DE69104059D1 - 1,3-bis-[3-(mono-[oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel. - Google Patents

1,3-bis-[3-(mono-[oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel.

Info

Publication number
DE69104059D1
DE69104059D1 DE69104059T DE69104059T DE69104059D1 DE 69104059 D1 DE69104059 D1 DE 69104059D1 DE 69104059 T DE69104059 T DE 69104059T DE 69104059 T DE69104059 T DE 69104059T DE 69104059 D1 DE69104059 D1 DE 69104059D1
Authority
DE
Germany
Prior art keywords
mono
hydroxy
polyhydroxyalkyl
aminocarbonyl
acylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69104059T
Other languages
English (en)
Other versions
DE69104059T2 (de
Inventor
Fulvio Uggeri
Marino Brocchetta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Application granted granted Critical
Publication of DE69104059D1 publication Critical patent/DE69104059D1/de
Publication of DE69104059T2 publication Critical patent/DE69104059T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69104059T 1990-11-16 1991-11-15 1,3-bis-[3-(mono-[oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel. Expired - Fee Related DE69104059T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT02208890A IT1245853B (it) 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
PCT/EP1991/002151 WO1992008691A1 (en) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them

Publications (2)

Publication Number Publication Date
DE69104059D1 true DE69104059D1 (de) 1994-10-20
DE69104059T2 DE69104059T2 (de) 1995-02-02

Family

ID=11191331

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0557345T Pending DE557345T1 (de) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel.
DE69104059T Expired - Fee Related DE69104059T2 (de) 1990-11-16 1991-11-15 1,3-bis-[3-(mono-[oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0557345T Pending DE557345T1 (de) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel.

Country Status (19)

Country Link
EP (1) EP0557345B1 (de)
JP (1) JP2977613B2 (de)
KR (1) KR930702281A (de)
AT (1) ATE111441T1 (de)
AU (1) AU646119B2 (de)
CA (1) CA2096136A1 (de)
DE (2) DE557345T1 (de)
DK (1) DK0557345T3 (de)
ES (1) ES2060415T3 (de)
GR (1) GR930300134T1 (de)
HU (1) HUT65652A (de)
IE (1) IE66460B1 (de)
IL (1) IL100054A (de)
IS (1) IS3781A7 (de)
IT (1) IT1245853B (de)
MX (1) MX9102103A (de)
NZ (1) NZ240566A (de)
WO (1) WO1992008691A1 (de)
ZA (1) ZA919065B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717799B1 (fr) * 1994-03-22 1996-07-19 Guerbet Sa Composés polyiodes : procédé de préparation ; composition de diagnostic.
ES2289172T3 (es) 2001-12-20 2008-02-01 Bone Support Ab Un nuevo sustituto mineral de hueso.
ATE430146T1 (de) * 2004-07-02 2009-05-15 Bracco Imaging Spa Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten
US7407647B2 (en) * 2005-12-07 2008-08-05 Cordis Corporation Organic radiographic contrasting agents for medical devices
US20070134163A1 (en) 2005-12-13 2007-06-14 Zhao Jonathon Z Radiographic contrasting agents and radio-opaque polymeric materials for medical devices
EP1989178B1 (de) * 2006-02-14 2012-10-31 Ge Healthcare As Kontrastmittel
AU2008273037B2 (en) 2007-07-12 2012-11-15 Ge Healthcare As Contrast agents
US20100221192A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
GB2453654A (en) * 2007-10-12 2009-04-15 Ge Healthcare As A compound for use in X-ray contrast examinations
CN101820923A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
WO2009047316A1 (en) 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
CN101820924A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 造影剂
CN101842120A (zh) * 2007-10-30 2010-09-22 通用电气医疗集团股份有限公司 造影剂
EP2231200A1 (de) * 2007-12-05 2010-09-29 GE Healthcare AS Kontrastmittel
EP2247314A4 (de) * 2008-02-01 2013-11-27 Univ Boston Kationische kontrastmittel und verfahren zu ihrer verwendung
US20110021824A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Adsorptive purification method for iodixanol
EP3220887A1 (de) 2014-11-21 2017-09-27 Technical University of Denmark Gelformulierungen zur lokalen arzneistoffabgabe
WO2016123583A1 (en) 2015-01-29 2016-08-04 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
WO2017198858A1 (en) 2016-05-20 2017-11-23 Technical University Of Denmark Palpable marker composition
US10639157B2 (en) 2017-03-14 2020-05-05 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
EP3982922A1 (de) 2019-06-12 2022-04-20 Technical University of Denmark Dissacharid-formulierungen zur kontrollierten arzneimittelfreisetzung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1491129A (en) * 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
CH626873A5 (de) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel

Also Published As

Publication number Publication date
IS3781A7 (is) 1992-05-17
CA2096136A1 (en) 1992-05-17
EP0557345B1 (de) 1994-09-14
IT9022088A0 (it) 1990-11-16
JPH06504268A (ja) 1994-05-19
DK0557345T3 (da) 1995-03-06
WO1992008691A1 (en) 1992-05-29
KR930702281A (ko) 1993-09-08
IL100054A (en) 1996-05-14
NZ240566A (en) 1994-02-25
DE69104059T2 (de) 1995-02-02
IE913986A1 (en) 1992-05-20
EP0557345A1 (de) 1993-09-01
IT1245853B (it) 1994-10-25
IT9022088A1 (it) 1992-05-17
ATE111441T1 (de) 1994-09-15
HUT65652A (en) 1994-07-28
AU646119B2 (en) 1994-02-10
GR930300134T1 (en) 1994-02-28
DE557345T1 (de) 1994-07-28
MX9102103A (es) 1992-06-01
ZA919065B (en) 1992-08-26
JP2977613B2 (ja) 1999-11-15
IE66460B1 (en) 1995-12-27
HU9301375D0 (en) 1993-09-28
AU8925391A (en) 1992-06-11
ES2060415T3 (es) 1994-11-16
IL100054A0 (en) 1992-08-18

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee