BR9902217A - Fabricação de d,1-alfa-tocoferol pela condensação catalisada por ácido de trimetilhidroquinona com isofitol. - Google Patents

Fabricação de d,1-alfa-tocoferol pela condensação catalisada por ácido de trimetilhidroquinona com isofitol.

Info

Publication number
BR9902217A
BR9902217A BR9902217-6A BR9902217A BR9902217A BR 9902217 A BR9902217 A BR 9902217A BR 9902217 A BR9902217 A BR 9902217A BR 9902217 A BR9902217 A BR 9902217A
Authority
BR
Brazil
Prior art keywords
acid
isofitol
condensation
trimethylhydroquinone
tocopherol
Prior art date
Application number
BR9902217-6A
Other languages
English (en)
Inventor
Marcel Baak
Werner Bonrath
Paul Kreienbuehl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9902217A publication Critical patent/BR9902217A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção: <B>"FABRICAçãO DE D,1-ALFA-TOCOFEROL PELA CONDENSAçãO CATALISADA POR áCIDO DE TRIMETILHIDROQUINONA COM ISOFITOL"<D>. Um processo para fabricação de d, 1-(-tocoferol pela condensação catalisada por ácido de trimetilhidroquinona com isofitol compreende a realização da condensação na presença de no máximo 0,4 % em peso baseado no peso de isofitol de ácido sulfúrico, ácido metanossulfónico, ácido etanossulfónico, ácido trifluorometanossulfónico, ácido p-toluenossulfónico e ácido fluorossulfónico em carbonato de etileno ou propileno ou uma mistura de ambos os carbonatos, ou uma mistura de um ou ambos os carbonatos e um solvente não-polar. O produto do processo é o membro mais ativo e industrialmente importante do grupo da vitamina E.
BR9902217-6A 1998-04-06 1999-04-05 Fabricação de d,1-alfa-tocoferol pela condensação catalisada por ácido de trimetilhidroquinona com isofitol. BR9902217A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98106237 1998-04-06

Publications (1)

Publication Number Publication Date
BR9902217A true BR9902217A (pt) 2000-05-02

Family

ID=8231723

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9902217-6A BR9902217A (pt) 1998-04-06 1999-04-05 Fabricação de d,1-alfa-tocoferol pela condensação catalisada por ácido de trimetilhidroquinona com isofitol.

Country Status (10)

Country Link
US (1) US6066745A (pt)
EP (1) EP0949255B1 (pt)
JP (1) JP2000053673A (pt)
KR (1) KR19990082913A (pt)
CN (1) CN1181068C (pt)
BR (1) BR9902217A (pt)
CA (1) CA2267826A1 (pt)
DE (1) DE69931421T2 (pt)
ES (1) ES2264230T3 (pt)
IN (1) IN188430B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369242B2 (en) 2000-03-17 2002-04-09 Roche Vitamins Inc. Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof
ES2204792T3 (es) 2000-08-18 2004-05-01 Roche Vitamins Ag Procedimiento par ala obtencion de (todo-rac)-alfa-tocoferol.
AU2003270295A1 (en) 2002-11-21 2004-06-15 Dsm Ip Assets B.V. MANUFACTURE OF Alpha-TOCOPHEROL
DE60317553T2 (de) * 2002-11-21 2008-10-23 Dsm Ip Assets B.V. Herstellung von tocoferylazetaten
ES2347552T3 (es) * 2003-01-13 2010-11-02 Dsm Ip Assets B.V. Proceso para la fabricacion de acetato de alfa-tocoferilo.
CA2638940C (en) * 2008-08-28 2009-09-15 Dalton Chemical Laboratories Inc. Improved synthesis of hexahydrodibenzopyranones
CN102276572B (zh) * 2011-09-14 2013-03-27 重庆大学 一种制备维生素e乙酸酯的方法
US11447459B2 (en) 2018-03-29 2022-09-20 Dsm Ip Assets B.V. Use of substituted chroman-6-ols with extended lipophilic side chains
WO2021122439A1 (en) 2019-12-19 2021-06-24 Dsm Ip Assets B.V. Formation of alpha tocopherol from 2,3,6-trimethylphenol
CN113083339B (zh) * 2021-04-15 2022-11-08 万华化学(四川)有限公司 一种用于制备维生素e的催化剂及其制备方法和应用
CN117203193A (zh) 2021-04-28 2023-12-08 帝斯曼知识产权资产管理有限公司 2,3,5-三甲基氢醌与不饱和醇的偶联
WO2024180228A1 (en) 2023-03-01 2024-09-06 Dsm Ip Assets B.V. Manufacturing 2,3,5-trimethylhydroquinone from a mixture of mesitol and 2,3,6-trimethylphenol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2411969A (en) * 1938-03-31 1946-12-03 Hoffmann La Roche Process for the preparation of synthetic dl-tocopherols
US2723278A (en) * 1954-01-25 1955-11-08 Hoffmann La Roche Preparation of alpha-tocopherol
CH506516A (de) * 1968-02-27 1971-04-30 Hoffmann La Roche Verfahren zur Herstellung von Chromanolen
US3708505A (en) * 1971-02-25 1973-01-02 Diamond Shamrock Corp Process for preparation of d,l-alpha tocopherol
US5663376A (en) * 1994-07-27 1997-09-02 Eisai Co., Ltd. Process for the preparation of α-tocopherol
WO1997028151A1 (de) * 1996-01-29 1997-08-07 Basf Aktiengesellschaft VERFAHREN ZUR HERSTELLUNG VON DL-α-TOCOPHEROL ODER DL-α-TOCOPHERYLACETAT

Also Published As

Publication number Publication date
CA2267826A1 (en) 1999-10-06
DE69931421T2 (de) 2006-11-09
US6066745A (en) 2000-05-23
KR19990082913A (ko) 1999-11-25
JP2000053673A (ja) 2000-02-22
DE69931421D1 (de) 2006-06-29
ES2264230T3 (es) 2006-12-16
CN1181068C (zh) 2004-12-22
EP0949255B1 (en) 2006-05-24
IN188430B (pt) 2002-09-21
EP0949255A1 (en) 1999-10-13
CN1234402A (zh) 1999-11-10

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired