JP2001515086A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2001515086A5 JP2001515086A5 JP2000509720A JP2000509720A JP2001515086A5 JP 2001515086 A5 JP2001515086 A5 JP 2001515086A5 JP 2000509720 A JP2000509720 A JP 2000509720A JP 2000509720 A JP2000509720 A JP 2000509720A JP 2001515086 A5 JP2001515086 A5 JP 2001515086A5
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- minutes
- added
- dmtr
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *SN(C(C=C1)=O)C1=O Chemical compound *SN(C(C=C1)=O)C1=O 0.000 description 11
- HPTLYPDZETUCSZ-UHFFFAOYSA-N O=C(C=CC1=O)N1SC1CCC#CCC1 Chemical compound O=C(C=CC1=O)N1SC1CCC#CCC1 HPTLYPDZETUCSZ-UHFFFAOYSA-N 0.000 description 1
- SNQDZVHQDVXJHD-UHFFFAOYSA-N O=C(C=CC1=O)N1Sc1ccccc1 Chemical compound O=C(C=CC1=O)N1Sc1ccccc1 SNQDZVHQDVXJHD-UHFFFAOYSA-N 0.000 description 1
- NAKJZULQYMOLMO-UHFFFAOYSA-N O=C(COCC1=O)N1Sc1ccccc1 Chemical compound O=C(COCC1=O)N1Sc1ccccc1 NAKJZULQYMOLMO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9717158.1A GB9717158D0 (en) | 1997-08-13 | 1997-08-13 | Solution synthesis of oligonucleotides and their phosphorothioate analogues |
| GB9717158.1 | 1997-08-13 | ||
| PCT/GB1998/002407 WO1999009041A2 (en) | 1997-08-13 | 1998-08-10 | Solution phase synthesis of oligonucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001515086A JP2001515086A (ja) | 2001-09-18 |
| JP2001515086A5 true JP2001515086A5 (https=) | 2006-01-12 |
Family
ID=10817430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000509720A Pending JP2001515086A (ja) | 1997-08-13 | 1998-08-10 | オリゴヌクレオチドの溶液相合成 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6506894B1 (https=) |
| EP (2) | EP1325927A3 (https=) |
| JP (1) | JP2001515086A (https=) |
| KR (1) | KR20010022840A (https=) |
| CN (1) | CN1231492C (https=) |
| AT (1) | ATE236916T1 (https=) |
| BR (1) | BR9811166A (https=) |
| CA (1) | CA2300874A1 (https=) |
| DE (1) | DE69813243T2 (https=) |
| DK (1) | DK1003758T3 (https=) |
| EA (1) | EA003091B1 (https=) |
| ES (1) | ES2197491T3 (https=) |
| GB (1) | GB9717158D0 (https=) |
| HU (1) | HUP0002684A3 (https=) |
| IL (1) | IL134517A (https=) |
| IN (1) | IN190784B (https=) |
| NO (1) | NO20000690L (https=) |
| NZ (1) | NZ502684A (https=) |
| PL (1) | PL338888A1 (https=) |
| TR (1) | TR200000384T2 (https=) |
| WO (1) | WO1999009041A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9924285D0 (en) * | 1999-10-14 | 1999-12-15 | Avecia Ltd | Process |
| GB0004889D0 (en) * | 2000-03-01 | 2000-04-19 | Avecia Ltd | Synthesis of oligonucleotides |
| WO2003045969A1 (en) * | 2001-11-21 | 2003-06-05 | Avecia Biotechnology Inc. | Coupling reagent for h-phosphonate chemistry |
| CN100379709C (zh) * | 2002-02-22 | 2008-04-09 | 霍尼韦尔国际公司 | 制备亚磷酸酯化(phosphitylated)化合物的方法 |
| GB0209539D0 (en) * | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
| WO2005077966A1 (en) * | 2004-02-10 | 2005-08-25 | Isis Pharmaceuticals, Inc. | Substituted pixyl protecting groups for oligonucleotide synthesis |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| US8272150B2 (en) * | 2008-12-12 | 2012-09-25 | Speedplay, Inc. | Shoe sole mounting standard for bicycle cleat |
| EP2382227A1 (en) | 2008-12-23 | 2011-11-02 | Girindus America, Inc. | Sulfurizing reagents and their use for oligonucleotides synthesis |
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| US8710210B2 (en) | 2010-06-30 | 2014-04-29 | Girindus America, Inc. | Method of using N-thio compounds for oligonucleotide synthesis |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| WO2013017469A1 (en) | 2011-07-29 | 2013-02-07 | Girindus America, Inc. | Sulfurization reagents on solid supports |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| CA2879066C (en) | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| WO2014085471A1 (en) * | 2012-11-28 | 2014-06-05 | Prognosdx Health, Inc. | Acid-activated compositions for the treatment of cancers, methods of their use and methods of their preparation |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
| WO2018215049A1 (en) * | 2017-05-23 | 2018-11-29 | F. Hoffmann-La Roche Ag | Process for galnac oligonucleotide conjugates |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3444300A (en) * | 1964-05-05 | 1969-05-13 | Chevron Res | N-polyhaloalkylthio compounds as fungicidal agents |
| FR1519704A (fr) * | 1967-02-14 | 1968-04-05 | Roussel Uclaf | Nouveaux composés dithiocarbamiques hétérocycliques et procédé de préparation |
| US3546185A (en) | 1968-03-20 | 1970-12-08 | Monsanto Co | Inhibiting premature vulcanization of diene rubbers |
| US5149798A (en) * | 1989-04-06 | 1992-09-22 | Worcester Foundation For Experimental Biology | Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses |
| EP0678096B1 (en) | 1993-01-08 | 1997-03-19 | HYBRIDON, Inc. | Synthesis of dimmer blocks and their use in assembling oligonucleotides |
| GB9501465D0 (en) * | 1995-01-25 | 1995-03-15 | King S College London | Nucleoside phosphorothioate derivatives,synthesis and use thereof |
| GB0004889D0 (en) * | 2000-03-01 | 2000-04-19 | Avecia Ltd | Synthesis of oligonucleotides |
-
1997
- 1997-08-13 GB GBGB9717158.1A patent/GB9717158D0/en active Pending
-
1998
- 1998-08-10 WO PCT/GB1998/002407 patent/WO1999009041A2/en not_active Ceased
- 1998-08-10 EA EA200000211A patent/EA003091B1/ru not_active IP Right Cessation
- 1998-08-10 EP EP03007651A patent/EP1325927A3/en not_active Withdrawn
- 1998-08-10 BR BR9811166-3A patent/BR9811166A/pt not_active IP Right Cessation
- 1998-08-10 NZ NZ502684A patent/NZ502684A/xx unknown
- 1998-08-10 EP EP98938782A patent/EP1003758B1/en not_active Expired - Lifetime
- 1998-08-10 HU HU0002684A patent/HUP0002684A3/hu unknown
- 1998-08-10 ES ES98938782T patent/ES2197491T3/es not_active Expired - Lifetime
- 1998-08-10 CN CNB988099314A patent/CN1231492C/zh not_active Expired - Fee Related
- 1998-08-10 DK DK98938782T patent/DK1003758T3/da active
- 1998-08-10 PL PL98338888A patent/PL338888A1/xx unknown
- 1998-08-10 CA CA002300874A patent/CA2300874A1/en not_active Abandoned
- 1998-08-10 KR KR1020007001442A patent/KR20010022840A/ko not_active Abandoned
- 1998-08-10 IL IL13451798A patent/IL134517A/en active IP Right Grant
- 1998-08-10 JP JP2000509720A patent/JP2001515086A/ja active Pending
- 1998-08-10 DE DE69813243T patent/DE69813243T2/de not_active Expired - Fee Related
- 1998-08-10 AT AT98938782T patent/ATE236916T1/de not_active IP Right Cessation
- 1998-08-10 US US09/485,606 patent/US6506894B1/en not_active Expired - Lifetime
- 1998-08-10 TR TR2000/00384T patent/TR200000384T2/xx unknown
- 1998-08-12 IN IN2353DE1998 patent/IN190784B/en unknown
-
2000
- 2000-02-11 NO NO20000690A patent/NO20000690L/no not_active Application Discontinuation
-
2002
- 2002-11-15 US US10/294,794 patent/US7019127B2/en not_active Expired - Lifetime
-
2005
- 2005-06-28 US US11/167,145 patent/US20050240015A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001515086A5 (https=) | ||
| FI114471B (fi) | Menetelmä nukleosidin 2', 3' -dideoksi-3' -tiapyrimidiini beta-isomeerin valmistamiseski | |
| US6090932A (en) | Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement | |
| JPS60502102A (ja) | オリゴヌクレオチドの製造法 | |
| Reese et al. | Solution phase synthesis of ISIS 2922 (Vitravene) by the modified H-phosphonate approach | |
| JPH07300492A (ja) | ▲ｎ４▼−アシル−５’−デオキシ−５−フルオロシチジン誘導体の新規製造法 | |
| JP2002516256A (ja) | 二環式糖成分を有する新規ヌクレオシド | |
| JP2002517404A (ja) | オリゴヌクレオチド合成のためのアクチベーター | |
| FR2709754A1 (fr) | Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale. | |
| JP2001515086A (ja) | オリゴヌクレオチドの溶液相合成 | |
| EP0638586B1 (en) | Nucleoside derivatives and methods for producing them | |
| Reese | The H-phosphonate approach to the synthesis of oligonucleotides and their phosphorothioate analogues in solution | |
| CN100484949C (zh) | 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法 | |
| CA2290364A1 (en) | Method of producing tiazofurin and other c-nucleosides | |
| US6518254B1 (en) | Ribonucleoside-TRIBOSE | |
| JP2013531665A (ja) | オリゴヌクレオチド合成のためにｎ−チオ化合物を用いる新規な方法 | |
| Hancox et al. | Some reactions of 4′-thionucleosides and their sulfones | |
| KR100393913B1 (ko) | 5-메틸우리딘으로부터디4티를제조하는방법 | |
| JPH06135988A (ja) | ヌクレオシド誘導体 | |
| WO1992006993A1 (fr) | Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments comprenant ces composes | |
| JP2002500617A (ja) | 有機リン誘導体の合成方法および組成物 | |
| CS9692A3 (en) | Process for preparing 3-fluoropyrimidine nucleosides | |
| EP0698610B1 (en) | Process for producing sialic acid derivative and novel sialic acid derivative | |
| WO1995012593A1 (en) | 5-0-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, process for producing the same, and use thereof | |
| JPH06135989A (ja) | ヌクレオシド誘導体 |