long-acting recombinant porcine fsh fusion protein, and preparation method and application thereof | |
| CN105121459A (zh) | 通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法 | |
| JP6336557B2 (ja) | 医薬製剤 | |
| JP2002533300A5 (enExample) | ||
| Wang et al. | Growth hormone receptor agonists and antagonists: From protein expression and purification to long‐acting formulations | |
| CA2389302A1 (en) | Delivery of proteins across polar epithelial cell layers | |
| JP2003512441A5 (enExample) | ||
| JP2000509603A (ja) | 糖タンパク質ホルモンスーパーアゴニスト | |
| JPH09157294A (ja) | 副甲状腺ホルモン誘導体 | |
| JP2003521223A5 (enExample) | ||
| CN102949731A (zh) | 与glp-2受体特异性结合的药物融合体 | |
| WO2000050071A1 (fr) | PROTEINE OmpA DE KLEBSIELLA PNEUMONIAE ASSOCIEE A L'HORMONE HCG OU A UN COMPOSE IMPLIQUE DANS LA PROLIFERATION DE CELLULES TUMORALES OU DANS LA FERTILITE | |
| KR20170100936A (ko) | G 단백질 연결 수용체 폴리펩타이드 리간드의 지속형 결합체 및 이의 제조방법 |