JP2000500346A - Ｋｉ−ｒａｓ突然変異の検出方法および該検出方法を実施するためのキット - Google Patents

Ｋｉ−ｒａｓ突然変異の検出方法および該検出方法を実施するためのキット

Info

Publication number
JP2000500346A
JP2000500346A JP9519622A JP51962297A JP2000500346A JP 2000500346 A JP2000500346 A JP 2000500346A JP 9519622 A JP9519622 A JP 9519622A JP 51962297 A JP51962297 A JP 51962297A JP 2000500346 A JP2000500346 A JP 2000500346A
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JP
Japan
Prior art keywords
mutation
pcr
ras
seq
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9519622A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000500346A5 (OSRAM
Inventor
ダグフィン オグレイド
アルネ ウルヴィク
ヤン ヤコブ クールンストラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2000500346A publication Critical patent/JP2000500346A/ja
Publication of JP2000500346A5 publication Critical patent/JP2000500346A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Saccharide Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Holo Graphy (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
JP9519622A 1995-11-17 1996-11-15 Ｋｉ−ｒａｓ突然変異の検出方法および該検出方法を実施するためのキット Pending JP2000500346A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO954667A NO954667D0 (no) 1995-11-17 1995-11-17 Fremgangsmåte til deteksjon av Ki-ras mutasjoner
NO954667 1995-11-17
PCT/NO1996/000271 WO1997019191A1 (en) 1995-11-17 1996-11-15 Method for detection of ki-ras mutations and kit to perform it

Publications (2)

Publication Number Publication Date
JP2000500346A true JP2000500346A (ja) 2000-01-18
JP2000500346A5 JP2000500346A5 (OSRAM) 2005-06-16

Family

ID=19898772

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9519622A Pending JP2000500346A (ja) 1995-11-17 1996-11-15 Ｋｉ−ｒａｓ突然変異の検出方法および該検出方法を実施するためのキット

Country Status (12)

Country Link
US (1) US6440661B1 (OSRAM)
EP (2) EP0868529B1 (OSRAM)
JP (1) JP2000500346A (OSRAM)
AT (2) ATE318934T1 (OSRAM)
AU (1) AU723980C (OSRAM)
DE (2) DE69630234T2 (OSRAM)
DK (2) DK0868529T3 (OSRAM)
ES (2) ES2262930T3 (OSRAM)
NO (2) NO954667D0 (OSRAM)
NZ (1) NZ322619A (OSRAM)
PT (2) PT1394272E (OSRAM)
WO (1) WO1997019191A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500004A (ja) * 2011-11-17 2015-01-05 ザ ジョンズ ホプキンス ユニバーシティー 膵嚢胞の鑑別

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9715034D0 (en) * 1997-07-18 1997-09-24 Zeneca Ltd Assay
CA2366778C (en) * 1999-04-09 2008-07-22 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US6531302B1 (en) * 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
EP1238113B1 (en) 1999-12-07 2010-02-24 EXACT Sciences Corporation Detection of lung neoplasms in stool
EP2351853A1 (en) * 2000-06-06 2011-08-03 Life Technologies Corporation Method and devices for multiplexing amplification reactions
US6605451B1 (en) * 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
EP2031070B1 (en) 2002-12-04 2013-07-17 Life Technologies Corporation Multiplex amplification of polynucleotides
US20080124714A1 (en) * 2004-05-14 2008-05-29 Exact Sciences Corporation Method for Stabilizing Biological Samples for Nucleic Acid Analysis
US20070134709A1 (en) * 2005-12-14 2007-06-14 Xiping Xu Usages of MTHFR gene polymorphisms in predicting homocysteine level, disease risk, and treatment effects and related methods and kit
GB2435512A (en) 2006-02-23 2007-08-29 Mologic Ltd A binding assay and assay device
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
BRPI0711011A2 (pt) 2006-05-18 2011-08-23 Molecular Profiling Inst Inc método para a determinação da intervenção médica para um estado de doença, método para a identificação de uma terapia de droga com capacidade de interação com um alvo molecular e sistema para a determinação da intervenção médica individualizada para um estado de doença
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
EP3181705A1 (en) 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
US20130005598A1 (en) * 2009-12-31 2013-01-03 The Regents Of The University Of Michigan Methods for Diagnosing The Malignant Potential of Pancreatic Cystic Lesions
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
GB201107466D0 (en) 2011-05-05 2011-06-15 Loktionov Alexandre Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
CN102796811B (zh) * 2011-05-26 2013-12-18 上海赛安生物医药科技有限公司 检测kras突变的试剂及方法
MX347611B (es) 2011-06-19 2017-05-04 Abogen Inc Dispositivos, soluciones y metodos para recoleccion de muestras.
KR20150090240A (ko) * 2012-11-30 2015-08-05 어플라이드 프로테오믹스, 인크. 결장 종양의 존재 또는 위험의 평가 방법
RU2717644C2 (ru) 2014-03-07 2020-03-24 ДиЭнЭй ГЕНОТЕК ИНК. Способ, композиция и набор для стабилизации дезоксирибонуклеиновых кислот в биологических образцах
GB2545361B (en) 2015-04-10 2018-01-24 Applied Proteomics Inc Methods of assessing colorectal cancer status
US10753936B2 (en) 2016-07-22 2020-08-25 Van Andel Research Institute Method of detecting the level of a glycan
CA3103983A1 (en) 2018-06-19 2019-12-26 Biontech Us Inc. Neoantigens and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871838A (en) * 1985-07-23 1989-10-03 The Board Of Rijks Universiteit Leiden Probes and methods for detecting activated ras oncogenes
US5137806A (en) * 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
IL97222A (en) * 1990-02-16 1995-08-31 Orion Yhtymae Oy Method and reagent for determining specific nucleotide variations
EP0672181B1 (en) 1992-04-01 2003-11-05 The Johns Hopkins University School Of Medicine Methods of detecting mammalian nucleic acids isolated from stool specimen and reagents therefor
EP0655090B1 (en) 1992-04-27 2000-12-27 The Trustees Of Dartmouth College Detection of gene sequences in biological fluids
JPH06167492A (ja) * 1992-11-30 1994-06-14 Otsuka Pharmaceut Co Ltd 変異癌遺伝子の検出測定方法
DE19512369A1 (de) * 1995-04-01 1996-10-02 Boehringer Mannheim Gmbh Vorrichtung zur Isolierung von Nukleinsäuren

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500004A (ja) * 2011-11-17 2015-01-05 ザ ジョンズ ホプキンス ユニバーシティー 膵嚢胞の鑑別

Also Published As

Publication number Publication date
AU723980B2 (en) 2000-09-07
NO324963B1 (no) 2008-01-14
DE69635848T2 (de) 2006-11-30
EP0868529A1 (en) 1998-10-07
EP1394272B1 (en) 2006-03-01
WO1997019191A1 (en) 1997-05-29
ATE251222T1 (de) 2003-10-15
DE69630234T2 (de) 2004-08-19
ES2262930T3 (es) 2006-12-01
PT1394272E (pt) 2006-07-31
DK1394272T3 (da) 2006-07-03
DE69630234D1 (de) 2003-11-06
DE69635848D1 (de) 2006-04-27
DK0868529T3 (da) 2004-02-02
AU723980C (en) 2002-10-24
NO954667D0 (no) 1995-11-17
EP1394272A1 (en) 2004-03-03
NO982246D0 (no) 1998-05-15
EP0868529B1 (en) 2003-10-01
US6440661B1 (en) 2002-08-27
NZ322619A (en) 1999-04-29
PT868529E (pt) 2004-02-27
NO982246L (no) 1998-07-07
ATE318934T1 (de) 2006-03-15
AU7656996A (en) 1997-06-11
ES2208766T3 (es) 2004-06-16

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