HK1026689A1 - 5-cyclo indole compounds as 5-ht1d receptor ligands - Google Patents

5-cyclo indole compounds as 5-ht1d receptor ligands

Info

Publication number
HK1026689A1
HK1026689A1 HK00101951A HK00101951A HK1026689A1 HK 1026689 A1 HK1026689 A1 HK 1026689A1 HK 00101951 A HK00101951 A HK 00101951A HK 00101951 A HK00101951 A HK 00101951A HK 1026689 A1 HK1026689 A1 HK 1026689A1
Authority
HK
Hong Kong
Prior art keywords
loweralkyl
optionally substituted
ht1d
membered
cyclo
Prior art date
Application number
HK00101951A
Other languages
English (en)
Inventor
Abdelmalik Slassi
Louise Edwards
Qingchang Meng
Sumanas Rakhit
Original Assignee
Nps Allelix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nps Allelix Corp filed Critical Nps Allelix Corp
Publication of HK1026689A1 publication Critical patent/HK1026689A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Structures Or Materials For Encapsulating Or Coating Semiconductor Devices Or Solid State Devices (AREA)
  • Hybrid Cells (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
HK00101951A 1996-11-26 2000-03-29 5-cyclo indole compounds as 5-ht1d receptor ligands HK1026689A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75580596A 1996-11-26 1996-11-26
PCT/CA1997/000900 WO1998023587A1 (en) 1996-11-26 1997-11-24 5-cyclo indole compounds as 5-ht1d receptor ligands

Publications (1)

Publication Number Publication Date
HK1026689A1 true HK1026689A1 (en) 2000-12-22

Family

ID=25040731

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00101951A HK1026689A1 (en) 1996-11-26 2000-03-29 5-cyclo indole compounds as 5-ht1d receptor ligands

Country Status (12)

Country Link
EP (1) EP0944595B1 (de)
JP (1) JP2001504501A (de)
CN (1) CN1289479C (de)
AT (1) ATE251136T1 (de)
AU (1) AU738668B2 (de)
CA (1) CA2273328C (de)
DE (1) DE69725337T2 (de)
ES (1) ES2208955T3 (de)
HK (1) HK1026689A1 (de)
TW (1) TW432059B (de)
WO (1) WO1998023587A1 (de)
ZA (1) ZA9710643B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100291A (en) * 1998-03-16 2000-08-08 Allelix Biopharmaceuticals Inc. Pyrrolidine-indole compounds having 5-HT6 affinity
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US6329390B1 (en) * 1998-07-17 2001-12-11 Nps Allelix Corp. 5-Bicycloindole compounds
US6562809B1 (en) * 1998-09-18 2003-05-13 Nps Allelix Corp. 3-bicycloindole compounds
CA2356638A1 (en) * 1998-12-23 2000-07-06 Nps Allelix Corp. Indole and indolizidine derivatives for the treatment of migraine
EP1803720A1 (de) * 2000-12-22 2007-07-04 Wyeth a Corporation of the State of Delaware Hetorocyclindazole und -Azaindazole Verbindungen als 5-Hydroxytryptamine-6 Liganden
CA2432654A1 (en) 2000-12-22 2002-07-04 Wyeth Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands
EP1592690A1 (de) 2003-02-14 2005-11-09 Wyeth Heterocyclyl-3-sulfonylazaindol- oder -azaindazolderivate als 5-hydroxytryptamin-6-liganden
US8030257B2 (en) 2005-05-13 2011-10-04 Exxonmobil Research And Engineering Company Catalytic antioxidants
CN102936240A (zh) * 2012-10-30 2013-02-20 浙江省医学科学院 一种(r)-5-取代-3-(n-苄氧羰基吡咯烷-2-基羰基)-1h-吲哚的合成方法
CN107698558B (zh) * 2017-10-24 2019-04-02 温州大学 一种氮杂环硫化物的制备方法及其净化提纯方法
US20200157088A1 (en) * 2017-12-01 2020-05-21 Taiwanj Pharmaceuticals Co., Ltd. Benzene fused heterocyclic compound and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB9226537D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5300645A (en) * 1993-04-14 1994-04-05 Eli Lilly And Company Tetrahydro-pyrido-indole
CN1121348A (zh) * 1993-04-22 1996-04-24 辉瑞研究及发展公司 吲哚衍生物作为5-ht1类激动剂用于治疗周期性偏头痛

Also Published As

Publication number Publication date
TW432059B (en) 2001-05-01
AU5112298A (en) 1998-06-22
WO1998023587A1 (en) 1998-06-04
CA2273328C (en) 2009-04-28
EP0944595B1 (de) 2003-10-01
AU738668B2 (en) 2001-09-20
ATE251136T1 (de) 2003-10-15
CN1245491A (zh) 2000-02-23
CA2273328A1 (en) 1998-06-04
CN1289479C (zh) 2006-12-13
JP2001504501A (ja) 2001-04-03
ZA9710643B (en) 1998-09-02
ES2208955T3 (es) 2004-06-16
EP0944595A1 (de) 1999-09-29
DE69725337D1 (de) 2003-11-06
DE69725337T2 (de) 2004-07-15

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20091124