EP2054384A4 - Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate - Google Patents
Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rateInfo
- Publication number
- EP2054384A4 EP2054384A4 EP06795662A EP06795662A EP2054384A4 EP 2054384 A4 EP2054384 A4 EP 2054384A4 EP 06795662 A EP06795662 A EP 06795662A EP 06795662 A EP06795662 A EP 06795662A EP 2054384 A4 EP2054384 A4 EP 2054384A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- aryl
- positively charged
- skin penetration
- penetration rate
- charged water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2006/052815 WO2008020270A1 (en) | 2006-08-15 | 2006-08-15 | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2054384A1 EP2054384A1 (en) | 2009-05-06 |
EP2054384A4 true EP2054384A4 (en) | 2010-11-03 |
Family
ID=39081992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06795662A Pending EP2054384A4 (en) | 2006-08-15 | 2006-08-15 | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2054384A4 (en) |
JP (1) | JP5424880B2 (en) |
CN (1) | CN101506161B (en) |
AU (1) | AU2006347391B2 (en) |
CA (1) | CA2660814C (en) |
HK (1) | HK1137425A1 (en) |
WO (1) | WO2008020270A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
PL2041068T3 (en) * | 2006-07-18 | 2017-05-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
ES2466346T3 (en) | 2006-10-02 | 2014-06-10 | Techfields Biochem Co. Ltd | Prodrugs of water soluble prostaglandins with positive charge and compounds related to very high skin penetration rates |
AU2006350707A1 (en) | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
ES2633020T3 (en) | 2006-12-10 | 2017-09-18 | Yu, Chongxi-Techfields Biochem | Systems for transdermal administration of beta-lactam antibiotics |
EP3181132A1 (en) | 2007-01-15 | 2017-06-21 | Chongxi Yu | Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates |
AU2007345952C1 (en) | 2007-01-31 | 2017-06-08 | Chongxi Yu | Positively charged water-soluble prodrugs of 1H-imidazo[4, 5-c]quinolin-4-amines and related compounds with very high skin penetration rates |
RU2509076C2 (en) | 2007-06-04 | 2014-03-10 | Текфилдз Инк | Prodrugs of nonsteroid anti-inflammatory agents (nsaia) with very high speed of penetration through skin and membranes, and new medical applications of above said prodrugs |
BR122021011394B1 (en) * | 2008-12-04 | 2021-09-28 | Chongxi Yu | HIGH PENETRATION COMPOSITION OF A MAIN DRUG, AND USE OF A HPC |
RU2627065C2 (en) | 2009-05-08 | 2017-08-03 | Текфилдз Байокем Ко., Лтд. | Prodrug compositions with high degree of penetration based on peptides and related compounds |
US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
AU2013262320B2 (en) | 2012-05-16 | 2018-02-22 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
JP2016516018A (en) | 2013-03-15 | 2016-06-02 | テックフィールズ ファーマ カンパニー リミテッド | Novel high-permeability drug and its composition for treating Parkinson's disease |
JP5940036B2 (en) * | 2013-10-08 | 2016-06-29 | テックフィールズ バイオケム カンパニー リミテッド | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin permeability |
EA201790806A1 (en) | 2014-11-05 | 2017-11-30 | Флексус Байосайенсиз, Инк. | IMMUNOREGULATING AGENTS |
US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
JP6290947B2 (en) * | 2016-02-05 | 2018-03-07 | テックフィールズ バイオケム カンパニー リミテッド | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin permeability |
US11186596B2 (en) | 2018-04-26 | 2021-11-30 | Adt Pharmaceuticals, Llc | Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses |
US20220274911A1 (en) * | 2020-09-09 | 2022-09-01 | Nanjing Heron Pharmaceutical Science And Technology Co., Ltd. | Arylpropionic acid derivative, pharmaceutical composition and preparation method and application thereof |
CN117916219A (en) * | 2021-07-06 | 2024-04-19 | 石家庄迪斯凯威医药科技有限公司 | Quaternary amine salt compound for resisting bladder cancer and application thereof |
WO2023046078A1 (en) * | 2021-09-24 | 2023-03-30 | 石家庄迪斯凯威医药科技有限公司 | Novel pranoprofen derivative, and pharmaceutical composition and use thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1377316A (en) * | 1972-06-27 | 1974-12-11 | Syntex Corp | Dialkylaminoalkyl esters of arylaliphatic acids and acid addition salts thereof |
US3896145A (en) * | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
GB1573322A (en) * | 1975-12-24 | 1980-08-20 | Hisamitsu Pharmaceutical Co | Phenylactic acid ester derivatives |
JPS58126846A (en) * | 1982-01-22 | 1983-07-28 | Kaken Pharmaceut Co Ltd | Propionic acid aminoalkyl ester derivative, its preparation and antiphlogistic and analgesic agent containing said derivative as active component |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1593024A (en) * | 1968-09-18 | 1970-05-25 | ||
ZA738203B (en) * | 1972-10-24 | 1975-05-28 | Janssen Pharmaceutica Nv | Aroyl-substituted phenylacetic acid derivatives |
IT1090782B (en) * | 1977-11-30 | 1985-06-26 | Menarini Sas | 2 4 BIPHENYLIL 2 DIETHYLAMIN ALCHYL PROPIONAMIDE ITS SALTS AND RELATED MANUFACTURING PROCEDURES |
JPS6452742A (en) * | 1987-04-27 | 1989-02-28 | Syntex Pharma Int | Omega-quaternary ammonium alkyl ester and thioester of acidic non-steroidal antiinflammatory |
IT1317826B1 (en) * | 2000-02-11 | 2003-07-15 | Dompe Spa | AMIDES, USEFUL IN THE INHIBITION OF THE CHEMOTAXIS OF NEUTROPHILES INDUCED BY IL-8. |
ITMI20010395A1 (en) * | 2001-02-27 | 2002-08-27 | Dompe Spa | OMEGA-AMINO ALKYLAMIDS OF R-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF CHEMOTAXIS OF POLYMORPHONUCLEATED AND MONONUCLEATE CELLS |
ITMI20012025A1 (en) * | 2001-09-28 | 2003-03-28 | Dompe Spa | QUATERNARY AMMONIUM SALTS OF OMEGA-AMINO ALKYLAMIDS OF R 2-ARY-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
2006
- 2006-08-15 JP JP2009524242A patent/JP5424880B2/en not_active Expired - Fee Related
- 2006-08-15 CN CN2006800556054A patent/CN101506161B/en active Active
- 2006-08-15 CA CA2660814A patent/CA2660814C/en active Active
- 2006-08-15 AU AU2006347391A patent/AU2006347391B2/en not_active Ceased
- 2006-08-15 WO PCT/IB2006/052815 patent/WO2008020270A1/en active Application Filing
- 2006-08-15 EP EP06795662A patent/EP2054384A4/en active Pending
-
2010
- 2010-01-28 HK HK10100928.5A patent/HK1137425A1/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1377316A (en) * | 1972-06-27 | 1974-12-11 | Syntex Corp | Dialkylaminoalkyl esters of arylaliphatic acids and acid addition salts thereof |
US3896145A (en) * | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
GB1573322A (en) * | 1975-12-24 | 1980-08-20 | Hisamitsu Pharmaceutical Co | Phenylactic acid ester derivatives |
JPS58126846A (en) * | 1982-01-22 | 1983-07-28 | Kaken Pharmaceut Co Ltd | Propionic acid aminoalkyl ester derivative, its preparation and antiphlogistic and analgesic agent containing said derivative as active component |
Non-Patent Citations (5)
Title |
---|
JARKKO RAUTIO ET AL: "Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 11, no. 2, 1 August 2000 (2000-08-01), pages 157 - 163, XP055049945, ISSN: 0928-0987, DOI: 10.1016/S0928-0987(00)00090-7 * |
KAGAKU: "JPS58126846A -PROPIONIC ACID AMINOALKYL ESTER DERIVATIVE, ITS PREPARATION AND ANTIPHLOGISTIC AND ANALGESIC AGENT CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT", 28 July 1983 (1983-07-28), XP055442267, Retrieved from the Internet <URL:file:///C:/Users/MH52034/Desktop/JPS58126846%20translation.pdf> [retrieved on 20180118] * |
No further relevant documents disclosed * |
See also references of WO2008020270A1 * |
SHANBHAG V R: "ESTER AND AMIDE PRODRUGS OF IBUPROFEN AND NAPROXEN: SYNTHESIS, ANTI-INFLAMMATORY ACTIVITY, AND GASTROINTESTINAL TOXICITY", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION, WASHINGTON, US, vol. 81, no. 2, 1 February 1992 (1992-02-01), pages 149 - 154, XP000248778, ISSN: 0022-3549, DOI: 10.1002/JPS.2600810210 * |
Also Published As
Publication number | Publication date |
---|---|
CN101506161A (en) | 2009-08-12 |
AU2006347391A1 (en) | 2008-02-21 |
AU2006347391B2 (en) | 2013-03-07 |
JP2010500989A (en) | 2010-01-14 |
EP2054384A1 (en) | 2009-05-06 |
CA2660814A1 (en) | 2008-02-21 |
HK1137425A1 (en) | 2010-07-30 |
CA2660814C (en) | 2017-07-18 |
JP5424880B2 (en) | 2014-02-26 |
WO2008020270A1 (en) | 2008-02-21 |
CN101506161B (en) | 2013-11-13 |
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