JP2001521890A5 - - Google Patents
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- Publication number
- JP2001521890A5 JP2001521890A5 JP2000518655A JP2000518655A JP2001521890A5 JP 2001521890 A5 JP2001521890 A5 JP 2001521890A5 JP 2000518655 A JP2000518655 A JP 2000518655A JP 2000518655 A JP2000518655 A JP 2000518655A JP 2001521890 A5 JP2001521890 A5 JP 2001521890A5
- Authority
- JP
- Japan
- Prior art keywords
- crosslinking agent
- polymer
- pharmaceutical composition
- agent
- monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003431 cross linking reagent Substances 0.000 description 12
- 239000000178 monomer Substances 0.000 description 11
- 229920000642 polymer Polymers 0.000 description 10
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- 229920001577 copolymer Polymers 0.000 description 4
- DYUWTXWIYMHBQS-UHFFFAOYSA-N n-prop-2-enylprop-2-en-1-amine Chemical compound C=CCNCC=C DYUWTXWIYMHBQS-UHFFFAOYSA-N 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 2
- 239000003833 bile salt Substances 0.000 description 2
- 229940093761 bile salts Drugs 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- VPYJNCGUESNPMV-UHFFFAOYSA-N triallylamine Chemical compound C=CCN(CC=C)CC=C VPYJNCGUESNPMV-UHFFFAOYSA-N 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/964,536 | 1997-11-05 | ||
| US08/964,536 US6083497A (en) | 1997-11-05 | 1997-11-05 | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
| PCT/US1998/022605 WO1999022721A2 (en) | 1997-11-05 | 1998-10-26 | Unsubstituted polydiallylamine for treating hypercholesterolemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001521890A JP2001521890A (ja) | 2001-11-13 |
| JP2001521890A5 true JP2001521890A5 (enExample) | 2006-01-05 |
| JP4649039B2 JP4649039B2 (ja) | 2011-03-09 |
Family
ID=25508662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000518655A Expired - Lifetime JP4649039B2 (ja) | 1997-11-05 | 1998-10-26 | 非置換ポリジアリルアミンを用いる高コレステロール血症の治療方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (6) | US6083497A (enExample) |
| EP (1) | EP1028717B1 (enExample) |
| JP (1) | JP4649039B2 (enExample) |
| KR (1) | KR20010031822A (enExample) |
| CN (1) | CN1278180A (enExample) |
| AR (1) | AR013742A1 (enExample) |
| AT (1) | ATE235236T1 (enExample) |
| AU (1) | AU746876B2 (enExample) |
| BR (1) | BR9813961A (enExample) |
| CA (1) | CA2309027C (enExample) |
| DE (1) | DE69812681T2 (enExample) |
| ES (1) | ES2196625T3 (enExample) |
| HU (1) | HUP0004279A3 (enExample) |
| IL (1) | IL135858A0 (enExample) |
| NO (1) | NO20002172L (enExample) |
| NZ (1) | NZ504216A (enExample) |
| PL (1) | PL340296A1 (enExample) |
| TW (1) | TW453878B (enExample) |
| WO (1) | WO1999022721A2 (enExample) |
| ZA (1) | ZA989673B (enExample) |
Families Citing this family (58)
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| AU778262B2 (en) * | 1999-10-19 | 2004-11-25 | Genzyme Corporation | Direct compression polymer tablet core |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
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| FI113613B (fi) * | 1999-11-24 | 2004-05-31 | Eritocap Oy | Elintarvikekoostumukset ja menetelmiä niiden valmistamiseksi |
| KR20040018359A (ko) | 2001-04-18 | 2004-03-03 | 젠자임 코포레이션 | 지방족 폴리아민으로 x 증후군을 치료하는 방법 |
| BR0209020A (pt) * | 2001-04-18 | 2004-08-10 | Genzyme Corp | Composição farmacêutica de polialilamina |
| ES2637020T3 (es) * | 2001-04-18 | 2017-10-10 | Genzyme Corporation | Uso de polímero de amina para reducir la glucosa sérica |
| WO2002085380A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for treating gout and reducing serum uric acid |
| EP1923064B1 (en) | 2001-04-18 | 2017-06-28 | Genzyme Corporation | Use of amine polymer for lowering serum glucose |
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| AT412473B (de) | 2003-01-15 | 2005-03-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur kontinuierlichen trocknung von n- bzw. amino-, ammonium- oder spirobicyclische ammoniumgruppen haltigen polymeren |
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| US20070014866A1 (en) * | 2005-07-15 | 2007-01-18 | Curt Hendrix | Composition for improving the efficacy and reducing the side effects of omega 3 fatty acids, fish oils and cardiovascular and diabetic treatments |
| JP2009507019A (ja) * | 2005-09-02 | 2009-02-19 | ジェンザイム・コーポレーション | リン酸塩を除去する方法およびそれに使用される重合体 |
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| KR101547925B1 (ko) * | 2005-09-15 | 2015-08-27 | 젠자임 코포레이션 | 아민 중합체에 대한 샤셋 제형 |
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| JP2011506449A (ja) * | 2007-12-14 | 2011-03-03 | ジェンザイム コーポレーション | コーティング医薬組成物 |
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| CA2790901C (en) * | 2010-02-24 | 2018-05-01 | Relypsa, Inc. | Amine polymers for use as bile acid sequestrants |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| CN102993348B (zh) * | 2011-09-09 | 2014-11-12 | 北大方正集团有限公司 | 一种烟酸司维拉姆及其制备方法和用途 |
| CN103012789B (zh) * | 2011-09-23 | 2015-02-25 | 北大方正集团有限公司 | 烟酸司维拉姆的制备方法 |
| EA030839B1 (ru) | 2011-10-28 | 2018-10-31 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей |
| WO2013063526A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| CN103030713A (zh) * | 2012-12-21 | 2013-04-10 | 江南大学 | 一种具有降血脂活性的低分子量葡聚糖-烟酸聚合物的制备方法 |
| MA41202A (fr) * | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| US10245284B2 (en) | 2015-08-19 | 2019-04-02 | Alpex Pharma S.A. | Granular composition for oral administration |
| CN119730861A (zh) * | 2022-08-22 | 2025-03-28 | 中美华世通生物医药科技(武汉)股份有限公司 | 铵盐聚合物及其制备方法和作为胆汁酸螯合剂的用途 |
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| US5556619A (en) | 1992-08-20 | 1996-09-17 | The Du Pont Merck Pharmaceutical Company | Crosslinked polymeric ammonium salts |
| US5310949A (en) | 1992-09-02 | 1994-05-10 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5274155A (en) | 1992-12-07 | 1993-12-28 | E. R. Squibb & Sons, Inc. | Intramolecular arbuzov process for the preparation of intermediates useful in the preparation of phosphorus containing HMG-COA reductase inhibitors |
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| US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| JP3498853B2 (ja) | 1993-09-27 | 2004-02-23 | 小野薬品工業株式会社 | ビフェニル誘導体 |
| MX9602812A (es) | 1994-01-18 | 1997-06-28 | Du Pont | Sales de amonio polimericas, reticuladas. |
| US5414068A (en) * | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
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-
1997
- 1997-11-05 US US08/964,536 patent/US6083497A/en not_active Expired - Lifetime
-
1998
- 1998-03-11 AR ARP980105512A patent/AR013742A1/es not_active Application Discontinuation
- 1998-10-23 ZA ZA989673A patent/ZA989673B/xx unknown
- 1998-10-26 CN CN98810752A patent/CN1278180A/zh active Pending
- 1998-10-26 KR KR1020007004892A patent/KR20010031822A/ko not_active Withdrawn
- 1998-10-26 CA CA002309027A patent/CA2309027C/en not_active Expired - Lifetime
- 1998-10-26 JP JP2000518655A patent/JP4649039B2/ja not_active Expired - Lifetime
- 1998-10-26 EP EP98957370A patent/EP1028717B1/en not_active Expired - Lifetime
- 1998-10-26 AT AT98957370T patent/ATE235236T1/de active
- 1998-10-26 DE DE69812681T patent/DE69812681T2/de not_active Expired - Lifetime
- 1998-10-26 WO PCT/US1998/022605 patent/WO1999022721A2/en not_active Ceased
- 1998-10-26 AU AU13646/99A patent/AU746876B2/en not_active Expired
- 1998-10-26 BR BR9813961-4A patent/BR9813961A/pt not_active Application Discontinuation
- 1998-10-26 PL PL98340296A patent/PL340296A1/xx unknown
- 1998-10-26 NZ NZ504216A patent/NZ504216A/xx not_active IP Right Cessation
- 1998-10-26 IL IL13585898A patent/IL135858A0/xx unknown
- 1998-10-26 ES ES98957370T patent/ES2196625T3/es not_active Expired - Lifetime
- 1998-10-26 HU HU0004279A patent/HUP0004279A3/hu unknown
- 1998-11-03 TW TW087118239A patent/TW453878B/zh not_active IP Right Cessation
-
1999
- 1999-05-13 US US09/311,103 patent/US6365186B1/en not_active Expired - Lifetime
- 1999-05-13 US US09/311,402 patent/US6264938B1/en not_active Expired - Lifetime
-
2000
- 2000-03-09 US US09/521,975 patent/US6248318B1/en not_active Expired - Lifetime
- 2000-04-27 NO NO20002172A patent/NO20002172L/no not_active Application Discontinuation
-
2001
- 2001-12-19 US US10/025,184 patent/US7638524B2/en not_active Expired - Fee Related
-
2009
- 2009-11-09 US US12/590,511 patent/US20100266526A1/en not_active Abandoned
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