ITMI20012025A0 - Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono - Google Patents
Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengonoInfo
- Publication number
- ITMI20012025A0 ITMI20012025A0 IT2001MI002025A ITMI20012025A ITMI20012025A0 IT MI20012025 A0 ITMI20012025 A0 IT MI20012025A0 IT 2001MI002025 A IT2001MI002025 A IT 2001MI002025A IT MI20012025 A ITMI20012025 A IT MI20012025A IT MI20012025 A0 ITMI20012025 A0 IT MI20012025A0
- Authority
- IT
- Italy
- Prior art keywords
- aminoalkylammides
- omega
- aryl
- contain
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/44—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI002025A ITMI20012025A1 (it) | 2001-09-28 | 2001-09-28 | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
AU2002338784A AU2002338784B2 (en) | 2001-09-28 | 2002-09-25 | Quaternary ammonium salts of omega-aminoalkylamides of R-2-aryl-propionic acids and pharmaceutical compositions containing them |
DK02777207.8T DK1430020T3 (en) | 2001-09-28 | 2002-09-25 | Quaternary ammonium salts of omega-AMINOALKYLAMIDER OF R-2-aryl-propionic acids and pharmaceutical compositions containing them, |
HU0401763A HU230541B1 (hu) | 2001-09-28 | 2002-09-25 | R-2-aril-propionsavak omega-aminoalkilamidjai kvaterner ammóniumsói és e vegyületeket tartalmazó gyógyszerészeti készítmények |
US10/487,679 US7026510B2 (en) | 2001-09-28 | 2002-09-25 | Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them |
ES02777207.8T ES2573531T3 (es) | 2001-09-28 | 2002-09-25 | Sales de amonio cuaternarias de omega-aminoalquilamidas de ácidos R-2-arilpropiónicos y composiciones farmacéuticas que las contienen |
JP2003532442A JP4405801B2 (ja) | 2001-09-28 | 2002-09-25 | R−2−アリール−プロピオン酸のオメガ−アミノアルキルアミドの4級アンモニウム塩及びそれらを含有する医薬組成物 |
PCT/EP2002/010746 WO2003029187A1 (en) | 2001-09-28 | 2002-09-25 | Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them |
RU2004113099/04A RU2291857C2 (ru) | 2001-09-28 | 2002-09-25 | Четвертичные аммониевые соли омега-аминоалкиламидов r-2-арилпропионовых кислот и содержащие их фармацевтические составы |
PT02777207T PT1430020E (pt) | 2001-09-28 | 2002-09-25 | Sais de amónio quaternário de omega-aminoalquilamidas de ácidos r-2-arilpropiónicos e composições farmacêuticas que os contêm |
SI200231073A SI1430020T1 (sl) | 2001-09-28 | 2002-09-25 | Kvaternarne amonijeve soli omega-aminoalkilamidov r-2-aril-propionskih kislin in farmacevtski sestavki, ki jih vsebujejo |
EP02777207.8A EP1430020B1 (en) | 2001-09-28 | 2002-09-25 | Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them |
PL369511A PL214275B1 (pl) | 2001-09-28 | 2002-09-25 | Czwartorzedowe sole amoniowe omega-aminoalkiloamidów kwasów R-2-arylo-propionowych, zawierajace je kompozycje farmaceutyczne i sposób ich wytwarzania |
CA2458035A CA2458035C (en) | 2001-09-28 | 2002-09-25 | Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them |
NO20041609A NO328879B1 (no) | 2001-09-28 | 2004-04-20 | R-2-aryl-propionamidforbindelser, fremgangsmate for deres fremstilling og farmasoytiske preparater som inneholder disse |
CY20161100463T CY1117657T1 (el) | 2001-09-28 | 2016-05-27 | Αλατα τεταρτοταγους αμμωνιου ωμεγα-αμινοαλκυλαμιδιων των r-2-αρυλ-προπιονικων οξεων και φαρμακευτικες συνθεσεις που περιεχουν αυτα |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI002025A ITMI20012025A1 (it) | 2001-09-28 | 2001-09-28 | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI20012025A0 true ITMI20012025A0 (it) | 2001-09-28 |
ITMI20012025A1 ITMI20012025A1 (it) | 2003-03-28 |
Family
ID=11448449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2001MI002025A ITMI20012025A1 (it) | 2001-09-28 | 2001-09-28 | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
Country Status (16)
Country | Link |
---|---|
US (1) | US7026510B2 (it) |
EP (1) | EP1430020B1 (it) |
JP (1) | JP4405801B2 (it) |
AU (1) | AU2002338784B2 (it) |
CA (1) | CA2458035C (it) |
CY (1) | CY1117657T1 (it) |
DK (1) | DK1430020T3 (it) |
ES (1) | ES2573531T3 (it) |
HU (1) | HU230541B1 (it) |
IT (1) | ITMI20012025A1 (it) |
NO (1) | NO328879B1 (it) |
PL (1) | PL214275B1 (it) |
PT (1) | PT1430020E (it) |
RU (1) | RU2291857C2 (it) |
SI (1) | SI1430020T1 (it) |
WO (1) | WO2003029187A1 (it) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1457485A1 (en) * | 2003-03-14 | 2004-09-15 | Dompé S.P.A. | Sulfonic acids, their derivatives and pharmaceutical compositions containing them |
WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
ES2333445T3 (es) * | 2004-03-23 | 2010-02-22 | Dompe' S.P.A. | Derivados del acido 2-fenilpropionico y composiciones farmaceuticas que los contienen. |
DK1856031T3 (da) * | 2004-12-15 | 2009-06-29 | Dompe Pha R Ma Spa Res & Mfg | 2-arylpropionsyrederivater og farmaceutiske sammensætninger indeholdende disse |
EP1739078A1 (de) | 2005-05-30 | 2007-01-03 | Jerini AG | C5a-Rezeptor-Antagonisten |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
WO2008010025A1 (en) * | 2006-07-18 | 2008-01-24 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
WO2008012605A1 (en) * | 2006-07-27 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate |
CN104610077B (zh) * | 2006-07-27 | 2020-04-14 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
CN103772259B (zh) * | 2006-08-08 | 2016-08-31 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药 |
EP2049482B1 (en) * | 2006-08-08 | 2015-10-21 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate |
CN103772258B (zh) * | 2006-08-08 | 2016-09-28 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药 |
EP2054384A4 (en) * | 2006-08-15 | 2010-11-03 | Techfields Biochem Co Ltd | POSITIVELY LOADED WATER-SOLUBLE PRODRUGS OF ARYL AND HETEROARYLPROPIONIC ACIDS WITH A VERY FAST SKIN PUNCHING RATE |
AU2013206218B2 (en) * | 2006-08-15 | 2016-06-30 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
PL2170826T3 (pl) | 2007-06-04 | 2022-09-05 | Techfields Inc | Proleki nsaia o bardzo wysokim współczynniku przenikania przez skórę i błony oraz ich nowe zastosowania lecznicze |
EP2201006B1 (en) * | 2007-10-18 | 2011-03-09 | Dompé S.p.a. | (r)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them |
CA3213470A1 (en) | 2008-12-04 | 2010-06-10 | Chongxi Yu | High penetration compositions and their applications |
WO2010075257A1 (en) | 2008-12-22 | 2010-07-01 | Chemocentryx, Inc. | C5ar antagonists |
WO2011006073A1 (en) | 2009-07-10 | 2011-01-13 | President And Fellows Of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
KR20130073822A (ko) * | 2011-12-23 | 2013-07-03 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 이온 액체, 비수 전해질 및 축전 장치 |
JP5940036B2 (ja) * | 2013-10-08 | 2016-06-29 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
CN106659697B (zh) * | 2014-05-30 | 2022-03-29 | 斯菲叶尔制药私有公司 | 作为抗结核剂的化合物 |
ES2926828T3 (es) | 2014-09-29 | 2022-10-28 | Chemocentryx Inc | Procesos e intermedios en la preparación de antagonistas de C5aR |
US11021443B2 (en) * | 2015-08-03 | 2021-06-01 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
TWI791423B (zh) | 2016-01-14 | 2023-02-11 | 美商卡默森屈有限公司 | C3腎絲球病變之治療方法 |
CN109310686B (zh) | 2016-04-04 | 2022-06-21 | 凯莫森特里克斯股份有限公司 | 可溶性C5aR拮抗剂 |
EP3630774B1 (en) | 2017-05-31 | 2022-11-23 | ChemoCentryx, Inc. | 5-5 fused rings as c5a inhibitors |
MA48803A (fr) | 2017-05-31 | 2020-04-08 | Chemocentryx Inc | Cycles 6-5 fusionnés utilisés en tant qu'inhibiteurs de c5a |
US20190144389A1 (en) | 2017-10-30 | 2019-05-16 | Chemocentryx, Inc. | Deuterated compounds as immunomodulators |
CA3086111A1 (en) | 2017-12-22 | 2019-06-27 | Chemocentryx, Inc. | Diaryl substituted 5,5-fused ring compounds as c5ar inhibitors |
KR20200109316A (ko) | 2017-12-22 | 2020-09-22 | 케모센트릭스, 인크. | C5aR 억제제로서의 디아릴 치환된 6,5-융합 고리 화합물 |
US20190300526A1 (en) | 2018-04-02 | 2019-10-03 | Chemocentryx, Inc. | PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS |
US20200231545A1 (en) * | 2019-01-03 | 2020-07-23 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use thereof |
MA55320A (fr) | 2019-03-11 | 2022-01-19 | Nocion Therapeutics Inc | Bloqueurs de canaux ioniques substitués par un ester et méthodes d'utilisation |
US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
JP2022525856A (ja) | 2019-03-11 | 2022-05-20 | ノシオン セラピューティクス,インコーポレイテッド | 荷電したイオンチャンネル遮断薬および使用方法 |
US11377422B2 (en) | 2019-03-11 | 2022-07-05 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
CA3155586A1 (en) | 2019-11-06 | 2021-05-14 | Bridget M. Cole | Charged ion channel blockers and methods for use |
EP4054586A4 (en) | 2019-11-06 | 2023-11-22 | Nocion Therapeutics, Inc. | CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE |
CN115279731A (zh) | 2020-03-11 | 2022-11-01 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
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FR1593024A (it) | 1968-09-18 | 1970-05-25 | ||
IT1090782B (it) * | 1977-11-30 | 1985-06-26 | Menarini Sas | 2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi |
IT1317826B1 (it) * | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
US20020160988A1 (en) * | 2001-02-20 | 2002-10-31 | Israel Institute For Biological Research | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof |
ITMI20010395A1 (it) * | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
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2001
- 2001-09-28 IT IT2001MI002025A patent/ITMI20012025A1/it unknown
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2002
- 2002-09-25 EP EP02777207.8A patent/EP1430020B1/en not_active Expired - Lifetime
- 2002-09-25 CA CA2458035A patent/CA2458035C/en not_active Expired - Fee Related
- 2002-09-25 AU AU2002338784A patent/AU2002338784B2/en not_active Ceased
- 2002-09-25 JP JP2003532442A patent/JP4405801B2/ja not_active Expired - Fee Related
- 2002-09-25 HU HU0401763A patent/HU230541B1/hu unknown
- 2002-09-25 RU RU2004113099/04A patent/RU2291857C2/ru not_active IP Right Cessation
- 2002-09-25 SI SI200231073A patent/SI1430020T1/sl unknown
- 2002-09-25 US US10/487,679 patent/US7026510B2/en not_active Expired - Lifetime
- 2002-09-25 WO PCT/EP2002/010746 patent/WO2003029187A1/en active Application Filing
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- 2002-09-25 PT PT02777207T patent/PT1430020E/pt unknown
- 2002-09-25 PL PL369511A patent/PL214275B1/pl unknown
- 2002-09-25 DK DK02777207.8T patent/DK1430020T3/en active
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2004
- 2004-04-20 NO NO20041609A patent/NO328879B1/no not_active IP Right Cessation
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HU230541B1 (hu) | 2016-11-28 |
ITMI20012025A1 (it) | 2003-03-28 |
JP2005504121A (ja) | 2005-02-10 |
JP4405801B2 (ja) | 2010-01-27 |
DK1430020T3 (en) | 2016-05-30 |
WO2003029187A1 (en) | 2003-04-10 |
PL369511A1 (en) | 2005-04-18 |
PT1430020E (pt) | 2016-06-08 |
CY1117657T1 (el) | 2017-05-17 |
NO20041609L (no) | 2004-04-20 |
PL214275B1 (pl) | 2013-07-31 |
US7026510B2 (en) | 2006-04-11 |
RU2291857C2 (ru) | 2007-01-20 |
CA2458035A1 (en) | 2003-04-10 |
RU2004113099A (ru) | 2005-09-10 |
HUP0401763A3 (en) | 2006-01-30 |
NO328879B1 (no) | 2010-06-07 |
EP1430020B1 (en) | 2016-03-02 |
HUP0401763A2 (hu) | 2004-12-28 |
SI1430020T1 (sl) | 2016-06-30 |
US20040266870A1 (en) | 2004-12-30 |
EP1430020A1 (en) | 2004-06-23 |
AU2002338784B2 (en) | 2008-08-14 |
ES2573531T3 (es) | 2016-06-08 |
CA2458035C (en) | 2011-04-12 |
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