IT1277934B1 - Processo per la cristallizzazione da acqua della s-n,n' -bis- ( 2-idrossi -1 -(idrossimetil) etil) -5- ((2 -idrossi -1- ossopropil) - Google Patents
Processo per la cristallizzazione da acqua della s-n,n' -bis- ( 2-idrossi -1 -(idrossimetil) etil) -5- ((2 -idrossi -1- ossopropil)Info
- Publication number
- IT1277934B1 IT1277934B1 ITRM950599A IT1277934B1 IT 1277934 B1 IT1277934 B1 IT 1277934B1 IT RM950599 A ITRM950599 A IT RM950599A IT 1277934 B1 IT1277934 B1 IT 1277934B1
- Authority
- IT
- Italy
- Prior art keywords
- solution
- crystallisation
- crystalline
- deionised water
- prepn
- Prior art date
Links
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 title abstract 3
- 238000002425 crystallisation Methods 0.000 title abstract 2
- 239000008367 deionised water Substances 0.000 title abstract 2
- 229960004647 iopamidol Drugs 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 239000013078 crystal Substances 0.000 abstract 3
- 239000007810 chemical reaction solvent Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000003226 decolorizating effect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95RM000599 IT1277934B1 (it) | 1995-09-08 | 1995-09-08 | Processo per la cristallizzazione da acqua della s-n,n' -bis- ( 2-idrossi -1 -(idrossimetil) etil) -5- ((2 -idrossi -1- ossopropil) |
DE69605528T DE69605528T2 (de) | 1995-09-08 | 1996-08-02 | Verfahren zur kristallisierung aus wasser von (s)-n,n'-bis[2-hydroxy-1-(hydroxymethiel)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzoldicarboxamide |
PL96320027A PL184937B1 (pl) | 1995-09-08 | 1996-08-02 | Sposób┴wytwarzania┴krystalicznej┴bezwodnej┴postaci┴(S)-NĆN'-bis[2-hydroksy-1-(hydroksymetylo)┴etylo]-5-[(2-hydroksy-1-oksopropylo)┴amino]-2Ć4Ć6-trijodo-1Ć3-benzenodikarboksyamidu |
CZ19971385A CZ288645B6 (cs) | 1995-09-08 | 1996-08-02 | Způsob krystalizace Iopamidolu |
ES96928403T ES2140887T3 (es) | 1995-09-08 | 1996-08-02 | Procedimiento para cristalizar en agua (s)-n-n'-bis(2-hidroxi-1-(hidroximetil)etil)-5-((2-hidroxi-1-oxopropil)amino)-2,4,6-triyodo-1,3-bencenodicarboxamida. |
EP96928403A EP0790979B1 (en) | 1995-09-08 | 1996-08-02 | Process for the crystallization from water of (s)-n,n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide |
CN96191028A CN1070843C (zh) | 1995-09-08 | 1996-08-02 | (s)-n,n'-二[2-羟基-1-(羟甲基)乙基)-5-[(2-羟基-1-氧代丙基)氨基]-2,4,6-三碘-1,3-苯二羧酰胺从水中结晶的方法 |
JP50604597A JP4070235B2 (ja) | 1995-09-08 | 1996-08-02 | (s)−n,n’−ビス[2−ヒドロキシ−1−(ヒドロキシメチル)エチル]−5−[(2−ヒドロキシ−1−オキソプロピル)アミノ]−2,4,6−トリヨード−1,3−ベンゼンジカルボキサアミドの、水からの結晶化方法 |
HU9801837A HU220965B1 (hu) | 1995-09-08 | 1996-08-02 | Eljárás (S)-N,N'-bisz[2-hidroxi-1-(hidroxi-metil)-etil]-5-[(2-hidroxi-1-oxo-propil)-amino]-2,4,6-trijód-1,3-benzol-dikarboxamid vízből való kristályosítására |
KR1019970702994A KR100270411B1 (ko) | 1995-09-08 | 1996-08-02 | (s)-n,n'-비스[2-히드록시-1-(히드록시메틸)에틸-5-[(2-히드록시-1-옥소프로필)아미노]-2,4,6-트리요오도-1,3-벤젠디카복사미드의물로부터의결정화방법 |
CA002204734A CA2204734C (en) | 1995-09-08 | 1996-08-02 | Process for the crystallization from water of (s)-n,n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide |
BR9606624A BR9606624A (pt) | 1995-09-08 | 1996-08-02 | Processo para a cristalização de (s)-n,n'-bisÚ2-hidróxi-1-(hidroximetil)etil¾-5-Ú(2-hidróxi-1-oxopropil)amino¾-2,4,6-triiodo-1,3-benzonodicar-boxamida a partir de água |
AT96928403T ATE187437T1 (de) | 1995-09-08 | 1996-08-02 | Verfahren zur kristallisierung aus wasser von (s)-n,n'-bis(2-hydroxy-1-(hydroxymethiel)ethyl> 5-((2-hydroxy-1-oxopropyl)amino>-2,4,6-triiodo- ,3- benzoldicarboxamide |
PCT/EP1996/003399 WO1997009300A1 (en) | 1995-09-08 | 1996-08-02 | Process for the crystallization from water of (s)-n,n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide |
AU67888/96A AU708195B2 (en) | 1995-09-08 | 1996-08-02 | Process for the crystallization from water of (S)-N,N'-bis{2-hydroxy-1-(hydroxymethyl)ethyl}-5-{(2-hydroxy -1-oxopropyl)amino}-2,4,6-triiodo-1,3-benzendicarboxamide |
IN1552MA1996 IN182280B (he) | 1995-09-08 | 1996-09-04 | |
ZA967504A ZA967504B (en) | 1995-09-08 | 1996-09-05 | Process for the crystallization fromwater of (s)-n,n'-bis[2-hydroxy-1-(hydroxymethyl]-5-[(2-hydroxy-1-oxo-propyl)amino]-2,4,6-triiodo-1,3-benzendicarboxymide |
US08/708,668 US5689002A (en) | 1995-09-08 | 1996-09-05 | Process for the crystallization from water of (S)-N,N'-bis 2-hydroxy-1-(hydroxymethyl)ethyl!-5- 2-hydroxy-1-oxopropyl)amino!-2,4,6-triiodo-1,3-benzendicarboxamide |
NO971863A NO308841B1 (no) | 1995-09-08 | 1997-04-23 | FremgangsmÕte ved krystallisasjon av (S)-N,N'-bis[2-hydroksy- 1-(hydroksymetyl)etyl]-5[(2-hydroksy-1-oksopropyl)amino]-2,4,6- trijod-1,3-benzendikarboksamid fra vann, samt anvendelser av (C1- C4-alkoholer |
MXPA/A/1997/003341A MXPA97003341A (en) | 1995-09-08 | 1997-05-07 | Process for the crystallization of (s) -n, n'-bis [2-hydroxy-1- (hydroxymethyl) ethyl] -5 - [(2-hydroxy-1-oxopropyl) amino] -2,4,6-triyodo -1,3-bencendicarboxamide from a |
HK98100990A HK1001861A1 (en) | 1995-09-08 | 1998-02-10 | Process for the crystallization from water of (s)-n,n'-bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydroxy-1-oxopropyl)amino)-2,4,6-triiodo-1,3-benzendicarboxamide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95RM000599 IT1277934B1 (it) | 1995-09-08 | 1995-09-08 | Processo per la cristallizzazione da acqua della s-n,n' -bis- ( 2-idrossi -1 -(idrossimetil) etil) -5- ((2 -idrossi -1- ossopropil) |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM950599A0 ITRM950599A0 (he) | 1995-09-08 |
ITRM950599A1 ITRM950599A1 (it) | 1997-03-08 |
IT1277934B1 true IT1277934B1 (it) | 1997-11-12 |
Family
ID=11403553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT95RM000599 IT1277934B1 (it) | 1995-09-08 | 1995-09-08 | Processo per la cristallizzazione da acqua della s-n,n' -bis- ( 2-idrossi -1 -(idrossimetil) etil) -5- ((2 -idrossi -1- ossopropil) |
Country Status (3)
Country | Link |
---|---|
IN (1) | IN182280B (he) |
IT (1) | IT1277934B1 (he) |
ZA (1) | ZA967504B (he) |
-
1995
- 1995-09-08 IT IT95RM000599 patent/IT1277934B1/it active IP Right Grant
-
1996
- 1996-09-04 IN IN1552MA1996 patent/IN182280B/en unknown
- 1996-09-05 ZA ZA967504A patent/ZA967504B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ITRM950599A0 (he) | 1995-09-08 |
IN182280B (he) | 1999-02-27 |
ZA967504B (en) | 1997-03-10 |
ITRM950599A1 (it) | 1997-03-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE2556736C2 (de) | Cephemverbindungen und sie enthaltende Arzneimittel | |
RU2451667C1 (ru) | Новый способ получения иопромида | |
EP1960349B1 (en) | Purification of iodixanol | |
RU2178415C2 (ru) | Усовершенствованный способ получения n-[3-(3-цианопиразоло[1,5-а]пиримидин-7-ил)фенил]-n-этил-ацетамида | |
CA2356942A1 (en) | Preparation of iodixanol | |
JP2005509025A5 (he) | ||
DE2927672A1 (de) | Verfahren zur herstellung des d-kampferats von l-carnitinamid und des d-kampferats von d-carnitinamid | |
WO2008104853A1 (en) | Processes for the preparation of pure ioversol | |
IT1277934B1 (it) | Processo per la cristallizzazione da acqua della s-n,n' -bis- ( 2-idrossi -1 -(idrossimetil) etil) -5- ((2 -idrossi -1- ossopropil) | |
IT1277950B1 (it) | Processo per la cristallizzazione da acqua della s-n,n'-bis (2-idrossi -1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino).2,4,6- | |
CN108191690A (zh) | 碘海醇节能环保的连续化制备方法 | |
JP2007521262A (ja) | イオヘキソールの製造方法 | |
JPS5822470B2 (ja) | 光学活性フエニルグリシンアミドと光学活性フエニルグリシンとの混合物を分離する方法 | |
US6500341B2 (en) | Process for the purification of water-soluble non-ionic contrast agents | |
AU708195B2 (en) | Process for the crystallization from water of (S)-N,N'-bis{2-hydroxy-1-(hydroxymethyl)ethyl}-5-{(2-hydroxy -1-oxopropyl)amino}-2,4,6-triiodo-1,3-benzendicarboxamide | |
US5817861A (en) | Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media | |
CA2710095C (en) | Method for reducing aminoisophthalic acid bisamide related impurities in preparation of non-ionic x-ray contrast agents | |
JP2013535435A (ja) | 造影剤の製造方法 | |
JP3759411B2 (ja) | 4−シアノ−3−ヒドロキシブタノイルヒドラジン類、その誘導体およびその製造方法 | |
KR20200077744A (ko) | 조영제 중간체의 신규 제조방법 및 이를 이용한 조영제의 제조방법 | |
JP4190032B2 (ja) | アミノアルコールを精製する方法 | |
DE966428T1 (de) | Verfahren zur kritallisation von (s)-n-n'-bis [2-hydroxy-1-(hydroxymethyl) ethyl]-5-[(2-hydroxy-1-xopropyl) amino]-2,4,6-trirodo-1,3-benzoldicarboxamid aus linearem oder verzweigtem (c5-c6) alkohol oder gemischen davon | |
RU2047616C1 (ru) | Способ получения 2,4,7-триамино-6-фенилптеридина | |
JP3258850B2 (ja) | 5−置換ジヒドロウラシル類の製造法 | |
FR2826651A1 (fr) | Forme cristalline d'une phenylethanolamine, sa preparation et compositions pharmaceutiques la contenant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |