JO3670B1 - ملح سكسينات من 7-سيكلوبنتيل -2- (5-بيبرازين-1-يل-بيريدين-2-يل أمينو) -7h-بيرولو [2، 3-d] بيريميدين -6-ثنائي ميثيل أميد حمض الكربوكسيل وعمليات تصنيعه - Google Patents

ملح سكسينات من 7-سيكلوبنتيل -2- (5-بيبرازين-1-يل-بيريدين-2-يل أمينو) -7h-بيرولو [2، 3-d] بيريميدين -6-ثنائي ميثيل أميد حمض الكربوكسيل وعمليات تصنيعه

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Publication number
JO3670B1
JO3670B1 JOP/2011/0332A JOP20110332A JO3670B1 JO 3670 B1 JO3670 B1 JO 3670B1 JO P20110332 A JOP20110332 A JO P20110332A JO 3670 B1 JO3670 B1 JO 3670B1
Authority
JO
Jordan
Prior art keywords
ylamino
piperazin
pyrrolo
pyridin
pyrimidine
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JOP/2011/0332A
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English (en)
Inventor
Vincent Calienni John
Gong Baoqing
Saxena Vishal
Prasad Koteswara Kapa
Chen Guang-Pei
Original Assignee
Novartis Ag
Astex Therapeutics Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094234&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3670(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Astex Therapeutics Ltd filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3670B1 publication Critical patent/JO3670B1/ar

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    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

<span dir="RTL">يتعلق هذا الإختراع بـ (1) عملية لتصنيع 7- بنتيل حلقي -2- (5- بيبرازين -1- يل- بيريدين -2- يل أمينو) -7</span>H- <span dir="RTL">بيرولو [2، 3</span>- d] <span dir="RTL">بيريميدين -6- حمض كربوكسيليك ثاني مثيل أميد وأملاح منها؛ (2) ملح (أملاح) جديد من 7- بنتيل حلقي -2- (5- بيبرازين -1- يل- بيريدين -2- يل أمينو) -7</span>H- <span dir="RTL">بيرولو [2، 3</span>- d] <span dir="RTL">بيريميدين -6- حمض كربوكسيليك ثاني مثيل أميد؛ (3) تركيبات صيدلية تحتوي عليها؛ و (4) طرق علاج تستخدم منها</span>.
JOP/2011/0332A 2010-11-10 2011-11-12 ملح سكسينات من 7-سيكلوبنتيل -2- (5-بيبرازين-1-يل-بيريدين-2-يل أمينو) -7h-بيرولو [2، 3-d] بيريميدين -6-ثنائي ميثيل أميد حمض الكربوكسيل وعمليات تصنيعه JO3670B1 (ar)

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US (4) US20120115878A1 (ar)
EP (2) EP2638030B1 (ar)
JP (4) JP2013542257A (ar)
KR (4) KR20200136493A (ar)
CN (4) CN103201275A (ar)
AR (2) AR083797A1 (ar)
AU (4) AU2011326620A1 (ar)
BR (2) BR112013010167B1 (ar)
CA (1) CA2815839C (ar)
CL (1) CL2013001282A1 (ar)
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EC (1) ECSP13012619A (ar)
ES (1) ES2803432T3 (ar)
GT (1) GT201300123A (ar)
IL (1) IL225580B (ar)
JO (1) JO3670B1 (ar)
MA (1) MA34653B1 (ar)
MX (1) MX370852B (ar)
MY (1) MY164274A (ar)
PE (1) PE20140065A1 (ar)
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