JP2020508691A5 - - Google Patents
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- JP2020508691A5 JP2020508691A5 JP2019548419A JP2019548419A JP2020508691A5 JP 2020508691 A5 JP2020508691 A5 JP 2020508691A5 JP 2019548419 A JP2019548419 A JP 2019548419A JP 2019548419 A JP2019548419 A JP 2019548419A JP 2020508691 A5 JP2020508691 A5 JP 2020508691A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- soluble
- fusion protein
- protein complex
- 15rαsu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020001507 fusion proteins Proteins 0.000 claims description 75
- 102000037865 fusion proteins Human genes 0.000 claims description 75
- 108090000623 proteins and genes Proteins 0.000 claims description 70
- 102000004169 proteins and genes Human genes 0.000 claims description 70
- 108090000172 Interleukin-15 Proteins 0.000 claims description 44
- 102000003812 Interleukin-15 Human genes 0.000 claims description 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108060003951 Immunoglobulin Proteins 0.000 claims description 14
- 239000012634 fragment Substances 0.000 claims description 14
- 102000018358 immunoglobulin Human genes 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
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- 108091007433 antigens Proteins 0.000 claims description 4
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- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
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- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
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- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022194613A JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762467623P | 2017-03-06 | 2017-03-06 | |
| US62/467,623 | 2017-03-06 | ||
| PCT/US2018/021220 WO2018165208A1 (en) | 2017-03-06 | 2018-03-06 | Il-15-based fusions to il-12 and il-18 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194613A Division JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508691A JP2020508691A (ja) | 2020-03-26 |
| JP2020508691A5 true JP2020508691A5 (enExample) | 2021-04-15 |
| JP7191030B2 JP7191030B2 (ja) | 2022-12-16 |
Family
ID=63448011
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548419A Active JP7191030B2 (ja) | 2017-03-06 | 2018-03-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2022194613A Pending JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A Active JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194613A Pending JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A Active JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US11129883B2 (enExample) |
| EP (1) | EP3592778A4 (enExample) |
| JP (3) | JP7191030B2 (enExample) |
| KR (4) | KR102867975B1 (enExample) |
| CN (2) | CN110785435B (enExample) |
| AU (1) | AU2018231170B2 (enExample) |
| CA (2) | CA3216726C (enExample) |
| WO (1) | WO2018165208A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2160401T3 (da) * | 2007-05-11 | 2014-10-20 | Altor Bioscience Corp | Fusionsmolekyler og il-15-varianter |
| EP3592778A4 (en) | 2017-03-06 | 2021-01-13 | Altor BioScience Corporation | IL-15-BASED FUSIONS TO IL-12 AND IL-18 |
| CN107384859A (zh) * | 2017-09-05 | 2017-11-24 | 四川新生命干细胞科技股份有限公司 | 一种高纯度nk细胞的分离培养方法 |
| US20190070262A1 (en) | 2017-09-06 | 2019-03-07 | Yale University | Interleukin-18 variants and methods of use |
| AU2019226392B2 (en) * | 2018-03-01 | 2025-02-27 | Fundación Para La Investigación Biomédica Del Hospital Gregorio Marañón | Method for obtaining regulatory T cells derived from thymic tissue and use of said cells as cell immunotherapy in immune system disorders |
| WO2020023713A1 (en) * | 2018-07-26 | 2020-01-30 | Nantbio, Inc. | Tri-cytokine txm compositions and methods |
| CN120535649A (zh) | 2018-08-30 | 2025-08-26 | 免疫生物公司 | 单链嵌合多肽和其用途 |
| AU2019328575B2 (en) | 2018-08-30 | 2024-07-11 | Immunitybio, Inc. | Single-chain and multi-chain chimeric polypeptides and uses thereof |
| JP7397874B2 (ja) | 2018-08-30 | 2023-12-13 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 多鎖キメラポリペプチドおよびその使用 |
| EP4744730A2 (en) * | 2018-09-07 | 2026-05-20 | Nantbio Inc | TARGETED IL-12 THERAPIES AND METHODS FOR STIMULATING HANK AND NK92MI CELLS |
| WO2020257639A1 (en) * | 2019-06-21 | 2020-12-24 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CN113166726A (zh) | 2019-07-08 | 2021-07-23 | 南克维斯特公司 | 单核细胞源性nk细胞 |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| CN113195706A (zh) * | 2019-07-08 | 2021-07-30 | 南克维斯特公司 | Ciml nk细胞及其方法 |
| US20210008107A1 (en) * | 2019-07-08 | 2021-01-14 | Nantkwest, Inc. | CIML NK cells and Methods Therefor |
| WO2021044439A1 (en) * | 2019-09-08 | 2021-03-11 | Immunoadaptive Cell Therapy Pvt Ltd. | Inducible cytokine signals & methods for immunotherapy |
| RU2753282C2 (ru) * | 2019-09-19 | 2021-08-12 | Закрытое Акционерное Общество "Биокад" | ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ |
| WO2021067863A2 (en) * | 2019-10-03 | 2021-04-08 | Xencor, Inc. | Targeted il-12 heterodimeric fc-fusion proteins |
| WO2021097227A1 (en) * | 2019-11-14 | 2021-05-20 | Altor Bioscience, Llc | Il-15 fusion protein enhanced adoptive cell therapeutics |
| KR102400884B1 (ko) * | 2019-11-15 | 2022-05-23 | 주식회사 제넥신 | 변형된 인터루킨-7 및 인터루킨-2를 포함하는 융합단백질 및 이의 용도 |
| US12187763B2 (en) | 2020-02-11 | 2025-01-07 | Immunitybio, Inc. | Chromatography resin and uses thereof |
| CA3169231A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of treating age-related and inflammatory diseases |
| AU2021220196A1 (en) | 2020-02-11 | 2022-08-04 | HCW Biologics, Inc. | Methods of activating regulatory T cells |
| CN115836087A (zh) | 2020-04-29 | 2023-03-21 | Hcw生物科技公司 | 抗cd26蛋白及其用途 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| GB202102049D0 (en) * | 2021-02-13 | 2021-03-31 | Psioxus Therapeutics Ltd | Viruses |
| EP4301846A4 (en) * | 2021-03-03 | 2025-03-05 | ImmunityBio, Inc. | HIGHLY EFFECTIVE M-CENK CELLS AND METHODS |
| EP4351320A1 (en) | 2021-06-09 | 2024-04-17 | ImmunityBio, Inc. | Methods and systems for producing a protein of interest in a plant |
| CN114853899B (zh) * | 2021-11-02 | 2024-05-28 | 北京华奥玄德生物医药科技有限公司 | 一种il-12和il-18变体的融合蛋白及其制备方法和用途 |
| CN119384289A (zh) | 2022-04-13 | 2025-01-28 | 免疫生物公司 | 用于治疗神经炎症性障碍的多链嵌合多肽 |
| US20260048099A1 (en) * | 2022-08-16 | 2026-02-19 | The United States Of America, As Represented By The Secretary, Deparment Of Health And Human Service | Synergistic interactions for improved cancer treatment |
| EP4688819A1 (en) * | 2023-03-31 | 2026-02-11 | ImmunityBio, Inc. | Il-12/il-18 superkines |
| EP4727962A2 (en) * | 2023-06-14 | 2026-04-22 | Fuse Biotherapeutics Inc. | Single-and multi-cytokine fusion proteins and uses thereof |
| WO2025068413A1 (en) * | 2023-09-28 | 2025-04-03 | Prokarium Limited | Interleukin 18 variants |
| WO2025184052A1 (en) * | 2024-02-26 | 2025-09-04 | Allegheny Singer Research Institute | Interleukin 2 and interleukin 12 fusion proteins and methods of using |
| WO2026024752A1 (en) | 2024-07-23 | 2026-01-29 | Immunitybio, Inc. | Compositions and methods related to potent cytotoxic m-cenk cells from cd3/cd14-depleted apheresis products |
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| KR100897938B1 (ko) * | 2007-05-30 | 2009-05-18 | 주식회사 제넥신 | 면역글로불린 융합 단백질 |
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| EP2619229B1 (en) | 2010-09-21 | 2016-04-06 | Altor BioScience Corporation | Multimeric il-15 soluble fusion molecules and methods of making and using same |
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| CA2850575C (en) | 2011-10-11 | 2020-12-15 | Universitat Zurich Prorektorat Mnw | Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy |
| KR102503476B1 (ko) * | 2014-06-30 | 2023-02-24 | 알토 바이오사이언스 코포레이션 | Il-15-베이즈드 분자 및 이의 사용 방법 |
| KR102392142B1 (ko) * | 2016-10-21 | 2022-04-28 | 알토 바이오사이언스 코포레이션 | 다량체 il-15 기반 분자 |
| EP3592778A4 (en) | 2017-03-06 | 2021-01-13 | Altor BioScience Corporation | IL-15-BASED FUSIONS TO IL-12 AND IL-18 |
| US20190048055A1 (en) | 2017-03-31 | 2019-02-14 | Altor Bioscience Corporation | Alt-803 in combination with anti-cd38 antibody for cancer therapies |
| KR20200090742A (ko) | 2017-08-28 | 2020-07-29 | 알토 바이오사이언스 엘엘씨 | Il-7 및 il-21에의 il-15 기반 융합 |
| US11168138B2 (en) | 2018-03-26 | 2021-11-09 | Altor Bioscience, Llc | Anti-PDL1, IL-15 and TGF-beta receptor combination molecules |
-
2018
- 2018-03-06 EP EP18764359.8A patent/EP3592778A4/en active Pending
- 2018-03-06 AU AU2018231170A patent/AU2018231170B2/en active Active
- 2018-03-06 KR KR1020247039400A patent/KR102867975B1/ko active Active
- 2018-03-06 JP JP2019548419A patent/JP7191030B2/ja active Active
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- 2018-03-06 WO PCT/US2018/021220 patent/WO2018165208A1/en not_active Ceased
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