BR9710498A - Vacina polinucleotìdica bovina para via intradérmica. - Google Patents
Vacina polinucleotìdica bovina para via intradérmica.Info
- Publication number
- BR9710498A BR9710498A BR9710498-1A BR9710498A BR9710498A BR 9710498 A BR9710498 A BR 9710498A BR 9710498 A BR9710498 A BR 9710498A BR 9710498 A BR9710498 A BR 9710498A
- Authority
- BR
- Brazil
- Prior art keywords
- vaccine
- bovine
- intradermal
- formula
- delivery device
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
- A61K39/265—Infectious rhinotracheitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16741—Use of virus, viral particle or viral elements as a vector
- C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18541—Use of virus, viral particle or viral elements as a vector
- C12N2760/18543—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Patente de Invenção: <B>''VACINA POLINUCLEOTìDICA BOVINA PARA VIA INTRADéRMICA''<D>. A fórmula de vacina bovina polinucleotídica compreende uma quantidade eficaz por via intradérmica de um plasmídio que associa uma seq³ência de DNA que codifica para um imunógeno de um agente patogênico bovino e um promotor que permite a expressão desse imunógeno in vivo nas células da pele, essa fórmula de vacina sendo adaptada para a administração intradérmica através de um aparelho de administração por jato líquido. A instalação portátil de vacinação bovina compreendendo um aparelho de administração por jato líquido e um frasco adaptado que compreende várias doses de uma tal fórmula de vacina, o aparelho de adminsiração sendo projetado para ministrar uma dose de fórmula de vacina em modo intradérmico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9609402A FR2751228B1 (fr) | 1996-07-19 | 1996-07-19 | Vaccin polynucleotidique bovin pour voie intradermique |
PCT/FR1997/001322 WO1998003196A1 (fr) | 1996-07-19 | 1997-07-16 | Vaccin polynucleotidique bovin pour voie intradermique |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9710498A true BR9710498A (pt) | 2000-01-18 |
Family
ID=9494496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9710498-1A BR9710498A (pt) | 1996-07-19 | 1997-07-16 | Vacina polinucleotìdica bovina para via intradérmica. |
Country Status (23)
Country | Link |
---|---|
US (2) | US6451770B1 (pt) |
EP (1) | EP0918540B1 (pt) |
JP (1) | JP2000515522A (pt) |
AP (1) | AP9701045A0 (pt) |
AR (1) | AR007863A1 (pt) |
AT (1) | ATE224732T1 (pt) |
AU (1) | AU722878B2 (pt) |
BR (1) | BR9710498A (pt) |
CA (1) | CA2261334C (pt) |
CO (1) | CO4700344A1 (pt) |
CZ (1) | CZ298216B6 (pt) |
DE (1) | DE69715879T2 (pt) |
ES (1) | ES2184122T3 (pt) |
FR (1) | FR2751228B1 (pt) |
HU (1) | HU224833B1 (pt) |
ID (1) | ID19427A (pt) |
IL (1) | IL127914A (pt) |
MA (1) | MA24271A1 (pt) |
MX (1) | MXPA99000684A (pt) |
NZ (1) | NZ333752A (pt) |
PL (1) | PL189184B1 (pt) |
WO (1) | WO1998003196A1 (pt) |
ZA (1) | ZA976285B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7294338B2 (en) * | 1996-07-19 | 2007-11-13 | Merial | Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies |
FR2751228B1 (fr) * | 1996-07-19 | 1998-11-20 | Rhone Merieux | Vaccin polynucleotidique bovin pour voie intradermique |
US6852705B2 (en) | 2000-01-21 | 2005-02-08 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
US7078388B2 (en) * | 2000-01-21 | 2006-07-18 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
FR2804028B1 (fr) * | 2000-01-21 | 2004-06-04 | Merial Sas | Vaccins adn ameliores pour animaux de rente |
US7906311B2 (en) | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
EP2390352A1 (en) | 2003-03-18 | 2011-11-30 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
US20050214316A1 (en) | 2003-11-13 | 2005-09-29 | Brown Thomas P | Methods of characterizing infectious bursal disease virus |
AU2005244673B2 (en) | 2004-02-19 | 2009-12-10 | The Governors Of The University Of Alberta | Leptin promoter polymorphisms and uses thereof |
CA2570156C (en) * | 2004-06-04 | 2014-09-30 | Merial Limited | Needle-free administration of felv vaccines |
ES2343270T3 (es) | 2005-04-25 | 2010-07-27 | Merial Ltd. | Vacunas contra el virus nipah. |
US8591457B2 (en) | 2005-08-10 | 2013-11-26 | Alza Corporation | Method for making a needle-free jet injection drug delivery device |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
CA2629522A1 (en) | 2005-11-14 | 2007-05-18 | Merial Limited | Gene therapy for renal failure |
US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
US20080274137A1 (en) * | 2007-05-02 | 2008-11-06 | Jean Christophe Francis Audonnet | DNA plasmids having improved expression and stability |
JP2010525812A (ja) | 2007-05-02 | 2010-07-29 | メリアル リミテッド | 発現及び安定性が改善されたdnaプラスミド |
MX2011005604A (es) | 2008-11-28 | 2011-09-01 | Merial Ltd | Vacuna recombinante para influenza aviar y sus usos. |
DK2414386T3 (en) | 2009-04-03 | 2016-02-22 | Merial Ltd | Birds of vaccines with newcastle disease virus vectors |
MX351643B (es) | 2009-12-28 | 2017-10-23 | Merial Ltd | Antigeno ndv recombinante y usos del mismo. |
US20130197612A1 (en) | 2010-02-26 | 2013-08-01 | Jack W. Lasersohn | Electromagnetic Radiation Therapy |
BR112012023852B1 (pt) | 2010-03-12 | 2020-11-10 | Biolex Therapeutics | vacinas recombinantes do vírus da língua azul e usos das mesmas |
PL2611460T3 (pl) | 2010-08-31 | 2017-02-28 | Merial, Inc. | Szczepionki przeciw herpeswirusom przenoszone z pomocą wirusa choroby newcastle |
WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
WO2012138789A2 (en) | 2011-04-04 | 2012-10-11 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
EP2694677A2 (en) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
WO2012145577A1 (en) | 2011-04-20 | 2012-10-26 | Merial Limited | Adjuvanted rabies vaccine with improved viscosity profile |
EP2701736A1 (en) | 2011-04-25 | 2014-03-05 | Advanced Bioscience Laboratories, Inc. | Truncated hiv envelope proteins (env), methods and compositions related thereto |
CA2837582C (en) | 2011-05-27 | 2021-03-02 | Merial Limited | Genetic vaccines against hendra virus and nipah virus |
ES2674439T3 (es) | 2011-06-01 | 2018-06-29 | Merial, Inc. | Administración sin aguja de vacunas contra el VSRRP |
LT2741740T (lt) | 2011-08-12 | 2017-08-10 | Merial, Inc. | Biologinių produktų, ypatingai vakcinų, vakuuminis konservavimas |
WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
AR089995A1 (es) | 2012-02-14 | 2014-10-01 | Merial Ltd | Vacunas de subunidades de rotavirus, metodos de preparacion y uso de las mismas |
CN104203271B (zh) | 2012-02-14 | 2017-08-25 | 梅里亚股份有限公司 | 表达狂犬病病毒和ox40蛋白的重组痘病毒载体及从其制造的疫苗 |
WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
EP2861248B1 (en) | 2012-06-13 | 2017-11-15 | Merial, Inc. | Reassortant btv and ahsv vaccines |
WO2014164697A1 (en) | 2013-03-12 | 2014-10-09 | Merial Limited | Reverse genetics schmallenberg virus vaccine compositions, and methods of use thereof |
AU2015343369B2 (en) | 2014-11-03 | 2018-11-22 | Georgia Tech Research Corporation | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
EA201890110A1 (ru) | 2015-06-23 | 2018-05-31 | Мериал, Инк. | Рекомбинантные вирусные векторы, содержащие минорные белки prrsv, и способы их получения и применения |
NZ740551A (en) | 2015-08-20 | 2019-10-25 | Boehringer Ingelheim Animal Health Usa Inc | Fcv recombinant vaccines and uses thereof |
MA43016A (fr) | 2015-09-29 | 2018-08-08 | Merial Inc | Vaccins à particules pseudo-virales (vlp) de parvovirus canin (cpv) et utilisations associées |
US9913891B2 (en) | 2015-11-23 | 2018-03-13 | Merial Inc. | FMDV and E2 fusion proteins and uses thereof |
TWI760322B (zh) | 2016-01-29 | 2022-04-11 | 美商百靈佳殷格翰動物保健美國有限公司 | 重組腺病毒載體裝載之fmdv疫苗及其用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2348709A1 (fr) * | 1976-04-23 | 1977-11-18 | Pistor Michel | Procede de traitement mesotherapique et dispositif d'injection,formant micro-injecteur automatique,en comportant application |
FR2652257B1 (fr) * | 1989-09-26 | 1992-11-27 | Rhone Merieux | Installation portative de vaccination porcine. |
AU650040B2 (en) * | 1990-07-24 | 1994-06-09 | Uab Research Foundation, The | Methods of use of bovine respiratory syncytial virus recombinant DNA, proteins vaccines, antibodies, and transformed cells |
GB9118204D0 (en) * | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
US5643578A (en) * | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
ATE254939T1 (de) * | 1993-07-31 | 2003-12-15 | Aradigm Corp | Nadelloser injektor |
DE69536091D1 (de) * | 1994-01-27 | 2010-09-09 | Univ Massachusetts Medical | Immunisierung durch Impfung von DNS Transkriptionseinheit |
US5736524A (en) * | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
FR2751228B1 (fr) * | 1996-07-19 | 1998-11-20 | Rhone Merieux | Vaccin polynucleotidique bovin pour voie intradermique |
-
1996
- 1996-07-19 FR FR9609402A patent/FR2751228B1/fr not_active Expired - Fee Related
-
1997
- 1997-07-11 AR ARP970103115A patent/AR007863A1/es active IP Right Grant
- 1997-07-16 DE DE69715879T patent/DE69715879T2/de not_active Expired - Lifetime
- 1997-07-16 ES ES97934575T patent/ES2184122T3/es not_active Expired - Lifetime
- 1997-07-16 ZA ZA976285A patent/ZA976285B/xx unknown
- 1997-07-16 EP EP97934575A patent/EP0918540B1/fr not_active Expired - Lifetime
- 1997-07-16 MA MA24718A patent/MA24271A1/fr unknown
- 1997-07-16 WO PCT/FR1997/001322 patent/WO1998003196A1/fr active IP Right Grant
- 1997-07-16 JP JP10506636A patent/JP2000515522A/ja active Pending
- 1997-07-16 NZ NZ333752A patent/NZ333752A/en not_active IP Right Cessation
- 1997-07-16 HU HU9902792A patent/HU224833B1/hu unknown
- 1997-07-16 IL IL12791497A patent/IL127914A/en not_active IP Right Cessation
- 1997-07-16 MX MXPA99000684A patent/MXPA99000684A/es active IP Right Grant
- 1997-07-16 CZ CZ0010699A patent/CZ298216B6/cs not_active IP Right Cessation
- 1997-07-16 PL PL97331237A patent/PL189184B1/pl unknown
- 1997-07-16 AT AT97934575T patent/ATE224732T1/de not_active IP Right Cessation
- 1997-07-16 BR BR9710498-1A patent/BR9710498A/pt not_active Application Discontinuation
- 1997-07-16 ID IDP972481A patent/ID19427A/id unknown
- 1997-07-16 AU AU37732/97A patent/AU722878B2/en not_active Expired
- 1997-07-16 CA CA2261334A patent/CA2261334C/en not_active Expired - Lifetime
- 1997-07-17 AP APAP/P/1997/001045A patent/AP9701045A0/en unknown
- 1997-07-18 CO CO97040984A patent/CO4700344A1/es unknown
-
1999
- 1999-01-15 US US09/232,469 patent/US6451770B1/en not_active Expired - Lifetime
-
2002
- 2002-02-15 US US10/077,489 patent/US6803361B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
MXPA99000684A (es) | 2006-02-10 |
DE69715879T2 (de) | 2003-01-23 |
FR2751228B1 (fr) | 1998-11-20 |
CA2261334C (en) | 2010-11-16 |
CA2261334A1 (en) | 1998-01-29 |
FR2751228A1 (fr) | 1998-01-23 |
US6803361B2 (en) | 2004-10-12 |
ZA976285B (en) | 1999-01-19 |
US6451770B1 (en) | 2002-09-17 |
WO1998003196A1 (fr) | 1998-01-29 |
DE69715879D1 (de) | 2002-10-31 |
HUP9902792A3 (en) | 2000-03-28 |
AP9701045A0 (en) | 1997-07-31 |
PL331237A1 (en) | 1999-07-05 |
CZ298216B6 (cs) | 2007-07-25 |
HU224833B1 (en) | 2006-03-28 |
PL189184B1 (pl) | 2005-07-29 |
CO4700344A1 (es) | 1998-12-29 |
IL127914A (en) | 2001-05-20 |
EP0918540B1 (fr) | 2002-09-25 |
ES2184122T3 (es) | 2003-04-01 |
US20020137716A1 (en) | 2002-09-26 |
AR007863A1 (es) | 1999-11-24 |
CZ10699A3 (cs) | 1999-04-14 |
JP2000515522A (ja) | 2000-11-21 |
ID19427A (id) | 1998-07-09 |
ATE224732T1 (de) | 2002-10-15 |
IL127914A0 (en) | 1999-11-30 |
MA24271A1 (fr) | 1998-04-01 |
EP0918540A1 (fr) | 1999-06-02 |
AU3773297A (en) | 1998-02-10 |
HUP9902792A2 (hu) | 1999-12-28 |
NZ333752A (en) | 2000-06-23 |
AU722878B2 (en) | 2000-08-10 |
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