IT1202904B - Sali di ornitina ed arginina di chetoacidi a catena ramificata e loro impiego nel trattamento di disfunzioni epatiche e renali - Google Patents

Sali di ornitina ed arginina di chetoacidi a catena ramificata e loro impiego nel trattamento di disfunzioni epatiche e renali

Info

Publication number
IT1202904B
IT1202904B IT21071/79A IT2107179A IT1202904B IT 1202904 B IT1202904 B IT 1202904B IT 21071/79 A IT21071/79 A IT 21071/79A IT 2107179 A IT2107179 A IT 2107179A IT 1202904 B IT1202904 B IT 1202904B
Authority
IT
Italy
Prior art keywords
chetoacids
ornitine
hepatic
branched
treatment
Prior art date
Application number
IT21071/79A
Other languages
English (en)
Italian (it)
Other versions
IT7921071A0 (it
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of IT7921071A0 publication Critical patent/IT7921071A0/it
Application granted granted Critical
Publication of IT1202904B publication Critical patent/IT1202904B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT21071/79A 1978-03-17 1979-03-16 Sali di ornitina ed arginina di chetoacidi a catena ramificata e loro impiego nel trattamento di disfunzioni epatiche e renali IT1202904B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/887,570 US4228099A (en) 1978-03-17 1978-03-17 Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders

Publications (2)

Publication Number Publication Date
IT7921071A0 IT7921071A0 (it) 1979-03-16
IT1202904B true IT1202904B (it) 1989-02-15

Family

ID=25391422

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21071/79A IT1202904B (it) 1978-03-17 1979-03-16 Sali di ornitina ed arginina di chetoacidi a catena ramificata e loro impiego nel trattamento di disfunzioni epatiche e renali

Country Status (17)

Country Link
US (1) US4228099A (enExample)
JP (1) JPS5838421B2 (enExample)
AU (1) AU517505B2 (enExample)
BE (1) BE874900A (enExample)
CA (1) CA1115729A (enExample)
DE (1) DE2910221A1 (enExample)
DK (1) DK153542C (enExample)
ES (1) ES478710A1 (enExample)
FI (1) FI72118C (enExample)
FR (1) FR2419723A1 (enExample)
GB (1) GB2017094B (enExample)
IE (1) IE48336B1 (enExample)
IT (1) IT1202904B (enExample)
LU (1) LU81057A1 (enExample)
NL (1) NL7902136A (enExample)
NO (1) NO151119C (enExample)
SE (1) SE446724B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296127A (en) * 1979-04-18 1981-10-20 The Johns Hopkins University Mixed salts of essential or semi-essential amino acids and nitrogen-free analogs thereof
DE3438455A1 (de) * 1984-10-19 1986-06-26 Institut Dr. Ziegler, Bettingen L-lysin- und l-histidinpyruvat
US4677121A (en) * 1985-01-22 1987-06-30 The Johns Hopkins University Method of inhibiting muscle protein degradation
US4752619A (en) * 1985-12-23 1988-06-21 The Johns Hopkins University Nutritional supplement for treatment of uremia
US4871552A (en) * 1986-09-25 1989-10-03 W. R. Grace & Co.-Conn. Hydantoins as animal food supplements
US4744990A (en) * 1986-09-25 1988-05-17 W. R. Grace & Co. Hydantoins as animal food supplements
US5639731A (en) * 1987-05-22 1997-06-17 Pripps Bryggerier Ab Amino acids for the preparation of a beverage
FR2615734B1 (fr) * 1987-05-27 1989-12-01 Synthelabo Compositions pharmaceutiques contenant un melange de sels de cetoacides et d'amino-acides utiles pour le traitement de l'uremie
FR2618331B1 (fr) * 1987-07-23 1991-10-04 Synthelabo Compositions pharmaceutiques utiles pour le traitement de l'uremie
AT393080B (de) * 1988-11-25 1991-08-12 Lubec Gert Pharmazeutische verwendung von arginin (salzen)
AT393079B (de) * 1989-03-06 1991-08-12 Lubec Gert Pharmazeutische verwendung von agmatin
SE462463B (sv) * 1988-12-02 1990-07-02 Decken Alexandra V D Livs- och fodermedel innehaallande ketosyror
JP2522034B2 (ja) * 1988-12-27 1996-08-07 味の素株式会社 α−ケト酸・アミノ酸塩化合物及びその製造方法
US5210098A (en) * 1990-09-21 1993-05-11 Regents Of The University Of Minnesota Use of pyruvate to treat acute renal failure
US5234696A (en) * 1991-12-27 1993-08-10 Abbott Laboratories Method of producing tablets, tablets produced thereby, and method of treatment using same
WO1996010927A1 (fr) 1994-10-07 1996-04-18 Firmenich S.A. Compositions aromatisantes et procede d'aromatisation
US5591736A (en) * 1995-07-03 1997-01-07 The Johns Hopkins University Method of retarding the progression of chronic renal failure
EP1377339A4 (en) * 2001-04-04 2006-05-31 Critical Therapeutics Inc PROCEDURE FOR PREVENTING AKUTER NIERENINSUFFIZIENZ
WO2006051940A1 (ja) * 2004-11-15 2006-05-18 Kyowa Hakko Kogyo Co., Ltd. Ｌ－オルニチン結晶およびその製造方法
GB0426141D0 (en) * 2004-11-26 2004-12-29 Ucl Biomedica Plc Treatment
JP5116479B2 (ja) 2004-11-26 2013-01-09 ユーシーエル ビジネス ピーエルシー オルニチンならびにフェニルアセテートまたはフェニルブチレートを含む、肝性脳症を治療するための組成物
ES2928586T3 (es) 2009-04-03 2022-11-21 Ocera Therapeutics Inc Fenilacetato de L-ornitina y métodos para elaborar el mismo
KR101715008B1 (ko) 2009-06-08 2017-03-22 유씨엘 비즈니스 피엘씨 Ｌ―오르니틴 페닐아세테이트를 사용한 문맥압 항진증의 치료 및 간 기능 회복
JP6087284B2 (ja) 2010-10-06 2017-03-01 オセラ セラピューティクス， インコーポレイテッド Ｌ−オルニチンフェニルアセテートを製造するための方法
DK3223829T3 (da) 2014-11-24 2020-02-10 Ucl Business Ltd Behandling af sygdomme associeret med hepatisk stellat-celleaktivering under anvendelse af ammoniak-sænkende terapier
HK1249434A1 (zh) 2015-08-18 2018-11-02 Ocera Therapeutics, Inc. 使用与苯乙酸盐和苯丁酸盐中的至少一种组合的l-鸟氨酸治疗和预防肌肉损失
CN106674057A (zh) * 2015-11-09 2017-05-17 江西乐维生物药业有限公司 L-精氨酸a-酮基异己酸盐的制备方法
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
WO2017090007A1 (en) * 2015-11-29 2017-06-01 Rao M Surya Compositions and methods for the treatment of urea cycle disorders and hepatic diseases
CA3063134A1 (en) 2017-05-11 2018-11-15 Ocera Therapeutics, Inc. Processes of making l-ornithine phenylacetate
US12109254B2 (en) 2017-11-29 2024-10-08 Edgar Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients
US11484579B2 (en) 2017-11-29 2022-11-01 Edgar L Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients
US11253496B2 (en) 2017-11-29 2022-02-22 Edgar L. Hull Alpha keto acid compositions for treating hypo-albuminemia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA814483A (en) * 1969-06-03 Abe Kyuji L-ornithine-l-aspartate
GB1034358A (en) 1963-05-01 1966-06-29 Chugai Pharmaceutical Co Ltd Body-protein-biosynthesis promoting composition
FR1432756A (fr) 1965-02-11 1966-03-25 D Opochimiotherapie Lab Pyruvates d'amino-acides et leur procédé de préparation
US3441650A (en) * 1965-07-23 1969-04-29 Lab Jacques Logeais Sa Therapy of ammonical intoxications by di-l-ornithine alpha-ketoglutarate
DE2335215B2 (de) 1972-07-13 1979-04-05 The Johns Hopkins University, Baltimore, Md. (V.St.A.) Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen
US4100293A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Treatment of hepatic disorders with therapeutic compositions comprising keto analogs of essential amino acids
US3950529A (en) * 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same

Also Published As

Publication number Publication date
FI72118B (fi) 1986-12-31
JPS5838421B2 (ja) 1983-08-23
DK110879A (da) 1979-09-18
JPS54163518A (en) 1979-12-26
IE790993L (en) 1979-09-17
SE446724B (sv) 1986-10-06
DK153542B (da) 1988-07-25
ES478710A1 (es) 1980-01-16
NL7902136A (nl) 1979-09-19
SE7902401L (sv) 1979-10-16
IE48336B1 (en) 1984-12-12
GB2017094A (en) 1979-10-03
AU517505B2 (en) 1981-08-06
BE874900A (fr) 1979-07-16
FR2419723B1 (enExample) 1982-10-29
LU81057A1 (fr) 1979-09-07
IT7921071A0 (it) 1979-03-16
FI72118C (fi) 1987-04-13
CA1115729A (en) 1982-01-05
DE2910221A1 (de) 1979-09-20
GB2017094B (en) 1982-07-07
NO151119C (no) 1985-02-13
AU4515479A (en) 1979-09-20
FI790901A7 (fi) 1979-09-18
FR2419723A1 (fr) 1979-10-12
NO790903L (no) 1979-09-18
DE2910221C2 (enExample) 1988-04-28
DK153542C (da) 1988-12-05
US4228099A (en) 1980-10-14
NO151119B (no) 1984-11-05

Similar Documents

Publication Publication Date Title
IT1202904B (it) Sali di ornitina ed arginina di chetoacidi a catena ramificata e loro impiego nel trattamento di disfunzioni epatiche e renali
SE7811533L (sv) Pumpanordning i form av en enhet och med forenderlig arbetskarakteristika
NL7604064A (nl) In water dispergeerbare esterharsen.
IT980836B (it) Procedimento per rendere dispersibi li i poligalattomannani e loro deri vati
AU5417979A (en) Isoquinoline derivatives and their use as anti-inflammatory and analgesic agents
FR2326234A1 (fr) Appareil de reduction en petits morceaux a rotor tournant dans une enveloppe et a outil fixe dans l'enveloppe
FI790106A7 (fi) Foerfarande och anordning foer framstaellning av varmraffinoermassa
MX146864A (es) Mejoras en sistema apto para permitir la modificacion de datos en un procesador y una unidad periferica
IT1094401B (it) Dipoli in linea microstriscia bilanciati simmetricamente
BR7802684A (pt) Poliester termofixavel soluvel em agua
SE405011B (sv) I vatten lettdispergerbart utflockningsmedel och anvendning av detsamma
IT1100469B (it) Arileteri delle n-alchil-piperidine e loro sali di addizione con acidi
IT1125792B (it) Poliesteri ramificati solubili o dispersibili in acqua e loro impiego come ausiliari in tintoria
BE880075A (nl) Diffusor in het bijzonder met grote tophoek
MX5720E (es) Procedimiento para preparar una composicion herbicida en emulsion acuosa
MX148596A (es) Mejoras en manguera para irrigacion
SE7805885L (sv) Forfarande och anordning for styrning av sleckvinklarna i vexelriktare
IT1110908B (it) Assorbimento delle linee di campo magnetico nelle celle di elettrolisi
SE7709905L (sv) Bensoesyror och forfarande for deras framstellning
IT1115531B (it) Sali di idrocarbil-tio-etiolammine e loro applicazione
IT1122740B (it) Derivati pirazolidin-dionici e loro applicazione in terapia
IT1083473B (it) Composti antrachinonici difficilmente solubili in acqua loro preparazione e loro impiego
IT1107070B (it) Coloranti poliazoici idrosolubili e loro procedimento di preparazione
IT1070025B (it) Coloranti trisazoici solunili in acqua,loro preparazione e loro impiego
PL190683A1 (pl) Aparat podajacy przedze w skrecarkach obraczkowych

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960329