DE69725337D1 - 5-cyclo-indolverbindungen als 5-ht1d rezeptor liganden - Google Patents
5-cyclo-indolverbindungen als 5-ht1d rezeptor ligandenInfo
- Publication number
- DE69725337D1 DE69725337D1 DE69725337T DE69725337T DE69725337D1 DE 69725337 D1 DE69725337 D1 DE 69725337D1 DE 69725337 T DE69725337 T DE 69725337T DE 69725337 T DE69725337 T DE 69725337T DE 69725337 D1 DE69725337 D1 DE 69725337D1
- Authority
- DE
- Germany
- Prior art keywords
- loweralkyl
- optionally substituted
- ht1d
- compounds
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Devices For Indicating Variable Information By Combining Individual Elements (AREA)
- Structures Or Materials For Encapsulating Or Coating Semiconductor Devices Or Solid State Devices (AREA)
- Hybrid Cells (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75580596A | 1996-11-26 | 1996-11-26 | |
US755805 | 1996-11-26 | ||
PCT/CA1997/000900 WO1998023587A1 (en) | 1996-11-26 | 1997-11-24 | 5-cyclo indole compounds as 5-ht1d receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69725337D1 true DE69725337D1 (de) | 2003-11-06 |
DE69725337T2 DE69725337T2 (de) | 2004-07-15 |
Family
ID=25040731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69725337T Expired - Fee Related DE69725337T2 (de) | 1996-11-26 | 1997-11-24 | 5-cyclo-indolverbindungen als 5-ht1d rezeptor liganden |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0944595B1 (de) |
JP (1) | JP2001504501A (de) |
CN (1) | CN1289479C (de) |
AT (1) | ATE251136T1 (de) |
AU (1) | AU738668B2 (de) |
CA (1) | CA2273328C (de) |
DE (1) | DE69725337T2 (de) |
ES (1) | ES2208955T3 (de) |
HK (1) | HK1026689A1 (de) |
TW (1) | TW432059B (de) |
WO (1) | WO1998023587A1 (de) |
ZA (1) | ZA9710643B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
US6251893B1 (en) * | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
US6329390B1 (en) * | 1998-07-17 | 2001-12-11 | Nps Allelix Corp. | 5-Bicycloindole compounds |
US6562809B1 (en) * | 1998-09-18 | 2003-05-13 | Nps Allelix Corp. | 3-bicycloindole compounds |
WO2000038677A1 (en) * | 1998-12-23 | 2000-07-06 | Allelix Biopharmaceuticals Inc. | Indole and indolizidine derivatives for the treatment of migraine |
DK1355904T3 (da) | 2000-12-22 | 2007-10-15 | Wyeth Corp | Heterocyclindazol- og -azaindazolforbindelser som 5-hydroxytryptamin-6-ligander |
EP1803720A1 (de) * | 2000-12-22 | 2007-07-04 | Wyeth a Corporation of the State of Delaware | Hetorocyclindazole und -Azaindazole Verbindungen als 5-Hydroxytryptamine-6 Liganden |
CA2515571A1 (en) | 2003-02-14 | 2004-09-02 | Wyeth | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
US8030257B2 (en) | 2005-05-13 | 2011-10-04 | Exxonmobil Research And Engineering Company | Catalytic antioxidants |
CN102936240A (zh) * | 2012-10-30 | 2013-02-20 | 浙江省医学科学院 | 一种(r)-5-取代-3-(n-苄氧羰基吡咯烷-2-基羰基)-1h-吲哚的合成方法 |
CN107698558B (zh) * | 2017-10-24 | 2019-04-02 | 温州大学 | 一种氮杂环硫化物的制备方法及其净化提纯方法 |
TW201938517A (zh) * | 2017-12-01 | 2019-10-01 | 景凱生物科技股份有限公司 | 苯並雜環化合物及其用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4833153A (en) * | 1985-11-08 | 1989-05-23 | Glaxo Group Limited | Indole derivatives |
GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
US5300645A (en) * | 1993-04-14 | 1994-04-05 | Eli Lilly And Company | Tetrahydro-pyrido-indole |
BR9406481A (pt) * | 1993-04-22 | 1996-01-09 | Pfizer Res & Dev | Derivados de indol como agonistas do tipo 5-HT1 para utilização na enxaqueca |
-
1997
- 1997-11-24 AU AU51122/98A patent/AU738668B2/en not_active Ceased
- 1997-11-24 WO PCT/CA1997/000900 patent/WO1998023587A1/en active IP Right Grant
- 1997-11-24 DE DE69725337T patent/DE69725337T2/de not_active Expired - Fee Related
- 1997-11-24 AT AT97945687T patent/ATE251136T1/de not_active IP Right Cessation
- 1997-11-24 CA CA002273328A patent/CA2273328C/en not_active Expired - Fee Related
- 1997-11-24 CN CNB971815127A patent/CN1289479C/zh not_active Expired - Fee Related
- 1997-11-24 ES ES97945687T patent/ES2208955T3/es not_active Expired - Lifetime
- 1997-11-24 JP JP52408398A patent/JP2001504501A/ja active Pending
- 1997-11-24 EP EP97945687A patent/EP0944595B1/de not_active Expired - Lifetime
- 1997-11-26 ZA ZA9710643A patent/ZA9710643B/xx unknown
- 1997-12-18 TW TW086119400A patent/TW432059B/zh not_active IP Right Cessation
-
2000
- 2000-03-29 HK HK00101951A patent/HK1026689A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2273328C (en) | 2009-04-28 |
DE69725337T2 (de) | 2004-07-15 |
ATE251136T1 (de) | 2003-10-15 |
JP2001504501A (ja) | 2001-04-03 |
EP0944595A1 (de) | 1999-09-29 |
EP0944595B1 (de) | 2003-10-01 |
HK1026689A1 (en) | 2000-12-22 |
AU738668B2 (en) | 2001-09-20 |
TW432059B (en) | 2001-05-01 |
CA2273328A1 (en) | 1998-06-04 |
WO1998023587A1 (en) | 1998-06-04 |
ZA9710643B (en) | 1998-09-02 |
ES2208955T3 (es) | 2004-06-16 |
AU5112298A (en) | 1998-06-22 |
CN1289479C (zh) | 2006-12-13 |
CN1245491A (zh) | 2000-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |