JP2001503736A5 - - Google Patents

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Publication number
JP2001503736A5
JP2001503736A5 JP1998510973A JP51097398A JP2001503736A5 JP 2001503736 A5 JP2001503736 A5 JP 2001503736A5 JP 1998510973 A JP1998510973 A JP 1998510973A JP 51097398 A JP51097398 A JP 51097398A JP 2001503736 A5 JP2001503736 A5 JP 2001503736A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998510973A
Other languages
English (en)
Japanese (ja)
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JP2001503736A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/014736 external-priority patent/WO1998007695A1/en
Publication of JP2001503736A publication Critical patent/JP2001503736A/ja
Publication of JP2001503736A5 publication Critical patent/JP2001503736A5/ja
Ceased legal-status Critical Current

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JP51097398A 1996-08-23 1997-08-20 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法 Ceased JP2001503736A (ja)

Applications Claiming Priority (23)

Application Number Priority Date Filing Date Title
US70223296A 1996-08-23 1996-08-23
US08/702,232 1996-08-23
US3158896P 1996-12-05 1996-12-05
US3254696P 1996-12-05 1996-12-05
US3158696P 1996-12-05 1996-12-05
US3158596P 1996-12-05 1996-12-05
US3254796P 1996-12-05 1996-12-05
US60/032,547 1996-12-05
US60/031,588 1996-12-05
US60/032,546 1996-12-05
US60/031,585 1996-12-05
US60/031,586 1996-12-05
US4571597P 1997-05-05 1997-05-05
US4684397P 1997-05-05 1997-05-05
US4556597P 1997-05-05 1997-05-05
US4571497P 1997-05-05 1997-05-05
US4556697P 1997-05-05 1997-05-05
US60/045,565 1997-05-05
US60/045,714 1997-05-05
US60/045,566 1997-05-05
US60/045,715 1997-05-05
US60/046,843 1997-05-05
PCT/US1997/014736 WO1998007695A1 (en) 1996-08-23 1997-08-20 Indolinone combinatorial libraries and related products and methods for the treatment of disease

Publications (2)

Publication Number Publication Date
JP2001503736A JP2001503736A (ja) 2001-03-21
JP2001503736A5 true JP2001503736A5 (https=) 2005-04-07

Family

ID=27582490

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51097398A Ceased JP2001503736A (ja) 1996-08-23 1997-08-20 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法

Country Status (8)

Country Link
EP (2) EP0929520B1 (https=)
JP (1) JP2001503736A (https=)
AT (1) ATE308520T1 (https=)
AU (1) AU4155697A (https=)
CA (1) CA2264220A1 (https=)
DE (1) DE69734521T9 (https=)
ES (1) ES2251741T3 (https=)
WO (1) WO1998007695A1 (https=)

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* Cited by examiner, † Cited by third party
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US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
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US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6486185B1 (en) 1997-05-07 2002-11-26 Sugen, Inc. 3-heteroarylidene-2-indolinone protein kinase inhibitors
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US6987113B2 (en) 1997-06-11 2006-01-17 Sugen, Inc. Tyrosine kinase inhibitors
US6051593A (en) 1997-06-20 2000-04-18 Sugen, Inc. 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
US6313158B1 (en) 1997-06-20 2001-11-06 Sugen, Inc. Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
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US6514981B1 (en) 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
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JP2002516851A (ja) * 1998-05-29 2002-06-11 ゲルハルト アイゼンブランド サイクリン依存性キナーゼを阻害する医薬製造のためのインジゴイドビスインドール誘導体の使用
US6319918B1 (en) 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
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US6680335B2 (en) 1998-09-28 2004-01-20 Sugen, Inc. Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
BR9916327A (pt) * 1998-12-17 2001-09-18 Hoffmann La Roche Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2
EP1149093A1 (en) * 1998-12-17 2001-10-31 F. Hoffmann-La Roche Ag 4-aryloxindoles as inhibitors of jnk protein kinases
CN1158283C (zh) * 1998-12-17 2004-07-21 霍夫曼-拉罗奇有限公司 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚
PT1149092E (pt) * 1998-12-17 2004-03-31 Hoffmann La Roche 4- e 5-alciniloxindois e 4- e 5-alceniloxindois
IL143920A0 (en) * 1998-12-31 2002-04-21 Sugen Inc 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same
JP4865129B2 (ja) * 1999-01-13 2012-02-01 ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク タンパク質キナーゼ阻害剤を設計するための新規の方法
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
AU3770000A (en) * 1999-03-24 2000-10-09 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
PT1233943E (pt) * 1999-11-24 2011-09-01 Sugen Inc Formulações para agentes farmacêuticos ionizáveis como ácidos livres ou bases livres
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
EP1255536B1 (en) 1999-12-22 2006-06-28 Sugen, Inc. Indolinone derivatives for modulation of c-kit tyrosine protein kinase
SI1255752T1 (sl) 2000-02-15 2007-12-31 Pharmacia & Upjohn Co Llc S pirolom substituirani zaviralci 2-indolinon protein kinaza
ES2243461T3 (es) 2000-02-28 2005-12-01 Sugen, Inc. Compuestos de 3-(pirolillactona) -2-indolinona como inhibidores quinasa.
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2003535847A (ja) 2000-06-02 2003-12-02 スージェン・インコーポレーテッド 蛋白質キナーゼ/ホスファターゼ阻害剤としてのインドリノン誘導体
JP2004502686A (ja) 2000-06-30 2004-01-29 スージェン・インコーポレーテッド 4−ヘテロアリール−3−ヘテロアリーリデニル−2−インドリノンおよび蛋白質キナーゼ阻害剤としてのその使用
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
US6504034B2 (en) 2001-01-23 2003-01-07 Hoffmann-La Roche Inc. Naphthostyrils
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
FR2821358B1 (fr) * 2001-02-27 2006-04-07 Aventis Pharma Sa Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique
DE10114138C2 (de) * 2001-03-16 2003-03-27 Schering Ag Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit
DE10117204A1 (de) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
AU2002303892A1 (en) 2001-05-30 2002-12-09 Jingrong Cui 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
DE10134196B4 (de) 2001-07-13 2005-08-18 Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
GB0302512D0 (en) * 2003-02-03 2003-03-05 Arrow Therapeutics Ltd Compounds
US7157577B2 (en) 2003-03-07 2007-01-02 Sugen Inc. 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
WO2005068424A1 (en) * 2004-01-20 2005-07-28 Cell Therapeutics Europe S.R.L. Indolinone derivatives as receptor tyrosine kinase ihibitors
SG176463A1 (en) 2005-02-22 2011-12-29 Univ Michigan Small molecule inhibitors of mdm2 and uses thereof
US7960548B2 (en) * 2005-04-29 2011-06-14 The Ohio State University Research Foundation Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis
BRPI0708615A2 (pt) 2006-03-07 2011-06-07 Array Biopharma Inc compostos de pirazol heterobicìclicos e métodos de uso
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
EP3037419B1 (en) * 2007-09-06 2019-09-04 Boston Biomedical, Inc. Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
EP2235004A4 (en) * 2007-12-21 2011-05-04 Univ Health Network INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL-SUBSTITUTED INDOLUND DERIVATIVES AS A KINASE-HEMMER FOR CANCER TREATMENT
JP5629752B2 (ja) 2009-04-06 2014-11-26 ユニバーシティ・ヘルス・ネットワークUniversity Health Network キナーゼインヒビターおよびこれを用いた癌の治療方法
JP5442906B2 (ja) 2010-04-06 2014-03-19 ユニバーシティ・ヘルス・ネットワーク キナーゼインヒビターおよびこれを用いた癌の治療方法
US9156827B2 (en) 2010-04-30 2015-10-13 The University Of Tokyo Anticancer agent
CN103183665B (zh) * 2011-12-30 2015-10-14 中国人民解放军军事医学科学院放射与辐射医学研究所 具有酪氨酸激酶抑制活性的物质、其制备方法及用途
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
EP3012248B1 (en) * 2013-06-20 2019-09-11 Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China Substance having tyrosine kinase inhibitory activity and preparation method and use thereof
SG11201602882VA (en) 2013-10-18 2016-05-30 Univ Health Network Treatment for pancreatic cancer
EP3122900A1 (en) 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
CN105481751A (zh) * 2014-09-16 2016-04-13 中国科学院海洋研究所 一类2-吲哚酮衍生物及其制备和应用
CN104326964A (zh) * 2014-09-16 2015-02-04 中国科学院海洋研究所 一类氟代2-吲哚酮衍生物及其制备和应用
CN107840818A (zh) * 2017-11-28 2018-03-27 四川理工学院 含氟二氧化吲哚化合物及其应用
CN108047119A (zh) * 2017-11-28 2018-05-18 四川理工学院 3-氟烯基氧化吲哚-3-三氟甲基氧化吲哚化合物及其应用
CN115073353B (zh) * 2021-03-15 2024-05-14 中国医学科学院药物研究所 木脂素类衍生物及其制法和其药物组合物与用途
CN120418240A (zh) * 2023-01-12 2025-08-01 深圳众格生物科技有限公司 具有irak4抑制活性的吲哚酮衍生物及其制备方法和应用

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