ATE306546T1 - Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d) - Google Patents
Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d)Info
- Publication number
- ATE306546T1 ATE306546T1 AT97938486T AT97938486T ATE306546T1 AT E306546 T1 ATE306546 T1 AT E306546T1 AT 97938486 T AT97938486 T AT 97938486T AT 97938486 T AT97938486 T AT 97938486T AT E306546 T1 ATE306546 T1 AT E306546T1
- Authority
- AT
- Austria
- Prior art keywords
- vegf
- endothelial cell
- growth factor
- cell growth
- vascular endothelial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2375196P | 1996-08-23 | 1996-08-23 | |
AUPO1825A AUPO182596A0 (en) | 1996-08-23 | 1996-08-23 | Growth factor |
AUPO3554A AUPO355496A0 (en) | 1996-11-11 | 1996-11-11 | Growth factor |
US3109796P | 1996-11-14 | 1996-11-14 | |
AUPO4954A AUPO495497A0 (en) | 1997-02-05 | 1997-02-05 | Growth factors |
US3881497P | 1997-02-10 | 1997-02-10 | |
AUPO7435A AUPO743597A0 (en) | 1997-06-19 | 1997-06-19 | Growth factor |
US5142697P | 1997-07-01 | 1997-07-01 | |
PCT/US1997/014696 WO1998007832A1 (en) | 1996-08-23 | 1997-08-21 | Recombinant vascular endothelial cell growth factor d (vegf-d) |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE306546T1 true ATE306546T1 (de) | 2005-10-15 |
Family
ID=46149776
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97938486T ATE306546T1 (de) | 1996-08-23 | 1997-08-21 | Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d) |
AT06121918T ATE434034T1 (de) | 1996-08-23 | 1997-08-21 | Rekombinanter vasculärer endothelzellen wachstumsfaktor d (vegf-d) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06121918T ATE434034T1 (de) | 1996-08-23 | 1997-08-21 | Rekombinanter vasculärer endothelzellen wachstumsfaktor d (vegf-d) |
Country Status (11)
Country | Link |
---|---|
US (14) | US6235713B1 (de) |
EP (4) | EP0956339B1 (de) |
JP (3) | JP2001517075A (de) |
AT (2) | ATE306546T1 (de) |
AU (1) | AU729880C (de) |
CA (1) | CA2263890C (de) |
DE (2) | DE69734359T2 (de) |
DK (3) | DK0956339T3 (de) |
ES (3) | ES2390107T3 (de) |
HK (1) | HK1025789A1 (de) |
WO (1) | WO1998007832A1 (de) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
AU696764B2 (en) | 1994-03-08 | 1998-09-17 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
US7423125B2 (en) | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
EP0848755B2 (de) | 1995-09-08 | 2011-02-09 | Genentech, Inc. | Vegf-verwandtes protein |
AU7142996A (en) | 1995-09-29 | 1997-04-28 | Universita' Degli Studi Di Siena | Regulated genes and uses thereof |
US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
EP0935001B2 (de) * | 1996-07-15 | 2011-08-10 | Chugai Seiyaku Kabushiki Kaisha | Neuartige vegf-ähnliche faktoren |
EP0956339B1 (de) | 1996-08-23 | 2005-10-12 | Ludwig Institute For Cancer Research | Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d) |
US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6391311B1 (en) | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
AU765888B2 (en) * | 1997-12-24 | 2003-10-02 | Vegenics Limited | Expression vectors and cell lines expressing vascular endothelial growth factor D, and method of treating melanomas |
EP1054687B8 (de) * | 1997-12-24 | 2008-07-16 | Vegenics Limited | Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen |
DK2016951T3 (da) * | 1998-03-17 | 2012-09-24 | Genentech Inc | VEGF- og BMP1-homologe polypeptider |
EP0984063A3 (de) * | 1998-08-31 | 2000-08-16 | Eli Lilly And Company | Vegf-verwandtes gen und protein |
US20030082670A1 (en) * | 1998-09-30 | 2003-05-01 | Ulf Eriksson | Platelet-derived growth factor C, DNA coding therefor, and uses thereof |
US20040053837A1 (en) * | 1998-09-30 | 2004-03-18 | Ludwig Institute For Cancer Research | Composition and method for modulating vasculogenesis or angiogenesis |
US20030211994A1 (en) * | 1998-09-30 | 2003-11-13 | Ludwig Institute For Cancer Research | Composition and method for modulating vasculogenesis or angiogenesis |
DE69942981D1 (de) | 1998-10-09 | 2011-01-05 | Vegenics Ltd | Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie |
US6958147B1 (en) | 1998-10-26 | 2005-10-25 | Licentia Ltd | Use of VEGF-C to prevent restenosis |
ATE275417T1 (de) * | 1998-10-26 | 2004-09-15 | Ludwig Inst Cancer Res | Verwendung von vegf-c und vegf-d genen oder proteinen zur vorbeugung der restenose |
EP1568375A1 (de) * | 1998-10-26 | 2005-08-31 | Ludwig Institute For Cancer Research | Verwendung von VEGF-C oder VEGF-D Genen oder Proteinen zur Vorbeugung der Restenose |
JP2002534061A (ja) | 1998-11-10 | 2002-10-15 | ルードヴィッヒ・インスティテュート・フォア・キャンサー・リサーチ | 血小板由来増殖因子d、それをコードするdna、及びその利用法 |
EP1137773B1 (de) * | 1998-12-07 | 2008-08-13 | ZymoGenetics, Inc. | Wachstumsfaktor-homologe zvegf-3 |
DK1140175T3 (da) * | 1998-12-21 | 2006-08-14 | Ludwig Inst Cancer Res | Antistoffer mod trunkeret VEGF-D og anvendelser deraf |
US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
DK1141293T3 (da) * | 1998-12-22 | 2007-11-12 | Janssen Pharmaceutica Nv | Vaskulær endotelial vækstfaktor-X |
US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
AU3501700A (en) | 1999-02-26 | 2000-09-14 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
US6764820B2 (en) | 1999-03-26 | 2004-07-20 | Ludwig Institute For Cancer Research | Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3) |
NZ514434A (en) * | 1999-03-26 | 2003-11-28 | Univ California | Modulation of vascular permeability by means of TIE2 receptor activators |
WO2000058511A1 (en) | 1999-03-26 | 2000-10-05 | Ludwig Institute For Cancer Research | Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3) |
US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
CA2381985A1 (en) * | 1999-08-16 | 2001-02-22 | Universita'degli Studi Di Siena | Vegf-d and angiogenic use thereof |
US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
US7045133B2 (en) | 2000-01-18 | 2006-05-16 | Ludwig Institute For Cancer Research | VEGF-D/VEGF-C/VEGF peptidomimetic inhibitor |
US7727971B2 (en) | 2000-02-04 | 2010-06-01 | Life Sciences Research Partners Vzw | Use of placental growth factor for treating ischemic muscle disease |
US6930089B2 (en) | 2000-02-04 | 2005-08-16 | D. Collen Research Foundation Vzw | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic disease or stroke |
US7105168B1 (en) | 2002-06-04 | 2006-09-12 | D. Collen Research Foundation Vzw | Method of improving ischemic muscle function by administering placental growth factor |
AU4643501A (en) * | 2000-02-04 | 2001-08-14 | Flanders Interuniversity Institute For Biotechnology (Vib) | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic diseases or stroke |
PL357099A1 (en) | 2000-02-07 | 2004-07-12 | Abbott Gmbh & Co.Kg | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
JP4981229B2 (ja) | 2000-02-25 | 2012-07-18 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | ハイブリッド血管内皮成長因子DNAsおよびタンパク質に関与する物質および方法 |
ES2234818T3 (es) * | 2000-03-02 | 2005-07-01 | Ludwig Institute For Cancer Research | Procedimiento para tratar canceres que expresan el factor de crecimiento endotelial d. |
AU2006201128B2 (en) * | 2000-03-02 | 2009-05-28 | Vegenics Limited | Methods for treating, screening for, and detecting cancers expressing vascular endothelial growth factor D |
US20020102260A1 (en) * | 2000-03-02 | 2002-08-01 | Marc Achen | Methods for treating neoplastic disease characterized by vascular endothelial growth factor D expression, for screening for neoplastic disease or metastatic risk, and for maintaining vascularization of tissue |
EP1519193B1 (de) * | 2000-03-02 | 2011-11-09 | Vegenics Pty Ltd | Verfahren zum Auffinden von Tumoren welche den vaskulären endothelialen Wachstumsfaktor D exprimieren |
EP1278544A4 (de) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | Albumin fusionsproteine |
AU6456501A (en) * | 2000-05-03 | 2001-11-12 | Ludwig Inst Cancer Res | A method for activating only the vascular endothelial growth factor receptor-3 and uses thereof |
EP1313512A4 (de) | 2000-08-04 | 2004-08-25 | Human Genome Sciences Inc | Vaskulärer endothel-wachstumsfaktor 2(15.02.02) |
US6793918B2 (en) * | 2000-11-01 | 2004-09-21 | Ludwig Institute For Cancer Research | In vivo stimulation of angiogenic activity |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
US7026462B2 (en) | 2000-12-07 | 2006-04-11 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
US7611711B2 (en) | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
CN1494552A (zh) | 2001-01-19 | 2004-05-05 | ·��ά��֢�о�Ժ | Flt4(VEGFR-3)作为靶用于肿瘤成像和抗肿瘤治疗 |
US20020164624A1 (en) * | 2001-02-12 | 2002-11-07 | Waldemar Debinski | VEGF-D expression in brain cancer |
MXPA03008560A (es) | 2001-03-22 | 2004-06-30 | Abbot Gmbh & Co Kg | Pirazolopirimidinas como agentes terapeuticos. |
US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
JP2004536579A (ja) | 2001-04-13 | 2004-12-09 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 血管内皮増殖因子2 |
AU2002345603B2 (en) * | 2001-06-07 | 2006-10-12 | Skinmedica, Inc. | Conditioned cell culture media and uses thereof |
AU2002322461B2 (en) * | 2001-07-12 | 2007-12-06 | Vegenics Limited | Lymphatic endothelial cells materials and methods |
US7514261B2 (en) * | 2001-08-09 | 2009-04-07 | Cornell Research Foundation, Inc. | Platelet-derived growth factor protection of cardiac myocardium |
US20030113324A1 (en) * | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
BR0213325A (pt) | 2001-10-15 | 2004-10-13 | Janssen Pharmaceutica Nv | Derivados de 4-fenil-4-[1h-imidazol-2-il]-piperidina substituìda para a redução de dano isquêmico |
EP2277910A1 (de) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Albumin Fusionsproteine |
JP2005536186A (ja) * | 2002-03-07 | 2005-12-02 | ルードビッヒ、インスティテュート、フォー、キャンサー、リサーチ | リンパ管および血管内皮細胞遺伝子 |
US7510714B2 (en) * | 2002-04-01 | 2009-03-31 | Trustees Of Dartmouth College | Methods for modulating angiogenesis |
US7241446B2 (en) * | 2002-04-01 | 2007-07-10 | Trustees Of Dartmouth College | Methods for modulating angiogenesis via VEGF |
US20030228283A1 (en) * | 2002-05-03 | 2003-12-11 | Ludwig Institute For Cancer Research | Preventing secondary lymphedema with VEGF-D DNA |
CN100418981C (zh) | 2002-06-10 | 2008-09-17 | 瓦西尼斯公司 | 在乳腺癌和膀胱癌中差异表达的基因及编码多肽 |
CA2493572A1 (en) | 2002-07-23 | 2004-01-29 | Ludwig Institute For Cancer Research | Methods and compositions for activating or inhibiting vegf-d and vegf-c |
US20040120950A1 (en) * | 2002-12-20 | 2004-06-24 | Kari Alitalo | Modulation of VEGF-C/VEGFR-3 interactions in the treatment of rheumatoid arthritis |
US20040248796A1 (en) * | 2003-02-04 | 2004-12-09 | Kari Alitalo | VEGF-B and PDGF modulation of stem cells |
WO2005016963A2 (en) * | 2003-06-12 | 2005-02-24 | Ludwig Institute For Cancer Research | Heparin binding veger-3 ligands |
US20050043235A1 (en) * | 2003-06-12 | 2005-02-24 | Kari Alitalo | Use of VEGF-C or VEGF-D in reconstructive surgery |
US20070110744A1 (en) * | 2003-09-08 | 2007-05-17 | Kari Alitalo | Lymphatic and blood endothelial cell genes |
US7284505B1 (en) | 2003-11-03 | 2007-10-23 | Paxton Stephen E | Skijor system |
US7780973B2 (en) * | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
WO2005063807A2 (en) * | 2003-12-29 | 2005-07-14 | Centelion | Treatment of coronary or peripheral ischemia |
US20050142161A1 (en) * | 2003-12-30 | 2005-06-30 | Freeman Lynetta J. | Collagen matrix for soft tissue augmentation |
WO2005087812A1 (en) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for vegf/pdgf family of growth factors |
US20060024302A1 (en) * | 2004-03-05 | 2006-02-02 | Ludwig Institute For Cancer Research | Chimeric anti-VEGF-D antibodies and humanized anti-VEGF-D antibodies and methods of using same |
WO2005093098A1 (en) * | 2004-03-12 | 2005-10-06 | Ludwig Institute For Cancer Research | Differential drug sensitivity |
US7595149B1 (en) | 2004-11-08 | 2009-09-29 | University Of Kentucky Research Foundation | Methods for cancer detection |
EP2314614B1 (de) | 2005-02-28 | 2015-11-25 | Sangamo BioSciences, Inc. | Anti-angiogene Verfahren und Zusammensetzungen |
EP1919944B1 (de) | 2005-08-15 | 2011-03-23 | Vegenics Pty Ltd | Modifizierte vegf und pdgf mit verbesserten angiogenen eigenschaften |
TW200732347A (en) * | 2005-10-06 | 2007-09-01 | Trophogen Inc | VEGF analogs and methods of use |
ES2350269T3 (es) * | 2006-01-18 | 2011-01-20 | The General Hospital Corporation | Métodos de aumento de la función linfática. |
ES2497641T3 (es) | 2006-05-17 | 2014-09-23 | The Ludwig Institute For Cancer Research | Dirección a la regulación de VEGF-B de transportadores de ácidos grasos para modular enfermedades humanas |
US9073997B2 (en) | 2007-02-02 | 2015-07-07 | Vegenics Pty Limited | Growth factor antagonists for organ transplant alloimmunity and arteriosclerosis |
WO2008096268A2 (en) * | 2007-02-07 | 2008-08-14 | Vegenics Limited | Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat secondary lymphedema and to improve reconstructive surgery |
US7811776B2 (en) | 2007-12-05 | 2010-10-12 | University Of Cincinnati | Use of VEGF-D in the diagnosis of lymphangioleiomyomatosis (LAM) disease |
AU2008341050B2 (en) | 2007-12-26 | 2013-10-24 | Vaccinex, Inc. | Anti-C35 antibody combination therapies and methods |
WO2009143584A1 (en) * | 2008-05-30 | 2009-12-03 | Vegenics Limited | Treatment of pulmonary edema |
US20100029491A1 (en) * | 2008-07-11 | 2010-02-04 | Maike Schmidt | Methods and compositions for diagnostic use for tumor treatment |
US8255807B2 (en) * | 2008-12-23 | 2012-08-28 | Ganz | Item customization and website customization |
AU2010230855A1 (en) * | 2009-04-03 | 2012-01-12 | Vegenics Limited | Anti-VEGF-D antibodies |
WO2011056494A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
WO2011106697A1 (en) * | 2010-02-25 | 2011-09-01 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
WO2011154308A1 (en) | 2010-06-08 | 2011-12-15 | Proyecto De Biomedicina Cima, S.L. | New compositions and cell therapy methods for the treatment of cirrhosis |
WO2012088563A1 (en) * | 2010-11-24 | 2012-07-05 | Vegenics Pty Limited | Vegfr-2-specific forms of vegf-d and vegf-c and uses thereof |
WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
US9415090B2 (en) * | 2011-06-01 | 2016-08-16 | Universität Heidelberg | VEGF-D/VEGFR2/3-mediated regulation of dendrites |
US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
CA3108181A1 (en) | 2012-07-30 | 2014-02-06 | Trophogen Inc. | Glycoprotein hormone long-acting superagonists |
US10457713B2 (en) | 2012-07-30 | 2019-10-29 | Trophogen, Inc. | Glycoprotein hormone long-acting superagonists |
EP2900265B1 (de) | 2012-09-27 | 2018-05-30 | Biocare Medical, LLC | Anti-uroplakin-ii-antikörper, systeme und verfahren |
US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
RS60026B1 (sr) | 2013-02-18 | 2020-04-30 | Vegenics Pty Ltd | Molekuli koji vezuju ligande i njihove upotrebe |
EP2962113B1 (de) | 2013-02-28 | 2019-04-03 | Biocare Medical, LLC | Systeme und verfahren mit anti-pd40-antikörpern |
EP3052522B1 (de) | 2013-10-03 | 2019-12-11 | Biocare Medical, LLC | Anti-sox10-antikörpersysteme und verfahren |
JP2017502079A (ja) | 2013-11-05 | 2017-01-19 | トロフォジェン インコーポレイテッド | 糖タンパク質ホルモン長時間作用性スーパーアゴニスト |
EP3924367A4 (de) * | 2019-04-04 | 2022-10-12 | Sree Chitra Tirunal Institute for Medical Sciences and Technology | Gefässendothelwachstumsfaktor (vegf) zur besseren wundheilung durch erhöhte angiogenese |
US20240150807A1 (en) * | 2021-03-10 | 2024-05-09 | Sumitomo Pharma Co., Ltd. | Method for Producing Cysteine Knot Protein |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5968778A (en) | 1989-01-12 | 1999-10-19 | Jurgen Hoppe | PDGF-AB, preparation process and pharmaceuticals containing them |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
US6207454B1 (en) * | 1989-10-16 | 2001-03-27 | Amgen Inc. | Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide |
US5476839A (en) * | 1990-07-10 | 1995-12-19 | Incyte Pharmaceuticals, Inc. | Basophil granule proteins |
JP3024311B2 (ja) | 1991-10-03 | 2000-03-21 | 味の素株式会社 | Il−2受容体重鎖に結合するポリペプチド |
JPH05271294A (ja) | 1992-01-24 | 1993-10-19 | Japan Found Cancer Res | ヒトプロヒビチンおよびそれをコードするdna |
PL307258A1 (en) | 1992-07-27 | 1995-05-15 | Pfizer | Peptides capable to block calcium canals with agelenopsis aperta |
US5510239A (en) * | 1993-10-18 | 1996-04-23 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of multidrug resistance-associated protein |
AU696764B2 (en) | 1994-03-08 | 1998-09-17 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
DE4423098A1 (de) | 1994-07-01 | 1996-01-04 | Hoechst Ag | Verwendung von Pyrimidingruppen enthaltenden konjugierten Verbindungen als Elektrolumineszenzmaterialien |
US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
US6645933B1 (en) * | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
US6221839B1 (en) * | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
JPH08185216A (ja) | 1994-12-28 | 1996-07-16 | Meidensha Corp | 工具姿勢パラメータ設定方法及びロボット制御装置 |
US5928939A (en) | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
CN1194090C (zh) | 1995-03-02 | 2005-03-23 | 阿穆拉德业务有限公司 | 一种新的生长因子和编码这种生长因子的基因序列 |
WO1996039421A1 (en) | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 3 |
EP0848755B2 (de) * | 1995-09-08 | 2011-02-09 | Genentech, Inc. | Vegf-verwandtes protein |
AU7142996A (en) * | 1995-09-29 | 1997-04-28 | Universita' Degli Studi Di Siena | Regulated genes and uses thereof |
JP3843488B2 (ja) | 1996-06-06 | 2006-11-08 | アイシン・エィ・ダブリュ株式会社 | 自動変速機の制御装置 |
EP0935001B2 (de) | 1996-07-15 | 2011-08-10 | Chugai Seiyaku Kabushiki Kaisha | Neuartige vegf-ähnliche faktoren |
EP0956339B1 (de) | 1996-08-23 | 2005-10-12 | Ludwig Institute For Cancer Research | Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d) |
AU5439998A (en) | 1996-12-06 | 1998-06-29 | Zymogenetics Inc. | Vascular endothelial growth factor |
US20020165174A1 (en) * | 1997-01-31 | 2002-11-07 | Gill Parkash S. | Methods and compositions for antisense VEGF oligonucleotides |
EP1054687B8 (de) | 1997-12-24 | 2008-07-16 | Vegenics Limited | Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen |
DE19817835C2 (de) | 1998-04-22 | 2000-05-18 | Billhofer Maschf Gmbh | Sichtkaschiervorrichtung |
DE19823359C1 (de) | 1998-05-15 | 1999-10-07 | Francotyp Postalia Gmbh | Vorrichtung zum Bedrucken von Postgut |
DK1140175T3 (da) | 1998-12-21 | 2006-08-14 | Ludwig Inst Cancer Res | Antistoffer mod trunkeret VEGF-D og anvendelser deraf |
CA2381985A1 (en) * | 1999-08-16 | 2001-02-22 | Universita'degli Studi Di Siena | Vegf-d and angiogenic use thereof |
US20050043235A1 (en) | 2003-06-12 | 2005-02-24 | Kari Alitalo | Use of VEGF-C or VEGF-D in reconstructive surgery |
US20070212390A1 (en) | 2005-09-22 | 2007-09-13 | Ludwig Institute For Cancer Research | Protease-resistant forms of VEGF-D, method of making and method of use |
FR2987282B1 (fr) | 2012-02-24 | 2017-12-29 | Fonds De L'espci Georges Charpak | Microcanal avec dispositif d'ouverture et/ou fermeture et/ou pompage |
US9405291B2 (en) | 2012-07-31 | 2016-08-02 | Fisher-Rosemount Systems, Inc. | Systems and methods to monitor an asset in an operating process unit |
US9516755B2 (en) | 2012-12-28 | 2016-12-06 | Intel Corporation | Multi-channel memory module |
US9426605B2 (en) | 2013-10-10 | 2016-08-23 | Yahoo! Inc. | Cross device information exchange using gestures and locations |
-
1997
- 1997-08-21 EP EP97938486A patent/EP0956339B1/de not_active Revoked
- 1997-08-21 EP EP06121918A patent/EP1749836B1/de not_active Expired - Lifetime
- 1997-08-21 AT AT97938486T patent/ATE306546T1/de not_active IP Right Cessation
- 1997-08-21 ES ES09162873T patent/ES2390107T3/es not_active Expired - Lifetime
- 1997-08-21 DK DK97938486T patent/DK0956339T3/da active
- 1997-08-21 ES ES97938486T patent/ES2251740T3/es not_active Expired - Lifetime
- 1997-08-21 JP JP51095398A patent/JP2001517075A/ja active Pending
- 1997-08-21 EP EP02018842A patent/EP1283268A3/de not_active Withdrawn
- 1997-08-21 CA CA2263890A patent/CA2263890C/en not_active Expired - Fee Related
- 1997-08-21 AU AU40796/97A patent/AU729880C/en not_active Ceased
- 1997-08-21 DK DK06121918T patent/DK1749836T3/da active
- 1997-08-21 DE DE69734359T patent/DE69734359T2/de not_active Expired - Lifetime
- 1997-08-21 DE DE69739469T patent/DE69739469D1/de not_active Expired - Lifetime
- 1997-08-21 WO PCT/US1997/014696 patent/WO1998007832A1/en active IP Right Grant
- 1997-08-21 US US08/915,795 patent/US6235713B1/en not_active Expired - Fee Related
- 1997-08-21 DK DK09162873.5T patent/DK2107109T3/da active
- 1997-08-21 ES ES06121918T patent/ES2327440T3/es not_active Expired - Lifetime
- 1997-08-21 EP EP09162873A patent/EP2107109B1/de not_active Expired - Lifetime
- 1997-08-21 AT AT06121918T patent/ATE434034T1/de not_active IP Right Cessation
-
1999
- 1999-04-22 US US09/296,275 patent/US6689580B1/en not_active Expired - Fee Related
-
2000
- 2000-05-17 HK HK00102970A patent/HK1025789A1/xx not_active IP Right Cessation
-
2002
- 2002-06-05 US US10/161,694 patent/US7410639B2/en not_active Expired - Fee Related
- 2002-10-22 US US10/274,953 patent/US7122654B2/en not_active Expired - Fee Related
-
2003
- 2003-11-12 US US10/705,476 patent/US20040175730A1/en not_active Abandoned
-
2005
- 2005-12-16 US US11/304,585 patent/US20060177428A1/en not_active Abandoned
-
2007
- 2007-01-24 JP JP2007013569A patent/JP2007167072A/ja active Pending
- 2007-03-28 US US11/692,753 patent/US20080145366A1/en not_active Abandoned
- 2007-06-29 US US11/772,089 patent/US7662932B2/en not_active Expired - Fee Related
- 2007-08-23 US US11/843,867 patent/US7871798B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/929,537 patent/US7785803B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/929,120 patent/US7928061B2/en not_active Expired - Fee Related
-
2009
- 2009-07-10 JP JP2009164162A patent/JP2009291198A/ja active Pending
-
2011
- 2011-03-16 US US13/049,308 patent/US8227410B2/en not_active Expired - Fee Related
-
2012
- 2012-05-17 US US13/474,273 patent/US8445234B2/en not_active Expired - Fee Related
-
2013
- 2013-04-19 US US13/866,266 patent/US8759286B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0956339T3 (da) | Rekombinant vaskulær endotelcellevækstfaktor D (VEGF-D) | |
NO973933L (no) | Vaskulær endotelvekstfaktor B | |
DE69941791D1 (de) | Von blutplättchen abstammender wachstumsfaktor d, dafür kodierende dns und deren verwendungen | |
DE3851153D1 (de) | Genetische modifizierung von endothelialen zellen. | |
PT93910A (pt) | Prodesso para a preparacao de uma proteina heterologa mediante secrecao a partir de uma celula | |
DE69839340D1 (de) | Mutanten DES VASKULÄREN, ENDOTHELZELLEN-SPEZIFISCHEN WACHSTUMSFAKTORS C (VEGF-C) UND DEREN VERWENDUNGEN | |
ATE309360T1 (de) | Vaskularer endothelialer wachstumsfaktor 2 | |
DE3786321D1 (de) | Expression von protein-c. | |
DK0409472T3 (da) | Knoglemorfogenetisk protein | |
DE69434332D1 (de) | Thrombin mutanten | |
IL70776A (en) | Recombinant dna molecule encoding at least one polypeptide displaying the immunogenicity of at least one merozoite antigen or asexual blood stage antigen of p.falciparum,vectors comprising the dna molecule,host cells transformed thereby,immunogenic polypeptides produced by host cells and compositions containing the polypeptides | |
ATE121776T1 (de) | Expression des biologisch aktiven faktors xiii. | |
WO2002050111A3 (en) | Isolated laminin 10 | |
WO2001053324A8 (en) | Novel haptotactic peptides | |
WO1990003394A3 (fr) | Nouvelles lymphokines, sequences d'adn codant pour ces lymphokines et compositions pharmaceutiques contenant ces lymphokines | |
WO2002059618A3 (en) | Growth factor polypeptides and nucleic acids encoding same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEIH | Change in the person of patent owner | ||
UEP | Publication of translation of european patent specification |
Ref document number: 0956339 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |