JP2001510154A5 - - Google Patents
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- Publication number
- JP2001510154A5 JP2001510154A5 JP2000502767A JP2000502767A JP2001510154A5 JP 2001510154 A5 JP2001510154 A5 JP 2001510154A5 JP 2000502767 A JP2000502767 A JP 2000502767A JP 2000502767 A JP2000502767 A JP 2000502767A JP 2001510154 A5 JP2001510154 A5 JP 2001510154A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- ethyl
- acetamide
- pyrrolidinyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/891,833 | 1997-07-14 | ||
| US08/891,833 US5763445A (en) | 1996-03-08 | 1997-07-14 | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| PCT/US1998/012769 WO1999003468A1 (en) | 1997-07-14 | 1998-06-19 | Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001510154A JP2001510154A (ja) | 2001-07-31 |
| JP2001510154A5 true JP2001510154A5 (https=) | 2006-01-05 |
Family
ID=25398903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000502767A Pending JP2001510154A (ja) | 1997-07-14 | 1998-06-19 | カッパアゴニスト化合物、製剤、ならびにそれらによる掻痒の予防法および治療法 |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US5763445A (https=) |
| EP (1) | EP0998281A1 (https=) |
| JP (1) | JP2001510154A (https=) |
| KR (1) | KR20010021853A (https=) |
| AU (1) | AU725232B2 (https=) |
| BR (1) | BR9810712A (https=) |
| CA (1) | CA2289055A1 (https=) |
| IL (1) | IL132388A0 (https=) |
| NO (2) | NO996352L (https=) |
| NZ (2) | NZ500439A (https=) |
| WO (1) | WO1999003468A1 (https=) |
| ZA (1) | ZA986208B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6190691B1 (en) | 1994-04-12 | 2001-02-20 | Adolor Corporation | Methods for treating inflammatory conditions |
| US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
| US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
| US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6303611B1 (en) * | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5763445A (en) * | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6750216B2 (en) * | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| CA2288828A1 (en) * | 1997-07-14 | 1999-01-28 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| AU1828399A (en) * | 1997-12-22 | 1999-07-12 | Alza Corporation | Novel formulations for the transdermal administration of asimadoline |
| DK1087934T3 (da) | 1998-04-01 | 2004-06-28 | Cardiome Pharma Corp | Aminocyclohexyletherforbindelser og anvendelser deraf |
| WO1999065932A1 (en) | 1998-06-18 | 1999-12-23 | Sepracor, Inc. | Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US7919119B2 (en) * | 1999-05-27 | 2011-04-05 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| US6383511B1 (en) * | 1999-10-25 | 2002-05-07 | Epicept Corporation | Local prevention or amelioration of pain from surgically closed wounds |
| AU1623801A (en) * | 1999-11-19 | 2001-05-30 | Palatin Technologies, Inc. | Opioid metallopeptide compositions and methods |
| US7115664B2 (en) * | 2000-03-16 | 2006-10-03 | Sepracor Inc. | Peptidomimetic ligands for cellular receptors and ion channels |
| AU2001282988B2 (en) | 2000-07-26 | 2006-01-05 | Atopic Pty Ltd | Methods for treating atopic disorders |
| KR100878667B1 (ko) * | 2000-08-08 | 2009-01-13 | 다이이찌 세이야꾸 가부시기가이샤 | 고흡수성 고형 제제 |
| US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7181547B1 (en) | 2001-06-28 | 2007-02-20 | Fortinet, Inc. | Identifying nodes in a ring network |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| AU2002331064B2 (en) * | 2001-08-10 | 2007-08-23 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7732451B2 (en) | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US6638981B2 (en) | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
| DE10252666A1 (de) * | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
| US7968548B2 (en) * | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| CA2524323C (en) | 2003-05-02 | 2012-05-15 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| US7345086B2 (en) | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| WO2005097087A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US8263638B2 (en) | 2004-11-08 | 2012-09-11 | Cardiome Pharma Corp. | Dosing regimens for ion channel modulating compounds |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| DE102007062550A1 (de) * | 2007-12-20 | 2009-06-25 | Westfälische Wilhelms-Universität Münster Körperschaft des öffentlichen Rechts | Perhydrochinoxalin-Derivate |
| US9314524B2 (en) * | 2007-12-31 | 2016-04-19 | Calla Therapeutics Llc | Topical formulations of Flucytosine |
| HK1220443A1 (zh) * | 2013-05-17 | 2017-05-05 | 奥古斯特沃尔夫博士有限两合公司-医药 | 用作止痛药的全氢喹喔啉衍生物 |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| JP6369783B2 (ja) * | 2014-06-12 | 2018-08-08 | 株式会社アーダン | 加水分解フィブロインを含む軟膏及びその製造方法 |
| US20210169848A1 (en) * | 2018-07-27 | 2021-06-10 | Vyne Therapeutics Inc. | Use of neurokinin-1 antagonists to treat pruritus |
| EP3932390A1 (en) * | 2020-07-02 | 2022-01-05 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical gel formulation containing asimadoline |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065573A (en) * | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| US4098904A (en) * | 1976-11-12 | 1978-07-04 | The Upjohn Company | Analgesic n-(2-aminocycloaliphatic)benzamides |
| US4212878A (en) * | 1978-01-26 | 1980-07-15 | The Upjohn Company | Phenylacetamide derivative analgesics |
| DE3003303C2 (de) | 1980-01-30 | 1984-03-08 | Siemens AG, 1000 Berlin und 8000 München | Verfahren zur Mattierung von hochglänzenden Epoxidharzoberflächen bei Leiterplatten |
| US4466977A (en) | 1981-04-09 | 1984-08-21 | The Upjohn Company | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics |
| US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
| US4360531A (en) | 1981-04-09 | 1982-11-23 | The Upjohn Company | Substituted cycloalkanes |
| US4438130A (en) * | 1981-11-12 | 1984-03-20 | The Upjohn Company | Analgesic 1-oxa-, aza- and thia-spirocyclic compounds |
| US4463013A (en) * | 1982-04-09 | 1984-07-31 | The Upjohn Company | Oxygen substituted amino-cyclohexyl-benzeneacetamides and -benzamides as water diuretic drugs |
| US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
| US4737493A (en) * | 1985-07-01 | 1988-04-12 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents |
| US4663343A (en) * | 1985-07-19 | 1987-05-05 | Warner-Lambert Company | Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds |
| FR2592879B1 (fr) * | 1986-01-13 | 1988-04-29 | Roussel Uclaf | Nouveaux derives de la decahydroquinoleine, leur procede de preparation, les intermediaires de preparation, leur application a titre de medicaments et les compositions les renfermant |
| GB8618188D0 (en) | 1986-07-25 | 1986-09-03 | Ici Plc | Diamine compounds |
| US4876269A (en) | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
| MY101368A (en) * | 1986-09-10 | 1991-09-05 | Bristol Myers Squibb Pharma Company | Benzo-fused cyclaolkane and oxa-and thai,cycloalkane trans-1, 2-daimine derivatives |
| EP0261842B1 (en) | 1986-09-17 | 1990-11-22 | Dr. Lo. Zambeletti S.p.A. | N1-acylated-(1-(phenyl or benzyl))-1,2-ethylene diamines |
| GB8801304D0 (en) | 1988-01-21 | 1988-02-17 | Ici Plc | Diamine compounds |
| US4855316A (en) * | 1988-02-18 | 1989-08-08 | Warner-Lambert Company | 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds |
| FR2627491B1 (fr) | 1988-02-18 | 1992-01-24 | Roussel Uclaf | Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| GB8804014D0 (en) * | 1988-02-23 | 1988-03-23 | Humphreys & Glasgow Ltd | Synthesis gas production |
| KR890012970A (ko) | 1988-02-23 | 1989-09-20 | 추후보충 | 테트라히드로 이소퀴놀린 유도체 |
| GB8804104D0 (en) * | 1988-02-23 | 1988-03-23 | Glaxo Group Ltd | Chemical compounds |
| EP0330467A1 (en) * | 1988-02-23 | 1989-08-30 | Glaxo Group Limited | Heterocyclic compounds |
| ES2075849T3 (es) | 1988-03-16 | 1995-10-16 | Smithkline Beecham Farma | Derivados heterociclicos. |
| FI892468A7 (fi) | 1988-05-23 | 1989-11-24 | Glaxo Group Ltd | Piperazinderivat. |
| US5021413B1 (en) | 1988-08-24 | 1994-12-13 | Sankyo Co | Analgesic thiomorpholins, their preparation, and pharmaceutical compositions containing them |
| GB8824400D0 (en) * | 1988-10-18 | 1988-11-23 | Glaxo Group Ltd | Chemical compounds |
| AU626949B2 (en) * | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| DK626889A (da) | 1988-12-16 | 1990-06-17 | Roussel Uclaf | Indanderivater, deres fremstilling samt laegemidler med indhold deraf |
| GB8830219D0 (en) | 1988-12-23 | 1989-02-22 | Zambeletti Spa L | Novel compounds |
| DE4034785A1 (de) | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
| US5232978A (en) * | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
| US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
| US4965278A (en) | 1989-04-21 | 1990-10-23 | Warner-Lambert Company | 7-(substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro[4,5]decanes as diuretics antiiflammatory, and cerebrovascular agents |
| CA2017020A1 (en) | 1989-05-18 | 1990-11-18 | Alan Naylor | Chemical compounds |
| GB8916395D0 (en) | 1989-07-18 | 1989-09-06 | Zambeletti Spa L | Pharmaceuticals |
| EP0585296A1 (en) * | 1991-05-21 | 1994-03-09 | Smithkline Beecham Farmaceutici S.p.A. | 2-(pyrrolidinyl-1-methyl)-piperidine derivatives and their use as kappa-recept or agonists |
| ES2121988T3 (es) | 1992-01-23 | 1998-12-16 | Toray Industries | Derivado de morfinano y uso medicinal. |
| DE4215213A1 (de) | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Arylacetamide |
| US5475019A (en) * | 1993-02-08 | 1995-12-12 | East Carolina University | Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compounds |
| WO1994018165A1 (en) | 1993-02-12 | 1994-08-18 | Pfizer Inc. | Sulfonamide compounds as opioid k-receptor agonists |
| NZ268969A (en) | 1993-07-23 | 1997-06-24 | Toray Industries | Morphinan derivatives and pharmaceutical compositions |
| WO1996006078A1 (en) | 1994-08-24 | 1996-02-29 | Pfizer Pharmaceuticals Inc. | N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides as kappa receptor antagonists |
| US5610271A (en) * | 1995-06-07 | 1997-03-11 | Torrey Pines Institute For Molecular Studies | Kappa receptor selective opioid peptides |
| DE19523502A1 (de) | 1995-06-28 | 1997-01-02 | Merck Patent Gmbh | Kappa-Opiatagonisten für entzündliche Darmerkrankungen |
| US5804595A (en) | 1995-12-05 | 1998-09-08 | Regents Of The University Of Minnesota | Kappa opioid receptor agonists |
| US6303611B1 (en) | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) * | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5688955A (en) * | 1996-03-08 | 1997-11-18 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5888494A (en) * | 1996-03-12 | 1999-03-30 | Adolor Corporation | Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith |
| DE69732868T2 (de) * | 1996-11-25 | 2006-04-13 | Toray Industries, Inc. | Mittel gegen Juckreiz |
| US5849762A (en) | 1997-07-14 | 1998-12-15 | Adolor Corporation | Peripherally acting anti-pruritic opiates |
| US5760023A (en) | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| CA2288828A1 (en) | 1997-07-14 | 1999-01-28 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| JP5610659B2 (ja) * | 2000-07-21 | 2014-10-22 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 多成分生物学的輸送システム |
-
1997
- 1997-07-14 US US08/891,833 patent/US5763445A/en not_active Expired - Fee Related
-
1998
- 1998-03-21 US US09/045,522 patent/US5981513A/en not_active Expired - Fee Related
- 1998-06-19 CA CA002289055A patent/CA2289055A1/en not_active Abandoned
- 1998-06-19 IL IL13238898A patent/IL132388A0/xx unknown
- 1998-06-19 KR KR1020007000417A patent/KR20010021853A/ko not_active Ceased
- 1998-06-19 NZ NZ500439A patent/NZ500439A/en unknown
- 1998-06-19 JP JP2000502767A patent/JP2001510154A/ja active Pending
- 1998-06-19 EP EP98930400A patent/EP0998281A1/en not_active Withdrawn
- 1998-06-19 BR BR9810712-7A patent/BR9810712A/pt not_active Application Discontinuation
- 1998-06-19 AU AU79801/98A patent/AU725232B2/en not_active Ceased
- 1998-06-19 NZ NZ513889A patent/NZ513889A/xx not_active Application Discontinuation
- 1998-06-19 WO PCT/US1998/012769 patent/WO1999003468A1/en not_active Ceased
- 1998-07-13 ZA ZA986208A patent/ZA986208B/xx unknown
-
1999
- 1999-05-07 US US09/307,517 patent/US6028063A/en not_active Expired - Fee Related
- 1999-11-08 US US09/436,057 patent/US6180623B1/en not_active Expired - Lifetime
- 1999-12-20 NO NO996352A patent/NO996352L/no not_active Application Discontinuation
-
2001
- 2001-01-26 US US09/769,450 patent/US20020042399A1/en not_active Abandoned
-
2003
- 2003-06-05 US US10/455,687 patent/US6960612B2/en not_active Expired - Fee Related
- 2003-06-05 US US10/455,545 patent/US7294647B2/en not_active Expired - Fee Related
-
2005
- 2005-09-14 NO NO20054249A patent/NO20054249L/no not_active Application Discontinuation
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