|
DE19819023A1
(de)
*
|
1998-04-29 |
1999-11-04 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
US6476078B2
(en)
|
1999-08-11 |
2002-11-05 |
Sepracor, Inc. |
Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
|
|
US6331571B1
(en)
|
1998-08-24 |
2001-12-18 |
Sepracor, Inc. |
Methods of treating and preventing attention deficit disorders
|
|
US6339106B1
(en)
|
1999-08-11 |
2002-01-15 |
Sepracor, Inc. |
Methods and compositions for the treatment and prevention of sexual dysfunction
|
|
US6974838B2
(en)
|
1998-08-24 |
2005-12-13 |
Sepracor Inc. |
Methods of treating or preventing pain using sibutramine metabolites
|
|
EP1323719A1
(en)
*
|
1999-03-30 |
2003-07-02 |
Nippon Soda Co., Ltd. |
Thienopyrimidine compounds and salts thereof and process for the preparation of the same
|
|
US6399826B1
(en)
|
1999-08-11 |
2002-06-04 |
Sepracor Inc. |
Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
|
|
DE19950647A1
(de)
*
|
1999-10-21 |
2001-04-26 |
Merck Patent Gmbh |
Imidazolderivate als Phosphodiesterase VII-Hemmer
|
|
DE10031585A1
(de)
*
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
2-Aminoalkyl-thieno[2,3-d]pyrimidine
|
|
CN1458933A
(zh)
*
|
2000-09-29 |
2003-11-26 |
日本曹达株式会社 |
噻吩并嘧啶化合物及其盐以及其制备方法
|
|
BR0206853A
(pt)
*
|
2001-02-02 |
2004-01-13 |
Merck Patent Ges Mit Beschroen |
Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antagonistas de receptor de endotelina ou tienopirimidinas e antagonistas de receptor de endotelina
|
|
US6610887B2
(en)
|
2001-04-13 |
2003-08-26 |
Sepracor Inc. |
Methods of preparing didesmethylsibutramine and other sibutramine derivatives
|
|
WO2002088138A1
(en)
*
|
2001-04-30 |
2002-11-07 |
Bayer Corporation |
Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines
|
|
US7375109B2
(en)
*
|
2001-09-04 |
2008-05-20 |
N.V. Organon |
Glycine-substituted thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
|
|
WO2003035653A1
(en)
*
|
2001-10-26 |
2003-05-01 |
Nippon Soda Co.,Ltd. |
Pyridothienopyrimidine compound and salt thereof
|
|
US7153412B2
(en)
|
2001-12-28 |
2006-12-26 |
Kabushiki Kaisha Toyota Chuo Kenkyusho |
Electrodes, electrochemical elements, gas sensors, and gas measurement methods
|
|
US7208516B2
(en)
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
|
US7276529B2
(en)
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
TW200410975A
(en)
*
|
2002-09-26 |
2004-07-01 |
Nihon Nohyaku Co Ltd |
New pesticide and method for using it, new substituted thienopyrimidine derivative, its intermediate, and method for producing it
|
|
GB0320300D0
(en)
*
|
2003-08-29 |
2003-10-01 |
Cancer Rec Tech Ltd |
Pyrimidothiophene compounds
|
|
DE10351436A1
(de)
*
|
2003-11-04 |
2005-06-09 |
Merck Patent Gmbh |
Verwendung von Thienopyrimidinen
|
|
GB0420719D0
(en)
*
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
|
GB0420722D0
(en)
*
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
|
AR059898A1
(es)
*
|
2006-03-15 |
2008-05-07 |
Janssen Pharmaceutica Nv |
Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
|
|
TW200845978A
(en)
*
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
|
TW200900065A
(en)
*
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
|
US9603848B2
(en)
|
2007-06-08 |
2017-03-28 |
Senomyx, Inc. |
Modulation of chemosensory receptors and ligands associated therewith
|
|
AU2008297877C1
(en)
*
|
2007-09-14 |
2013-11-07 |
Addex Pharma S.A. |
1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones
|
|
DE602008004794D1
(de)
*
|
2007-09-14 |
2011-03-10 |
Addex Pharmaceuticals Sa |
1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyridinyl-2'-one
|
|
KR20100065191A
(ko)
|
2007-09-14 |
2010-06-15 |
오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 |
1,3-이치환된 4-(아릴-x-페닐)-1h-피리딘-2-온
|
|
US8785486B2
(en)
*
|
2007-11-14 |
2014-07-22 |
Janssen Pharmaceuticals, Inc. |
Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
|
|
US20100227853A1
(en)
*
|
2008-04-18 |
2010-09-09 |
Trustees Of Boston College |
Inhibitors of cyclic amp phosphodiesterases
|
|
US8586733B2
(en)
|
2008-07-31 |
2013-11-19 |
Senomyx, Inc. |
Processes and intermediates for making sweet taste enhancers
|
|
EP2344470B1
(en)
|
2008-09-02 |
2013-11-06 |
Janssen Pharmaceuticals, Inc. |
3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
|
|
CN102186477B
(zh)
|
2008-10-16 |
2013-07-17 |
奥梅-杨森制药有限公司 |
作为代谢型谷氨酸受体调节剂的吲哚和苯并吗啉衍生物
|
|
CN102232074B
(zh)
|
2008-11-28 |
2014-12-03 |
奥梅-杨森制药有限公司 |
作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
|
|
AR076861A1
(es)
|
2009-05-12 |
2011-07-13 |
Addex Pharma Sa |
Derivados de 1,2,4-triazolo (4,3-a)piridina y su uso como moduladores alostericos positivos de los receptores de mglur2
|
|
WO2010130422A1
(en)
|
2009-05-12 |
2010-11-18 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
US8993591B2
(en)
|
2010-11-08 |
2015-03-31 |
Janssen Pharmaceuticals, Inc. |
1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
|
|
ES2552455T3
(es)
|
2010-11-08 |
2015-11-30 |
Janssen Pharmaceuticals, Inc. |
Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
|
|
CA2814998C
(en)
|
2010-11-08 |
2019-10-29 |
Janssen Pharmaceuticals, Inc. |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
WO2013012918A1
(en)
|
2011-07-19 |
2013-01-24 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
|
EP2804603A1
(en)
|
2012-01-10 |
2014-11-26 |
President and Fellows of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
NZ703926A
(en)
|
2012-08-06 |
2018-04-27 |
Senomyx Inc |
Sweet flavor modifier
|
|
JO3155B1
(ar)
|
2013-02-19 |
2017-09-20 |
Senomyx Inc |
معدِّل نكهة حلوة
|
|
JO3368B1
(ar)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
|
|
JO3367B1
(ar)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
|
|
PH12019500127B1
(en)
|
2014-01-21 |
2022-05-04 |
Janssen Pharmaceutica Nv |
Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
|
|
SMT201900545T1
(it)
|
2014-01-21 |
2019-11-13 |
Janssen Pharmaceutica Nv |
Combinazioni comprendenti modulatori allosterici positivi o agonisti ortosterici del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo
|
|
JP6687550B2
(ja)
|
2014-06-23 |
2020-04-22 |
セルジーン コーポレイション |
肝疾患又は肝機能異常を治療するためのアプレミラスト
|
|
AU2016378723B2
(en)
|
2015-12-22 |
2021-09-30 |
SHY Therapeutics LLC |
Compounds for the treatment of cancer and inflammatory disease
|
|
MX2019014875A
(es)
|
2017-06-21 |
2021-01-29 |
SHY Therapeutics LLC |
Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.
|
|
MX2021001193A
(es)
|
2018-08-07 |
2021-04-28 |
Firmenich Incorporated |
2,2-dioxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-sustituidos y formulaciones y usos de los mismos.
|
|
US12391705B2
(en)
|
2018-12-19 |
2025-08-19 |
Shy Therapeutics, Llc |
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
|
|
CN116178374B
(zh)
*
|
2023-01-13 |
2024-10-08 |
河北医科大学 |
小电导钙激活钾离子通道激动剂及其合成和应用
|