JP2000515522A - 経皮内用のウシポリヌクレオチドワクチン製剤 - Google Patents
経皮内用のウシポリヌクレオチドワクチン製剤Info
- Publication number
- JP2000515522A JP2000515522A JP10506636A JP50663698A JP2000515522A JP 2000515522 A JP2000515522 A JP 2000515522A JP 10506636 A JP10506636 A JP 10506636A JP 50663698 A JP50663698 A JP 50663698A JP 2000515522 A JP2000515522 A JP 2000515522A
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- virus
- vaccine preparation
- dna sequence
- intradermal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
- A61K39/265—Infectious rhinotracheitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16741—Use of virus, viral particle or viral elements as a vector
- C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18541—Use of virus, viral particle or viral elements as a vector
- C12N2760/18543—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. ウシの病原物質の免疫源をコードするDNA配列と、皮膚の細胞中でイン ビボでこの免疫源を発現させるプロモータとを組み合わせた、皮内経路で有効な 量のプラスミドを含む、液体ジェット投与装置を用いた皮内投与用の、ウシ用の ポリヌクレオチドワクチン製剤。 2. プラスミドが皮内経路に適した媒体中に0.1から0.9ml、好ましくは0.2か ら0.6ml、さらに好ましくは0.4から0.5mlの投与量で存在し、液体ジェット により皮内経路で投与される、請求項1に記載のワクチン製剤。 3. プラスミドがワクチン製剤中に10ngから1mg、好ましくは100ngから 500μg、さらに好ましくは0.5μから50μgの皮内で有効な量で存在する請求項 1または2に記載のワクチン製剤。 4. DNA配列がBRSVウイルス、IBRウイルス、BVDウイルスおよび PI3ウイルスよりなる群の中から選択される病原物質の免疫源をコードする請 求項3に記載のワクチン製剤。 5. DNA配列がIBRウイルスのgB遺伝子および/またはgD遺伝子をコ ードする請求項4に記載のワクチン製剤。 6. DNA配列がBRSVウイルスのG遺伝子および/またはF遺伝子をコー ドする請求項4に記載のワクチン製剤。 7. DNA配列がBVDウイルスのE2遺伝子および/またはE1遺伝子をコ ードする請求項4に記載のワクチン製剤。 8. DNA配列がPI3ウイルスのHN遺伝子および/またはF遺伝子をコー ドする請求項4に記載のワクチン製剤。 9. プロモータがhCMVIEプロモータのような強力な真核生物プロモータ である請求項1から8のいずれか一項に記載のワクチン製剤。 10. 皮内液体噴射投与器具、好ましくはPigjetの器具に合った複数の投与バイ アル内に収容された請求項1から9のいずれか一項に記載のワクチン製剤。 11. ワクチン製剤の投与量を皮内経路で伝達する液体噴射投与器具と、請求項 1から10のいずれか一項に記載のワクチン製剤を数回分の投与量で含む適当な バイアルとで構成される携帯型ウシワクチンユニット。 12. 液体噴射投与器具が1から10個、特に4から6個、好ましくは5または 6個のノズルを有する注射ヘッドを含む請求項11に記載の装置。 13. ウシの免疫源をコードするDNA配列とこの型の免疫源を発現させるプロ モータを組み合わせるプラスミドの、液体噴射投与器具を用いた皮内投与に適し たポリヌクレオチドワクチン製剤の製造での使用。 14. 10ngから1mg、好ましくは100ngから500μg、さらに好ましくは0.5 μから50μgのDNAを、投与量0.1から0.9ml、好ましくは0.2から0.6ml、 さらに好ましくは0.4から0.5mlで含む請求項13に記載の使用。 15. DNA配列がBRSVウイルス、IBRウイルス、BVDウイルスおよび PI3ウイルスよりなる群の中から選択される病原物質の免疫源をコードする請 求項12に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9609402A FR2751228B1 (fr) | 1996-07-19 | 1996-07-19 | Vaccin polynucleotidique bovin pour voie intradermique |
FR96/09402 | 1996-07-19 | ||
PCT/FR1997/001322 WO1998003196A1 (fr) | 1996-07-19 | 1997-07-16 | Vaccin polynucleotidique bovin pour voie intradermique |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2000515522A true JP2000515522A (ja) | 2000-11-21 |
Family
ID=9494496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10506636A Pending JP2000515522A (ja) | 1996-07-19 | 1997-07-16 | 経皮内用のウシポリヌクレオチドワクチン製剤 |
Country Status (23)
Country | Link |
---|---|
US (2) | US6451770B1 (ja) |
EP (1) | EP0918540B1 (ja) |
JP (1) | JP2000515522A (ja) |
AP (1) | AP9701045A0 (ja) |
AR (1) | AR007863A1 (ja) |
AT (1) | ATE224732T1 (ja) |
AU (1) | AU722878B2 (ja) |
BR (1) | BR9710498A (ja) |
CA (1) | CA2261334C (ja) |
CO (1) | CO4700344A1 (ja) |
CZ (1) | CZ298216B6 (ja) |
DE (1) | DE69715879T2 (ja) |
ES (1) | ES2184122T3 (ja) |
FR (1) | FR2751228B1 (ja) |
HU (1) | HU224833B1 (ja) |
ID (1) | ID19427A (ja) |
IL (1) | IL127914A (ja) |
MA (1) | MA24271A1 (ja) |
MX (1) | MXPA99000684A (ja) |
NZ (1) | NZ333752A (ja) |
PL (1) | PL189184B1 (ja) |
WO (1) | WO1998003196A1 (ja) |
ZA (1) | ZA976285B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004500375A (ja) * | 2000-01-21 | 2004-01-08 | メリアル | 生産型動物用の改良されたdnaワクチン |
Families Citing this family (44)
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US7294338B2 (en) * | 1996-07-19 | 2007-11-13 | Merial | Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies |
FR2751228B1 (fr) * | 1996-07-19 | 1998-11-20 | Rhone Merieux | Vaccin polynucleotidique bovin pour voie intradermique |
US7078388B2 (en) * | 2000-01-21 | 2006-07-18 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
US6852705B2 (en) | 2000-01-21 | 2005-02-08 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
US7906311B2 (en) | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
EP1606419A1 (en) | 2003-03-18 | 2005-12-21 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
WO2005049794A2 (en) | 2003-11-13 | 2005-06-02 | University Of Georgia Research Foundation, Inc. | Methods of characterizing infectious bursal disease virus |
ATE510928T1 (de) | 2004-02-19 | 2011-06-15 | Univ Alberta | Leptinpromotor-polymorphismen und verwendungen davon |
CA2570156C (en) * | 2004-06-04 | 2014-09-30 | Merial Limited | Needle-free administration of felv vaccines |
ES2343270T3 (es) | 2005-04-25 | 2010-07-27 | Merial Ltd. | Vacunas contra el virus nipah. |
US8591457B2 (en) | 2005-08-10 | 2013-11-26 | Alza Corporation | Method for making a needle-free jet injection drug delivery device |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
EP3147296A1 (en) | 2005-11-14 | 2017-03-29 | Merial, Inc. | Gene therapy for renal failure |
US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
KR101445903B1 (ko) | 2007-05-02 | 2014-09-29 | 메리얼 리미티드 | 향상된 발현 및 안정성을 갖는 dna 플라스미드 |
US20080274137A1 (en) * | 2007-05-02 | 2008-11-06 | Jean Christophe Francis Audonnet | DNA plasmids having improved expression and stability |
EP2367566B2 (en) | 2008-11-28 | 2019-11-27 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant avian influenza vaccine and uses thereof |
CN102428099B (zh) | 2009-04-03 | 2016-03-16 | 梅里亚有限公司 | 运载新城疫病毒的禽疫苗 |
CA2785653C (en) | 2009-12-28 | 2018-05-01 | Merial Limited | Recombinant ndv antigen and uses thereof |
US20130197612A1 (en) | 2010-02-26 | 2013-08-01 | Jack W. Lasersohn | Electromagnetic Radiation Therapy |
CN103492410A (zh) | 2010-03-12 | 2014-01-01 | 梅里亚有限公司 | 蓝舌病毒重组疫苗和其使用 |
MX344103B (es) | 2010-08-31 | 2016-12-05 | Merial Ltd | Vacunas de virus herpes vectorizado con virus de enfermedad de newcastle. |
WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
EP2694678A2 (en) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
AU2012240240A1 (en) | 2011-04-04 | 2013-05-09 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
US9216213B2 (en) | 2011-04-20 | 2015-12-22 | Merial, Inc. | Adjuvanted rabies vaccine with improved viscosity profile |
CN103945864A (zh) | 2011-04-25 | 2014-07-23 | 先进生物学实验室股份有限公司 | 截短的hiv包膜蛋白(env)、其相关方法和组合物 |
CA2837582C (en) | 2011-05-27 | 2021-03-02 | Merial Limited | Genetic vaccines against hendra virus and nipah virus |
US9669085B2 (en) | 2011-06-01 | 2017-06-06 | Merial Inc. | Needle-free administration of PRRSV vaccines |
CN103841963B (zh) | 2011-08-12 | 2018-04-24 | 梅里亚股份有限公司 | 用于生物产品特别是疫苗的真空辅助保存 |
WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
NZ628270A (en) | 2012-02-14 | 2016-09-30 | Merial Inc | Recombinant poxviral vectors expressing both rabies and ox40 proteins, and vaccines made therefrom |
MX353786B (es) | 2012-02-14 | 2018-01-29 | Merial Inc | Vacunas de subunidades de rotavirus, metodos de preparacion y uso de las mismas. |
WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
EP2861248B1 (en) | 2012-06-13 | 2017-11-15 | Merial, Inc. | Reassortant btv and ahsv vaccines |
EP2968514A1 (en) | 2013-03-12 | 2016-01-20 | Merial, Inc. | Reverse genetics schmallenberg virus vaccine compositions, and methods of use thereof |
NZ731659A (en) | 2014-11-03 | 2018-10-26 | Merial Inc | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
PL3313864T3 (pl) | 2015-06-23 | 2022-01-03 | Boehringer Ingelheim Animal Health USA Inc. | Rekombinowane wektory wirusowe zawierające drugorzędne białko prrsv oraz sposoby ich wytwarzania i zastosowania |
CA2996143A1 (en) | 2015-08-20 | 2017-02-23 | Merial, Inc. | Fcv recombinant vaccines and uses thereof |
FI3355915T3 (fi) | 2015-09-29 | 2024-01-12 | Boehringer Ingelheim Animal Health Usa Inc | Koirien parvoviruksen (CPV) viruksen kaltaisten hiukkasten (VLP) rokotteet ja niiden käytöt |
KR102153303B1 (ko) | 2015-11-23 | 2020-09-09 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | Fmdv 및 e2 융합 단백질 및 이의 용도 |
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WO1992001471A1 (en) * | 1990-07-24 | 1992-02-06 | The Uab Research Foundation | Methods of use of bovine respiratory syncytial virus recombinant dna, proteins vaccines, antibodies, and transformed cells |
WO1995020660A2 (en) * | 1994-01-27 | 1995-08-03 | University Of Massachusetts Medical Center | Immunization by inoculation of dna transcription unit |
FR2751228B1 (fr) * | 1996-07-19 | 1998-11-20 | Rhone Merieux | Vaccin polynucleotidique bovin pour voie intradermique |
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1996
- 1996-07-19 FR FR9609402A patent/FR2751228B1/fr not_active Expired - Fee Related
-
1997
- 1997-07-11 AR ARP970103115A patent/AR007863A1/es active IP Right Grant
- 1997-07-16 EP EP97934575A patent/EP0918540B1/fr not_active Expired - Lifetime
- 1997-07-16 DE DE69715879T patent/DE69715879T2/de not_active Expired - Lifetime
- 1997-07-16 CZ CZ0010699A patent/CZ298216B6/cs not_active IP Right Cessation
- 1997-07-16 IL IL12791497A patent/IL127914A/en not_active IP Right Cessation
- 1997-07-16 BR BR9710498-1A patent/BR9710498A/pt not_active Application Discontinuation
- 1997-07-16 ZA ZA976285A patent/ZA976285B/xx unknown
- 1997-07-16 WO PCT/FR1997/001322 patent/WO1998003196A1/fr active IP Right Grant
- 1997-07-16 ES ES97934575T patent/ES2184122T3/es not_active Expired - Lifetime
- 1997-07-16 NZ NZ333752A patent/NZ333752A/en not_active IP Right Cessation
- 1997-07-16 JP JP10506636A patent/JP2000515522A/ja active Pending
- 1997-07-16 PL PL97331237A patent/PL189184B1/pl unknown
- 1997-07-16 MX MXPA99000684A patent/MXPA99000684A/es active IP Right Grant
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1999
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Cited By (1)
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JP2004500375A (ja) * | 2000-01-21 | 2004-01-08 | メリアル | 生産型動物用の改良されたdnaワクチン |
Also Published As
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NZ333752A (en) | 2000-06-23 |
US6451770B1 (en) | 2002-09-17 |
ES2184122T3 (es) | 2003-04-01 |
IL127914A0 (en) | 1999-11-30 |
US6803361B2 (en) | 2004-10-12 |
CO4700344A1 (es) | 1998-12-29 |
CA2261334A1 (en) | 1998-01-29 |
IL127914A (en) | 2001-05-20 |
MXPA99000684A (es) | 2006-02-10 |
HUP9902792A3 (en) | 2000-03-28 |
EP0918540B1 (fr) | 2002-09-25 |
US20020137716A1 (en) | 2002-09-26 |
ATE224732T1 (de) | 2002-10-15 |
WO1998003196A1 (fr) | 1998-01-29 |
HUP9902792A2 (hu) | 1999-12-28 |
AR007863A1 (es) | 1999-11-24 |
AU722878B2 (en) | 2000-08-10 |
DE69715879T2 (de) | 2003-01-23 |
CA2261334C (en) | 2010-11-16 |
FR2751228B1 (fr) | 1998-11-20 |
DE69715879D1 (de) | 2002-10-31 |
ID19427A (id) | 1998-07-09 |
CZ298216B6 (cs) | 2007-07-25 |
HU224833B1 (en) | 2006-03-28 |
BR9710498A (pt) | 2000-01-18 |
EP0918540A1 (fr) | 1999-06-02 |
ZA976285B (en) | 1999-01-19 |
MA24271A1 (fr) | 1998-04-01 |
FR2751228A1 (fr) | 1998-01-23 |
PL331237A1 (en) | 1999-07-05 |
CZ10699A3 (cs) | 1999-04-14 |
AP9701045A0 (en) | 1997-07-31 |
PL189184B1 (pl) | 2005-07-29 |
AU3773297A (en) | 1998-02-10 |
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