JP2003512441A5 - - Google Patents

Info

Publication number

JP2003512441A5

JP2003512441A5 JP2001532809A JP2001532809A JP2003512441A5 JP 2003512441 A5 JP2003512441 A5 JP 2003512441A5 JP 2001532809 A JP2001532809 A JP 2001532809A JP 2001532809 A JP2001532809 A JP 2001532809A JP 2003512441 A5 JP2003512441 A5 JP 2003512441A5

Authority

JP

Japan

Prior art keywords

protein drug

mucosa

activity

domain

pseudomonas exotoxin

Prior art date

2000-10-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
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• 102000004169 proteins and genes Human genes 0.000 claims 36
• 108090000623 proteins and genes Proteins 0.000 claims 36
• 229940079593 drug Drugs 0.000 claims 32
• 239000003814 drug Substances 0.000 claims 32
• 230000000694 effects Effects 0.000 claims 24
• 210000004877 mucosa Anatomy 0.000 claims 23
• 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims 19
• 238000000034 method Methods 0.000 claims 14
• 102000005962 receptors Human genes 0.000 claims 13
• 108020003175 receptors Proteins 0.000 claims 13
• 108091005804 Peptidases Proteins 0.000 claims 11
• 239000004365 Protease Substances 0.000 claims 11
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 11
• 230000005859 cell recognition Effects 0.000 claims 11
• 241000124008 Mammalia Species 0.000 claims 10
• 238000003776 cleavage reaction Methods 0.000 claims 9
• 230000007017 scission Effects 0.000 claims 9
• 230000005730 ADP ribosylation Effects 0.000 claims 8
• 150000001413 amino acids Chemical group 0.000 claims 6
• 102000004190 Enzymes Human genes 0.000 claims 5
• 108090000790 Enzymes Proteins 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 230000009885 systemic effect Effects 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 102000004127 Cytokines Human genes 0.000 claims 4
• 108090000695 Cytokines Proteins 0.000 claims 4
• 102000015696 Interleukins Human genes 0.000 claims 4
• 108010063738 Interleukins Proteins 0.000 claims 4
• 230000027455 binding Effects 0.000 claims 4
• 230000004071 biological effect Effects 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 4
• 230000002163 immunogen Effects 0.000 claims 4
• 239000002773 nucleotide Substances 0.000 claims 4
• 125000003729 nucleotide group Chemical group 0.000 claims 4
• 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 4
• 230000005062 synaptic transmission Effects 0.000 claims 4
• 230000007704 transition Effects 0.000 claims 4
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 108020001507 fusion proteins Proteins 0.000 claims 2
• 102000037865 fusion proteins Human genes 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 210000004876 tela submucosa Anatomy 0.000 claims 2
• 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
• 102000052510 DNA-Binding Proteins Human genes 0.000 claims 1
• 108700020911 DNA-Binding Proteins Proteins 0.000 claims 1
• 102000003951 Erythropoietin Human genes 0.000 claims 1
• 108090000394 Erythropoietin Proteins 0.000 claims 1
• 102000018997 Growth Hormone Human genes 0.000 claims 1
• 108010051696 Growth Hormone Proteins 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 102000014150 Interferons Human genes 0.000 claims 1
• 108010050904 Interferons Proteins 0.000 claims 1
• 102000004856 Lectins Human genes 0.000 claims 1
• 108090001090 Lectins Proteins 0.000 claims 1
• 230000000975 bioactive effect Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229940105423 erythropoietin Drugs 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 210000004392 genitalia Anatomy 0.000 claims 1
• 239000000122 growth hormone Substances 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 229940079322 interferon Drugs 0.000 claims 1
• 239000002523 lectin Substances 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 102000019758 lipid binding proteins Human genes 0.000 claims 1
• 108091016323 lipid binding proteins Proteins 0.000 claims 1
• 102000006240 membrane receptors Human genes 0.000 claims 1
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1