GT201200280A - Procedimiento - Google Patents

Procedimiento

Info

Publication number
GT201200280A
GT201200280A GT201200280A GT201200280A GT201200280A GT 201200280 A GT201200280 A GT 201200280A GT 201200280 A GT201200280 A GT 201200280A GT 201200280 A GT201200280 A GT 201200280A GT 201200280 A GT201200280 A GT 201200280A
Authority
GT
Guatemala
Prior art keywords
amino
methylipiridine
monohidrate
trifluorometil
fluorophenoxy
Prior art date
Application number
GT201200280A
Other languages
English (en)
Inventor
Stiehl Juergen
Heilmann Werner
Lögers Michael
Rehse Joachim
Gottfried Michael
Wichmann Saskia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44070712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201200280(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT201200280A publication Critical patent/GT201200280A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACIÓN DE 4-{4-[({[4-CLORO-3-(TRIFLUOROMETIL)FENIL]AMINO}CARBONIL)AMINO]-3-FLUOROFENOXI}-N-METILPIRIDINA-2-CARBOXAMIDA, SUS SALES Y SU MONOHIDRATO.
GT201200280A 2010-04-15 2012-10-11 Procedimiento GT201200280A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10004022 2010-04-15

Publications (1)

Publication Number Publication Date
GT201200280A true GT201200280A (es) 2014-07-23

Family

ID=44070712

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201200280A GT201200280A (es) 2010-04-15 2012-10-11 Procedimiento

Country Status (39)

Country Link
US (5) US8748622B2 (es)
EP (1) EP2558448B1 (es)
JP (1) JP5934182B2 (es)
KR (2) KR20170129276A (es)
CN (2) CN102947271B (es)
AR (2) AR081060A1 (es)
AU (1) AU2011240113B2 (es)
BR (1) BR112012026117B1 (es)
CA (1) CA2796238C (es)
CL (1) CL2012002840A1 (es)
CO (1) CO6630136A2 (es)
CR (1) CR20120526A (es)
CU (2) CU24123B1 (es)
DK (1) DK2558448T3 (es)
DO (2) DOP2012000268A (es)
EC (1) ECSP12012234A (es)
ES (1) ES2542610T3 (es)
GT (1) GT201200280A (es)
HK (1) HK1200831A1 (es)
HR (1) HRP20150885T1 (es)
HU (1) HUE026821T2 (es)
IL (2) IL222348B (es)
JO (1) JO3158B1 (es)
MA (1) MA34156B1 (es)
MX (1) MX2012011734A (es)
MY (2) MY162359A (es)
NZ (1) NZ602997A (es)
PE (2) PE20160838A1 (es)
PL (1) PL2558448T3 (es)
PT (1) PT2558448E (es)
RS (1) RS54219B1 (es)
RU (1) RU2581585C2 (es)
SG (2) SG10201501221UA (es)
SI (1) SI2558448T1 (es)
TN (1) TN2012000492A1 (es)
TW (2) TWI539951B (es)
UA (1) UA110613C2 (es)
UY (2) UY33290A (es)
WO (1) WO2011128261A1 (es)

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NZ553804A (en) * 2004-09-29 2010-07-30 Bayer Schering Pharma Ag Thermodynamically stable form of bay 43-9006 tosylate
EP1868579B1 (en) 2005-03-07 2010-09-29 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
AR092439A1 (es) 2012-09-06 2015-04-22 Bayer Healthcare Llc Composicion farmaceutica recubierta que contiene regorafenib
MY183969A (en) 2012-09-25 2021-03-17 Bayer Pharma AG Combination of regorafenib and acetylsalicylic acid for treating cancer
CN104250227A (zh) * 2013-06-29 2014-12-31 广东东阳光药业有限公司 瑞戈非尼新晶型及其制备方法
US9518020B2 (en) 2013-10-04 2016-12-13 Hetero Research Foundation Process for Regorafenib
CN105218439B (zh) * 2014-06-06 2018-11-20 连云港润众制药有限公司 一种瑞格非尼的晶体及其制备方法
US9790185B2 (en) 2014-07-09 2017-10-17 Shilpa Medicare Limited Process for the preparation of regorafenib and its crystalline forms
CN104557689B (zh) * 2015-01-26 2016-06-29 重庆两江药物研发中心有限公司 制备4-[4-({[4-氯-3-(三氟甲基)苯基]氨基甲酰}氨基)-3-氟苯氧基]-n-甲基吡啶-2-甲酰胺及其一水合物的方法
CN104592105B (zh) * 2015-02-10 2017-01-18 杭州朱养心药业有限公司 瑞戈非尼及其制法
CN105330600B (zh) * 2015-11-30 2018-05-22 山东罗欣药业集团股份有限公司 一种瑞戈菲尼的制备方法
CA3011662A1 (en) * 2016-01-18 2017-07-27 Natco Pharma Ltd An improved process for the preparation of regorafenib
CN107118153A (zh) * 2016-02-25 2017-09-01 石药集团中奇制药技术（石家庄）有限公司 一种瑞戈非尼一水合物晶型及其制备方法
CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
FI3630112T3 (fi) 2017-06-02 2024-05-02 Bayer Healthcare Llc Regorafenibin ja nivolumabin yhdistelmä syövän hoidossa
CN109438336B (zh) * 2018-11-27 2019-11-22 广东安诺药业股份有限公司 一种瑞戈非尼水合物的制备方法
CN109438337B (zh) * 2018-11-27 2019-08-09 广东安诺药业股份有限公司 一种瑞戈非尼中间体的制备工艺
EP3861989A1 (en) 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Pharmaceutical composition containing regorafenib and a stabilizing agent
WO2021160708A1 (en) 2020-02-14 2021-08-19 Bayer Aktiengesellschaft Combination of regorafenib and msln-ttc for treating cancer
CN114315710B (zh) * 2022-01-07 2024-04-26 江苏豪森药业集团有限公司 一种制备或纯化瑞戈非尼的方法

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Also Published As

Publication number Publication date
MA34156B1 (fr) 2013-04-03
CU24123B1 (es) 2015-08-27
AR081060A1 (es) 2012-06-06
IL253119A0 (en) 2017-08-31
AU2011240113B2 (en) 2014-12-18
RU2581585C2 (ru) 2016-04-20
JP5934182B2 (ja) 2016-06-15
CU20140060A7 (es) 2014-10-02
SG10201501221UA (en) 2015-04-29
CN102947271B (zh) 2016-11-09
CN102947271A (zh) 2013-02-27
CN103980191A (zh) 2014-08-13
RS54219B1 (en) 2015-12-31
DK2558448T3 (en) 2015-08-24
AR116395A2 (es) 2021-05-05
IL222348A0 (en) 2012-12-31
HUE026821T2 (en) 2016-07-28
RU2012148386A (ru) 2014-05-20
KR20130061670A (ko) 2013-06-11
HRP20150885T1 (hr) 2015-10-09
JP2013523851A (ja) 2013-06-17
PT2558448E (pt) 2015-09-01
SG184172A1 (en) 2012-11-29
IL253119B (en) 2018-03-29
CU20120147A7 (es) 2013-01-30
ECSP12012234A (es) 2012-11-30
MY162359A (en) 2017-06-15
UA110613C2 (uk) 2016-01-25
TW201204356A (en) 2012-02-01
TW201509415A (zh) 2015-03-16
PE20160838A1 (es) 2016-09-24
US20140221661A1 (en) 2014-08-07
DOP2012000268A (es) 2012-12-15
NZ602997A (en) 2014-10-31
CL2012002840A1 (es) 2013-01-18
DOP2016000285A (es) 2016-11-30
JO3158B1 (ar) 2017-09-20
MX2012011734A (es) 2012-12-17
CR20120526A (es) 2013-03-11
TN2012000492A1 (en) 2014-04-01
ES2542610T3 (es) 2015-08-07
AU2011240113A1 (en) 2012-10-11
HK1200831A1 (en) 2015-08-14
KR101800041B1 (ko) 2017-11-21
EP2558448A1 (en) 2013-02-20
US20170057918A1 (en) 2017-03-02
BR112012026117B1 (pt) 2022-08-30
US20170334857A1 (en) 2017-11-23
SI2558448T1 (sl) 2015-11-30
TWI475992B (zh) 2015-03-11
EP2558448B1 (en) 2015-05-20
US10822305B2 (en) 2020-11-03
CA2796238C (en) 2019-12-31
KR20170129276A (ko) 2017-11-24
UY33290A (es) 2011-12-01
CO6630136A2 (es) 2013-03-01
CA2796238A1 (en) 2011-10-20
BR112012026117A8 (pt) 2017-12-19
US9458107B2 (en) 2016-10-04
US8748622B2 (en) 2014-06-10
PE20130181A1 (es) 2013-02-23
MY177066A (en) 2020-09-03
PL2558448T3 (pl) 2015-10-30
UY39590A (es) 2022-01-31
BR112012026117A2 (pt) 2015-09-08
WO2011128261A1 (en) 2011-10-20
TWI539951B (zh) 2016-07-01
US20130116442A1 (en) 2013-05-09
IL222348B (en) 2018-08-30
US20190144391A1 (en) 2019-05-16

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