JP2000504925A - 血管内皮増殖因子レセプターのレベルに関連する疾患または病状を治療するための方法および薬剤 - Google Patents

血管内皮増殖因子レセプターのレベルに関連する疾患または病状を治療するための方法および薬剤

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Publication number
JP2000504925A
JP2000504925A JP9515329A JP51532997A JP2000504925A JP 2000504925 A JP2000504925 A JP 2000504925A JP 9515329 A JP9515329 A JP 9515329A JP 51532997 A JP51532997 A JP 51532997A JP 2000504925 A JP2000504925 A JP 2000504925A
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Prior art keywords
nucleic acid
ribozyme
rna
vegf
flt
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JP9515329A
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Japanese (ja)
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JP2000504925A5 (enExample
Inventor
パヴコ，パメラ
マクスウィゲン，ジェームズ
スティンチコーム，ダン・ティー
エスコベド，ジェイム
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リボザイム・ファーマシューティカルズ・インコーポレーテッド
チロン・コーポレーション
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Publication of JP2000504925A publication Critical patent/JP2000504925A/ja
Publication of JP2000504925A5 publication Critical patent/JP2000504925A5/ja
Ceased legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP9515329A 1995-10-26 1996-10-25 血管内皮増殖因子レセプターのレベルに関連する疾患または病状を治療するための方法および薬剤 Ceased JP2000504925A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US597495P 1995-10-26 1995-10-26
US60/005,974 1995-10-26
US08/584,040 1996-01-11
US08/584,040 US6346398B1 (en) 1995-10-26 1996-01-11 Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor
PCT/US1996/017480 WO1997015662A2 (en) 1995-10-26 1996-10-25 Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor

Publications (2)

Publication Number Publication Date
JP2000504925A true JP2000504925A (ja) 2000-04-25
JP2000504925A5 JP2000504925A5 (enExample) 2004-10-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP9515329A Ceased JP2000504925A (ja) 1995-10-26 1996-10-25 血管内皮増殖因子レセプターのレベルに関連する疾患または病状を治療するための方法および薬剤

Country Status (7)

Country Link
US (5) US6346398B1 (enExample)
EP (1) EP0859837A2 (enExample)
JP (1) JP2000504925A (enExample)
AU (1) AU7666296A (enExample)
CA (1) CA2235368A1 (enExample)
DE (1) DE69638198D1 (enExample)
WO (1) WO1997015662A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2009000106A (ja) * 2001-05-29 2009-01-08 Sirna Therapeutics Inc 女性生殖疾病及び状態の核酸に基づく調節

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US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
US6710174B2 (en) * 2001-09-13 2004-03-23 Isis Pharmaceuticals, Inc. Antisense inhibition of vascular endothelial growth factor receptor-1 expression
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US20040142895A1 (en) * 1995-10-26 2004-07-22 Sirna Therapeutics, Inc. Nucleic acid-based modulation of gene expression in the vascular endothelial growth factor pathway
US20040220128A1 (en) * 1995-10-26 2004-11-04 Sirna Therapeutics, Inc. Nucleic acid based modulation of female reproductive diseases and conditions
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US7097829B2 (en) * 1996-11-21 2006-08-29 Cedars-Sinai Medical Center Transgenic cells transfected with pituitary tumor transforming gene (PTTG)) expression vectors and uses therefor
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AU7666296A (en) 1997-05-15
WO1997015662A3 (en) 1997-07-10
US6818447B1 (en) 2004-11-16
US6346398B1 (en) 2002-02-12
CA2235368A1 (en) 1997-05-01
US20050227937A1 (en) 2005-10-13
DE69638198D1 (de) 2010-07-22
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