JP2001504501A - ５−ｈｔ▲下１ｄ▼レセプターのリガンドとしての５−シクロインドール化合物 - Google Patents

５−ｈｔ▲下１ｄ▼レセプターのリガンドとしての５−シクロインドール化合物

Info

Publication number
JP2001504501A
JP2001504501A JP52408398A JP52408398A JP2001504501A JP 2001504501 A JP2001504501 A JP 2001504501A JP 52408398 A JP52408398 A JP 52408398A JP 52408398 A JP52408398 A JP 52408398A JP 2001504501 A JP2001504501 A JP 2001504501A
Authority
JP
Japan
Prior art keywords
indole
ethyl
dimethylamino
pyrrolidinylethyl
aza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP52408398A
Other languages
English (en)
Japanese (ja)
Inventor
スラシー，アブデルマリク
エドワーズ，ルイス
メン，キンチャン
ラキィート，サマナス
Original Assignee
アレリックス バイオファーマスーティカルス インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アレリックス バイオファーマスーティカルス インコーポレーテッド filed Critical アレリックス バイオファーマスーティカルス インコーポレーテッド
Publication of JP2001504501A publication Critical patent/JP2001504501A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Structures Or Materials For Encapsulating Or Coating Semiconductor Devices Or Solid State Devices (AREA)
  • Hybrid Cells (AREA)
JP52408398A 1996-11-26 1997-11-24 ５−ｈｔ▲下１ｄ▼レセプターのリガンドとしての５−シクロインドール化合物 Pending JP2001504501A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75580596A 1996-11-26 1996-11-26
US08/755,805 1996-11-26
PCT/CA1997/000900 WO1998023587A1 (en) 1996-11-26 1997-11-24 5-cyclo indole compounds as 5-ht1d receptor ligands

Publications (1)

Publication Number Publication Date
JP2001504501A true JP2001504501A (ja) 2001-04-03

Family

ID=25040731

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52408398A Pending JP2001504501A (ja) 1996-11-26 1997-11-24 ５−ｈｔ▲下１ｄ▼レセプターのリガンドとしての５−シクロインドール化合物

Country Status (12)

Country Link
EP (1) EP0944595B1 (es)
JP (1) JP2001504501A (es)
CN (1) CN1289479C (es)
AT (1) ATE251136T1 (es)
AU (1) AU738668B2 (es)
CA (1) CA2273328C (es)
DE (1) DE69725337T2 (es)
ES (1) ES2208955T3 (es)
HK (1) HK1026689A1 (es)
TW (1) TW432059B (es)
WO (1) WO1998023587A1 (es)
ZA (1) ZA9710643B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021505555A (ja) * 2017-12-01 2021-02-18 タイワンジェ ファーマシューティカルズ カンパニー リミテッドＴａｉｗａｎｊ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． ベンゼン縮合複素環化合物およびその使用

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100291A (en) * 1998-03-16 2000-08-08 Allelix Biopharmaceuticals Inc. Pyrrolidine-indole compounds having 5-HT6 affinity
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US6329390B1 (en) * 1998-07-17 2001-12-11 Nps Allelix Corp. 5-Bicycloindole compounds
US6562809B1 (en) * 1998-09-18 2003-05-13 Nps Allelix Corp. 3-bicycloindole compounds
WO2000038677A1 (en) * 1998-12-23 2000-07-06 Allelix Biopharmaceuticals Inc. Indole and indolizidine derivatives for the treatment of migraine
DK1355904T3 (da) 2000-12-22 2007-10-15 Wyeth Corp Heterocyclindazol- og -azaindazolforbindelser som 5-hydroxytryptamin-6-ligander
EP1803720A1 (en) * 2000-12-22 2007-07-04 Wyeth a Corporation of the State of Delaware Heterocyclindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands
CA2515571A1 (en) 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
US8030257B2 (en) 2005-05-13 2011-10-04 Exxonmobil Research And Engineering Company Catalytic antioxidants
CN102936240A (zh) * 2012-10-30 2013-02-20 浙江省医学科学院 一种(r)-5-取代-3-(n-苄氧羰基吡咯烷-2-基羰基)-1h-吲哚的合成方法
CN107698558B (zh) * 2017-10-24 2019-04-02 温州大学 一种氮杂环硫化物的制备方法及其净化提纯方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB9226537D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5300645A (en) * 1993-04-14 1994-04-05 Eli Lilly And Company Tetrahydro-pyrido-indole
BR9406481A (pt) * 1993-04-22 1996-01-09 Pfizer Res & Dev Derivados de indol como agonistas do tipo 5-HT1 para utilização na enxaqueca

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021505555A (ja) * 2017-12-01 2021-02-18 タイワンジェ ファーマシューティカルズ カンパニー リミテッドＴａｉｗａｎｊ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． ベンゼン縮合複素環化合物およびその使用

Also Published As

Publication number Publication date
CA2273328C (en) 2009-04-28
DE69725337T2 (de) 2004-07-15
ATE251136T1 (de) 2003-10-15
EP0944595A1 (en) 1999-09-29
EP0944595B1 (en) 2003-10-01
HK1026689A1 (en) 2000-12-22
AU738668B2 (en) 2001-09-20
TW432059B (en) 2001-05-01
DE69725337D1 (de) 2003-11-06
CA2273328A1 (en) 1998-06-04
WO1998023587A1 (en) 1998-06-04
ZA9710643B (en) 1998-09-02
ES2208955T3 (es) 2004-06-16
AU5112298A (en) 1998-06-22
CN1289479C (zh) 2006-12-13
CN1245491A (zh) 2000-02-23

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