JP2001514483A5 - - Google Patents

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JP2001514483A5
JP2001514483A5 JP1998509122A JP50912298A JP2001514483A5 JP 2001514483 A5 JP2001514483 A5 JP 2001514483A5 JP 1998509122 A JP1998509122 A JP 1998509122A JP 50912298 A JP50912298 A JP 50912298A JP 2001514483 A5 JP2001514483 A5 JP 2001514483A5
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JP
Japan
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JP1998509122A
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Japanese (ja)
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JP2001514483A (ja
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Priority claimed from US08/690,494 external-priority patent/US5942391A/en
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JP50912298A 1996-07-31 1997-07-30 核酸増幅法:分枝―伸長増幅方法(ram) Pending JP2001514483A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/690,494 1996-07-31
US08/690,494 US5942391A (en) 1994-06-22 1996-07-31 Nucleic acid amplification method: ramification-extension amplification method (RAM)
PCT/US1997/013391 WO1998004746A1 (en) 1996-07-31 1997-07-30 Nucleic acid amplification method: ramification-extension amplification method (ram)

Publications (2)

Publication Number Publication Date
JP2001514483A JP2001514483A (ja) 2001-09-11
JP2001514483A5 true JP2001514483A5 (enExample) 2005-04-07

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JP50912298A Pending JP2001514483A (ja) 1996-07-31 1997-07-30 核酸増幅法:分枝―伸長増幅方法(ram)

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US (3) US5942391A (enExample)
EP (1) EP0915991B1 (enExample)
JP (1) JP2001514483A (enExample)
AT (1) ATE339515T1 (enExample)
DE (1) DE69736668T2 (enExample)
ES (1) ES2273371T3 (enExample)
WO (1) WO1998004746A1 (enExample)

Families Citing this family (264)

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Publication number Priority date Publication date Assignee Title
US6261808B1 (en) * 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US7135312B2 (en) 1993-04-15 2006-11-14 University Of Rochester Circular DNA vectors for synthesis of RNA and DNA
WO2000033244A2 (en) * 1998-11-27 2000-06-08 Synaptics (Uk) Limited Position sensor
US5942391A (en) * 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US6593086B2 (en) * 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6143495A (en) * 1995-11-21 2000-11-07 Yale University Unimolecular segment amplification and sequencing
ES2262902T3 (es) 1995-12-05 2006-12-01 Jorn Erland Koch Una reaccion en cascada de amplificacion de acido nucleico.
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
AU730633B2 (en) * 1996-05-29 2001-03-08 Phillip Belgrader Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US20040229221A1 (en) * 1997-05-08 2004-11-18 Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
JP4294740B2 (ja) 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
JP4472171B2 (ja) * 1998-03-04 2010-06-02 アクゾ・ノベル・エヌ・ベー エプスタイン−バーウイルス(ebv)核酸の増幅と検出のためのオリゴヌクレオチド
CA2325468C (en) * 1998-03-25 2008-11-18 Ulf Landegren Rolling circle replication of padlock probes
US8063190B2 (en) * 1998-06-02 2011-11-22 Tom Robin Caine Boyde Nucleic acid-linked conjugates and methods for making and using them
DE69940430D1 (de) 1998-06-24 2009-04-02 Illumina Inc Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US6218118B1 (en) * 1998-07-09 2001-04-17 Agilent Technologies, Inc. Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry
WO2000004193A1 (en) * 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
AU5570699A (en) * 1998-08-17 2000-03-06 Packard Bioscience Company Rolling circle-based analysis of polynucleotide sequence
JP3267576B2 (ja) * 1998-11-09 2002-03-18 三光純薬株式会社 プローブ高分子の形成方法
WO2000036141A1 (en) * 1998-12-15 2000-06-22 Diatech Pty. Ltd. A method of amplification of a circularised nucleic acid probe
US6830884B1 (en) * 1998-12-15 2004-12-14 Molecular Staging Inc. Method of amplification
US7033753B1 (en) 1999-01-15 2006-04-25 University Of Rochester Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms
GB9904991D0 (en) * 1999-03-05 1999-04-28 Univ Nottingham Genetic screening
CN1350591A (zh) * 1999-03-18 2002-05-22 埃克西库恩公司 以单一步骤制备和检测复合生物样品中的核酸
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6326173B1 (en) 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
JP2002541475A (ja) * 1999-04-12 2002-12-03 ナノゲン/ベクトン・ディッキンソン・パートナーシップ 鎖置換増幅およびバイオエレクトロニック・マイクロチップ技術を用いる核酸配列の増幅および分離
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
EP1196632A2 (en) * 1999-05-07 2002-04-17 Yale University Multiple tag analysis
US6620584B1 (en) 1999-05-20 2003-09-16 Illumina Combinatorial decoding of random nucleic acid arrays
US6838444B1 (en) 1999-06-01 2005-01-04 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
US6964847B1 (en) * 1999-07-14 2005-11-15 Packard Biosciences Company Derivative nucleic acids and uses thereof
DE60026641T2 (de) * 1999-07-15 2007-01-25 Qiagen Gmbh Verfahren zur Trennung von teilchenförmigen Substraten aus einer Lösung indem man den Teilchenverlust minimiert
WO2001025481A1 (en) * 1999-10-04 2001-04-12 Olympus Optical Co., Ltd. Method of detecting nucleic acid
US7534568B2 (en) 1999-10-29 2009-05-19 Hologic Inc. Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
US7118860B2 (en) * 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US6248535B1 (en) * 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
CA2401962A1 (en) 2000-02-07 2001-08-09 Illumina, Inc. Nucleic acid detection methods using universal priming
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
EP1990428B1 (en) 2000-02-07 2010-12-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
EP1130113A1 (en) 2000-02-15 2001-09-05 Johannes Petrus Schouten Multiplex ligation dependent amplification assay
DE60136335D1 (de) 2000-02-16 2008-12-11 Illumina Inc Parallele genotypisierung mehrerer patientenproben
US7205129B1 (en) 2000-02-28 2007-04-17 Qiagen Gmbh Method for reducing artifacts in nucleic acid amplification
US6936443B2 (en) * 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
DE60141205D1 (de) * 2000-04-03 2010-03-18 Cytyc Corp Nachweis und typisierung des papillomavirus mittels pna-sonden
US6368801B1 (en) * 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
JP5508654B2 (ja) 2000-04-14 2014-06-04 コーネル・リサーチ・ファンデーション・インコーポレイテッド リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法
US6291187B1 (en) 2000-05-12 2001-09-18 Molecular Staging, Inc. Poly-primed amplification of nucleic acid sequences
CA2410950A1 (en) * 2000-05-30 2001-12-06 Hans-Michael Wenz Methods for detecting target nucleic acids using coupled ligation and amplification
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
US6420144B1 (en) 2000-06-28 2002-07-16 Salus Therapeutics, Inc. Method for automated molecular cloning
US6323009B1 (en) 2000-06-28 2001-11-27 Molecular Staging, Inc. Multiply-primed amplification of nucleic acid sequences
WO2002002792A1 (en) 2000-06-30 2002-01-10 Molecular Staging, Inc. Signal amplification with lollipop probes
AU2002246612B2 (en) 2000-10-24 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
WO2002061133A2 (en) 2000-11-09 2002-08-08 Yale University Nucleic acid detection using structured probes
AR031640A1 (es) * 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
WO2002055739A2 (en) * 2001-01-15 2002-07-18 Cytyc Corporation Nucleic acid extraction solution and use thereof
GB0101397D0 (en) * 2001-01-19 2001-03-07 Amersham Pharm Biotech Uk Ltd Suppression of non-specific nucleic acid amplication
GB0104163D0 (en) * 2001-02-20 2001-04-11 Crime Solutions Ltd Security system
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
EP1262563A3 (en) * 2001-05-31 2003-02-05 Takara Bio Inc. Method for immobilizing DNA on a surface
JP4473573B2 (ja) 2001-07-26 2010-06-02 ストラタジーン カリフォルニア 多部位突然変異誘発
US20050037353A1 (en) * 2001-10-15 2005-02-17 Zhang David Y. Highly sensitive methods for protein detection in proteomics
US7361489B2 (en) * 2001-10-15 2008-04-22 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
US6617137B2 (en) * 2001-10-15 2003-09-09 Molecular Staging Inc. Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US7297485B2 (en) * 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US6977148B2 (en) * 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
US7632671B2 (en) * 2001-11-29 2009-12-15 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
EP1461458A4 (en) * 2001-12-03 2005-10-26 Illumina Inc MULTIPLEX DETECTION METHOD Methylation
US20060088826A1 (en) * 2001-12-28 2006-04-27 Van Eijk Michael Josephus Ther Discrimination and detection of target nucleotide sequences using mass spectrometry
US8395769B2 (en) * 2002-01-10 2013-03-12 Chemimage Corporation Method for analysis of pathogenic microorganisms using raman spectroscopic techniques
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
JP4527984B2 (ja) 2002-02-01 2010-08-18 ライフ テクノロジーズ コーポレーション 増強された効力を有するオリゴヌクレオチド組成物
EP1572902B1 (en) 2002-02-01 2014-06-11 Life Technologies Corporation HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
EP1992706B1 (en) 2002-02-21 2014-11-19 Alere San Diego, Inc. Recombinase polymerase amplification
US20030175828A1 (en) * 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US20030236205A1 (en) * 2002-06-21 2003-12-25 Zhang David Y. Hybridization signal amplification method (HSAM) nanostructures for diagnostic and therapeutic uses
EP1636561B1 (en) 2002-07-15 2011-02-09 Board Of Regents, The University Of Texas System Combinatorial protein library screening by periplasmic expression
KR101170653B1 (ko) 2002-08-12 2012-08-03 제네렉스, 인코포레이티드 폭스바이러스 및 암과 관련된 방법 및 조성물
US20040086892A1 (en) * 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
US20060094016A1 (en) * 2002-12-02 2006-05-04 Niall Gormley Determination of methylation of nucleic acid sequences
US20060035233A1 (en) * 2002-12-02 2006-02-16 Niall Gormley Recovery of original template
US20040115643A1 (en) * 2002-12-12 2004-06-17 Lizardi Paul M. Thermodynamic equilibrium extension of primers
US20040121338A1 (en) * 2002-12-19 2004-06-24 Alsmadi Osama A. Real-time detection of rolling circle amplification products
US7955795B2 (en) * 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US6977153B2 (en) 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US20040248103A1 (en) * 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
US20040248104A1 (en) * 2003-06-05 2004-12-09 Zohar Yakhini Methods and reagents for profiling quantities of nucleic acids
DK1633888T3 (da) 2003-06-17 2009-07-13 Keygene Nv Midler og fremgangsmåde til påvisning af målnucleotidsekvenser under anvendelse af ligeringsassays med forbedrede oligonucleotidprobepar
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
CN1878866B (zh) 2003-07-25 2012-08-01 安比恩股份有限公司 用于从固定的样品中制备rna的方法和组合物
WO2005026329A2 (en) * 2003-09-12 2005-03-24 Cornell Research Foundation, Inc. Methods for identifying target nucleic acid molecules
AU2003295732A1 (en) * 2003-11-21 2005-07-14 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
EP1716250B1 (en) * 2004-01-07 2015-08-05 Third Wave Technologies, Inc. Determination of hepatitis c virus genotype
WO2005072133A2 (en) * 2004-01-27 2005-08-11 Zoragen, Inc. Nucleic acid detection
US7622281B2 (en) * 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
US7566532B1 (en) 2004-07-02 2009-07-28 Quest Diagnostics Investments Incorporated Methods for detecting retroviruses
US7309589B2 (en) 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
CA2581086C (en) 2004-09-14 2023-11-07 The Regents Of The University Of Colorado, A Body Corporate Method for treatment with bucindolol based on genetic targeting
WO2006085749A1 (en) * 2005-01-07 2006-08-17 De Ruiter Seeds R & D B.V. Plant virus designated tomato torrado virus
WO2006076650A2 (en) * 2005-01-12 2006-07-20 Applera Corporation Compositions, methods, and kits for selective amplification of nucleic acids
US8309303B2 (en) 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
US7989166B2 (en) * 2005-04-12 2011-08-02 In Situ Rcp A/S Circle probes and their use in the identification of biomolecules
US8080393B2 (en) * 2005-04-12 2011-12-20 Olink Ab Methods for production of oligonucleotides
US8062850B2 (en) 2005-07-25 2011-11-22 Alere San Diego, Inc. Methods for multiplexing recombinase polymerase amplification
KR101772375B1 (ko) * 2005-09-07 2017-08-29 신라젠(주) Gm-csf를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
WO2007061284A1 (en) 2005-11-22 2007-05-31 Plant Research International B.V. Multiplex nucleic acid detection
GB0524069D0 (en) * 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
WO2007063807A1 (ja) * 2005-11-29 2007-06-07 Olympus Corporation 核酸の一次構造変化の解析方法
EP1998800A2 (en) 2006-01-18 2008-12-10 University Of Chicago Compositions and methods related to staphylococcal bacterium proteins
EP1975254A4 (en) * 2006-01-20 2009-12-02 Olympus Corp METHOD FOR DETECTING NUCLEOTIDE SEQUENCES WITH AN INTRAMOLE PROBE
US20080057499A1 (en) * 2006-02-06 2008-03-06 Affymetrix, Inc. Methods for high specificity whole genome amplification and hybridization
WO2007092538A2 (en) 2006-02-07 2007-08-16 President And Fellows Of Harvard College Methods for making nucleotide probes for sequencing and synthesis
WO2007107710A1 (en) * 2006-03-17 2007-09-27 Solexa Limited Isothermal methods for creating clonal single molecule arrays
CA2650993C (en) 2006-05-04 2015-06-16 Asm Scientific, Inc. Recombinase polymerase amplification
US20100055672A1 (en) * 2006-05-11 2010-03-04 Geneohm Sciences, Inc. 100% sequence identity detection methods for variable genomes
EP1878803A1 (en) * 2006-07-10 2008-01-16 Wageningen Universiteit Methods of detecting root knot nematodes
CN100460519C (zh) * 2006-08-29 2009-02-11 中国科学院南海海洋研究所 检测对虾传染性皮下及造血组织坏死病毒的试剂盒及方法
ES2741138T3 (es) 2006-09-15 2020-02-10 Childrens Hospital Of Eastern Ontario Res Institute Inc Rhabdovirus oncolítico de Farmington
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US8067179B2 (en) 2006-11-30 2011-11-29 Research Development Foundation Immunoglobulin libraries
EP1939303A1 (en) 2006-12-27 2008-07-02 Wageningen Universiteit Method for detecting cyst nematodes
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
NL1033431C2 (nl) 2007-02-20 2008-08-21 Expressive Res Bv Bepaling van kwaliteitskenmerken bij land- of tuinbouwproducten.
US8629245B2 (en) 2007-05-01 2014-01-14 Research Development Foundation Immunoglobulin Fc libraries
US9689031B2 (en) * 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
CA2718905A1 (en) 2008-03-17 2009-09-24 Expressive Research B.V. Expression-linked gene discovery
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
CA2739581A1 (en) 2008-10-06 2010-04-15 University Of Chicago Compositions and methods related to bacterial eap, emp, and/or adsa proteins
WO2010068102A1 (en) 2008-12-10 2010-06-17 Monsanto Invest N.V. Novel plant virus
DE102008062372B3 (de) * 2008-12-17 2010-06-17 Medizinische Hochschule Hannover Nachweiskonjugat und Verfahren zur Analyse
CN102325900A (zh) 2008-12-19 2012-01-18 安莎种子控股有限公司 Cysdv抗性黄瓜植物的育种方法
JP5789250B2 (ja) 2009-04-03 2015-10-07 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago プロテインA(SpA)変種に関連する組成物および方法
WO2011127032A1 (en) 2010-04-05 2011-10-13 University Of Chicago Compositions and methods related to protein a (spa) antibodies as an enhancer of immune response
WO2010126614A2 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
WO2010135310A1 (en) 2009-05-20 2010-11-25 Biosite Incorporated Dna glycosylase/lyase and ap endonuclease substrates
ES3022638T3 (en) 2009-06-05 2025-05-28 Abbott Diagnostics Scarborough Inc Recombinase polymerase amplification reagents
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
EP2294912A1 (en) 2009-09-04 2011-03-16 Wageningen Universiteit Method for increasing the level of zeaxanthin in a plant line, method for selecting a plant or part thereof, including a seed and tuber, and use thereof
WO2011032088A1 (en) 2009-09-11 2011-03-17 Arca Biopharma, Inc. Polymorphisms in the pde3a gene
US8747837B2 (en) 2009-09-14 2014-06-10 Jennerex, Inc. Oncolytic vaccinia virus combination cancer therapy
WO2011049439A1 (en) 2009-10-19 2011-04-28 Universiteit Twente Method for selecting bone forming mesenchymal stem cells
EP2510088B1 (en) 2009-12-10 2016-10-05 Ottawa Hospital Research Institute Oncolytic rhabdovirus
CA2822747A1 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction
AU2011205863B2 (en) 2010-01-18 2014-08-28 Universiteit Utrecht Holding B.V. Means and methods for distinguishing FECV and FIPV
US20110262989A1 (en) * 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
WO2011162612A1 (en) 2010-06-25 2011-12-29 Wageningen Universiteit Method for modulating the level of phosphorylation of starch in a plant line, method for selecting a plant or part thereof, including a seed and tuber, and use thereof
CA2803298C (en) 2010-07-02 2020-07-14 The University Of Chicago Compositions and methods related to protein a (spa) variants
MX351242B (es) 2010-07-16 2017-10-05 Stichting Vu Vumc Star Un metodo para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad.
EP2614074A1 (en) 2010-09-09 2013-07-17 The University of Chicago Methods and compositions involving protective staphylococcal antigens
US8715933B2 (en) * 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
WO2012049279A1 (en) 2010-10-14 2012-04-19 Universitaet Des Saarlandes MEANS AND METHODS APPLYING SINGLE NUCLEOTIDE PRIMER EXTENSION WITH ION PAIR-, REVERSED-PHASE HPLC (SIRPH) FOR THE DIAGNOSIS OF SNPs
EP2640849B1 (en) 2010-11-16 2016-04-06 Nabsys 2.0 LLC Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
AU2012204467B2 (en) 2011-01-04 2016-08-18 Sillajen, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
EP2665833B1 (en) 2011-01-17 2017-04-19 Life Technologies Corporation Workflow for detection of ligands using nucleic acids
AU2012214643B2 (en) 2011-02-07 2016-12-15 Research Development Foundation Engineered immunoglobulin Fc polypeptides
WO2012109574A2 (en) 2011-02-11 2012-08-16 Nabsys, Inc. Assay methods using dna binding proteins
EP2681566A2 (en) 2011-02-28 2014-01-08 University of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
CA2829300A1 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
NL2006378C2 (en) 2011-03-11 2012-09-12 Univ Wageningen Tyclv resistance.
AU2012231884B2 (en) 2011-03-18 2017-03-09 Stichting Vumc A method of analysing a blood sample of a subject for the presence of a disease marker
US9085631B2 (en) 2011-04-08 2015-07-21 Nov Vac APS Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus
US9567649B2 (en) 2011-04-28 2017-02-14 Jørn Erland Koch System for identification of microorganism and detection of infectious disease
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
WO2012165943A1 (en) 2011-05-27 2012-12-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of an infectious disease marker
ES2627529T3 (es) 2011-06-08 2017-07-28 Children's Hospital Of Eastern Ontario Research Institute Inc. Composiciones para tratamiento de glioblastoma
WO2013009175A1 (en) 2011-07-08 2013-01-17 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
WO2013010074A1 (en) 2011-07-13 2013-01-17 Primeradx, Inc. Multimodal methods for simultaneous detection and quantification of multiple nucleic acids in a sample
SG2014009682A (en) 2011-08-09 2014-05-29 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of a foetal disease or condition marker
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
EP2766388A1 (en) 2011-10-12 2014-08-20 Møller, Niels Iversen Peptides derived from campylobacter jejuni and their use in vaccination
WO2013058907A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
WO2013096798A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Amplification of a sequence from a ribonucleic acid
EP2809783A2 (en) 2012-02-02 2014-12-10 Invenra, Inc. High throughput screen for biologically active polypeptides
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
EP2653559A1 (en) * 2012-04-20 2013-10-23 Samsung Electronics Co., Ltd Polynucleotide and use thereof
NZ702285A (en) 2012-04-26 2016-07-29 Univ Chicago Staphylococcal coagulase antigens and methods of their use
AU2013271404B2 (en) 2012-06-08 2017-10-12 Ionian Technologies, Llc Nucleic acid amplifications
US10781426B2 (en) 2012-09-23 2020-09-22 Erasmus University Medical Center Rotterdam Human Betacoronavirus lineage C and identification of N-terminal dipeptidyl peptidase as its virus receptor
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
WO2014113557A1 (en) 2013-01-18 2014-07-24 Nabsys, Inc. Enhanced probe binding
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
CA2901501C (en) 2013-02-21 2023-03-07 Children's Hospital Of Eastern Ontario Research Institute Inc. Vaccine composition
US9618510B2 (en) 2013-03-13 2017-04-11 Meso Scale Technologies, Llc. Assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
AU2014312208B2 (en) 2013-08-28 2019-07-25 Becton, Dickinson And Company Massively parallel single cell analysis
MX2016004283A (es) 2013-10-03 2016-10-12 Oklahoma Med Res Found Biomarcadores para la actividad, e intesidad y arrebato de la enfermedad lupus eritematoso sistemico.
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
CN111128302B (zh) * 2013-11-26 2022-10-11 杭州联川基因诊断技术有限公司 一种设计pcr引物的方法
EP4227685A3 (en) 2013-12-03 2024-02-28 Evaxion Biotech A/S Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
WO2017062863A1 (en) 2015-10-09 2017-04-13 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
KR102379877B1 (ko) 2013-12-11 2022-03-30 아큐라젠 홀딩스 리미티드 희귀 서열 변이를 검출하기 위한 조성물 및 방법
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
KR102497054B1 (ko) 2014-05-15 2023-02-06 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
GB2528647A (en) * 2014-07-10 2016-02-03 Momentum Bioscience Ltd Detecting viable microorganisms
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
JP2017536087A (ja) 2014-09-24 2017-12-07 グッド スタート ジェネティクス, インコーポレイテッド 遺伝子アッセイのロバストネスを増大させるためのプロセス制御
EP3777883A1 (en) 2014-11-13 2021-02-17 Evaxion Biotech ApS Peptides derived from acinetobacter baumannii and their use in vaccination
EP3224362B1 (en) 2014-11-26 2024-09-25 The Regents of The University of California Therapeutic compositions comprising transcription factors and methods of making and using the same
EP4095261B1 (en) 2015-01-06 2025-05-28 Molecular Loop Biosciences, Inc. Screening for structural variants
ES2957554T3 (es) 2015-01-12 2024-01-22 Evaxion Biotech Aps Tratamiento y profilaxis de infección por K. pneumoniae
AU2016219511B2 (en) 2015-02-09 2020-11-12 Research Development Foundation Engineered immunoglobulin Fc polypeptides displaying improved complement activation
EP3070178B1 (en) 2015-03-20 2020-02-12 Albert-Ludwigs-Universität Freiburg Method for diagnosing breast cancer
WO2017005670A1 (en) 2015-07-04 2017-01-12 Evaxion Biotech Aps Proteins and nucleic acids useful in vaccines targeting pseudomonas aeruginosa
WO2017040380A2 (en) 2015-08-28 2017-03-09 Research Development Foundation Engineered antibody fc variants
ES2987912T1 (es) 2015-11-10 2024-11-18 Vilmorin & Cie Resistencia a ToLCNDV en calabaza
US12163184B2 (en) 2015-12-03 2024-12-10 Accuragen Holdings Limited Methods and compositions for forming ligation products
EP3419654B1 (en) 2016-02-22 2022-04-27 Evaxion Biotech A/S Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
WO2017201102A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
SG11201901296TA (en) 2016-08-15 2019-03-28 Accuragen Holdings Ltd Compositions and methods for detecting rare sequence variants
US11447835B2 (en) * 2016-10-19 2022-09-20 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis C virus
WO2018127545A1 (en) 2017-01-05 2018-07-12 Evaxion Biotech Aps Vaccines targeting pseudomonas aeruginosa
CA3049778C (en) 2017-01-26 2024-06-18 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
US12140592B2 (en) 2017-06-16 2024-11-12 Oklahoma Medical Research Foundation Biomarkers for assessing risk of transitioning to systemic lupus erythematosus classification and disease pathogenesis
CN120210336A (zh) 2017-10-06 2025-06-27 10X基因组学有限公司 Rna模板化连接
WO2019126313A1 (en) * 2017-12-22 2019-06-27 The University Of Chicago Multiplex 5mc marker barcode counting for methylation detection in cell-free dna
EP4647508A2 (en) 2018-04-02 2025-11-12 Enumera Molecular, Inc. Methods, systems, and compositions for counting nucleic acid molecules
WO2019238765A1 (en) 2018-06-12 2019-12-19 Keygene N.V. Nucleic acid amplification method
CN112601823A (zh) 2018-06-12 2021-04-02 安可济控股有限公司 用于形成连接产物的方法和组合物
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
EP3836967A4 (en) 2018-07-30 2022-06-15 ReadCoor, LLC METHODS AND SYSTEMS FOR SAMPLE PROCESSING OR ANALYSIS
KR102554477B1 (ko) 2018-10-18 2023-07-11 오클라호마 메디컬 리써치 화운데이션 질병 활성도의 특징을 규명하는 전신 홍반성 낭창(sle) 질병 활성도 면역 지수를 위한 생체지표
EP3870207A1 (en) 2018-10-22 2021-09-01 Evaxion Biotech ApS Vaccines targeting m. catharrhalis
CN113474466A (zh) 2019-02-21 2021-10-01 主基因有限公司 多倍体基因分型
EP3931206A1 (en) 2019-02-27 2022-01-05 Evaxion Biotech ApS Vaccines targeting h. influenzae
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES
WO2020240025A1 (en) 2019-05-31 2020-12-03 Cartana Ab Method of detecting target nucleic acid molecules
ES2960366T3 (es) 2019-08-09 2024-03-04 Univ Freiburg Albert Ludwigs Método para diagnosticar cáncer de mama
AU2020348308A1 (en) 2019-09-16 2022-05-12 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of SWI-SNF mutant tumors
US20230050225A1 (en) 2020-01-06 2023-02-16 Evaxion Biotech A/S Vaccines targeting Neisseria gonorrhoeae
AU2021345359A1 (en) 2020-09-21 2023-05-11 Enumera Molecular, Inc. Compositions and methods for isolation of cell-free dna
JP2024526293A (ja) 2021-07-05 2024-07-17 エヴァクシオン・バイオテック・アクティエセルスカブ 淋菌を標的とするワクチン
AU2023283773A1 (en) 2022-06-10 2024-12-19 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US4786600A (en) * 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
ATE92538T1 (de) * 1988-01-21 1993-08-15 Genentech Inc Verstaerkung und nachweis von nukleinsaeuresequenzen.
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
JPH04501353A (ja) * 1988-07-26 1992-03-12 ジエネラブス・テクノロジーズ・インコーポレイテツド Rna及びdna増幅法
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
CA2046713A1 (en) * 1990-10-16 1992-04-17 Richard M. Martinelli Amplification of midivariant dna templates
JP3183510B2 (ja) * 1990-12-31 2001-07-09 プロメガ・コーポレイシヨン Rnaレプリカーゼのdna依存性rnaポリメラーゼ活性を用いる核酸増幅
JP3080178B2 (ja) * 1991-02-18 2000-08-21 東洋紡績株式会社 核酸配列の増幅方法およびそのための試薬キット
JP3085409B2 (ja) * 1991-03-29 2000-09-11 東洋紡績株式会社 標的核酸配列の検出方法およびそのための試薬キット
PT726962E (pt) * 1991-12-23 2006-10-31 Chiron Corp Sondas para hiv para uso em ensaios de hibridacao em sanduiche em fase de solucao
US5834202A (en) 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5422252A (en) * 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
CA2164706C (en) * 1993-06-09 2001-04-10 Alec Mian Magnetic cycle reaction
US5601978A (en) 1993-09-03 1997-02-11 Abbott Laboratories Oligonucleotides and methods for the detection of chlamydia trachomatis
NL9301957A (nl) * 1993-11-11 1995-06-01 U Gene Research Bv Werkwijze voor het identificeren van micro-organismen, en daarvoor bruikbare hulpmiddelen.
US5523204A (en) * 1993-12-10 1996-06-04 Becton Dickinson And Company Detection of nucleic acids in cells by strand displacement amplification
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5876924A (en) * 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5942391A (en) * 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
WO1995035390A1 (en) * 1994-06-22 1995-12-28 Mount Sinai School Of Medicine Of The City University Of New York Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes
US5616465A (en) 1995-08-09 1997-04-01 The Regents Of The University Of California Detection and isolation of nucleic acid sequences using competitive hybridization probes
US6143495A (en) 1995-11-21 2000-11-07 Yale University Unimolecular segment amplification and sequencing
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
WO2000004193A1 (en) 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
WO2000015779A2 (en) 1998-09-15 2000-03-23 Yale University Molecular cloning using rolling circle amplification
US6255082B1 (en) 1998-09-15 2001-07-03 Yale University Artificial long terminal repeat vectors
CA2367400A1 (en) 1999-04-06 2000-10-12 Yale University Fixed address analysis of sequence tags
AU6770800A (en) 1999-08-13 2001-03-13 Yale University Analysis of sequence tags with hairpin primers

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