JP2001514000A5 - - Google Patents
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- Publication number
- JP2001514000A5 JP2001514000A5 JP2000507804A JP2000507804A JP2001514000A5 JP 2001514000 A5 JP2001514000 A5 JP 2001514000A5 JP 2000507804 A JP2000507804 A JP 2000507804A JP 2000507804 A JP2000507804 A JP 2000507804A JP 2001514000 A5 JP2001514000 A5 JP 2001514000A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- domain
- cell
- eliciting
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 26
- 210000004027 cell Anatomy 0.000 description 25
- 102000039446 nucleic acids Human genes 0.000 description 22
- 108020004707 nucleic acids Proteins 0.000 description 22
- 150000007523 nucleic acids Chemical class 0.000 description 22
- 229920001184 polypeptide Polymers 0.000 description 18
- 102000004196 processed proteins & peptides Human genes 0.000 description 18
- 239000000427 antigen Substances 0.000 description 12
- 102000036639 antigens Human genes 0.000 description 12
- 108091007433 antigens Proteins 0.000 description 12
- 230000028993 immune response Effects 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 241000124008 Mammalia Species 0.000 description 6
- 241000186366 Mycobacterium bovis Species 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 230000004927 fusion Effects 0.000 description 6
- 241000186359 Mycobacterium Species 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 230000002163 immunogen Effects 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 101710088334 Diacylglycerol acyltransferase/mycolyltransferase Ag85B Proteins 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 201000008827 tuberculosis Diseases 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 101710166488 6 kDa early secretory antigenic target Proteins 0.000 description 1
- 101710088335 Diacylglycerol acyltransferase/mycolyltransferase Ag85A Proteins 0.000 description 1
- 241000186781 Listeria Species 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97114614A EP0902086A1 (en) | 1997-08-22 | 1997-08-22 | Tuberculosis vaccine |
| EP97114614.7 | 1997-08-22 | ||
| PCT/EP1998/005109 WO1999010496A1 (en) | 1997-08-22 | 1998-08-12 | Tuberculosis vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001514000A JP2001514000A (ja) | 2001-09-11 |
| JP2001514000A5 true JP2001514000A5 (https=) | 2006-01-05 |
| JP4255209B2 JP4255209B2 (ja) | 2009-04-15 |
Family
ID=8227261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000507804A Expired - Lifetime JP4255209B2 (ja) | 1997-08-22 | 1998-08-12 | 結核ワクチン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6673353B1 (https=) |
| EP (2) | EP0902086A1 (https=) |
| JP (1) | JP4255209B2 (https=) |
| AT (1) | ATE347599T1 (https=) |
| AU (1) | AU9435098A (https=) |
| CA (1) | CA2301879C (https=) |
| CY (1) | CY1106350T1 (https=) |
| DE (1) | DE69836588T2 (https=) |
| DK (1) | DK1007686T3 (https=) |
| ES (1) | ES2274580T3 (https=) |
| PT (1) | PT1007686E (https=) |
| SI (1) | SI1007686T1 (https=) |
| WO (1) | WO1999010496A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001072329A1 (en) | 2000-03-29 | 2001-10-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
| US7662396B2 (en) | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
| US7820180B2 (en) * | 2004-09-24 | 2010-10-26 | The Trustees Of The University Of Pennsylvania | Listeria-based and LLO-based vaccines |
| US7794729B2 (en) | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
| ID29858A (id) | 1998-11-04 | 2001-10-18 | Isis Innovation | Uji diagnostik tuberkulosis |
| GB0006693D0 (en) * | 2000-03-20 | 2000-05-10 | Glaxo Group Ltd | Vaccine |
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| US6855320B2 (en) | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| US7700344B2 (en) | 2001-03-26 | 2010-04-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
| KR101192652B1 (ko) * | 2003-02-06 | 2012-10-19 | 앤저 테라퓨틱스 인코퍼레이티드 | 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법 |
| PT1618128E (pt) * | 2003-04-23 | 2010-10-13 | Max Planck Gesellschaft | Vacina de tuberculose com eficácia melhorada |
| EP1649869A1 (en) | 2004-10-21 | 2006-04-26 | Vakzine Projekt Management GmbH | Combination of a recombinant mycobacterium and a biologically active agent as a vaccine |
| CN101198358B (zh) * | 2004-12-01 | 2013-06-26 | Aeras全球Tb疫苗基金会 | 具有增强的逃出内体能力的重组bcg菌株 |
| US8268326B2 (en) | 2006-08-15 | 2012-09-18 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
| DK2977456T3 (en) | 2006-08-15 | 2018-01-22 | Univ Pennsylvania | Compositions comprising HMW-MAA and fragments thereof for the treatment of cancer |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US20110129499A1 (en) | 2008-05-19 | 2011-06-02 | Paulo Maciag | Dual delivery system for heterologous antigens |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| PT2403935T (pt) | 2009-03-04 | 2017-09-22 | Univ Pennsylvania | Composições compreendendo fatores angiogénicos e metedos para a sua utilização |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| HUE039038T2 (hu) * | 2010-09-20 | 2018-12-28 | Vakzine Projekt Man Gmbh | Rekombináns mycobakterium, mint emberekben alkalmazható vakcina |
| US9226958B2 (en) | 2010-10-01 | 2016-01-05 | University Of Georgia Research Foundation, Inc. | Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
| JP6006909B2 (ja) * | 2010-12-21 | 2016-10-12 | マックス−プランク−ゲゼルシャフト ツール フェルデルンク デル ヴィッセンシャフテン エー．ファウ． | ワクチンとしての組み換えマイコバクテリウム |
| SI2656070T1 (sl) | 2010-12-21 | 2016-05-31 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Ugotavljanje učinkovitosti živega rekombinantnega antimikobakterijskega cepljenja |
| AU2012229218B2 (en) | 2011-03-11 | 2017-03-02 | Advaxis, Inc. | Listeria-based adjuvants |
| BR102012003790A2 (pt) | 2012-02-17 | 2014-04-22 | Fundacao Butantan | Cepa de mycobacterium recombinante, composição imunogênica e uso |
| CN104411327A (zh) | 2012-03-12 | 2015-03-11 | 阿德瓦希斯公司 | 李斯特菌疫苗治疗以后的抑制细胞功能抑制 |
| EP2834356A4 (en) * | 2012-04-02 | 2015-09-02 | Univ Arizona | RECOMBINANT BACTERIUM FOR INDUCING A CELLULAR IMMUNE RESPONSE |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5504005A (en) * | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
-
1997
- 1997-08-22 EP EP97114614A patent/EP0902086A1/en not_active Withdrawn
-
1998
- 1998-08-12 EP EP98947427A patent/EP1007686B1/en not_active Expired - Lifetime
- 1998-08-12 AT AT98947427T patent/ATE347599T1/de active
- 1998-08-12 AU AU94350/98A patent/AU9435098A/en not_active Abandoned
- 1998-08-12 DE DE69836588T patent/DE69836588T2/de not_active Expired - Lifetime
- 1998-08-12 SI SI9830871T patent/SI1007686T1/sl unknown
- 1998-08-12 PT PT98947427T patent/PT1007686E/pt unknown
- 1998-08-12 ES ES98947427T patent/ES2274580T3/es not_active Expired - Lifetime
- 1998-08-12 CA CA2301879A patent/CA2301879C/en not_active Expired - Lifetime
- 1998-08-12 DK DK98947427T patent/DK1007686T3/da active
- 1998-08-12 US US09/485,717 patent/US6673353B1/en not_active Expired - Lifetime
- 1998-08-12 WO PCT/EP1998/005109 patent/WO1999010496A1/en not_active Ceased
- 1998-08-12 JP JP2000507804A patent/JP4255209B2/ja not_active Expired - Lifetime
-
2007
- 2007-03-01 CY CY20071100297T patent/CY1106350T1/el unknown
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