JO3158B1 - عملية تحضير 4- {4 - [({[4-كلورو-3- (ترايفلوروميثيل) -فينيل] أمينو} الكربونيل)أمينو]-3-فلوروفينوكسي}- } -n-ميثلبريدين-2-كربوكساميد، وملح ومونوهيدرات منه - Google Patents
عملية تحضير 4- {4 - [({[4-كلورو-3- (ترايفلوروميثيل) -فينيل] أمينو} الكربونيل)أمينو]-3-فلوروفينوكسي}- } -n-ميثلبريدين-2-كربوكساميد، وملح ومونوهيدرات منهInfo
- Publication number
- JO3158B1 JO3158B1 JOP/2011/0125A JOP20110125A JO3158B1 JO 3158 B1 JO3158 B1 JO 3158B1 JO P20110125 A JOP20110125 A JO P20110125A JO 3158 B1 JO3158 B1 JO 3158B1
- Authority
- JO
- Jordan
- Prior art keywords
- amino
- fluorophenoxy
- methylpyridine
- carboxamide
- monohydrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Abstract
يتعلق الاختراع الحالي بعملية (process) لتحضير: 4-{4-[({[4-chloro-3-(trifluoromethyl)¬phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, أملاحه وmonohydrate منه.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10004022 | 2010-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3158B1 true JO3158B1 (ar) | 2017-09-20 |
Family
ID=44070712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2011/0125A JO3158B1 (ar) | 2010-04-15 | 2011-04-13 | عملية تحضير 4- {4 - [({[4-كلورو-3- (ترايفلوروميثيل) -فينيل] أمينو} الكربونيل)أمينو]-3-فلوروفينوكسي}- } -n-ميثلبريدين-2-كربوكساميد، وملح ومونوهيدرات منه |
Country Status (39)
Country | Link |
---|---|
US (5) | US8748622B2 (ar) |
EP (1) | EP2558448B1 (ar) |
JP (1) | JP5934182B2 (ar) |
KR (2) | KR101800041B1 (ar) |
CN (2) | CN102947271B (ar) |
AR (2) | AR081060A1 (ar) |
AU (1) | AU2011240113B2 (ar) |
BR (1) | BR112012026117B1 (ar) |
CA (1) | CA2796238C (ar) |
CL (1) | CL2012002840A1 (ar) |
CO (1) | CO6630136A2 (ar) |
CR (1) | CR20120526A (ar) |
CU (2) | CU24123B1 (ar) |
DK (1) | DK2558448T3 (ar) |
DO (2) | DOP2012000268A (ar) |
EC (1) | ECSP12012234A (ar) |
ES (1) | ES2542610T3 (ar) |
GT (1) | GT201200280A (ar) |
HK (1) | HK1200831A1 (ar) |
HR (1) | HRP20150885T1 (ar) |
HU (1) | HUE026821T2 (ar) |
IL (2) | IL222348B (ar) |
JO (1) | JO3158B1 (ar) |
MA (1) | MA34156B1 (ar) |
MX (1) | MX2012011734A (ar) |
MY (2) | MY162359A (ar) |
NZ (1) | NZ602997A (ar) |
PE (2) | PE20130181A1 (ar) |
PL (1) | PL2558448T3 (ar) |
PT (1) | PT2558448E (ar) |
RS (1) | RS54219B1 (ar) |
RU (1) | RU2581585C2 (ar) |
SG (2) | SG184172A1 (ar) |
SI (1) | SI2558448T1 (ar) |
TN (1) | TN2012000492A1 (ar) |
TW (2) | TWI475992B (ar) |
UA (1) | UA110613C2 (ar) |
UY (2) | UY33290A (ar) |
WO (1) | WO2011128261A1 (ar) |
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SG155996A1 (en) * | 2004-09-29 | 2009-10-29 | Bayer Schering Pharma Ag | Thermodynamically stable form of bay 43-9006 tosylate |
SG160364A1 (en) | 2005-03-07 | 2010-04-29 | Bayer Schering Pharma Ag | Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer |
AR081060A1 (es) | 2010-04-15 | 2012-06-06 | Bayer Schering Pharma Ag | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida |
JO3479B1 (ar) * | 2012-09-06 | 2020-07-05 | Bayer Healthcare Llc | تركيبة دوائية مغلفة تحتوي على ريجورافنيب |
MX357035B (es) | 2012-09-25 | 2018-06-25 | Bayer Pharma AG | Combinacion de regorafenib y acido acetilsalicilico para el tratamiento del cancer. |
CN104250227A (zh) * | 2013-06-29 | 2014-12-31 | 广东东阳光药业有限公司 | 瑞戈非尼新晶型及其制备方法 |
US9518020B2 (en) | 2013-10-04 | 2016-12-13 | Hetero Research Foundation | Process for Regorafenib |
CN105218439B (zh) * | 2014-06-06 | 2018-11-20 | 连云港润众制药有限公司 | 一种瑞格非尼的晶体及其制备方法 |
US9790185B2 (en) | 2014-07-09 | 2017-10-17 | Shilpa Medicare Limited | Process for the preparation of regorafenib and its crystalline forms |
CN104557689B (zh) * | 2015-01-26 | 2016-06-29 | 重庆两江药物研发中心有限公司 | 制备4-[4-({[4-氯-3-(三氟甲基)苯基]氨基甲酰}氨基)-3-氟苯氧基]-n-甲基吡啶-2-甲酰胺及其一水合物的方法 |
CN104592105B (zh) * | 2015-02-10 | 2017-01-18 | 杭州朱养心药业有限公司 | 瑞戈非尼及其制法 |
CN105330600B (zh) * | 2015-11-30 | 2018-05-22 | 山东罗欣药业集团股份有限公司 | 一种瑞戈菲尼的制备方法 |
SG11201806116SA (en) * | 2016-01-18 | 2018-08-30 | Natco Pharma Ltd | An improved process for the preparation of regorafenib |
CN107118153A (zh) * | 2016-02-25 | 2017-09-01 | 石药集团中奇制药技术(石家庄)有限公司 | 一种瑞戈非尼一水合物晶型及其制备方法 |
CN105879049B (zh) * | 2016-05-13 | 2019-03-26 | 浙江大学 | 一种瑞戈非尼与β-环糊精的包合物及其制备方法 |
CA3065125A1 (en) | 2017-06-02 | 2018-12-06 | Bayer Aktiengesellschaft | Combination of regorafenib and pd-1/pd-l1(2) inhibitors for treating cancer |
CN109438337B (zh) * | 2018-11-27 | 2019-08-09 | 广东安诺药业股份有限公司 | 一种瑞戈非尼中间体的制备工艺 |
CN109438336B (zh) * | 2018-11-27 | 2019-11-22 | 广东安诺药业股份有限公司 | 一种瑞戈非尼水合物的制备方法 |
EP3861989A1 (en) | 2020-02-07 | 2021-08-11 | Bayer Aktiengesellschaft | Pharmaceutical composition containing regorafenib and a stabilizing agent |
WO2021160708A1 (en) | 2020-02-14 | 2021-08-19 | Bayer Aktiengesellschaft | Combination of regorafenib and msln-ttc for treating cancer |
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2011
- 2011-03-23 AR ARP110100982A patent/AR081060A1/es not_active Application Discontinuation
- 2011-03-24 UY UY0001033290A patent/UY33290A/es active IP Right Grant
- 2011-04-08 BR BR112012026117-7A patent/BR112012026117B1/pt active IP Right Grant
- 2011-04-08 DK DK11712881.9T patent/DK2558448T3/en active
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- 2011-04-08 PE PE2012002008A patent/PE20130181A1/es active IP Right Grant
- 2011-04-08 MA MA35304A patent/MA34156B1/fr unknown
- 2011-04-08 US US13/640,959 patent/US8748622B2/en active Active
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- 2011-04-08 KR KR1020127026728A patent/KR101800041B1/ko active IP Right Grant
- 2011-04-08 KR KR1020177032906A patent/KR20170129276A/ko not_active Application Discontinuation
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