ITMI20020148A1 - Nuovi corticosteroidi - Google Patents

Nuovi corticosteroidi

Info

Publication number
ITMI20020148A1
ITMI20020148A1 IT2002MI000148A ITMI20020148A ITMI20020148A1 IT MI20020148 A1 ITMI20020148 A1 IT MI20020148A1 IT 2002MI000148 A IT2002MI000148 A IT 2002MI000148A IT MI20020148 A ITMI20020148 A IT MI20020148A IT MI20020148 A1 ITMI20020148 A1 IT MI20020148A1
Authority
IT
Italy
Prior art keywords
corticosteroids
new
new corticosteroids
Prior art date
Application number
IT2002MI000148A
Other languages
English (en)
Italian (it)
Inventor
Ennio Ongini
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Priority to IT2002MI000148A priority Critical patent/ITMI20020148A1/it
Publication of ITMI20020148A0 publication Critical patent/ITMI20020148A0/it
Priority to MXPA04007337A priority patent/MXPA04007337A/es
Priority to PL03370457A priority patent/PL370457A1/xx
Priority to US10/501,335 priority patent/US20060052594A1/en
Priority to JP2003564063A priority patent/JP2005516070A/ja
Priority to AU2003210161A priority patent/AU2003210161B2/en
Priority to CA002473249A priority patent/CA2473249A1/en
Priority to PCT/EP2003/000394 priority patent/WO2003064443A2/en
Priority to NZ534147A priority patent/NZ534147A/en
Priority to EP03734674A priority patent/EP1470150A2/en
Priority to BR0307027-1A priority patent/BR0307027A/pt
Publication of ITMI20020148A1 publication Critical patent/ITMI20020148A1/it
Priority to NO20043595A priority patent/NO327364B1/no
Priority to AU2008258133A priority patent/AU2008258133A1/en
Priority to US12/464,562 priority patent/US20090221543A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IT2002MI000148A 2002-01-29 2002-01-29 Nuovi corticosteroidi ITMI20020148A1 (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT2002MI000148A ITMI20020148A1 (it) 2002-01-29 2002-01-29 Nuovi corticosteroidi
BR0307027-1A BR0307027A (pt) 2002-01-29 2003-01-16 Compostos derivados de nitróxi de compostos esteróides, uso dos compostos, e, formulações farmacêuticas
CA002473249A CA2473249A1 (en) 2002-01-29 2003-01-16 New corticosteroids
NZ534147A NZ534147A (en) 2002-01-29 2003-01-16 New corticosteroids
US10/501,335 US20060052594A1 (en) 2002-01-29 2003-01-16 New corticosteroids
JP2003564063A JP2005516070A (ja) 2002-01-29 2003-01-16 新規なコルチコステロイド類
AU2003210161A AU2003210161B2 (en) 2002-01-29 2003-01-16 New corticosteroids
MXPA04007337A MXPA04007337A (es) 2002-01-29 2003-01-16 Corticosteroides novedosos.
PCT/EP2003/000394 WO2003064443A2 (en) 2002-01-29 2003-01-16 New corticosteroids
PL03370457A PL370457A1 (en) 2002-01-29 2003-01-16 New corticosteroids
EP03734674A EP1470150A2 (en) 2002-01-29 2003-01-16 Corticosteroids nitrate derivatives
NO20043595A NO327364B1 (no) 2002-01-29 2004-08-27 Nitrooksyderivater av steroidforbindelser, anvendelse derav, og farmasoytisk formulering omfattende slike
AU2008258133A AU2008258133A1 (en) 2002-01-29 2008-12-15 New corticosteroids
US12/464,562 US20090221543A1 (en) 2002-01-29 2009-05-12 New corticosteroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI000148A ITMI20020148A1 (it) 2002-01-29 2002-01-29 Nuovi corticosteroidi

Publications (2)

Publication Number Publication Date
ITMI20020148A0 ITMI20020148A0 (it) 2002-01-29
ITMI20020148A1 true ITMI20020148A1 (it) 2003-07-29

Family

ID=11449016

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002MI000148A ITMI20020148A1 (it) 2002-01-29 2002-01-29 Nuovi corticosteroidi

Country Status (12)

Country Link
US (2) US20060052594A1 (enExample)
EP (1) EP1470150A2 (enExample)
JP (1) JP2005516070A (enExample)
AU (2) AU2003210161B2 (enExample)
BR (1) BR0307027A (enExample)
CA (1) CA2473249A1 (enExample)
IT (1) ITMI20020148A1 (enExample)
MX (1) MXPA04007337A (enExample)
NO (1) NO327364B1 (enExample)
NZ (1) NZ534147A (enExample)
PL (1) PL370457A1 (enExample)
WO (1) WO2003064443A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007513114A (ja) * 2003-12-02 2007-05-24 ニコックス エス エイ 抗高血圧薬としてのカルベジロール及びその他のベータ遮断薬のニトロオキシ誘導体
WO2007025632A2 (en) * 2005-09-02 2007-03-08 Nicox S.A. Nitrooxy derivatives op glucocorticoids
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US20100234334A1 (en) * 2007-02-05 2010-09-16 Nicox S.A. Nitric oxide releasing steroids
EP1964550A1 (en) * 2007-03-01 2008-09-03 NicOx S.A. Glucocorticoid-nitrooxyderivative compositions
WO2009037584A2 (en) * 2007-08-10 2009-03-26 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
WO2009071990A2 (en) * 2007-08-31 2009-06-11 Topigen Pharmaceuticals Inc. No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
ES2324007A1 (es) * 2007-10-25 2009-07-28 Ferrer Internacional, S.A. Una forma amorfa de un compuesto antiinflamatorio.
KR101975843B1 (ko) * 2008-05-23 2019-05-09 더 유니버시티 오브 브리티쉬 콜롬비아 리포좀 나노입자에 사용하기 위한 변형된 약물
CN101624414B (zh) * 2008-07-07 2013-02-13 天津金耀集团有限公司 一种抑制血管新生的硝酸酯药物
AU2009277381B2 (en) * 2008-07-31 2014-04-24 Nicox S.A. Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
WO2010015528A1 (en) 2008-08-05 2010-02-11 Nicox S.A. New no-releasing steroids for the treatment of retina and macula lutea diseases
CN102040643B (zh) * 2009-10-16 2013-01-09 天津金耀集团有限公司 环索奈德硝酸酯衍生物
US8716268B2 (en) * 2010-06-07 2014-05-06 Chao Liu Nitrate esters of corticoid compounds useful as diuretics
MX394528B (es) 2016-11-08 2025-03-24 Regeneron Pharma Esteroides y conjugados de proteinas de los mismos.
KR20250008984A (ko) 2017-05-18 2025-01-16 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
SG11202004151YA (en) 2017-11-07 2020-06-29 Regeneron Pharma Hydrophilic linkers for antibody drug conjugates
CA3086926A1 (en) 2018-01-08 2019-07-11 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
CN108484714A (zh) * 2018-03-13 2018-09-04 岳阳环宇药业有限公司 地夫可特的制备工艺
SG11202010909RA (en) 2018-05-09 2020-12-30 Regeneron Pharma Anti-msr1 antibodies and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1037451B (de) * 1957-04-04 1958-08-28 Schering Ag Verfahren zur Herstellung der Aminoacetate von gesaettigten und ungesaettigten 21-Hydroxypregnan-verbindungen bzw. deren wasserloeslichen Saeureadditionsprodukten
US3183252A (en) 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
US3494941A (en) 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (enExample) 1971-05-07 1973-12-28
CY1359A (en) * 1981-02-02 1987-08-07 Schering Corp Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
US6248723B1 (en) * 1997-06-10 2001-06-19 National Jewish Medical And Research Center Method for treatment of inflammatory disease
US6254853B1 (en) * 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases

Also Published As

Publication number Publication date
JP2005516070A (ja) 2005-06-02
AU2003210161B2 (en) 2008-12-04
PL370457A1 (en) 2005-05-30
NZ534147A (en) 2006-09-29
ITMI20020148A0 (it) 2002-01-29
US20060052594A1 (en) 2006-03-09
CA2473249A1 (en) 2003-08-07
BR0307027A (pt) 2004-11-03
EP1470150A2 (en) 2004-10-27
NO20043595L (no) 2004-10-20
NO327364B1 (no) 2009-06-15
WO2003064443A2 (en) 2003-08-07
WO2003064443A3 (en) 2004-02-26
MXPA04007337A (es) 2004-11-26
AU2008258133A1 (en) 2009-01-08
US20090221543A1 (en) 2009-09-03

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