JP2001517248A - β−ラクタム抗生物質の製造で有用なアミノチアゾール誘導体 - Google Patents
β−ラクタム抗生物質の製造で有用なアミノチアゾール誘導体Info
- Publication number
- JP2001517248A JP2001517248A JP52524899A JP52524899A JP2001517248A JP 2001517248 A JP2001517248 A JP 2001517248A JP 52524899 A JP52524899 A JP 52524899A JP 52524899 A JP52524899 A JP 52524899A JP 2001517248 A JP2001517248 A JP 2001517248A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- group
- lactam antibiotics
- formula
- lactam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.式 式中: Xはハロゲン、C1−C4アルキルであり; Hetは、それ自体かもしくはベンゼン環と縮合された、N、S、Oから構成さ れる群から選ばれる最低1個のヘテロ原子を環中に有する5もしくは6項のヘテ ロ環であり; Rは、H、C1−C4アルキル、その酸官能基が遊離、塩化もしくはエステル化さ れている−CH2−COOHもしくはC(CH3)2−COOH、 である、 のアミノチアゾール誘導体。 2.XがClである、請求の範囲1に記載の誘導体。 3.Rが、トリチル(Tr)、テトラヒドロピラニル(THP)、tert−ブチル ジメチルシリル(TBDMS)、トリメチルシリル(TMS)およびメトキシメ チル(MOM)から成る群のなかから選ばれる、請求の範囲1および2に記載の 誘導体。 4.Hetがから成る群のなかから選ばれる、請求の範囲1から3までに記載の誘導体。 5.それに従って式(I)の誘導体が有機溶媒の存在下に−30℃と+80℃との間 の温度でβ−ラクタム核と縮合される、β−ラクタム抗生物質の製造方法。 6.前記溶媒が、ジクロロメタン、酢酸エチル、ジメチルホルムアミド、ジメチ ルアセトアミド、N−メチル−2−ピロリドン、アセトン、ジメチルスルホキシ ド、メタノール、エタノール、イソプロパノールおよびスルホランを含む群のな かから選ばれる、請求の範囲5に記載の方法。 7.前記縮合が−5℃と+40℃との間の温度で実施される、請求の範囲5および 6に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI002439A IT1295935B1 (it) | 1997-10-30 | 1997-10-30 | Derivati aminotiazolici utili nella preparazione di antibiotici b -lattamici |
IT97A002439 | 1997-10-30 | ||
PCT/EP1997/006654 WO1999023082A1 (en) | 1997-10-30 | 1997-11-28 | AMINOTHIAZOLE DERIVATIVES USEFUL IN THE PREPARATION OF β-LACTAM ANTIBIOTICS |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001517248A true JP2001517248A (ja) | 2001-10-02 |
Family
ID=11378130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52524899A Ceased JP2001517248A (ja) | 1997-10-30 | 1997-11-28 | β−ラクタム抗生物質の製造で有用なアミノチアゾール誘導体 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6255480B1 (ja) |
EP (1) | EP0948491B1 (ja) |
JP (1) | JP2001517248A (ja) |
AT (1) | ATE258169T1 (ja) |
AU (1) | AU5558198A (ja) |
DE (1) | DE69727315T2 (ja) |
DK (1) | DK0948491T3 (ja) |
ES (1) | ES2213229T3 (ja) |
IT (1) | IT1295935B1 (ja) |
PT (1) | PT948491E (ja) |
WO (1) | WO1999023082A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100448856C (zh) * | 2006-06-26 | 2009-01-07 | 山东金城医药化工股份有限公司 | 一种催化合成ae-活性酯的工艺 |
CN103012312B (zh) * | 2012-12-04 | 2015-05-06 | 山东鑫泉医药有限公司 | 氨噻肟酸生产废水回用的方法 |
CN103588790A (zh) * | 2013-11-29 | 2014-02-19 | 中国科学院长春应用化学研究所 | 7-氨基-3-氯-3-头孢-4-羧酸-对硝基苄基酯的制备方法 |
CN103588789A (zh) * | 2013-11-29 | 2014-02-19 | 中国科学院长春应用化学研究所 | 7-氨基-3-氯-3-头孢-4-羧酸的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2758001A1 (de) * | 1977-12-24 | 1979-07-12 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
US4703046A (en) * | 1978-09-08 | 1987-10-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and processes for preparation thereof |
EP0037380B1 (en) * | 1980-03-28 | 1984-09-12 | BIOCHEMIE Gesellschaft m.b.H. | New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production |
DE3177090D1 (en) | 1980-12-31 | 1989-09-28 | Fujisawa Pharmaceutical Co | 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof |
EP0210815A3 (en) * | 1985-07-25 | 1988-04-20 | Beecham Group Plc | 6-beta-(alpha-etherified oxyimino)-acylamino penicillanic-acid derivatives, their preparation and use |
GB9024223D0 (en) | 1990-11-07 | 1990-12-19 | Fermentech Ltd | Production of hyaluronic acid |
GB9216759D0 (en) | 1992-08-07 | 1992-09-23 | Finpael Spa | Process for the production of 7-amino thiazolyl cephalosporins |
AT402928B (de) * | 1994-12-23 | 1997-09-25 | Biochemie Gmbh | Neues verfahren zur herstellung von cefotaxim |
GB9519883D0 (en) | 1995-09-29 | 1995-11-29 | Fujisawa Pharmaceutical Co | New cephem compounds |
MY127641A (en) | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
IN184690B (ja) * | 1996-03-18 | 2000-09-23 | Ranbaxy Lab Ltd |
-
1997
- 1997-10-30 IT IT97MI002439A patent/IT1295935B1/it active IP Right Grant
- 1997-11-28 US US09/331,702 patent/US6255480B1/en not_active Expired - Lifetime
- 1997-11-28 AT AT97952008T patent/ATE258169T1/de not_active IP Right Cessation
- 1997-11-28 ES ES97952008T patent/ES2213229T3/es not_active Expired - Lifetime
- 1997-11-28 EP EP97952008A patent/EP0948491B1/en not_active Expired - Lifetime
- 1997-11-28 WO PCT/EP1997/006654 patent/WO1999023082A1/en active IP Right Grant
- 1997-11-28 DE DE1997627315 patent/DE69727315T2/de not_active Expired - Fee Related
- 1997-11-28 PT PT97952008T patent/PT948491E/pt unknown
- 1997-11-28 JP JP52524899A patent/JP2001517248A/ja not_active Ceased
- 1997-11-28 DK DK97952008T patent/DK0948491T3/da active
- 1997-11-28 AU AU55581/98A patent/AU5558198A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE258169T1 (de) | 2004-02-15 |
AU5558198A (en) | 1999-05-24 |
WO1999023082A1 (en) | 1999-05-14 |
DE69727315T2 (de) | 2004-11-18 |
EP0948491B1 (en) | 2004-01-21 |
ES2213229T3 (es) | 2004-08-16 |
PT948491E (pt) | 2004-06-30 |
US6255480B1 (en) | 2001-07-03 |
DE69727315D1 (de) | 2004-02-26 |
IT1295935B1 (it) | 1999-05-28 |
ITMI972439A1 (it) | 1999-04-30 |
DK0948491T3 (da) | 2004-04-13 |
EP0948491A1 (en) | 1999-10-13 |
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Legal Events
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