JP2000512273A - 高収率立体特異性マンノシル化 - Google Patents
高収率立体特異性マンノシル化Info
- Publication number
- JP2000512273A JP2000512273A JP09542741A JP54274197A JP2000512273A JP 2000512273 A JP2000512273 A JP 2000512273A JP 09542741 A JP09542741 A JP 09542741A JP 54274197 A JP54274197 A JP 54274197A JP 2000512273 A JP2000512273 A JP 2000512273A
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- formula
- compound
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Paper (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Organic Insulating Materials (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 式: [式中、Xは、アルキルまたはアリールであり、Rは、低級アルキル、分岐アル キル、アリール、アラルキル、またはOG[Gは、低級アルキル、分岐アルキル 、アリール、またはアラルキル]である。] で示される化合物の調製方法であって、式: [式中、Rは前記と同じ意味である。] で示される化合物を、ルイス酸の存在下において、式XOH[式中、Xは、アル キルまたはアリールである。]で示される化合物と反応させることを含んで成る 方法。 2. フッ化マンノシルを、三フッ化硼素−エーテレートの存在下において、ア ルコールまたはフェノールと反応させることによって、反応が実施される請求項 1に記載の方法。 3. Xが、 である請求項1に記載の方法。 4. Xが、である請求項1に記載の方法。 5. 式: [式中、Rは、低級アルキル、分岐アルキル、アリール、アラルキル、またはア ルコキシであるが、メチルではない。] で示される化合物。 6. XがOCH2CH3である請求項5に記載の化合物。 7. XがCH2PHである請求項5に記載の化合物。 8. XがCH(CH3)2である請求項5に記載の化合物。 9. XがC(CH3)3である請求項5に記載の化合物。 10. 式: [式中、Rは、低級アルキル、分岐アルキル、アリール、アラルキル、またはア ルコキシであり、Sは、アルキルまたはアリールである。] で示される化合物。 11. 式:[式中、Rは、低級アルキル、分岐アルキル、アリール、アラルキル、またはア ルコキシであり、Sは、アルキルまたはアリールである。] で示される化合物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/650,653 | 1996-05-20 | ||
US08/650,653 US5712387A (en) | 1996-05-20 | 1996-05-20 | High yield stereospecific mannosylation |
PCT/US1997/008726 WO1997044344A1 (en) | 1996-05-20 | 1997-05-20 | High yield stereospecific mannosylation |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000512273A true JP2000512273A (ja) | 2000-09-19 |
JP4412743B2 JP4412743B2 (ja) | 2010-02-10 |
Family
ID=24609746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54274197A Expired - Fee Related JP4412743B2 (ja) | 1996-05-20 | 1997-05-20 | 高収率立体特異性マンノシル化 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5712387A (ja) |
EP (1) | EP0912587B1 (ja) |
JP (1) | JP4412743B2 (ja) |
AT (1) | ATE259822T1 (ja) |
AU (1) | AU712905B2 (ja) |
CA (1) | CA2255666C (ja) |
DE (1) | DE69727680T2 (ja) |
ES (1) | ES2216152T3 (ja) |
PT (1) | PT912587E (ja) |
WO (1) | WO1997044344A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012017306A (ja) * | 2010-07-09 | 2012-01-26 | Central Glass Co Ltd | 2,3,4,6−テトラ−o−アシル−d−マンノピラノシルフルオリド高純度品の工業的製造方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1897533A1 (en) * | 2006-09-08 | 2008-03-12 | Revotar Biopharmaceuticals AG | Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions |
EP1903049A1 (en) * | 2006-09-08 | 2008-03-26 | Revotar Biopharmaceuticals AG | Crystalline forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyloxy)-phenyl] hexane |
AU2011249843A1 (en) | 2010-05-07 | 2012-11-29 | Revotar Biopharmaceuticals Ag | Process for the preparation of Bimosiamose |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3626028A1 (de) * | 1985-09-14 | 1987-03-19 | Hoechst Ag | Verfahren zur herstellung von am sauerstoff geschuetzten glycosylfluoriden |
EP0267996A1 (en) * | 1986-11-20 | 1988-05-25 | Tamir Biotechnology Ltd. | New nucleotide derivatives |
JPH02144151A (ja) * | 1988-11-22 | 1990-06-01 | Dainippon Ink & Chem Inc | グリコシド縮合用触媒及びアリールグリコシド類の製造方法 |
US5218097A (en) * | 1988-12-07 | 1993-06-08 | Ciba-Geigy Corporation | Process for the preparation of protected mono-sugar and oligo-sugar halides |
JP2774417B2 (ja) * | 1991-08-07 | 1998-07-09 | 株式会社ディ・ディ・エス研究所 | ペプチド骨格を有する分枝鎖型糖複合体及び微粒子キャリヤー |
JP2710900B2 (ja) * | 1992-09-02 | 1998-02-10 | 株式会社ディ・ディ・エス研究所 | 酸性官能基を有する脂質誘導体及び同誘導体によって被覆された微粒子キャリヤー |
DE4329093A1 (de) * | 1993-08-30 | 1995-03-02 | Bayer Ag | Substituierte Aminoalkylglycoside |
-
1996
- 1996-05-20 US US08/650,653 patent/US5712387A/en not_active Expired - Lifetime
-
1997
- 1997-05-20 ES ES97925707T patent/ES2216152T3/es not_active Expired - Lifetime
- 1997-05-20 AU AU30766/97A patent/AU712905B2/en not_active Ceased
- 1997-05-20 DE DE69727680T patent/DE69727680T2/de not_active Expired - Lifetime
- 1997-05-20 WO PCT/US1997/008726 patent/WO1997044344A1/en not_active Application Discontinuation
- 1997-05-20 PT PT97925707T patent/PT912587E/pt unknown
- 1997-05-20 CA CA002255666A patent/CA2255666C/en not_active Expired - Fee Related
- 1997-05-20 JP JP54274197A patent/JP4412743B2/ja not_active Expired - Fee Related
- 1997-05-20 AT AT97925707T patent/ATE259822T1/de active
- 1997-05-20 EP EP97925707A patent/EP0912587B1/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012017306A (ja) * | 2010-07-09 | 2012-01-26 | Central Glass Co Ltd | 2,3,4,6−テトラ−o−アシル−d−マンノピラノシルフルオリド高純度品の工業的製造方法 |
Also Published As
Publication number | Publication date |
---|---|
ATE259822T1 (de) | 2004-03-15 |
ES2216152T3 (es) | 2004-10-16 |
AU3076697A (en) | 1997-12-09 |
US5712387A (en) | 1998-01-27 |
EP0912587A4 (en) | 2001-12-19 |
CA2255666A1 (en) | 1997-11-27 |
CA2255666C (en) | 2007-07-31 |
EP0912587B1 (en) | 2004-02-18 |
PT912587E (pt) | 2004-06-30 |
DE69727680T2 (de) | 2004-12-02 |
DE69727680D1 (de) | 2004-03-25 |
JP4412743B2 (ja) | 2010-02-10 |
WO1997044344A1 (en) | 1997-11-27 |
AU712905B2 (en) | 1999-11-18 |
EP0912587A1 (en) | 1999-05-06 |
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