UA110613C2 - Спосіб одержання 4-{4-[({[4-хлор-3-(трифторметил)феніл]аміно}карбоніл)аміно]-3-фторфенокси}-n-метилпіридин-2-карбоксаміду, його солей і моногідрату - Google Patents

Спосіб одержання 4-{4-[({[4-хлор-3-(трифторметил)феніл]аміно}карбоніл)аміно]-3-фторфенокси}-n-метилпіридин-2-карбоксаміду, його солей і моногідрату

Info

Publication number
UA110613C2
UA110613C2 UAA201212983A UAA201212983A UA110613C2 UA 110613 C2 UA110613 C2 UA 110613C2 UA A201212983 A UAA201212983 A UA A201212983A UA A201212983 A UAA201212983 A UA A201212983A UA 110613 C2 UA110613 C2 UA 110613C2
Authority
UA
Ukraine
Prior art keywords
amino
fluorophenoxy
methylpyridine
monohydrate
trifluoromethyl
Prior art date
Application number
UAA201212983A
Other languages
English (en)
Inventor
Юрген Штіль
Вернер ХАЙЛЬМАНН
Міхаель Льогерс
Йоахім Резе
Міхаель Готтфрід
Саскіа Віхманн
Original Assignee
БАЄР ХЕЛСКЕР ЛЛСі
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44070712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA110613(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by БАЄР ХЕЛСКЕР ЛЛСі filed Critical БАЄР ХЕЛСКЕР ЛЛСі
Publication of UA110613C2 publication Critical patent/UA110613C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Представлений винахід стосується способу одержання 4-{4-[({[4-хлор-3-(трифторметил)феніл]аміно}карбоніл)аміно]-3-фторфенокси}-N-метилпіридин-2-карбоксаміду, його солі і моногідрату.
UAA201212983A 2010-04-15 2011-08-04 Спосіб одержання 4-{4-[({[4-хлор-3-(трифторметил)феніл]аміно}карбоніл)аміно]-3-фторфенокси}-n-метилпіридин-2-карбоксаміду, його солей і моногідрату UA110613C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10004022 2010-04-15
PCT/EP2011/055508 WO2011128261A1 (en) 2010-04-15 2011-04-08 Process for the preparation of 4- {4-[({[4 -chloro-3 -(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-n-methylpyridine-2-carboxamide, its salts and monohydrate

Publications (1)

Publication Number Publication Date
UA110613C2 true UA110613C2 (uk) 2016-01-25

Family

ID=44070712

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201212983A UA110613C2 (uk) 2010-04-15 2011-08-04 Спосіб одержання 4-{4-[({[4-хлор-3-(трифторметил)феніл]аміно}карбоніл)аміно]-3-фторфенокси}-n-метилпіридин-2-карбоксаміду, його солей і моногідрату

Country Status (39)

Country Link
US (5) US8748622B2 (uk)
EP (1) EP2558448B1 (uk)
JP (1) JP5934182B2 (uk)
KR (2) KR20170129276A (uk)
CN (2) CN102947271B (uk)
AR (2) AR081060A1 (uk)
AU (1) AU2011240113B2 (uk)
BR (1) BR112012026117B1 (uk)
CA (1) CA2796238C (uk)
CL (1) CL2012002840A1 (uk)
CO (1) CO6630136A2 (uk)
CR (1) CR20120526A (uk)
CU (2) CU24123B1 (uk)
DK (1) DK2558448T3 (uk)
DO (2) DOP2012000268A (uk)
EC (1) ECSP12012234A (uk)
ES (1) ES2542610T3 (uk)
GT (1) GT201200280A (uk)
HK (1) HK1200831A1 (uk)
HR (1) HRP20150885T1 (uk)
HU (1) HUE026821T2 (uk)
IL (2) IL222348B (uk)
JO (1) JO3158B1 (uk)
MA (1) MA34156B1 (uk)
MX (1) MX2012011734A (uk)
MY (2) MY177066A (uk)
NZ (1) NZ602997A (uk)
PE (2) PE20160838A1 (uk)
PL (1) PL2558448T3 (uk)
PT (1) PT2558448E (uk)
RS (1) RS54219B1 (uk)
RU (1) RU2581585C2 (uk)
SG (2) SG184172A1 (uk)
SI (1) SI2558448T1 (uk)
TN (1) TN2012000492A1 (uk)
TW (2) TWI539951B (uk)
UA (1) UA110613C2 (uk)
UY (2) UY33290A (uk)
WO (1) WO2011128261A1 (uk)

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Also Published As

Publication number Publication date
MY177066A (en) 2020-09-03
PL2558448T3 (pl) 2015-10-30
TWI539951B (zh) 2016-07-01
BR112012026117B1 (pt) 2022-08-30
CO6630136A2 (es) 2013-03-01
US8748622B2 (en) 2014-06-10
EP2558448B1 (en) 2015-05-20
US20170057918A1 (en) 2017-03-02
CN102947271A (zh) 2013-02-27
KR101800041B1 (ko) 2017-11-21
UY39590A (es) 2022-01-31
PE20160838A1 (es) 2016-09-24
IL222348B (en) 2018-08-30
ES2542610T3 (es) 2015-08-07
TW201509415A (zh) 2015-03-16
BR112012026117A2 (pt) 2015-09-08
GT201200280A (es) 2014-07-23
RU2581585C2 (ru) 2016-04-20
SG184172A1 (en) 2012-11-29
WO2011128261A1 (en) 2011-10-20
HRP20150885T1 (hr) 2015-10-09
AU2011240113B2 (en) 2014-12-18
IL222348A0 (en) 2012-12-31
RU2012148386A (ru) 2014-05-20
CU20120147A7 (es) 2013-01-30
MA34156B1 (fr) 2013-04-03
BR112012026117A8 (pt) 2017-12-19
CN102947271B (zh) 2016-11-09
HUE026821T2 (en) 2016-07-28
JP2013523851A (ja) 2013-06-17
CU20140060A7 (es) 2014-10-02
HK1200831A1 (en) 2015-08-14
TWI475992B (zh) 2015-03-11
US10822305B2 (en) 2020-11-03
DOP2016000285A (es) 2016-11-30
CR20120526A (es) 2013-03-11
PE20130181A1 (es) 2013-02-23
UY33290A (es) 2011-12-01
MX2012011734A (es) 2012-12-17
AU2011240113A1 (en) 2012-10-11
KR20170129276A (ko) 2017-11-24
MY162359A (en) 2017-06-15
CL2012002840A1 (es) 2013-01-18
DOP2012000268A (es) 2012-12-15
TW201204356A (en) 2012-02-01
US20190144391A1 (en) 2019-05-16
ECSP12012234A (es) 2012-11-30
CA2796238C (en) 2019-12-31
US20130116442A1 (en) 2013-05-09
CN103980191A (zh) 2014-08-13
JO3158B1 (ar) 2017-09-20
CU24123B1 (es) 2015-08-27
RS54219B1 (en) 2015-12-31
US20170334857A1 (en) 2017-11-23
US9458107B2 (en) 2016-10-04
IL253119B (en) 2018-03-29
SG10201501221UA (en) 2015-04-29
AR116395A2 (es) 2021-05-05
DK2558448T3 (en) 2015-08-24
PT2558448E (pt) 2015-09-01
SI2558448T1 (sl) 2015-11-30
NZ602997A (en) 2014-10-31
IL253119A0 (en) 2017-08-31
JP5934182B2 (ja) 2016-06-15
TN2012000492A1 (en) 2014-04-01
EP2558448A1 (en) 2013-02-20
AR081060A1 (es) 2012-06-06
US20140221661A1 (en) 2014-08-07
KR20130061670A (ko) 2013-06-11
CA2796238A1 (en) 2011-10-20

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