JP2000506835A - 治療用の修飾サイトカイン - Google Patents
治療用の修飾サイトカインInfo
- Publication number
- JP2000506835A JP2000506835A JP9530545A JP53054597A JP2000506835A JP 2000506835 A JP2000506835 A JP 2000506835A JP 9530545 A JP9530545 A JP 9530545A JP 53054597 A JP53054597 A JP 53054597A JP 2000506835 A JP2000506835 A JP 2000506835A
- Authority
- JP
- Japan
- Prior art keywords
- tnf
- ligand
- cells
- necrosis factor
- tumor necrosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
- A61K47/6898—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nanotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000358A IT1282692B1 (it) | 1996-02-27 | 1996-02-27 | Citochine modificate per l'uso in terapia |
| IT96A000358 | 1996-05-03 | ||
| PCT/EP1997/000704 WO1997031655A2 (en) | 1996-02-27 | 1997-02-14 | Modified cytokines for therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000506835A true JP2000506835A (ja) | 2000-06-06 |
Family
ID=11373397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9530545A Pending JP2000506835A (ja) | 1996-02-27 | 1997-02-14 | 治療用の修飾サイトカイン |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0885015A2 (enrdf_load_html_response) |
| JP (1) | JP2000506835A (enrdf_load_html_response) |
| AU (1) | AU1769497A (enrdf_load_html_response) |
| CA (1) | CA2247308A1 (enrdf_load_html_response) |
| IT (1) | IT1282692B1 (enrdf_load_html_response) |
| WO (1) | WO1997031655A2 (enrdf_load_html_response) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016175916A (ja) * | 2011-04-29 | 2016-10-06 | ロシュ グリクアート アーゲー | 新規なイムノコンジュゲート |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000012554A1 (fr) * | 1998-08-28 | 2000-03-09 | Commissariat A L'energie Atomique | Procede de synthese d'une chimiokine marquee, chimiokine marquee et trousse d'analyse |
| FR2783528A1 (fr) * | 1998-08-28 | 2000-03-24 | Commissariat Energie Atomique | Procede de synthese d'une chimiokine marquee, chimiokine marquee et trousse d'analyse |
| DE19845798A1 (de) * | 1998-09-29 | 2000-04-13 | Schering Ag | Verwendung von Neoangiogenese-Markern für Diagnose und Therapie von Tumoren, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
| EP2244738B1 (en) | 2008-01-25 | 2020-03-04 | Gavish-Galilee Bio Applications Ltd | Targeting of innate immune response to tumour site |
| TWI684600B (zh) | 2014-03-21 | 2020-02-11 | 美商艾伯維有限公司 | 抗－ｅｇｆｒ抗體及抗體藥物結合物 |
| BR112018075630A2 (pt) | 2016-06-08 | 2019-03-19 | Abbvie Inc. | anticorpos anti-cd98 e conjugados de fármaco de anticorpo |
| US20200002421A1 (en) | 2016-06-08 | 2020-01-02 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| CN109641962A (zh) | 2016-06-08 | 2019-04-16 | 艾伯维公司 | 抗b7-h3抗体和抗体药物偶联物 |
| CN116284404A (zh) | 2016-06-08 | 2023-06-23 | 艾伯维公司 | 抗b7-h3抗体和抗体药物偶联物 |
| MA50134A (fr) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine Inc | Anticorps anti-protéine 1 contenant un domaine anti-cub (cdcp1), conjugués anticorps-médicament et leurs méthodes d'utilisation |
| CA3064697A1 (en) | 2017-04-19 | 2018-10-25 | Bluefin Biomedicine, Inc. | Anti-vtcn1 antibodies and antibody drug conjugates |
| JP7657440B2 (ja) | 2017-06-12 | 2025-04-07 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗－ｉｌ１ｒａｐ抗体および抗体薬物コンジュゲート |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| WO2025126157A1 (en) | 2023-12-15 | 2025-06-19 | Advesya | Anti-il-1rap binding domains and antibody-drug conjugates thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5578287A (en) * | 1992-06-09 | 1996-11-26 | Neorx Corporation | Three-step pretargeting methods using improved biotin-active agent |
| EP0682705A1 (en) * | 1993-02-03 | 1995-11-22 | N.V. Innogenetics S.A. | Tnf-alpha muteins and a process for preparing them |
| ATE254631T1 (de) * | 1993-12-07 | 2003-12-15 | Neorx Corp | Pretargeting verfahren und mitteln |
-
1996
- 1996-02-27 IT IT96MI000358A patent/IT1282692B1/it active IP Right Grant
-
1997
- 1997-02-14 WO PCT/EP1997/000704 patent/WO1997031655A2/en not_active Application Discontinuation
- 1997-02-14 JP JP9530545A patent/JP2000506835A/ja active Pending
- 1997-02-14 EP EP97903285A patent/EP0885015A2/en not_active Withdrawn
- 1997-02-14 CA CA002247308A patent/CA2247308A1/en not_active Abandoned
- 1997-02-14 AU AU17694/97A patent/AU1769497A/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016175916A (ja) * | 2011-04-29 | 2016-10-06 | ロシュ グリクアート アーゲー | 新規なイムノコンジュゲート |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997031655A2 (en) | 1997-09-04 |
| AU1769497A (en) | 1997-09-16 |
| CA2247308A1 (en) | 1997-09-04 |
| EP0885015A2 (en) | 1998-12-23 |
| WO1997031655A3 (en) | 1997-11-13 |
| ITMI960358A0 (enrdf_load_html_response) | 1996-02-27 |
| IT1282692B1 (it) | 1998-03-31 |
| ITMI960358A1 (it) | 1997-08-27 |
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