IT9022088A0 - 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliirossi-al-chil)aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil-propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono. - Google Patents

1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliirossi-al-chil)aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil-propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono.

Info

Publication number
IT9022088A0
IT9022088A0 IT9022088A IT2208890A IT9022088A0 IT 9022088 A0 IT9022088 A0 IT 9022088A0 IT 9022088 A IT9022088 A IT 9022088A IT 2208890 A IT2208890 A IT 2208890A IT 9022088 A0 IT9022088 A0 IT 9022088A0
Authority
IT
Italy
Prior art keywords
mono
hydroxy
polyyroxy
aminocarbonil
triiod
Prior art date
Application number
IT9022088A
Other languages
English (en)
Other versions
IT1245853B (it
IT9022088A1 (it
Inventor
Fulvio Uggeri
Marino Brocchetta
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Publication of IT9022088A0 publication Critical patent/IT9022088A0/it
Priority to IT02208890A priority Critical patent/IT1245853B/it
Priority to IS3781A priority patent/IS3781A7/is
Priority to NZ240566A priority patent/NZ240566A/en
Priority to IL10005491A priority patent/IL100054A/en
Priority to DE0557345T priority patent/DE557345T1/de
Priority to HU9301375A priority patent/HUT65652A/hu
Priority to DK91919864.8T priority patent/DK0557345T3/da
Priority to EP91919864A priority patent/EP0557345B1/en
Priority to MX9102103A priority patent/MX9102103A/es
Priority to AT91919864T priority patent/ATE111441T1/de
Priority to ZA919065A priority patent/ZA919065B/xx
Priority to IE398691A priority patent/IE66460B1/en
Priority to DE69104059T priority patent/DE69104059T2/de
Priority to PCT/EP1991/002151 priority patent/WO1992008691A1/en
Priority to CA002096136A priority patent/CA2096136A1/en
Priority to ES91919864T priority patent/ES2060415T3/es
Priority to AU89253/91A priority patent/AU646119B2/en
Priority to JP3517985A priority patent/JP2977613B2/ja
Publication of IT9022088A1 publication Critical patent/IT9022088A1/it
Priority to KR1019930701423A priority patent/KR930702281A/ko
Priority to GR930300134T priority patent/GR930300134T1/el
Application granted granted Critical
Publication of IT1245853B publication Critical patent/IT1245853B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT02208890A 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono IT1245853B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT02208890A IT1245853B (it) 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
IS3781A IS3781A7 (is) 1990-11-16 1991-11-11 1,3-Bis-[3- (mono-eða poly-hydroxy) acylamino-5- (mono-eða poly-hydroxy-alkyl) aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- eða hydroxy-alkyl-própan efni, aðferðir til framleiðslu þeirra og röntgengeisla-skuggaefni sem innihalda þau
NZ240566A NZ240566A (en) 1990-11-16 1991-11-12 Symmetrical and asymmetrical 1,3-bis-[3-(mono- or
IL10005491A IL100054A (en) 1990-11-16 1991-11-14 1, 3 - Bite -] 3 -) Mono - or Poly - Hydroxy (Asylamino - 5 -) Mono - or Poly - Hydroxy - Alkyl (Aminocrobonyl - 2, 4, 6 - Triodo - Benzville - A
ZA919065A ZA919065B (en) 1990-11-16 1991-11-15 1,3-bis-(3-(mono-or poly-hydroxy)acylamino-5-(mono-or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino)-hydroxy-or hydroxyalkyl-propanes,their methods of preparation and x-ray contrast media containing them
PCT/EP1991/002151 WO1992008691A1 (en) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them
DK91919864.8T DK0557345T3 (da) 1990-11-16 1991-11-15 1,3-bis-(3-(mono- eller polyhydroxy)acylamino-5-(mono- eller polyhydroxyalkyl)aminocarbonyl-2,4,6- trijodbenzoylamino)-hydroxy- eller -hydroxyalkylpropaner, fremgangsmåder til fremstilling heraf samt røntgenkontrastmidler indeholdende disse
EP91919864A EP0557345B1 (en) 1990-11-16 1991-11-15 1,3-bis- 3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them
MX9102103A MX9102103A (es) 1990-11-16 1991-11-15 Compuestos de contraste para diagnosticos con rayos x, procedimiento para su preparacion y composiciones que los contienen.
AT91919864T ATE111441T1 (de) 1990-11-16 1991-11-15 1,3-bis-(3-(mono-(oder polyhydroxy)acylamino-5- (mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6- trijodobenzoylamino>-hydroxy- oder hydroxyalkyl- propane, deren herstellung und diese enthaltende röntgenkontrastmittel.
DE0557345T DE557345T1 (de) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel.
IE398691A IE66460B1 (en) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes their methods of preparation and X-ray contrast media containing them
DE69104059T DE69104059T2 (de) 1990-11-16 1991-11-15 1,3-bis-[3-(mono-[oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel.
HU9301375A HUT65652A (en) 1990-11-16 1991-11-15 Process for producing 1,3-bis-/3-(mono- or poly-hydroxy)acylamino-5-(mono-or polyhydroxyalkyl)-aminocarbonyl-2,4,6-triiodo-benzoyl-amino/-hydroxy- or hydroxyalkyl-propanes and x-ray contrast media containing them
CA002096136A CA2096136A1 (en) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- or poly-hydroxy)acylamino-5- (mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6- triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them
ES91919864T ES2060415T3 (es) 1990-11-16 1991-11-15 1,3-bis(3-(mono- o poli-hidroxi)acilamino-5-(mono- o polihidroxialquil)aminocarbonil-2,4,6-triyodo-benzoilamino)hidroxi- o hidroxialquil-propanos, procedimiento para su preparacion y medios de contraste para rayos x que los contienen.
AU89253/91A AU646119B2 (en) 1990-11-16 1991-11-15 1,3-bis-(3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino) -hydroxy- or hydroxyalkyl-propanes, their methods of preparation and X-ray contrast media containing them
JP3517985A JP2977613B2 (ja) 1990-11-16 1991-11-15 １，３−ビス−［３−（モノ−またはポリ−ヒドロキシ）アシルアミノ−５−（モノ−またはポリ−ヒドロキシアルキル）アミノカルボニル−２，４，６−トリヨ−ド−ベンゾイル−アミノ］−ヒドロキシ−またはヒドロキシアルキル−プロパン類、それらの製造法、およびそれらを含有する造影剤
KR1019930701423A KR930702281A (ko) 1990-11-16 1993-05-12 1,3-비스-[3-아미노카르보닐-2,4,6-트리요오도-벤조일-아미노]-히드록시- 또는 히드록시알킬-프로판, 그의 제조 방법 및 그를 함유하는 x선 조영 매체
GR930300134T GR930300134T1 (en) 1990-11-16 1994-02-28 1,3-bis- 3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino)-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02208890A IT1245853B (it) 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono

Publications (3)

Publication Number Publication Date
IT9022088A0 true IT9022088A0 (it) 1990-11-16
IT9022088A1 IT9022088A1 (it) 1992-05-17
IT1245853B IT1245853B (it) 1994-10-25

Family

ID=11191331

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02208890A IT1245853B (it) 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono

Country Status (19)

Country Link
EP (1) EP0557345B1 (it)
JP (1) JP2977613B2 (it)
KR (1) KR930702281A (it)
AT (1) ATE111441T1 (it)
AU (1) AU646119B2 (it)
CA (1) CA2096136A1 (it)
DE (2) DE557345T1 (it)
DK (1) DK0557345T3 (it)
ES (1) ES2060415T3 (it)
GR (1) GR930300134T1 (it)
HU (1) HUT65652A (it)
IE (1) IE66460B1 (it)
IL (1) IL100054A (it)
IS (1) IS3781A7 (it)
IT (1) IT1245853B (it)
MX (1) MX9102103A (it)
NZ (1) NZ240566A (it)
WO (1) WO1992008691A1 (it)
ZA (1) ZA919065B (it)

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Publication number Priority date Publication date Assignee Title
FR2717799B1 (fr) * 1994-03-22 1996-07-19 Guerbet Sa Composés polyiodes : procédé de préparation ; composition de diagnostic.
ATE365566T1 (de) 2001-12-20 2007-07-15 Bone Support Ab Neuer knochenmineralien-ersatzstoff
WO2006002873A2 (en) 2004-07-02 2006-01-12 Bracco Imaging Spa 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri )
US7407647B2 (en) 2005-12-07 2008-08-05 Cordis Corporation Organic radiographic contrasting agents for medical devices
US20070134163A1 (en) 2005-12-13 2007-06-14 Zhao Jonathon Z Radiographic contrasting agents and radio-opaque polymeric materials for medical devices
WO2007094677A1 (en) * 2006-02-14 2007-08-23 Ge Healthcare As Contrast agents
KR101555457B1 (ko) 2007-07-12 2015-09-23 지이 헬스케어 에이에스 조영제
EP2203189B1 (en) * 2007-10-12 2012-07-18 GE Healthcare AS Contrast agents
GB2453654A (en) * 2007-10-12 2009-04-15 Ge Healthcare As A compound for use in X-ray contrast examinations
EP2200655B1 (en) 2007-10-12 2012-07-18 GE Healthcare AS Contrast agents
ES2413160T3 (es) * 2007-10-12 2013-07-15 Ge Healthcare As Agentes de contraste
JP2011500533A (ja) 2007-10-12 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
WO2009056555A1 (en) * 2007-10-30 2009-05-07 Ge Healthcare As Contrast agents
JP2011506286A (ja) * 2007-12-05 2011-03-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
EP2247314A4 (en) * 2008-02-01 2013-11-27 Univ Boston CATIONIC CONTRASTING AGENTS AND METHOD FOR THEIR USE
US20110021824A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Adsorptive purification method for iodixanol
WO2016079330A1 (en) 2014-11-21 2016-05-26 Technical University Of Denmark Gel formulations for local drug release
US10610366B2 (en) 2015-01-29 2020-04-07 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
JP7086863B2 (ja) 2016-05-20 2022-06-20 テクニカル ユニバーシティ オブ デンマーク 触診可能なマーカー組成物
US10639157B2 (en) 2017-03-14 2020-05-05 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
US20220339285A1 (en) 2019-06-12 2022-10-27 Technical University Of Denmark Dissacharide formulations for controlled drug release

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1491129A (en) * 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
CH626873A5 (it) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel

Also Published As

Publication number Publication date
ES2060415T3 (es) 1994-11-16
GR930300134T1 (en) 1994-02-28
HUT65652A (en) 1994-07-28
WO1992008691A1 (en) 1992-05-29
JPH06504268A (ja) 1994-05-19
HU9301375D0 (en) 1993-09-28
DK0557345T3 (da) 1995-03-06
IL100054A0 (en) 1992-08-18
IE66460B1 (en) 1995-12-27
IT1245853B (it) 1994-10-25
IT9022088A1 (it) 1992-05-17
IL100054A (en) 1996-05-14
EP0557345A1 (en) 1993-09-01
AU8925391A (en) 1992-06-11
KR930702281A (ko) 1993-09-08
DE557345T1 (de) 1994-07-28
EP0557345B1 (en) 1994-09-14
DE69104059T2 (de) 1995-02-02
JP2977613B2 (ja) 1999-11-15
IE913986A1 (en) 1992-05-20
NZ240566A (en) 1994-02-25
AU646119B2 (en) 1994-02-10
ZA919065B (en) 1992-08-26
CA2096136A1 (en) 1992-05-17
IS3781A7 (is) 1992-05-17
MX9102103A (es) 1992-06-01
DE69104059D1 (de) 1994-10-20
ATE111441T1 (de) 1994-09-15

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Effective date: 19941129