JP2001517075A - 組換え血管内皮細胞増殖因子d(vegf―d) - Google Patents
組換え血管内皮細胞増殖因子d(vegf―d)Info
- Publication number
- JP2001517075A JP2001517075A JP51095398A JP51095398A JP2001517075A JP 2001517075 A JP2001517075 A JP 2001517075A JP 51095398 A JP51095398 A JP 51095398A JP 51095398 A JP51095398 A JP 51095398A JP 2001517075 A JP2001517075 A JP 2001517075A
- Authority
- JP
- Japan
- Prior art keywords
- vegf
- polypeptide
- seq
- nucleic acid
- endothelial cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003556 vascular endothelial cell Anatomy 0.000 title claims description 15
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 title description 2
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 144
- 210000004027 cell Anatomy 0.000 claims abstract description 118
- 210000002889 endothelial cell Anatomy 0.000 claims abstract description 96
- 230000008728 vascular permeability Effects 0.000 claims abstract description 49
- 230000004663 cell proliferation Effects 0.000 claims abstract description 43
- 230000033115 angiogenesis Effects 0.000 claims abstract description 39
- 239000005557 antagonist Substances 0.000 claims abstract description 35
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 30
- 238000004519 manufacturing process Methods 0.000 claims abstract description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 10
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 claims abstract 43
- 102000009519 Vascular Endothelial Growth Factor D Human genes 0.000 claims abstract 41
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 189
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 179
- 229920001184 polypeptide Polymers 0.000 claims description 176
- 239000002299 complementary DNA Substances 0.000 claims description 74
- 150000007523 nucleic acids Chemical class 0.000 claims description 74
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 59
- 102000039446 nucleic acids Human genes 0.000 claims description 57
- 108020004707 nucleic acids Proteins 0.000 claims description 57
- 241000124008 Mammalia Species 0.000 claims description 49
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 49
- 239000013598 vector Substances 0.000 claims description 41
- 239000012634 fragment Substances 0.000 claims description 39
- 108020004414 DNA Proteins 0.000 claims description 38
- 239000000523 sample Substances 0.000 claims description 38
- 230000004071 biological effect Effects 0.000 claims description 36
- 102000005962 receptors Human genes 0.000 claims description 36
- 108020003175 receptors Proteins 0.000 claims description 36
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 claims description 35
- 230000027455 binding Effects 0.000 claims description 32
- 239000002773 nucleotide Substances 0.000 claims description 31
- 125000003729 nucleotide group Chemical group 0.000 claims description 31
- 230000014509 gene expression Effects 0.000 claims description 27
- 238000012360 testing method Methods 0.000 claims description 24
- 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 21
- 230000004936 stimulating effect Effects 0.000 claims description 20
- 206010029113 Neovascularisation Diseases 0.000 claims description 16
- 239000003153 chemical reaction reagent Substances 0.000 claims description 15
- 210000005073 lymphatic endothelial cell Anatomy 0.000 claims description 15
- 102100035194 Placenta growth factor Human genes 0.000 claims description 14
- 125000000539 amino acid group Chemical group 0.000 claims description 14
- 208000011580 syndromic disease Diseases 0.000 claims description 13
- 230000017531 blood circulation Effects 0.000 claims description 12
- 230000009762 endothelial cell differentiation Effects 0.000 claims description 12
- 230000035755 proliferation Effects 0.000 claims description 12
- 230000000692 anti-sense effect Effects 0.000 claims description 11
- 108010082093 Placenta Growth Factor Proteins 0.000 claims description 10
- 230000001965 increasing effect Effects 0.000 claims description 10
- 239000013636 protein dimer Substances 0.000 claims description 10
- 230000024245 cell differentiation Effects 0.000 claims description 9
- 230000002685 pulmonary effect Effects 0.000 claims description 9
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 8
- 206010025476 Malabsorption Diseases 0.000 claims description 8
- 229960002897 heparin Drugs 0.000 claims description 8
- 229920000669 heparin Polymers 0.000 claims description 8
- 238000001727 in vivo Methods 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 238000003752 polymerase chain reaction Methods 0.000 claims description 7
- 230000004083 survival effect Effects 0.000 claims description 7
- DLZKEQQWXODGGZ-KCJUWKMLSA-N 2-[[(2r)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetic acid Chemical group OC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 DLZKEQQWXODGGZ-KCJUWKMLSA-N 0.000 claims description 6
- 230000005856 abnormality Effects 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 6
- 230000012292 cell migration Effects 0.000 claims description 5
- 239000001963 growth medium Substances 0.000 claims description 5
- 238000013508 migration Methods 0.000 claims description 5
- 230000002829 reductive effect Effects 0.000 claims description 5
- 230000003213 activating effect Effects 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 230000000747 cardiac effect Effects 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 102000053602 DNA Human genes 0.000 claims description 3
- 108091008605 VEGF receptors Proteins 0.000 claims description 3
- 230000001766 physiological effect Effects 0.000 claims description 3
- 230000001131 transforming effect Effects 0.000 claims description 3
- 230000002792 vascular Effects 0.000 claims description 3
- 101000851030 Homo sapiens Vascular endothelial growth factor receptor 3 Proteins 0.000 claims description 2
- 102000003839 Human Proteins Human genes 0.000 claims description 2
- 108090000144 Human Proteins Proteins 0.000 claims description 2
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000000833 heterodimer Substances 0.000 claims description 2
- 239000000710 homodimer Substances 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 claims description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
- 102000009520 Vascular Endothelial Growth Factor C Human genes 0.000 claims 3
- 102100038217 Vascular endothelial growth factor B Human genes 0.000 claims 3
- 102000057840 human FLT4 Human genes 0.000 claims 1
- 239000003102 growth factor Substances 0.000 abstract description 22
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 73
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 description 73
- 101000742599 Homo sapiens Vascular endothelial growth factor D Proteins 0.000 description 64
- 108090000623 proteins and genes Proteins 0.000 description 62
- 102000004169 proteins and genes Human genes 0.000 description 43
- 235000018102 proteins Nutrition 0.000 description 40
- 241000699666 Mus <mouse, genus> Species 0.000 description 33
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 description 32
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 28
- 102100038234 Vascular endothelial growth factor D Human genes 0.000 description 24
- 238000003556 assay Methods 0.000 description 23
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 22
- 230000000694 effects Effects 0.000 description 20
- 102000009521 Vascular Endothelial Growth Factor B Human genes 0.000 description 19
- 235000001014 amino acid Nutrition 0.000 description 19
- 238000004166 bioassay Methods 0.000 description 19
- 238000009396 hybridization Methods 0.000 description 18
- 210000004072 lung Anatomy 0.000 description 17
- 210000001519 tissue Anatomy 0.000 description 17
- 108091026890 Coding region Proteins 0.000 description 14
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 14
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 14
- 239000003636 conditioned culture medium Substances 0.000 description 13
- 239000013612 plasmid Substances 0.000 description 13
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 12
- 102100039064 Interleukin-3 Human genes 0.000 description 11
- 108010002386 Interleukin-3 Proteins 0.000 description 11
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 11
- 230000006870 function Effects 0.000 description 11
- 229940076264 interleukin-3 Drugs 0.000 description 11
- 108020004999 messenger RNA Proteins 0.000 description 11
- 239000006228 supernatant Substances 0.000 description 11
- 108010075944 Erythropoietin Receptors Proteins 0.000 description 10
- 102100036509 Erythropoietin receptor Human genes 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 10
- 230000001086 cytosolic effect Effects 0.000 description 10
- 239000002609 medium Substances 0.000 description 10
- 210000004899 c-terminal region Anatomy 0.000 description 9
- 235000018417 cysteine Nutrition 0.000 description 9
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 9
- 230000002297 mitogenic effect Effects 0.000 description 9
- 238000002835 absorbance Methods 0.000 description 8
- 210000000349 chromosome Anatomy 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 230000002068 genetic effect Effects 0.000 description 8
- 238000002955 isolation Methods 0.000 description 8
- 230000026731 phosphorylation Effects 0.000 description 8
- 238000006366 phosphorylation reaction Methods 0.000 description 8
- 108091033319 polynucleotide Proteins 0.000 description 8
- 102000040430 polynucleotide Human genes 0.000 description 8
- 239000002157 polynucleotide Substances 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- 108700010039 chimeric receptor Proteins 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 241000701447 unidentified baculovirus Species 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 101000742598 Mus musculus Vascular endothelial growth factor D Proteins 0.000 description 6
- 108010076504 Protein Sorting Signals Proteins 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000004913 activation Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000006143 cell culture medium Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- 241000894007 species Species 0.000 description 6
- 101710117545 C protein Proteins 0.000 description 5
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 description 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 5
- 206010027476 Metastases Diseases 0.000 description 5
- 102000016663 Vascular Endothelial Growth Factor Receptor-3 Human genes 0.000 description 5
- 210000001766 X chromosome Anatomy 0.000 description 5
- 238000007792 addition Methods 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 5
- 230000001143 conditioned effect Effects 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000004069 differentiation Effects 0.000 description 5
- 239000013604 expression vector Substances 0.000 description 5
- 102000058223 human VEGFA Human genes 0.000 description 5
- 230000006698 induction Effects 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- 239000013642 negative control Substances 0.000 description 5
- 239000013641 positive control Substances 0.000 description 5
- 102000027426 receptor tyrosine kinases Human genes 0.000 description 5
- 108091008146 restriction endonucleases Proteins 0.000 description 5
- 238000006467 substitution reaction Methods 0.000 description 5
- 238000001890 transfection Methods 0.000 description 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 description 4
- 108091060290 Chromatid Proteins 0.000 description 4
- 108020004635 Complementary DNA Proteins 0.000 description 4
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 4
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 101001131829 Homo sapiens P protein Proteins 0.000 description 4
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 description 4
- 101000742579 Homo sapiens Vascular endothelial growth factor B Proteins 0.000 description 4
- 101100372766 Mus musculus Kdr gene Proteins 0.000 description 4
- 101100481410 Mus musculus Tek gene Proteins 0.000 description 4
- 230000004988 N-glycosylation Effects 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 210000004756 chromatid Anatomy 0.000 description 4
- 238000003776 cleavage reaction Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 229940126864 fibroblast growth factor Drugs 0.000 description 4
- 102000047119 human OCA2 Human genes 0.000 description 4
- 102000058241 human VEGFB Human genes 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 230000004807 localization Effects 0.000 description 4
- 210000001077 lymphatic endothelium Anatomy 0.000 description 4
- 210000001161 mammalian embryo Anatomy 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 230000031864 metaphase Effects 0.000 description 4
- 230000009401 metastasis Effects 0.000 description 4
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 4
- 230000035772 mutation Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 108091008598 receptor tyrosine kinases Proteins 0.000 description 4
- 230000007017 scission Effects 0.000 description 4
- 239000013605 shuttle vector Substances 0.000 description 4
- 210000002027 skeletal muscle Anatomy 0.000 description 4
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 239000011800 void material Substances 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 108020005544 Antisense RNA Proteins 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 3
- 101100481408 Danio rerio tie2 gene Proteins 0.000 description 3
- 206010058314 Dysplasia Diseases 0.000 description 3
- 101150009958 FLT4 gene Proteins 0.000 description 3
- 101001001487 Homo sapiens Phosphatidylinositol-glycan biosynthesis class F protein Proteins 0.000 description 3
- 101000742596 Homo sapiens Vascular endothelial growth factor C Proteins 0.000 description 3
- 238000000636 Northern blotting Methods 0.000 description 3
- 102000001938 Plasminogen Activators Human genes 0.000 description 3
- 108010001014 Plasminogen Activators Proteins 0.000 description 3
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 description 3
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000001042 affinity chromatography Methods 0.000 description 3
- 238000003149 assay kit Methods 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000035605 chemotaxis Effects 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000003184 complementary RNA Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 238000006471 dimerization reaction Methods 0.000 description 3
- 210000002257 embryonic structure Anatomy 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 238000001114 immunoprecipitation Methods 0.000 description 3
- 238000007901 in situ hybridization Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000013011 mating Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 229940127126 plasminogen activator Drugs 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000012723 sample buffer Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 238000002864 sequence alignment Methods 0.000 description 3
- 238000012163 sequencing technique Methods 0.000 description 3
- 238000002741 site-directed mutagenesis Methods 0.000 description 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
- 206010060965 Arterial stenosis Diseases 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 101100381481 Caenorhabditis elegans baz-2 gene Proteins 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- 206010069729 Collateral circulation Diseases 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 102100021866 Hepatocyte growth factor Human genes 0.000 description 2
- 208000029663 Hypophosphatemia Diseases 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 description 2
- 101100047936 Mus musculus Tmsb4x gene Proteins 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 208000037273 Pathologic Processes Diseases 0.000 description 2
- 108091000080 Phosphotransferase Proteins 0.000 description 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
- 101100372762 Rattus norvegicus Flt1 gene Proteins 0.000 description 2
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 description 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 210000002403 aortic endothelial cell Anatomy 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000003399 chemotactic effect Effects 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 210000003917 human chromosome Anatomy 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000000411 inducer Substances 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 210000004897 n-terminal region Anatomy 0.000 description 2
- 230000036963 noncompetitive effect Effects 0.000 description 2
- 230000000263 nonmitogenic effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000000963 osteoblast Anatomy 0.000 description 2
- 230000009054 pathological process Effects 0.000 description 2
- 102000020233 phosphotransferase Human genes 0.000 description 2
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 2
- 230000004853 protein function Effects 0.000 description 2
- 230000006798 recombination Effects 0.000 description 2
- 238000005215 recombination Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 102220240796 rs553605556 Human genes 0.000 description 2
- 210000003079 salivary gland Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229940104230 thymidine Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- NMWKYTGJWUAZPZ-WWHBDHEGSA-N (4S)-4-[[(4R,7S,10S,16S,19S,25S,28S,31R)-31-[[(2S)-2-[[(1R,6R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,53S,56S,59S,62S,65S,68S,71S,76S,79S,85S)-47-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-18-(4-aminobutyl)-27,68-bis(3-amino-3-oxopropyl)-36,71,76-tribenzyl-39-(3-carbamimidamidopropyl)-24-(2-carboxyethyl)-21,56-bis(carboxymethyl)-65,85-bis[(1R)-1-hydroxyethyl]-59-(hydroxymethyl)-62,79-bis(1H-imidazol-4-ylmethyl)-9-methyl-33-(2-methylpropyl)-8,11,17,20,23,26,29,32,35,38,41,48,54,57,60,63,66,69,72,74,77,80,83,86-tetracosaoxo-30-propan-2-yl-3,4,44,45-tetrathia-7,10,16,19,22,25,28,31,34,37,40,49,55,58,61,64,67,70,73,75,78,81,84,87-tetracosazatetracyclo[40.31.14.012,16.049,53]heptaoctacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-7-(3-carbamimidamidopropyl)-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-4-ylmethyl)-10-methyl-6,9,12,15,18,21,24,27,30-nonaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](Cc4ccccc4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(=O)N[C@@H](C)C(O)=O NMWKYTGJWUAZPZ-WWHBDHEGSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 208000008190 Agammaglobulinemia Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010001557 Albinism Diseases 0.000 description 1
- 208000036487 Arthropathies Diseases 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 108010081589 Becaplermin Proteins 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000019300 CLIPPERS Diseases 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 241000256137 Chironomus tentans Species 0.000 description 1
- 241000256135 Chironomus thummi Species 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 241000543381 Cliftonia monophylla Species 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 108700010070 Codon Usage Proteins 0.000 description 1
- 208000001353 Coffin-Lowry syndrome Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 101150097493 D gene Proteins 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 108010069941 DNA receptor Proteins 0.000 description 1
- 101100540419 Danio rerio kdrl gene Proteins 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010011891 Deafness neurosensory Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 101000658547 Escherichia coli (strain K12) Type I restriction enzyme EcoKI endonuclease subunit Proteins 0.000 description 1
- 101000658543 Escherichia coli Type I restriction enzyme EcoAI endonuclease subunit Proteins 0.000 description 1
- 101000658546 Escherichia coli Type I restriction enzyme EcoEI endonuclease subunit Proteins 0.000 description 1
- 101000658530 Escherichia coli Type I restriction enzyme EcoR124II endonuclease subunit Proteins 0.000 description 1
- 101000658540 Escherichia coli Type I restriction enzyme EcoprrI endonuclease subunit Proteins 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 101150097448 FD gene Proteins 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 108091092584 GDNA Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000009465 Growth Factor Receptors Human genes 0.000 description 1
- 108010009202 Growth Factor Receptors Proteins 0.000 description 1
- 101000658545 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Type I restriction enyme HindI endonuclease subunit Proteins 0.000 description 1
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000545744 Hirudinea Species 0.000 description 1
- 108010093488 His-His-His-His-His-His Proteins 0.000 description 1
- 101001104102 Homo sapiens X-linked retinitis pigmentosa GTPase regulator Proteins 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 description 1
- 206010021027 Hypomagnesaemia Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 108010036176 Melitten Proteins 0.000 description 1
- 101000658548 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaIXP endonuclease subunit Proteins 0.000 description 1
- 101000658542 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIIP endonuclease subunit Proteins 0.000 description 1
- 101000658529 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIP endonuclease subunit Proteins 0.000 description 1
- 101100118984 Mus musculus Epor gene Proteins 0.000 description 1
- 101000808007 Mus musculus Vascular endothelial growth factor A Proteins 0.000 description 1
- 241000699667 Mus spretus Species 0.000 description 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 201000007908 Ocular Albinism Diseases 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 208000019851 Opitz G/BBB syndrome Diseases 0.000 description 1
- 102000016978 Orphan receptors Human genes 0.000 description 1
- 108070000031 Orphan receptors Proteins 0.000 description 1
- 108091008606 PDGF receptors Proteins 0.000 description 1
- 201000003692 Partington syndrome Diseases 0.000 description 1
- 102000013566 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 102000010752 Plasminogen Inactivators Human genes 0.000 description 1
- 108010077971 Plasminogen Inactivators Proteins 0.000 description 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 1
- 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 102000002067 Protein Subunits Human genes 0.000 description 1
- 108010001267 Protein Subunits Proteins 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000036448 RPGR-related retinopathy Diseases 0.000 description 1
- 101100014660 Rattus norvegicus Gimap8 gene Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 102000001848 Salivary Proteins and Peptides Human genes 0.000 description 1
- 108010029987 Salivary Proteins and Peptides Proteins 0.000 description 1
- 208000009966 Sensorineural Hearing Loss Diseases 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 101001042773 Staphylococcus aureus (strain COL) Type I restriction enzyme SauCOLORF180P endonuclease subunit Proteins 0.000 description 1
- 101000838760 Staphylococcus aureus (strain MRSA252) Type I restriction enzyme SauMRSORF196P endonuclease subunit Proteins 0.000 description 1
- 101000838761 Staphylococcus aureus (strain MSSA476) Type I restriction enzyme SauMSSORF170P endonuclease subunit Proteins 0.000 description 1
- 101000838758 Staphylococcus aureus (strain MW2) Type I restriction enzyme SauMW2ORF169P endonuclease subunit Proteins 0.000 description 1
- 101001042566 Staphylococcus aureus (strain Mu50 / ATCC 700699) Type I restriction enzyme SauMu50ORF195P endonuclease subunit Proteins 0.000 description 1
- 101000838763 Staphylococcus aureus (strain N315) Type I restriction enzyme SauN315I endonuclease subunit Proteins 0.000 description 1
- 101000838759 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) Type I restriction enzyme SepRPIP endonuclease subunit Proteins 0.000 description 1
- 101000838756 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) Type I restriction enzyme SsaAORF53P endonuclease subunit Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 description 1
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 description 1
- 201000001858 Wilson-Turner syndrome Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 102100040092 X-linked retinitis pigmentosa GTPase regulator Human genes 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000006427 angiogenic response Effects 0.000 description 1
- 206010003230 arteritis Diseases 0.000 description 1
- 238000013096 assay test Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- 108010028263 bacteriophage T3 RNA polymerase Proteins 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004900 c-terminal fragment Anatomy 0.000 description 1
- 238000003352 cell adhesion assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 210000003711 chorioallantoic membrane Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 108091036078 conserved sequence Proteins 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000027326 copulation Effects 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 150000002019 disulfides Chemical class 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 210000003890 endocrine cell Anatomy 0.000 description 1
- 230000010595 endothelial cell migration Effects 0.000 description 1
- 108091007231 endothelial receptors Proteins 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 210000000442 hair follicle cell Anatomy 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000003317 immunochromatography Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 230000007040 lung development Effects 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000001365 lymphatic vessel Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical group NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 238000010232 migration assay Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 238000007479 molecular analysis Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000013631 noncovalent dimer Substances 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 239000002797 plasminogen activator inhibitor Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 108010017843 platelet-derived growth factor A Proteins 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 210000003055 polytene chromosome Anatomy 0.000 description 1
- 230000026341 positive regulation of angiogenesis Effects 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 208000002673 retinitis pigmentosa 6 Diseases 0.000 description 1
- 108091010987 retinoic acid binding proteins Proteins 0.000 description 1
- 102000003702 retinoic acid receptors Human genes 0.000 description 1
- 108090000064 retinoic acid receptors Proteins 0.000 description 1
- 201000007714 retinoschisis Diseases 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 231100000879 sensorineural hearing loss Toxicity 0.000 description 1
- 208000023573 sensorineural hearing loss disease Diseases 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002325 somatostatin-secreting cell Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 201000008489 transsexualism Diseases 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 230000006444 vascular growth Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2375196P | 1996-08-23 | 1996-08-23 | |
| AUPO1825A AUPO182596A0 (en) | 1996-08-23 | 1996-08-23 | Growth factor |
| US60/023,751 | 1996-08-23 | ||
| AUPO3554A AUPO355496A0 (en) | 1996-11-11 | 1996-11-11 | Growth factor |
| US3109796P | 1996-11-14 | 1996-11-14 | |
| US60/031,097 | 1996-11-14 | ||
| AUPO4954A AUPO495497A0 (en) | 1997-02-05 | 1997-02-05 | Growth factors |
| US3881497P | 1997-02-10 | 1997-02-10 | |
| US60/038,814 | 1997-02-10 | ||
| AUPO7435A AUPO743597A0 (en) | 1997-06-19 | 1997-06-19 | Growth factor |
| US5142697P | 1997-07-01 | 1997-07-01 | |
| US7435 | 1997-07-01 | ||
| US4954 | 1997-07-01 | ||
| US1825 | 1997-07-01 | ||
| US60/051,426 | 1997-07-01 | ||
| US3554 | 1997-07-01 | ||
| PCT/US1997/014696 WO1998007832A1 (en) | 1996-08-23 | 1997-08-21 | Recombinant vascular endothelial cell growth factor d (vegf-d) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007013569A Division JP2007167072A (ja) | 1996-08-23 | 2007-01-24 | 組換え血管内皮細胞増殖因子d(vegf−d) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001517075A true JP2001517075A (ja) | 2001-10-02 |
Family
ID=46149776
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51095398A Pending JP2001517075A (ja) | 1996-08-23 | 1997-08-21 | 組換え血管内皮細胞増殖因子d(vegf―d) |
| JP2007013569A Pending JP2007167072A (ja) | 1996-08-23 | 2007-01-24 | 組換え血管内皮細胞増殖因子d(vegf−d) |
| JP2009164162A Pending JP2009291198A (ja) | 1996-08-23 | 2009-07-10 | 組換え血管内皮細胞増殖因子d(vegf−d) |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007013569A Pending JP2007167072A (ja) | 1996-08-23 | 2007-01-24 | 組換え血管内皮細胞増殖因子d(vegf−d) |
| JP2009164162A Pending JP2009291198A (ja) | 1996-08-23 | 2009-07-10 | 組換え血管内皮細胞増殖因子d(vegf−d) |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US6235713B1 (https=) |
| EP (4) | EP2107109B1 (https=) |
| JP (3) | JP2001517075A (https=) |
| AT (2) | ATE434034T1 (https=) |
| AU (1) | AU729880C (https=) |
| CA (1) | CA2263890C (https=) |
| DE (2) | DE69739469D1 (https=) |
| DK (3) | DK2107109T3 (https=) |
| ES (3) | ES2327440T3 (https=) |
| WO (1) | WO1998007832A1 (https=) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003517265A (ja) * | 1997-12-24 | 2003-05-27 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 血管内皮増殖因子dを発現する発現ベクターおよび細胞系、およびメラノーマを治療する方法 |
| JP2009511492A (ja) * | 2005-10-06 | 2009-03-19 | トロフォゲン,インコーポレイテッド | Vegf類縁体および使用方法 |
| US10457713B2 (en) | 2012-07-30 | 2019-10-29 | Trophogen, Inc. | Glycoprotein hormone long-acting superagonists |
| US10544200B2 (en) | 2013-11-05 | 2020-01-28 | Trophogen, Inc. | Glycoprotein hormone long-acting superagonists |
| US10766941B2 (en) | 2012-07-30 | 2020-09-08 | Trophogen Inc. | Glycoprotein hormone long-acting superagonists |
| WO2022191252A1 (ja) * | 2021-03-10 | 2022-09-15 | 住友ファーマ株式会社 | システインノットタンパク質の製造方法 |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
| US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
| US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
| US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
| US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
| ES2249762T3 (es) | 1994-03-08 | 2006-04-01 | Human Genome Sciences, Inc. | Factor de crecimiento del endotelio vascular 2. |
| US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| EP1353952B1 (en) | 1994-11-14 | 2007-04-11 | Ludwig Institute For Cancer Research | Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7423125B2 (en) | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
| DE69628652T3 (de) | 1995-09-08 | 2012-05-03 | Genentech, Inc. | Vegf-verwandtes protein |
| DE69634412T3 (de) | 1995-09-29 | 2013-07-04 | Vegenics Pty Ltd | Regulierte gene und ihre verwendungen |
| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| WO1998002543A1 (fr) * | 1996-07-15 | 1998-01-22 | Chugai Research Institute For Molecular Medicine, Inc. | Nouveaux facteurs analogues au vegf |
| WO1998007832A1 (en) | 1996-08-23 | 1998-02-26 | Ludwig Institute For Cancer Research | Recombinant vascular endothelial cell growth factor d (vegf-d) |
| US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6391311B1 (en) | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
| AU765888B2 (en) * | 1997-12-24 | 2003-10-02 | Vegenics Limited | Expression vectors and cell lines expressing vascular endothelial growth factor D, and method of treating melanomas |
| DE69939374D1 (de) * | 1998-03-17 | 2008-10-02 | Genentech Inc | Zu vegf und bmp1 homologe polypeptide |
| EP0984063A3 (en) * | 1998-08-31 | 2000-08-16 | Eli Lilly And Company | VEGF Related gene and protein |
| US20030211994A1 (en) * | 1998-09-30 | 2003-11-13 | Ludwig Institute For Cancer Research | Composition and method for modulating vasculogenesis or angiogenesis |
| US20030082670A1 (en) * | 1998-09-30 | 2003-05-01 | Ulf Eriksson | Platelet-derived growth factor C, DNA coding therefor, and uses thereof |
| US20040053837A1 (en) * | 1998-09-30 | 2004-03-18 | Ludwig Institute For Cancer Research | Composition and method for modulating vasculogenesis or angiogenesis |
| AU774266B2 (en) | 1998-10-09 | 2004-06-24 | Vegenics Limited | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| EP1568375A1 (en) * | 1998-10-26 | 2005-08-31 | Ludwig Institute For Cancer Research | Use of VEGF-C or VEGF-D gene or protein to prevent restenosis |
| EP1126870B1 (en) * | 1998-10-26 | 2004-09-08 | Ludwig Institute For Cancer Research | Use of vegf-c or vegf-d gene or protein to prevent restenosis |
| US6958147B1 (en) | 1998-10-26 | 2005-10-25 | Licentia Ltd | Use of VEGF-C to prevent restenosis |
| AU770899B2 (en) | 1998-11-10 | 2004-03-04 | Licentia Ltd | Platelet-derived growth factor D, DNA coding therefor, and uses thereof |
| AU764039B2 (en) * | 1998-12-07 | 2003-08-07 | Zymogenetics Inc. | Growth factor homolog ZVEGF3 |
| DE69930872T8 (de) | 1998-12-21 | 2007-05-03 | Ludwig Institute For Cancer Research | Antikörper gegen verkürzten vegf-d und deren verwendungen |
| US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
| WO2000037641A2 (en) * | 1998-12-22 | 2000-06-29 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-x |
| US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
| EP2357192A1 (en) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
| WO2000058511A1 (en) * | 1999-03-26 | 2000-10-05 | Ludwig Institute For Cancer Research | Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3) |
| US6764820B2 (en) | 1999-03-26 | 2004-07-20 | Ludwig Institute For Cancer Research | Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3) |
| PT1165115E (pt) * | 1999-03-26 | 2003-10-31 | Univ California | Modulacao da permeabilidade vascular por meio dos activadores do receptor tie2 |
| US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| WO2001012669A1 (en) * | 1999-08-16 | 2001-02-22 | Universita' Degli Studi Di Siena | Vegf-d and angiogenic use thereof |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| EP1248642A4 (en) * | 2000-01-18 | 2005-05-18 | Ludwig Inst Cancer Res | PEPTIDOMIMETIC INHIBITOR OF VEGF-D / VEGF-C / VEGF |
| US7727971B2 (en) | 2000-02-04 | 2010-06-01 | Life Sciences Research Partners Vzw | Use of placental growth factor for treating ischemic muscle disease |
| US7105168B1 (en) | 2002-06-04 | 2006-09-12 | D. Collen Research Foundation Vzw | Method of improving ischemic muscle function by administering placental growth factor |
| AU4643501A (en) * | 2000-02-04 | 2001-08-14 | Flanders Interuniversity Institute For Biotechnology (Vib) | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic diseases or stroke |
| US6930089B2 (en) | 2000-02-04 | 2005-08-16 | D. Collen Research Foundation Vzw | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic disease or stroke |
| JP2003521543A (ja) | 2000-02-07 | 2003-07-15 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 2−ベンゾチアゾリル尿素誘導体およびそのプロテインキナーゼ阻害剤としての使用 |
| AU3988401A (en) * | 2000-02-25 | 2001-09-03 | Ludwig Inst Cancer Res | Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins |
| PT1259248E (pt) * | 2000-03-02 | 2005-04-29 | Ludwig Inst Cancer Res | Metodos para tratar, rastrear e detectar cancros que expressam o factor de crescimento vascular endotelial d |
| US20020102260A1 (en) * | 2000-03-02 | 2002-08-01 | Marc Achen | Methods for treating neoplastic disease characterized by vascular endothelial growth factor D expression, for screening for neoplastic disease or metastatic risk, and for maintaining vascularization of tissue |
| EP1519193B1 (en) * | 2000-03-02 | 2011-11-09 | Vegenics Pty Ltd | Methods for detecting cancers expressing vascular endothelial growth factor D |
| AU2006201128B2 (en) * | 2000-03-02 | 2009-05-28 | Vegenics Limited | Methods for treating, screening for, and detecting cancers expressing vascular endothelial growth factor D |
| EP2206720A1 (en) | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2001264565B2 (en) * | 2000-05-03 | 2006-12-07 | Vegenics Limited | A method for activating only the vascular endothelial growth factor receptor-3 and uses thereof |
| MXPA02003434A (es) | 2000-08-04 | 2002-09-02 | Human Genome Sciences Inc | Factor de crecimiento endotelial vascular 2. |
| WO2002036131A1 (en) * | 2000-11-01 | 2002-05-10 | Ludwig Institute For Cancer Research | In vivo stimulation of angiogenic activity |
| AU2002228841C1 (en) | 2000-12-07 | 2006-11-23 | Sangamo Biosciences, Inc | Regulation of angiogenesis with zinc finger proteins |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| US7611711B2 (en) | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
| US20020164624A1 (en) * | 2001-02-12 | 2002-11-07 | Waldemar Debinski | VEGF-D expression in brain cancer |
| MXPA03008560A (es) | 2001-03-22 | 2004-06-30 | Abbot Gmbh & Co Kg | Pirazolopirimidinas como agentes terapeuticos. |
| CA2444632A1 (en) | 2001-04-13 | 2002-10-24 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
| EP1406573A4 (en) * | 2001-06-07 | 2005-03-30 | Skinmedica Inc | CONDITIONED CELL CULTURE MEDIA AND ITS USES |
| WO2003006104A2 (en) * | 2001-07-12 | 2003-01-23 | Ludwig Institute For Cancer Research | Lymphatic endothelial cells materials and methods |
| WO2003013570A1 (en) * | 2001-08-09 | 2003-02-20 | Cornell Research Foundation, Inc. | Platelet-derived growth factor protection of cardiac myocardium |
| US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
| US20030113324A1 (en) | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
| NZ531733A (en) | 2001-10-15 | 2006-04-28 | Janssen Pharmaceutica Nv | Substituted 4-phenyl-4-[1H-imidazol-2-YL]- piperidine derivatives for reducing ischaemic damage |
| EP2261250B1 (en) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
| WO2003104428A2 (en) | 2002-01-21 | 2003-12-18 | Vaccinex, Inc. | Gene differentially expressed in breast and bladder cancer and encoded polypeptides |
| AU2003217966A1 (en) * | 2002-03-07 | 2003-10-08 | Licentia, Ltd. | Lymphatic and blood endothelial cell genes |
| US7241446B2 (en) * | 2002-04-01 | 2007-07-10 | Trustees Of Dartmouth College | Methods for modulating angiogenesis via VEGF |
| US7510714B2 (en) * | 2002-04-01 | 2009-03-31 | Trustees Of Dartmouth College | Methods for modulating angiogenesis |
| US20030228283A1 (en) * | 2002-05-03 | 2003-12-11 | Ludwig Institute For Cancer Research | Preventing secondary lymphedema with VEGF-D DNA |
| WO2004009773A2 (en) | 2002-07-23 | 2004-01-29 | Ludwig Institute For Cancer Research | Methods and compositions for activating or inhibiting vegf-d and vegf-c |
| US20040120950A1 (en) * | 2002-12-20 | 2004-06-24 | Kari Alitalo | Modulation of VEGF-C/VEGFR-3 interactions in the treatment of rheumatoid arthritis |
| US20040248796A1 (en) * | 2003-02-04 | 2004-12-09 | Kari Alitalo | VEGF-B and PDGF modulation of stem cells |
| WO2005016963A2 (en) * | 2003-06-12 | 2005-02-24 | Ludwig Institute For Cancer Research | Heparin binding veger-3 ligands |
| EP1635860A2 (en) * | 2003-06-12 | 2006-03-22 | Ludwig Institute For Cancer Research | Use of vegf-c or vegf-d in reconstructive surgery |
| US20070110744A1 (en) * | 2003-09-08 | 2007-05-17 | Kari Alitalo | Lymphatic and blood endothelial cell genes |
| US7284505B1 (en) | 2003-11-03 | 2007-10-23 | Paxton Stephen E | Skijor system |
| US7780973B2 (en) * | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
| JP2007536909A (ja) * | 2003-12-29 | 2007-12-20 | センテリオン | 冠動脈または末梢性虚血の治療 |
| US20050142161A1 (en) * | 2003-12-30 | 2005-06-30 | Freeman Lynetta J. | Collagen matrix for soft tissue augmentation |
| WO2005087177A2 (en) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Chimeric anti-vegf-d antibodies and humanized anti-vegf-d antibodies and methods of using same |
| US20050282233A1 (en) * | 2004-03-05 | 2005-12-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for VEGF/PDGF family of growth factors |
| EP1725678A1 (en) * | 2004-03-12 | 2006-11-29 | Ludwig Institute For Cancer Research | Differential drug sensitivity |
| US7595149B1 (en) | 2004-11-08 | 2009-09-29 | University Of Kentucky Research Foundation | Methods for cancer detection |
| EP2314614B1 (en) | 2005-02-28 | 2015-11-25 | Sangamo BioSciences, Inc. | Anti-angiogenic methods and compositions |
| EP1919944B1 (en) | 2005-08-15 | 2011-03-23 | Vegenics Pty Ltd | Modified vegf and pdgf with improved angiogenic properties |
| TWI428143B (zh) | 2006-01-18 | 2014-03-01 | Gen Hospital Corp | 增加淋巴功能之方法 |
| AU2007254243B2 (en) | 2006-05-17 | 2013-06-13 | Ludwig Institute For Cancer Research | Targeting VEGF-B regulation of fatty acid transporters to modulate human diseases |
| US9073997B2 (en) | 2007-02-02 | 2015-07-07 | Vegenics Pty Limited | Growth factor antagonists for organ transplant alloimmunity and arteriosclerosis |
| WO2008096268A2 (en) * | 2007-02-07 | 2008-08-14 | Vegenics Limited | Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat secondary lymphedema and to improve reconstructive surgery |
| US7811776B2 (en) | 2007-12-05 | 2010-10-12 | University Of Cincinnati | Use of VEGF-D in the diagnosis of lymphangioleiomyomatosis (LAM) disease |
| NZ586544A (en) | 2007-12-26 | 2012-07-27 | Vaccinex Inc | Anti-c35 antibody in combination with an ani-her2 antibody in cancer therapies and methods |
| US20110142839A1 (en) * | 2008-05-30 | 2011-06-16 | Vegenics Limited | Treatment of pulmonary edema |
| US20100029491A1 (en) * | 2008-07-11 | 2010-02-04 | Maike Schmidt | Methods and compositions for diagnostic use for tumor treatment |
| US8255807B2 (en) * | 2008-12-23 | 2012-08-28 | Ganz | Item customization and website customization |
| JP2012522491A (ja) * | 2009-04-03 | 2012-09-27 | ベジニクス ピーティーワイ リミテッド | 抗vegf−d抗体 |
| WO2011056494A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
| EP2538965B1 (en) * | 2010-02-25 | 2017-04-12 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| WO2011154308A1 (en) | 2010-06-08 | 2011-12-15 | Proyecto De Biomedicina Cima, S.L. | New compositions and cell therapy methods for the treatment of cirrhosis |
| WO2012088563A1 (en) * | 2010-11-24 | 2012-07-05 | Vegenics Pty Limited | Vegfr-2-specific forms of vegf-d and vegf-c and uses thereof |
| US8852592B2 (en) | 2011-05-10 | 2014-10-07 | Biocare Medical, Llc | Systems and methods for anti-PAX8 antibodies |
| US9415090B2 (en) * | 2011-06-01 | 2016-08-16 | Universität Heidelberg | VEGF-D/VEGFR2/3-mediated regulation of dendrites |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| US9429577B2 (en) | 2012-09-27 | 2016-08-30 | Biocare Medical, Llc | Anti-uroplakin II antibodies systems and methods |
| US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| PT2956476T (pt) | 2013-02-18 | 2020-02-21 | Vegenics Pty Ltd | Moléculas de ligação e usos destas |
| EP2962113B1 (en) | 2013-02-28 | 2019-04-03 | Biocare Medical, LLC | Anti-p40 antibodies systems and methods |
| WO2015051320A2 (en) | 2013-10-03 | 2015-04-09 | Biocare Medical, Llc | Anti-sox10 antibody systems and methods |
| EP3924367A4 (en) * | 2019-04-04 | 2022-10-12 | Sree Chitra Tirunal Institute for Medical Sciences and Technology | VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) FOR BETTER WOUND HEALING THROUGH ENHANCED ANGIOGENESIS |
| WO2024259161A2 (en) * | 2023-06-14 | 2024-12-19 | Yale University | Methods and compositions for treating respiratory disorders |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968778A (en) * | 1989-01-12 | 1999-10-19 | Jurgen Hoppe | PDGF-AB, preparation process and pharmaceuticals containing them |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US6207454B1 (en) * | 1989-10-16 | 2001-03-27 | Amgen Inc. | Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide |
| US5476839A (en) * | 1990-07-10 | 1995-12-19 | Incyte Pharmaceuticals, Inc. | Basophil granule proteins |
| JP3024311B2 (ja) | 1991-10-03 | 2000-03-21 | 味の素株式会社 | Il−2受容体重鎖に結合するポリペプチド |
| JPH05271294A (ja) | 1992-01-24 | 1993-10-19 | Japan Found Cancer Res | ヒトプロヒビチンおよびそれをコードするdna |
| NZ253611A (en) | 1992-07-27 | 1996-09-25 | Pfizer | Polypeptide found in the venom of the agelenopsis spider and its use as a calcium channel blocker |
| US5510239A (en) * | 1993-10-18 | 1996-04-23 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of multidrug resistance-associated protein |
| ES2249762T3 (es) * | 1994-03-08 | 2006-04-01 | Human Genome Sciences, Inc. | Factor de crecimiento del endotelio vascular 2. |
| DE4423098A1 (de) | 1994-07-01 | 1996-01-04 | Hoechst Ag | Verwendung von Pyrimidingruppen enthaltenden konjugierten Verbindungen als Elektrolumineszenzmaterialien |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US6221839B1 (en) * | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
| US6645933B1 (en) * | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
| JPH08185216A (ja) | 1994-12-28 | 1996-07-16 | Meidensha Corp | 工具姿勢パラメータ設定方法及びロボット制御装置 |
| US5928939A (en) | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
| NZ301611A (en) | 1995-03-02 | 2000-02-28 | Amrad Operations Pty Ltd | a peptide having vascular endothelial growth factor like properties, nucleic acid molecule encoding it and its use |
| WO1996039421A1 (en) | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 3 |
| DE69628652T3 (de) * | 1995-09-08 | 2012-05-03 | Genentech, Inc. | Vegf-verwandtes protein |
| DE69634412T3 (de) | 1995-09-29 | 2013-07-04 | Vegenics Pty Ltd | Regulierte gene und ihre verwendungen |
| JP3843488B2 (ja) | 1996-06-06 | 2006-11-08 | アイシン・エィ・ダブリュ株式会社 | 自動変速機の制御装置 |
| WO1998002543A1 (fr) * | 1996-07-15 | 1998-01-22 | Chugai Research Institute For Molecular Medicine, Inc. | Nouveaux facteurs analogues au vegf |
| WO1998007832A1 (en) | 1996-08-23 | 1998-02-26 | Ludwig Institute For Cancer Research | Recombinant vascular endothelial cell growth factor d (vegf-d) |
| AU5439998A (en) * | 1996-12-06 | 1998-06-29 | Zymogenetics Inc. | Vascular endothelial growth factor |
| US20020165174A1 (en) * | 1997-01-31 | 2002-11-07 | Gill Parkash S. | Methods and compositions for antisense VEGF oligonucleotides |
| CN1345247A (zh) | 1997-12-24 | 2002-04-17 | 路德维格癌症研究所 | 表达血管内皮生长因子d的表达载体和细胞系以及治疗黑素瘤的方法 |
| DE19817835C2 (de) | 1998-04-22 | 2000-05-18 | Billhofer Maschf Gmbh | Sichtkaschiervorrichtung |
| DE19823359C1 (de) | 1998-05-15 | 1999-10-07 | Francotyp Postalia Gmbh | Vorrichtung zum Bedrucken von Postgut |
| DE69930872T8 (de) * | 1998-12-21 | 2007-05-03 | Ludwig Institute For Cancer Research | Antikörper gegen verkürzten vegf-d und deren verwendungen |
| WO2001012669A1 (en) * | 1999-08-16 | 2001-02-22 | Universita' Degli Studi Di Siena | Vegf-d and angiogenic use thereof |
| EP1635860A2 (en) | 2003-06-12 | 2006-03-22 | Ludwig Institute For Cancer Research | Use of vegf-c or vegf-d in reconstructive surgery |
| US20070212390A1 (en) | 2005-09-22 | 2007-09-13 | Ludwig Institute For Cancer Research | Protease-resistant forms of VEGF-D, method of making and method of use |
| FR2987282B1 (fr) | 2012-02-24 | 2017-12-29 | Fonds De L'espci Georges Charpak | Microcanal avec dispositif d'ouverture et/ou fermeture et/ou pompage |
| US9405291B2 (en) | 2012-07-31 | 2016-08-02 | Fisher-Rosemount Systems, Inc. | Systems and methods to monitor an asset in an operating process unit |
| US9516755B2 (en) | 2012-12-28 | 2016-12-06 | Intel Corporation | Multi-channel memory module |
| US9426605B2 (en) | 2013-10-10 | 2016-08-23 | Yahoo! Inc. | Cross device information exchange using gestures and locations |
-
1997
- 1997-08-21 WO PCT/US1997/014696 patent/WO1998007832A1/en not_active Ceased
- 1997-08-21 CA CA2263890A patent/CA2263890C/en not_active Expired - Fee Related
- 1997-08-21 AT AT06121918T patent/ATE434034T1/de not_active IP Right Cessation
- 1997-08-21 ES ES06121918T patent/ES2327440T3/es not_active Expired - Lifetime
- 1997-08-21 EP EP09162873A patent/EP2107109B1/en not_active Expired - Lifetime
- 1997-08-21 DK DK09162873.5T patent/DK2107109T3/da active
- 1997-08-21 ES ES09162873T patent/ES2390107T3/es not_active Expired - Lifetime
- 1997-08-21 DE DE69739469T patent/DE69739469D1/de not_active Expired - Lifetime
- 1997-08-21 DE DE69734359T patent/DE69734359T2/de not_active Expired - Lifetime
- 1997-08-21 AU AU40796/97A patent/AU729880C/en not_active Ceased
- 1997-08-21 EP EP02018842A patent/EP1283268A3/en not_active Withdrawn
- 1997-08-21 JP JP51095398A patent/JP2001517075A/ja active Pending
- 1997-08-21 DK DK97938486T patent/DK0956339T3/da active
- 1997-08-21 AT AT97938486T patent/ATE306546T1/de not_active IP Right Cessation
- 1997-08-21 EP EP97938486A patent/EP0956339B1/en not_active Revoked
- 1997-08-21 EP EP06121918A patent/EP1749836B1/en not_active Expired - Lifetime
- 1997-08-21 US US08/915,795 patent/US6235713B1/en not_active Expired - Fee Related
- 1997-08-21 ES ES97938486T patent/ES2251740T3/es not_active Expired - Lifetime
- 1997-08-21 DK DK06121918T patent/DK1749836T3/da active
-
1999
- 1999-04-22 US US09/296,275 patent/US6689580B1/en not_active Expired - Fee Related
-
2002
- 2002-06-05 US US10/161,694 patent/US7410639B2/en not_active Expired - Fee Related
- 2002-10-22 US US10/274,953 patent/US7122654B2/en not_active Expired - Fee Related
-
2003
- 2003-11-12 US US10/705,476 patent/US20040175730A1/en not_active Abandoned
-
2005
- 2005-12-16 US US11/304,585 patent/US20060177428A1/en not_active Abandoned
-
2007
- 2007-01-24 JP JP2007013569A patent/JP2007167072A/ja active Pending
- 2007-03-28 US US11/692,753 patent/US20080145366A1/en not_active Abandoned
- 2007-06-29 US US11/772,089 patent/US7662932B2/en not_active Expired - Fee Related
- 2007-08-23 US US11/843,867 patent/US7871798B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/929,120 patent/US7928061B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/929,537 patent/US7785803B2/en not_active Expired - Fee Related
-
2009
- 2009-07-10 JP JP2009164162A patent/JP2009291198A/ja active Pending
-
2011
- 2011-03-16 US US13/049,308 patent/US8227410B2/en not_active Expired - Fee Related
-
2012
- 2012-05-17 US US13/474,273 patent/US8445234B2/en not_active Expired - Fee Related
-
2013
- 2013-04-19 US US13/866,266 patent/US8759286B2/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003517265A (ja) * | 1997-12-24 | 2003-05-27 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 血管内皮増殖因子dを発現する発現ベクターおよび細胞系、およびメラノーマを治療する方法 |
| JP2009511492A (ja) * | 2005-10-06 | 2009-03-19 | トロフォゲン,インコーポレイテッド | Vegf類縁体および使用方法 |
| JP2013177458A (ja) * | 2005-10-06 | 2013-09-09 | Trophogen Inc | Vegf類縁体および使用方法 |
| US9078860B2 (en) | 2005-10-06 | 2015-07-14 | Trophogen, Inc. | VEGF analogs |
| US10457713B2 (en) | 2012-07-30 | 2019-10-29 | Trophogen, Inc. | Glycoprotein hormone long-acting superagonists |
| US10766941B2 (en) | 2012-07-30 | 2020-09-08 | Trophogen Inc. | Glycoprotein hormone long-acting superagonists |
| US10544200B2 (en) | 2013-11-05 | 2020-01-28 | Trophogen, Inc. | Glycoprotein hormone long-acting superagonists |
| WO2022191252A1 (ja) * | 2021-03-10 | 2022-09-15 | 住友ファーマ株式会社 | システインノットタンパク質の製造方法 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001517075A (ja) | 組換え血管内皮細胞増殖因子d(vegf―d) | |
| US5607918A (en) | Vascular endothelial growth factor-B and DNA coding therefor | |
| US5928939A (en) | Vascular endothelial growth factor-b and dna coding therefor | |
| HK1025789B (en) | Recombinant vascular endothelial cell growth factor d (vegf-d) | |
| JP4324709B6 (ja) | レセプターリガンドvegf−c | |
| JP4324709B2 (ja) | レセプターリガンドvegf−c |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20040315 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20040510 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040616 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050412 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050708 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20050822 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051012 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20060926 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070124 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20070208 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20070215 |