JP2000053673A - ｄ，ｌ―アルファ―トコフェロ―ルの製造方法 - Google Patents

ｄ，ｌ―アルファ―トコフェロ―ルの製造方法

Info

Publication number
JP2000053673A
JP2000053673A JP11098266A JP9826699A JP2000053673A JP 2000053673 A JP2000053673 A JP 2000053673A JP 11098266 A JP11098266 A JP 11098266A JP 9826699 A JP9826699 A JP 9826699A JP 2000053673 A JP2000053673 A JP 2000053673A
Authority
JP
Japan
Prior art keywords
acid
tocopherol
isophytol
mixture
heptane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP11098266A
Other languages
English (en)
Japanese (ja)
Inventor
Marcel Baak
マルセル・バーク
Bonrart Werner
ヴェルナー・ボンラート
Paul Kreienbuehl
パウル・クライアンビュール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2000053673A publication Critical patent/JP2000053673A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP11098266A 1998-04-06 1999-04-06 ｄ，ｌ―アルファ―トコフェロ―ルの製造方法 Withdrawn JP2000053673A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98106237.5 1998-04-06
EP98106237 1998-04-06

Publications (1)

Publication Number Publication Date
JP2000053673A true JP2000053673A (ja) 2000-02-22

Family

ID=8231723

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11098266A Withdrawn JP2000053673A (ja) 1998-04-06 1999-04-06 ｄ，ｌ―アルファ―トコフェロ―ルの製造方法

Country Status (10)

Country Link
US (1) US6066745A (enExample)
EP (1) EP0949255B1 (enExample)
JP (1) JP2000053673A (enExample)
KR (1) KR19990082913A (enExample)
CN (1) CN1181068C (enExample)
BR (1) BR9902217A (enExample)
CA (1) CA2267826A1 (enExample)
DE (1) DE69931421T2 (enExample)
ES (1) ES2264230T3 (enExample)
IN (1) IN188430B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514959A (ja) * 2003-01-13 2006-05-18 ディーエスエム アイピー アセッツ ビー．ブイ． 酢酸α−トコフェリルの製造方法
JP2006515280A (ja) * 2002-11-21 2006-05-25 ディーエスエム アイピー アセッツ ビー．ブイ． トコフェリルアセタートの製造

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369242B2 (en) * 2000-03-17 2002-04-09 Roche Vitamins Inc. Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof
ES2204792T3 (es) 2000-08-18 2004-05-01 Roche Vitamins Ag Procedimiento par ala obtencion de (todo-rac)-alfa-tocoferol.
DE10393642B4 (de) * 2002-11-21 2017-03-30 Dsm Ip Assets B.V. Herstellung von α-Tocopherol
CA2638940C (en) * 2008-08-28 2009-09-15 Dalton Chemical Laboratories Inc. Improved synthesis of hexahydrodibenzopyranones
CN102276572B (zh) * 2011-09-14 2013-03-27 重庆大学 一种制备维生素e乙酸酯的方法
US11447459B2 (en) 2018-03-29 2022-09-20 Dsm Ip Assets B.V. Use of substituted chroman-6-ols with extended lipophilic side chains
EP4077301A1 (en) 2019-12-19 2022-10-26 DSM IP Assets B.V. Formation of alpha tocopherol from 2,3,6-trimethylphenol
CN113083339B (zh) * 2021-04-15 2022-11-08 万华化学(四川)有限公司 一种用于制备维生素e的催化剂及其制备方法和应用
JP2024517559A (ja) 2021-04-28 2024-04-23 ディーエスエム アイピー アセッツ ビー．ブイ． ２，３，５－トリメチルヒドロキノン及び不飽和アルコールのカップリング
CN120752212A (zh) 2023-03-01 2025-10-03 帝斯曼知识产权资产管理有限公司 由2,4,6-三甲酚和2,3,6-三甲基苯酚的混合物制造2,3,5-三甲基对苯二酚

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2411969A (en) * 1938-03-31 1946-12-03 Hoffmann La Roche Process for the preparation of synthetic dl-tocopherols
US2723278A (en) * 1954-01-25 1955-11-08 Hoffmann La Roche Preparation of alpha-tocopherol
CH506516A (de) * 1968-02-27 1971-04-30 Hoffmann La Roche Verfahren zur Herstellung von Chromanolen
US3708505A (en) * 1971-02-25 1973-01-02 Diamond Shamrock Corp Process for preparation of d,l-alpha tocopherol
US5663376A (en) * 1994-07-27 1997-09-02 Eisai Co., Ltd. Process for the preparation of α-tocopherol
CN1211243A (zh) * 1996-01-29 1999-03-17 Basf公司 dl－α－生育酚或乙酸dl－α－生育酚酯的制备

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006515280A (ja) * 2002-11-21 2006-05-25 ディーエスエム アイピー アセッツ ビー．ブイ． トコフェリルアセタートの製造
JP4932158B2 (ja) * 2002-11-21 2012-05-16 ディーエスエム アイピー アセッツ ビー．ブイ． トコフェリルアセタートの製造
JP2006514959A (ja) * 2003-01-13 2006-05-18 ディーエスエム アイピー アセッツ ビー．ブイ． 酢酸α−トコフェリルの製造方法

Also Published As

Publication number Publication date
CN1181068C (zh) 2004-12-22
DE69931421T2 (de) 2006-11-09
DE69931421D1 (de) 2006-06-29
BR9902217A (pt) 2000-05-02
CN1234402A (zh) 1999-11-10
EP0949255B1 (en) 2006-05-24
CA2267826A1 (en) 1999-10-06
KR19990082913A (ko) 1999-11-25
ES2264230T3 (es) 2006-12-16
EP0949255A1 (en) 1999-10-13
US6066745A (en) 2000-05-23
IN188430B (enExample) 2002-09-21

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Effective date: 20040319

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Effective date: 20060606