JP2001515086A5 - - Google Patents
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- Publication number
- JP2001515086A5 JP2001515086A5 JP2000509720A JP2000509720A JP2001515086A5 JP 2001515086 A5 JP2001515086 A5 JP 2001515086A5 JP 2000509720 A JP2000509720 A JP 2000509720A JP 2000509720 A JP2000509720 A JP 2000509720A JP 2001515086 A5 JP2001515086 A5 JP 2001515086A5
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- minutes
- added
- dmtr
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *SN(C(C=C1)=O)C1=O Chemical compound *SN(C(C=C1)=O)C1=O 0.000 description 11
- HPTLYPDZETUCSZ-UHFFFAOYSA-N O=C(C=CC1=O)N1SC1CCC#CCC1 Chemical compound O=C(C=CC1=O)N1SC1CCC#CCC1 HPTLYPDZETUCSZ-UHFFFAOYSA-N 0.000 description 1
- SNQDZVHQDVXJHD-UHFFFAOYSA-N O=C(C=CC1=O)N1Sc1ccccc1 Chemical compound O=C(C=CC1=O)N1Sc1ccccc1 SNQDZVHQDVXJHD-UHFFFAOYSA-N 0.000 description 1
- NAKJZULQYMOLMO-UHFFFAOYSA-N O=C(COCC1=O)N1Sc1ccccc1 Chemical compound O=C(COCC1=O)N1Sc1ccccc1 NAKJZULQYMOLMO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9717158.1A GB9717158D0 (en) | 1997-08-13 | 1997-08-13 | Solution synthesis of oligonucleotides and their phosphorothioate analogues |
| GB9717158.1 | 1997-08-13 | ||
| PCT/GB1998/002407 WO1999009041A2 (en) | 1997-08-13 | 1998-08-10 | Solution phase synthesis of oligonucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001515086A JP2001515086A (ja) | 2001-09-18 |
| JP2001515086A5 true JP2001515086A5 (https=) | 2006-01-12 |
Family
ID=10817430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000509720A Pending JP2001515086A (ja) | 1997-08-13 | 1998-08-10 | オリゴヌクレオチドの溶液相合成 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6506894B1 (https=) |
| EP (2) | EP1325927A3 (https=) |
| JP (1) | JP2001515086A (https=) |
| KR (1) | KR20010022840A (https=) |
| CN (1) | CN1231492C (https=) |
| AT (1) | ATE236916T1 (https=) |
| BR (1) | BR9811166A (https=) |
| CA (1) | CA2300874A1 (https=) |
| DE (1) | DE69813243T2 (https=) |
| DK (1) | DK1003758T3 (https=) |
| EA (1) | EA003091B1 (https=) |
| ES (1) | ES2197491T3 (https=) |
| GB (1) | GB9717158D0 (https=) |
| HU (1) | HUP0002684A3 (https=) |
| IL (1) | IL134517A (https=) |
| IN (1) | IN190784B (https=) |
| NO (1) | NO20000690L (https=) |
| NZ (1) | NZ502684A (https=) |
| PL (1) | PL338888A1 (https=) |
| TR (1) | TR200000384T2 (https=) |
| WO (1) | WO1999009041A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9924285D0 (en) * | 1999-10-14 | 1999-12-15 | Avecia Ltd | Process |
| GB0004889D0 (en) * | 2000-03-01 | 2000-04-19 | Avecia Ltd | Synthesis of oligonucleotides |
| AU2002339175A1 (en) * | 2001-11-21 | 2003-06-10 | Avecia Biotechnology Inc. | Coupling reagent for h-phosphonate chemistry |
| CN100379709C (zh) * | 2002-02-22 | 2008-04-09 | 霍尼韦尔国际公司 | 制备亚磷酸酯化(phosphitylated)化合物的方法 |
| GB0209539D0 (en) * | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
| US20070276139A1 (en) * | 2004-02-10 | 2007-11-29 | Quanlai Song | Substituted Pixyl Protecting Groups for Oligonucleotide Synthesis |
| RU2572826C2 (ru) | 2008-12-02 | 2016-01-20 | Чиралджен, Лтд. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
| US8272150B2 (en) * | 2008-12-12 | 2012-09-25 | Speedplay, Inc. | Shoe sole mounting standard for bicycle cleat |
| CN102307889A (zh) | 2008-12-23 | 2012-01-04 | 集润德斯股份公司 | 硫化剂及其用于寡核苷酸合成的用途 |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| CA2805546A1 (en) | 2010-06-30 | 2012-01-05 | Girindus America, Inc. | A new method of using n-thio compounds for oligonucleotide synthesis |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| AU2012284265B2 (en) | 2011-07-19 | 2017-08-17 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US20140179875A1 (en) | 2011-07-29 | 2014-06-26 | Girindus America, Inc. | Sulfurization reagents on solid supports |
| CN104684923B (zh) | 2012-07-13 | 2018-09-28 | 株式会社新日本科学 | 手性核酸佐剂 |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | キラル制御 |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| WO2014085471A1 (en) * | 2012-11-28 | 2014-06-05 | Prognosdx Health, Inc. | Acid-activated compositions for the treatment of cancers, methods of their use and methods of their preparation |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| WO2018215049A1 (en) * | 2017-05-23 | 2018-11-29 | F. Hoffmann-La Roche Ag | Process for galnac oligonucleotide conjugates |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3444300A (en) * | 1964-05-05 | 1969-05-13 | Chevron Res | N-polyhaloalkylthio compounds as fungicidal agents |
| FR1519704A (fr) * | 1967-02-14 | 1968-04-05 | Roussel Uclaf | Nouveaux composés dithiocarbamiques hétérocycliques et procédé de préparation |
| US3546185A (en) | 1968-03-20 | 1970-12-08 | Monsanto Co | Inhibiting premature vulcanization of diene rubbers |
| US5149798A (en) * | 1989-04-06 | 1992-09-22 | Worcester Foundation For Experimental Biology | Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses |
| ATE150464T1 (de) * | 1993-01-08 | 1997-04-15 | Hybridon Inc | Synthese von dimer-blöcken und ihre verwendung bei der zusammensetzung von oligonukleotiden |
| GB9501465D0 (en) | 1995-01-25 | 1995-03-15 | King S College London | Nucleoside phosphorothioate derivatives,synthesis and use thereof |
| GB0004889D0 (en) * | 2000-03-01 | 2000-04-19 | Avecia Ltd | Synthesis of oligonucleotides |
-
1997
- 1997-08-13 GB GBGB9717158.1A patent/GB9717158D0/en active Pending
-
1998
- 1998-08-10 US US09/485,606 patent/US6506894B1/en not_active Expired - Lifetime
- 1998-08-10 NZ NZ502684A patent/NZ502684A/xx unknown
- 1998-08-10 CN CNB988099314A patent/CN1231492C/zh not_active Expired - Fee Related
- 1998-08-10 IL IL13451798A patent/IL134517A/en active IP Right Grant
- 1998-08-10 DK DK98938782T patent/DK1003758T3/da active
- 1998-08-10 DE DE69813243T patent/DE69813243T2/de not_active Expired - Fee Related
- 1998-08-10 HU HU0002684A patent/HUP0002684A3/hu unknown
- 1998-08-10 CA CA002300874A patent/CA2300874A1/en not_active Abandoned
- 1998-08-10 JP JP2000509720A patent/JP2001515086A/ja active Pending
- 1998-08-10 EA EA200000211A patent/EA003091B1/ru not_active IP Right Cessation
- 1998-08-10 KR KR1020007001442A patent/KR20010022840A/ko not_active Abandoned
- 1998-08-10 ES ES98938782T patent/ES2197491T3/es not_active Expired - Lifetime
- 1998-08-10 EP EP03007651A patent/EP1325927A3/en not_active Withdrawn
- 1998-08-10 TR TR2000/00384T patent/TR200000384T2/xx unknown
- 1998-08-10 WO PCT/GB1998/002407 patent/WO1999009041A2/en not_active Ceased
- 1998-08-10 EP EP98938782A patent/EP1003758B1/en not_active Expired - Lifetime
- 1998-08-10 PL PL98338888A patent/PL338888A1/xx unknown
- 1998-08-10 BR BR9811166-3A patent/BR9811166A/pt not_active IP Right Cessation
- 1998-08-10 AT AT98938782T patent/ATE236916T1/de not_active IP Right Cessation
- 1998-08-12 IN IN2353DE1998 patent/IN190784B/en unknown
-
2000
- 2000-02-11 NO NO20000690A patent/NO20000690L/no not_active Application Discontinuation
-
2002
- 2002-11-15 US US10/294,794 patent/US7019127B2/en not_active Expired - Lifetime
-
2005
- 2005-06-28 US US11/167,145 patent/US20050240015A1/en not_active Abandoned
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