HK1217015A1 - Prodrugs of positively charged water-soluble diflunisal and related compounds - Google Patents

Prodrugs of positively charged water-soluble diflunisal and related compounds

Info

Publication number
HK1217015A1
HK1217015A1 HK16105026.9A HK16105026A HK1217015A1 HK 1217015 A1 HK1217015 A1 HK 1217015A1 HK 16105026 A HK16105026 A HK 16105026A HK 1217015 A1 HK1217015 A1 HK 1217015A1
Authority
HK
Hong Kong
Prior art keywords
diflunisal
prodrugs
soluble
positively charged
related compounds
Prior art date
Application number
HK16105026.9A
Other languages
Chinese (zh)
Inventor
于崇曦
徐麗娜
Original Assignee
Yu Chongxi
Techfields Biochem Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201510594436.2A external-priority patent/CN105439877B/en
Application filed by Yu Chongxi, Techfields Biochem Co Ltd filed Critical Yu Chongxi
Publication of HK1217015A1 publication Critical patent/HK1217015A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16105026.9A 2006-07-26 2016-05-03 Prodrugs of positively charged water-soluble diflunisal and related compounds HK1217015A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510594436.2A CN105439877B (en) 2006-07-26 2006-07-26 The prodrug of positively charged water-soluble Diflunisal and related compound
PCT/IB2006/052563 WO2008012603A1 (en) 2006-07-26 2006-07-26 Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate
CN200680055458.0A CN101500983B (en) 2006-07-26 2006-07-26 Positively charged water-soluble prodrugs of diflunisal and related compounds with fast skin penetration rate

Publications (1)

Publication Number Publication Date
HK1217015A1 true HK1217015A1 (en) 2016-12-16

Family

ID=38981173

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10100503.8A HK1136814A1 (en) 2006-07-26 2010-01-18 Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate
HK16105026.9A HK1217015A1 (en) 2006-07-26 2016-05-03 Prodrugs of positively charged water-soluble diflunisal and related compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK10100503.8A HK1136814A1 (en) 2006-07-26 2010-01-18 Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate

Country Status (3)

Country Link
CN (1) CN101500983B (en)
HK (2) HK1136814A1 (en)
WO (1) WO2008012603A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
ES2466346T3 (en) 2006-10-02 2014-06-10 Techfields Biochem Co. Ltd Prodrugs of water soluble prostaglandins with positive charge and compounds related to very high skin penetration rates
AU2006350707A1 (en) 2006-11-08 2008-05-15 Chongxi Yu Transdermal delivery systems of peptides and related compounds
PL2121593T3 (en) 2006-12-10 2015-11-30 Chongxi Yu Transdermal delivery systems of beta-lactam antibiotics
EP3181132A1 (en) 2007-01-15 2017-06-21 Chongxi Yu Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates
PL2115140T3 (en) 2007-01-31 2017-03-31 Yu Positively charged water-soluble prodrugs of 1H-imidazo[4,5-c]quinolin-4-amines and related compounds with very high skin penetration rates
US9371284B2 (en) 2007-06-04 2016-06-21 Techfields Pharma Co., Ltd. Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses
KR20230085223A (en) * 2008-12-04 2023-06-13 충시 위 High Penetration Compositions and Their Applications
US8575217B2 (en) 2009-03-16 2013-11-05 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
CN102459313A (en) 2009-05-08 2012-05-16 上海泰飞尔生化技术有限公司 High penetration prodrug compositions of peptides and peptide-related compounds
US9969751B2 (en) 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
KR102309973B1 (en) 2012-05-16 2021-10-06 테크필즈 파마 코., 엘티디. High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
JP2016516018A (en) 2013-03-15 2016-06-02 テックフィールズ ファーマ カンパニー リミテッド Novel high-permeability drug and its composition for treating Parkinson's disease
US20160168108A1 (en) 2014-12-16 2016-06-16 Adt Pharmaceuticals, Inc. Method of treating or preventing ras-mediated diseases
US9862698B2 (en) 2014-12-16 2018-01-09 Adt Pharmaceuticals, Inc. Indenyl compounds, pharmaceutical compositions, and medical uses thereof
CN106924272B (en) * 2015-12-31 2021-04-13 中国医学科学院药物研究所 Application of methyl salicylate glucoside in preparation of medicines for preventing and/or treating systemic lupus erythematosus and complications thereof
JP7169008B2 (en) 2018-04-26 2022-11-10 エーディーティー ファーマシューティカルズ，エルエルシー Anti-Cancer Indene, Indane, Azaindene, Azaindane, Pharmaceutical Compositions and Uses
CN113999126B (en) * 2021-12-03 2024-05-24 浙江东亚药业股份有限公司 Preparation method of trimebutine
WO2023134732A1 (en) * 2022-01-17 2023-07-20 Techfields Pharma Co., Ltd. Prevention or treatment of cardiovascular diseases with high penetration prodrugs of aspirin and other nsaids
CN115448905B (en) * 2022-09-28 2023-06-09 浙江越甲药业有限公司 Benzoic acid ester derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3488380A (en) * 1966-03-30 1970-01-06 Bristol Myers Co Carbamate esters and their method of preparation
US3476791A (en) * 1966-05-04 1969-11-04 Trustees Of Ohio State Univ Th O-thiocarbamoyl benzoic acid esters
AU2004201178A1 (en) * 1999-02-26 2004-04-22 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US7985422B2 (en) * 2002-08-05 2011-07-26 Torrent Pharmaceuticals Limited Dosage form
WO2006076034A2 (en) * 2004-05-21 2006-07-20 Bhanu, Kalra Stabilized two component system for chemilumiescent assay in immunodiagnostics

Also Published As

Publication number Publication date
WO2008012603A1 (en) 2008-01-31
CN101500983B (en) 2015-09-16
CN101500983A (en) 2009-08-05
HK1136814A1 (en) 2010-07-09

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