|
US6906093B2
(en)
|
1995-06-07 |
2005-06-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
|
US6147106A
(en)
|
1997-08-20 |
2000-11-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
|
US6316635B1
(en)
|
1995-06-07 |
2001-11-13 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
US6696448B2
(en)
|
1996-06-05 |
2004-02-24 |
Sugen, Inc. |
3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
|
|
WO1998024432A2
(en)
*
|
1996-12-05 |
1998-06-11 |
Sugen, Inc. |
Use of indolinone compounds as modulators of protein kinases
|
|
JP2002511852A
(ja)
*
|
1997-05-07 |
2002-04-16 |
スージェン・インコーポレーテッド |
蛋白質キナーゼ活性の調節剤としての２−インドリノン誘導体
|
|
US6486185B1
(en)
|
1997-05-07 |
2002-11-26 |
Sugen, Inc. |
3-heteroarylidene-2-indolinone protein kinase inhibitors
|
|
US6316429B1
(en)
|
1997-05-07 |
2001-11-13 |
Sugen, Inc. |
Bicyclic protein kinase inhibitors
|
|
US6987113B2
(en)
|
1997-06-11 |
2006-01-17 |
Sugen, Inc. |
Tyrosine kinase inhibitors
|
|
US6051593A
(en)
|
1997-06-20 |
2000-04-18 |
Sugen, Inc. |
3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
|
|
US6313158B1
(en)
|
1997-06-20 |
2001-11-06 |
Sugen, Inc. |
Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
|
|
GB9716557D0
(en)
*
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
|
GB9718913D0
(en)
|
1997-09-05 |
1997-11-12 |
Glaxo Group Ltd |
Substituted oxindole derivatives
|
|
US6531502B1
(en)
|
1998-01-21 |
2003-03-11 |
Sugen, Inc. |
3-Methylidenyl-2-indolinone modulators of protein kinase
|
|
WO1999048868A2
(en)
*
|
1998-03-26 |
1999-09-30 |
Sugen, Inc. |
Heterocyclic classes of compounds for the modulating tyrosine protein kinase
|
|
US6514981B1
(en)
|
1998-04-02 |
2003-02-04 |
Sugen, Inc. |
Methods of modulating tyrosine protein kinase function with indolinone compounds
|
|
US6569868B2
(en)
|
1998-04-16 |
2003-05-27 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
SK287132B6
(sk)
*
|
1998-05-29 |
2009-12-07 |
Sugen, Inc. |
Farmaceutická kompozícia obsahujúca pyrolom substituovaný 2-indolinón, súprava obsahujúca uvedenú kompozíciu a použitie pyrolom substituovaného 2-indolinónu
|
|
ATE233560T1
(de)
*
|
1998-05-29 |
2003-03-15 |
Centre Nat Rech Scient |
Verwendung von indigoähnlichen bisindolen zur herstellung eines arzneimittels zur hemmung cyclin abhängiger kinasen
|
|
DE19824922A1
(de)
*
|
1998-06-04 |
1999-12-09 |
Boehringer Ingelheim Pharma |
Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
US6319918B1
(en)
|
1998-06-04 |
2001-11-20 |
Boehringer Ingelheim Pharma Kg |
Substituted indolinones with kinase inhibitory activity
|
|
US6680335B2
(en)
|
1998-09-28 |
2004-01-20 |
Sugen, Inc. |
Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
|
|
CN1136217C
(zh)
|
1998-12-17 |
2004-01-28 |
霍夫曼-拉罗奇有限公司 |
作为jnk蛋白质激酶抑制剂的4-芳基羟吲哚
|
|
BR9916327A
(pt)
|
1998-12-17 |
2001-09-18 |
Hoffmann La Roche |
Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2
|
|
BR9916272A
(pt)
*
|
1998-12-17 |
2001-09-04 |
Hoffmann La Roche |
4 e 5-alquiniloxindóis e 4 e 5-alqueniloxindóis
|
|
KR20010108024A
(ko)
*
|
1998-12-17 |
2001-12-07 |
프리돌린 클라우스너, 롤란드 비. 보레르 |
단백질 키나제 억제제로서의 4,5-피라진옥신돌
|
|
US6153634A
(en)
*
|
1998-12-17 |
2000-11-28 |
Hoffmann-La Roche Inc. |
4,5-azolo-oxindoles
|
|
MXPA01006742A
(es)
*
|
1998-12-31 |
2004-04-21 |
Sugen Inc |
Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer.
|
|
WO2000042213A1
(en)
|
1999-01-13 |
2000-07-20 |
The Research Foundation Of State University Of New York |
A novel method for designing protein kinase inhibitors
|
|
GB9904933D0
(en)
|
1999-03-04 |
1999-04-28 |
Glaxo Group Ltd |
Compounds
|
|
US6492398B1
(en)
|
1999-03-04 |
2002-12-10 |
Smithkline Beechman Corporation |
Thiazoloindolinone compounds
|
|
US6624171B1
(en)
|
1999-03-04 |
2003-09-23 |
Smithkline Beecham Corporation |
Substituted aza-oxindole derivatives
|
|
EP1165513A1
(en)
*
|
1999-03-24 |
2002-01-02 |
Sugen, Inc. |
Indolinone compounds as kinase inhibitors
|
|
US6689806B1
(en)
|
1999-03-24 |
2004-02-10 |
Sugen, Inc. |
Indolinone compounds as kinase inhibitors
|
|
US6878733B1
(en)
|
1999-11-24 |
2005-04-12 |
Sugen, Inc. |
Formulations for pharmaceutical agents ionizable as free acids or free bases
|
|
WO2001037820A2
(en)
*
|
1999-11-24 |
2001-05-31 |
Sugen, Inc. |
Ionizable indolinone derivatives and their use as ptk ligands
|
|
US6313310B1
(en)
|
1999-12-15 |
2001-11-06 |
Hoffmann-La Roche Inc. |
4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
|
|
ATE331514T1
(de)
*
|
1999-12-22 |
2006-07-15 |
Sugen Inc |
Indolinonderivate zur abänderung der c-kit tyrosinproteinkinase
|
|
JP3663382B2
(ja)
|
2000-02-15 |
2005-06-22 |
スージェン・インコーポレーテッド |
ピロール置換２−インドリノン蛋白質キナーゼ阻害剤
|
|
EP1259514B9
(en)
|
2000-02-28 |
2005-11-09 |
Sugen, Inc. |
3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
|
|
US6620818B1
(en)
|
2000-03-01 |
2003-09-16 |
Smithkline Beecham Corporation |
Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
|
|
MY128450A
(en)
|
2000-05-24 |
2007-02-28 |
Upjohn Co |
1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
|
|
JP2003535847A
(ja)
|
2000-06-02 |
2003-12-02 |
スージェン・インコーポレーテッド |
蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体
|
|
WO2002002551A1
(en)
*
|
2000-06-30 |
2002-01-10 |
Sugen, Inc. |
4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
|
|
GB0016454D0
(en)
|
2000-07-04 |
2000-08-23 |
Hoffmann La Roche |
Thienopyrrolidinones
|
|
US6504034B2
(en)
|
2001-01-23 |
2003-01-07 |
Hoffmann-La Roche Inc. |
Naphthostyrils
|
|
AR042586A1
(es)
|
2001-02-15 |
2005-06-29 |
Sugen Inc |
3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
|
|
FR2821358B1
(fr)
*
|
2001-02-27 |
2006-04-07 |
Aventis Pharma Sa |
Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique
|
|
DE10114138C2
(de)
*
|
2001-03-16 |
2003-03-27 |
Schering Ag |
Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit
|
|
DE10117204A1
(de)
|
2001-04-06 |
2002-10-10 |
Boehringer Ingelheim Pharma |
In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
US6599902B2
(en)
|
2001-05-30 |
2003-07-29 |
Sugen, Inc. |
5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
|
|
DE10134196B4
(de)
*
|
2001-07-13 |
2005-08-18 |
Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt |
Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen
|
|
US7005445B2
(en)
|
2001-10-22 |
2006-02-28 |
The Research Foundation Of State University Of New York |
Protein kinase and phosphatase inhibitors and methods for designing them
|
|
GB0302512D0
(en)
*
|
2003-02-03 |
2003-03-05 |
Arrow Therapeutics Ltd |
Compounds
|
|
US7157577B2
(en)
|
2003-03-07 |
2007-01-02 |
Sugen Inc. |
5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
|
|
WO2005068424A1
(en)
*
|
2004-01-20 |
2005-07-28 |
Cell Therapeutics Europe S.R.L. |
Indolinone derivatives as receptor tyrosine kinase ihibitors
|
|
US7759383B2
(en)
|
2005-02-22 |
2010-07-20 |
The Regents Of The University Of Michigan |
Small molecule inhibitors of MDM2 and the uses thereof
|
|
WO2006119148A2
(en)
*
|
2005-04-29 |
2006-11-09 |
The Ohio State University Research Foundation |
Keratinocyte growth factor receptor - tyrosine specific inhibitors for the prevention of cancer metastatis
|
|
WO2007103308A2
(en)
|
2006-03-07 |
2007-09-13 |
Array Biopharma Inc. |
Heterobicyclic pyrazole compounds and methods of use
|
|
US7838542B2
(en)
|
2006-06-29 |
2010-11-23 |
Kinex Pharmaceuticals, Llc |
Bicyclic compositions and methods for modulating a kinase cascade
|
|
CA2736177A1
(en)
*
|
2007-09-06 |
2009-03-12 |
Boston Biomedical, Inc. |
Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
|
|
EP2235004A4
(en)
*
|
2007-12-21 |
2011-05-04 |
Univ Health Network |
INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL-SUBSTITUTED INDOLUND DERIVATIVES AS A KINASE-HEMMER FOR CANCER TREATMENT
|
|
ES2465971T3
(es)
|
2009-04-06 |
2014-06-09 |
University Health Network |
Inhibidores de quinasa y método para tratar cáncer con los mismos
|
|
SI2556071T1
(sl)
|
2010-04-06 |
2016-12-30 |
University Health Network |
Kinazni inhibitorji in njihova uporaba pri zdravljenju raka
|
|
WO2011136319A1
(ja)
*
|
2010-04-30 |
2011-11-03 |
国立大学法人 東京大学 |
抗がん剤
|
|
CN103183665B
(zh)
*
|
2011-12-30 |
2015-10-14 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
具有酪氨酸激酶抑制活性的物质、其制备方法及用途
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
EP3012248B1
(en)
*
|
2013-06-20 |
2019-09-11 |
Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China |
Substance having tyrosine kinase inhibitory activity and preparation method and use thereof
|
|
WO2015054781A1
(en)
|
2013-10-18 |
2015-04-23 |
University Health Network |
Treatment for pancreatic cancer
|
|
RU2016141385A
(ru)
|
2014-03-24 |
2018-04-28 |
Дженентек, Инк. |
Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf
|
|
CN104326964A
(zh)
*
|
2014-09-16 |
2015-02-04 |
中国科学院海洋研究所 |
一类氟代2-吲哚酮衍生物及其制备和应用
|
|
CN105481751A
(zh)
*
|
2014-09-16 |
2016-04-13 |
中国科学院海洋研究所 |
一类2-吲哚酮衍生物及其制备和应用
|
|
CN108047119A
(zh)
*
|
2017-11-28 |
2018-05-18 |
四川理工学院 |
3-氟烯基氧化吲哚-3-三氟甲基氧化吲哚化合物及其应用
|
|
CN107840818A
(zh)
*
|
2017-11-28 |
2018-03-27 |
四川理工学院 |
含氟二氧化吲哚化合物及其应用
|
|
CN115073353B
(zh)
*
|
2021-03-15 |
2024-05-14 |
中国医学科学院药物研究所 |
木脂素类衍生物及其制法和其药物组合物与用途
|
|
EP4650354A1
(en)
*
|
2023-01-12 |
2025-11-19 |
Shenzhen Zhongge Biological Technology Co., Ltd. |
Indolone derivative having irak4 inhibitory activity, and preparation method therefor and use thereof
|