HK1136814A1 - Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate - Google Patents

Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate

Info

Publication number
HK1136814A1
HK1136814A1 HK10100503.8A HK10100503A HK1136814A1 HK 1136814 A1 HK1136814 A1 HK 1136814A1 HK 10100503 A HK10100503 A HK 10100503A HK 1136814 A1 HK1136814 A1 HK 1136814A1
Authority
HK
Hong Kong
Prior art keywords
diflunisal
positively charged
related compounds
skin penetration
penetration rate
Prior art date
Application number
HK10100503.8A
Other languages
Chinese (zh)
Inventor
于崇曦
徐麗娜
Original Assignee
于崇曦
上海泰飛爾生化技術有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 于崇曦, 上海泰飛爾生化技術有限公司 filed Critical 于崇曦
Publication of HK1136814A1 publication Critical patent/HK1136814A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
HK10100503.8A 2006-07-26 2010-01-18 Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate HK1136814A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2006/052563 WO2008012603A1 (en) 2006-07-26 2006-07-26 Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate

Publications (1)

Publication Number Publication Date
HK1136814A1 true HK1136814A1 (en) 2010-07-09

Family

ID=38981173

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10100503.8A HK1136814A1 (en) 2006-07-26 2010-01-18 Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate
HK16105026.9A HK1217015A1 (en) 2006-07-26 2016-05-03 Prodrugs of positively charged water-soluble diflunisal and related compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK16105026.9A HK1217015A1 (en) 2006-07-26 2016-05-03 Prodrugs of positively charged water-soluble diflunisal and related compounds

Country Status (3)

Country Link
CN (1) CN101500983B (en)
HK (2) HK1136814A1 (en)
WO (1) WO2008012603A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
ES2466346T3 (en) 2006-10-02 2014-06-10 Techfields Biochem Co. Ltd Prodrugs of water soluble prostaglandins with positive charge and compounds related to very high skin penetration rates
AU2006350707A1 (en) 2006-11-08 2008-05-15 Chongxi Yu Transdermal delivery systems of peptides and related compounds
ES2633020T3 (en) 2006-12-10 2017-09-18 Yu, Chongxi-Techfields Biochem Systems for transdermal administration of beta-lactam antibiotics
EP3181132A1 (en) 2007-01-15 2017-06-21 Chongxi Yu Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates
AU2007345952C1 (en) 2007-01-31 2017-06-08 Chongxi Yu Positively charged water-soluble prodrugs of 1H-imidazo[4, 5-c]quinolin-4-amines and related compounds with very high skin penetration rates
RU2509076C2 (en) 2007-06-04 2014-03-10 Текфилдз Инк Prodrugs of nonsteroid anti-inflammatory agents (nsaia) with very high speed of penetration through skin and membranes, and new medical applications of above said prodrugs
BR122021011394B1 (en) * 2008-12-04 2021-09-28 Chongxi Yu HIGH PENETRATION COMPOSITION OF A MAIN DRUG, AND USE OF A HPC
CA2755069A1 (en) 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
RU2627065C2 (en) 2009-05-08 2017-08-03 Текфилдз Байокем Ко., Лтд. Prodrug compositions with high degree of penetration based on peptides and related compounds
US9969751B2 (en) 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
AU2013262320B2 (en) 2012-05-16 2018-02-22 Techfields Pharma Co., Ltd. High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
JP2016516018A (en) * 2013-03-15 2016-06-02 テックフィールズ ファーマ カンパニー リミテッド Novel high-permeability drug and its composition for treating Parkinson's disease
US9862698B2 (en) 2014-12-16 2018-01-09 Adt Pharmaceuticals, Inc. Indenyl compounds, pharmaceutical compositions, and medical uses thereof
US20160168108A1 (en) 2014-12-16 2016-06-16 Adt Pharmaceuticals, Inc. Method of treating or preventing ras-mediated diseases
CN106924272B (en) * 2015-12-31 2021-04-13 中国医学科学院药物研究所 Application of methyl salicylate glucoside in preparation of medicines for preventing and/or treating systemic lupus erythematosus and complications thereof
US11186596B2 (en) 2018-04-26 2021-11-30 Adt Pharmaceuticals, Llc Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses
CN113999126A (en) * 2021-12-03 2022-02-01 浙江东亚药业股份有限公司 Preparation method of trimebutine
WO2023134732A1 (en) * 2022-01-17 2023-07-20 Techfields Pharma Co., Ltd. Prevention or treatment of cardiovascular diseases with high penetration prodrugs of aspirin and other nsaids
CN117776940A (en) * 2022-09-28 2024-03-29 浙江越甲药业有限公司 Benzoic acid ester derivatives

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Publication number Priority date Publication date Assignee Title
US3488380A (en) * 1966-03-30 1970-01-06 Bristol Myers Co Carbamate esters and their method of preparation
US3476791A (en) * 1966-05-04 1969-11-04 Trustees Of Ohio State Univ Th O-thiocarbamoyl benzoic acid esters
AU2004201178A1 (en) * 1999-02-26 2004-04-22 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US7985422B2 (en) * 2002-08-05 2011-07-26 Torrent Pharmaceuticals Limited Dosage form
US20050272108A1 (en) * 2004-05-21 2005-12-08 Bhanu Kalra Stabilized two component system for chemiluminescent assay in immunodiagnostics

Also Published As

Publication number Publication date
CN101500983A (en) 2009-08-05
WO2008012603A1 (en) 2008-01-31
CN101500983B (en) 2015-09-16
HK1217015A1 (en) 2016-12-16

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