JP2020508691A5 - - Google Patents
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- JP2020508691A5 JP2020508691A5 JP2019548419A JP2019548419A JP2020508691A5 JP 2020508691 A5 JP2020508691 A5 JP 2020508691A5 JP 2019548419 A JP2019548419 A JP 2019548419A JP 2019548419 A JP2019548419 A JP 2019548419A JP 2020508691 A5 JP2020508691 A5 JP 2020508691A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- soluble
- fusion protein
- protein complex
- 15rαsu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020001507 fusion proteins Proteins 0.000 claims description 75
- 102000037865 fusion proteins Human genes 0.000 claims description 75
- 108090000623 proteins and genes Proteins 0.000 claims description 70
- 102000004169 proteins and genes Human genes 0.000 claims description 70
- 108090000172 Interleukin-15 Proteins 0.000 claims description 44
- 102000003812 Interleukin-15 Human genes 0.000 claims description 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108060003951 Immunoglobulin Proteins 0.000 claims description 14
- 239000012634 fragment Substances 0.000 claims description 14
- 102000018358 immunoglobulin Human genes 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 108010017535 Interleukin-15 Receptors Proteins 0.000 claims description 7
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- 208000035473 Communicable disease Diseases 0.000 claims description 5
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- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 3
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- 108091008036 Immune checkpoint proteins Proteins 0.000 claims description 2
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
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- 108020004705 Codon Proteins 0.000 description 1
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- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
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- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
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- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
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- 210000003651 basophil Anatomy 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
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- 230000002489 hematologic effect Effects 0.000 description 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022194613A JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762467623P | 2017-03-06 | 2017-03-06 | |
| US62/467,623 | 2017-03-06 | ||
| PCT/US2018/021220 WO2018165208A1 (en) | 2017-03-06 | 2018-03-06 | Il-15-based fusions to il-12 and il-18 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194613A Division JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508691A JP2020508691A (ja) | 2020-03-26 |
| JP2020508691A5 true JP2020508691A5 (enExample) | 2021-04-15 |
| JP7191030B2 JP7191030B2 (ja) | 2022-12-16 |
Family
ID=63448011
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548419A Active JP7191030B2 (ja) | 2017-03-06 | 2018-03-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2022194613A Pending JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A Active JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194613A Pending JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A Active JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US11129883B2 (enExample) |
| EP (1) | EP3592778A4 (enExample) |
| JP (3) | JP7191030B2 (enExample) |
| KR (4) | KR102625293B1 (enExample) |
| CN (2) | CN110785435B (enExample) |
| AU (1) | AU2018231170B2 (enExample) |
| CA (2) | CA3055318C (enExample) |
| WO (1) | WO2018165208A1 (enExample) |
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| EP2388266B1 (en) * | 2007-05-11 | 2014-04-23 | Altor BioScience Corporation | Fusion molecules and IL-15 variants |
| KR102625293B1 (ko) * | 2017-03-06 | 2024-01-15 | 알토 바이오사이언스 엘엘씨 | Il-12 및 il-18로의 il-15-기반 융합 |
| CN107384859A (zh) * | 2017-09-05 | 2017-11-24 | 四川新生命干细胞科技股份有限公司 | 一种高纯度nk细胞的分离培养方法 |
| JP7795181B2 (ja) | 2017-09-06 | 2026-01-07 | イェール ユニバーシティー | インターロイキン－１８バリアントとその利用法 |
| CN119876019A (zh) * | 2018-03-01 | 2025-04-25 | 格雷戈里奥马拉尼翁医院生物医学研究基金会 | 获得源自胸腺组织的调节性t细胞的方法及所述细胞作为细胞免疫疗法在免疫系统失调中的用途 |
| WO2020023713A1 (en) * | 2018-07-26 | 2020-01-30 | Nantbio, Inc. | Tri-cytokine txm compositions and methods |
| CN112996805A (zh) * | 2018-08-30 | 2021-06-18 | Hcw生物科技公司 | 多链嵌合多肽和其用途 |
| CA3109139A1 (en) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
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| WO2020051363A1 (en) * | 2018-09-07 | 2020-03-12 | Nantbio, Inc. | Targeted il-12 treatments and methods to stimulate hank and nk92mi cells |
| AU2020294797B2 (en) * | 2019-06-21 | 2025-12-18 | Immunitybio, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CA3117134A1 (en) * | 2019-07-08 | 2021-01-14 | Nantkwest, Inc. | Ciml nk cells and methods therefor |
| CN113166726A (zh) | 2019-07-08 | 2021-07-23 | 南克维斯特公司 | 单核细胞源性nk细胞 |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| US20210008107A1 (en) * | 2019-07-08 | 2021-01-14 | Nantkwest, Inc. | CIML NK cells and Methods Therefor |
| WO2021044439A1 (en) * | 2019-09-08 | 2021-03-11 | Immunoadaptive Cell Therapy Pvt Ltd. | Inducible cytokine signals & methods for immunotherapy |
| RU2753282C2 (ru) * | 2019-09-19 | 2021-08-12 | Закрытое Акционерное Общество "Биокад" | ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ |
| EP4037700A2 (en) * | 2019-10-03 | 2022-08-10 | Xencor, Inc. | Targeted il-12 heterodimeric fc-fusion proteins |
| WO2021097227A1 (en) * | 2019-11-14 | 2021-05-20 | Altor Bioscience, Llc | Il-15 fusion protein enhanced adoptive cell therapeutics |
| KR102400884B1 (ko) * | 2019-11-15 | 2022-05-23 | 주식회사 제넥신 | 변형된 인터루킨-7 및 인터루킨-2를 포함하는 융합단백질 및 이의 용도 |
| WO2021163299A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Chromatography resin and uses thereof |
| CA3169243A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| CN116670163A (zh) | 2020-02-11 | 2023-08-29 | Hcw生物科技公司 | 治疗年龄相关疾病和炎性疾病的方法 |
| AU2021262794B2 (en) | 2020-04-29 | 2026-06-18 | Immunitybio, Inc. | Anti-CD26 proteins and uses thereof |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| GB202102049D0 (en) * | 2021-02-13 | 2021-03-31 | Psioxus Therapeutics Ltd | Viruses |
| US20240228964A9 (en) * | 2021-03-03 | 2024-07-11 | Immunitybio, Inc. | Highly Potent M-CENK Cells And Methods |
| EP4351320A1 (en) | 2021-06-09 | 2024-04-17 | ImmunityBio, Inc. | Methods and systems for producing a protein of interest in a plant |
| CN114853899B (zh) * | 2021-11-02 | 2024-05-28 | 北京华奥玄德生物医药科技有限公司 | 一种il-12和il-18变体的融合蛋白及其制备方法和用途 |
| US12594323B2 (en) | 2022-04-13 | 2026-04-07 | Immunitybio, Inc. | Methods of reducing neuroinflammation |
| US20240150422A1 (en) * | 2022-07-18 | 2024-05-09 | Onko-Innate Pty Ltd | Il-12 fc fusion proteins and uses thereof |
| US20260048099A1 (en) * | 2022-08-16 | 2026-02-19 | The United States Of America, As Represented By The Secretary, Deparment Of Health And Human Service | Synergistic interactions for improved cancer treatment |
| US20240327484A1 (en) * | 2023-03-31 | 2024-10-03 | Immunitybio, Inc. | Il-12/il-18 superkines |
| JP2026524303A (ja) * | 2023-06-14 | 2026-07-22 | フューズ バイオセラピューティクス インコーポレイテッド | 単一及び複数サイトカイン融合タンパク質、並びにその使用 |
| WO2025068413A1 (en) * | 2023-09-28 | 2025-04-03 | Prokarium Limited | Interleukin 18 variants |
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| MX2019004681A (es) * | 2016-10-21 | 2019-10-07 | Altor Bioscience Corp | Moleculas basadas en il-15 multimericas. |
| KR102625293B1 (ko) | 2017-03-06 | 2024-01-15 | 알토 바이오사이언스 엘엘씨 | Il-12 및 il-18로의 il-15-기반 융합 |
| US20190048055A1 (en) | 2017-03-31 | 2019-02-14 | Altor Bioscience Corporation | Alt-803 in combination with anti-cd38 antibody for cancer therapies |
| JP2020533971A (ja) | 2017-08-28 | 2020-11-26 | アルター・バイオサイエンス・コーポレーション | Ｉｌ−１５をベースとするｉｌ−７及びｉｌ−２１への融合物 |
| US11168138B2 (en) | 2018-03-26 | 2021-11-09 | Altor Bioscience, Llc | Anti-PDL1, IL-15 and TGF-beta receptor combination molecules |
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2018
- 2018-03-06 KR KR1020197029313A patent/KR102625293B1/ko active Active
- 2018-03-06 WO PCT/US2018/021220 patent/WO2018165208A1/en not_active Ceased
- 2018-03-06 KR KR1020257032318A patent/KR20250150164A/ko active Pending
- 2018-03-06 US US15/913,837 patent/US11129883B2/en active Active
- 2018-03-06 EP EP18764359.8A patent/EP3592778A4/en active Pending
- 2018-03-06 JP JP2019548419A patent/JP7191030B2/ja active Active
- 2018-03-06 CA CA3055318A patent/CA3055318C/en active Active
- 2018-03-06 CN CN201880016721.8A patent/CN110785435B/zh active Active
- 2018-03-06 AU AU2018231170A patent/AU2018231170B2/en active Active
- 2018-03-06 CN CN202311813891.8A patent/CN117986384A/zh active Pending
- 2018-03-06 KR KR1020237042270A patent/KR102739572B1/ko active Active
- 2018-03-06 KR KR1020247039400A patent/KR102867975B1/ko active Active
- 2018-03-06 CA CA3216726A patent/CA3216726C/en active Active
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2021
- 2021-09-27 US US17/486,683 patent/US11571470B2/en active Active
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2022
- 2022-08-19 US US17/820,980 patent/US11612645B2/en active Active
- 2022-12-06 JP JP2022194613A patent/JP2023027174A/ja active Pending
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2023
- 2023-02-13 US US18/168,428 patent/US11872272B2/en active Active
- 2023-12-01 US US18/526,598 patent/US11975059B2/en active Active
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2024
- 2024-03-20 US US18/611,464 patent/US20240252609A1/en not_active Abandoned
- 2024-05-21 JP JP2024082540A patent/JP7720950B2/ja active Active
- 2024-09-25 US US18/896,286 patent/US12233116B2/en active Active
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2025
- 2025-01-15 US US19/021,639 patent/US20250152686A1/en active Pending
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