AU517505B2 - Ornithine and arginine salts of branched chain keto acids - Google Patents

Ornithine and arginine salts of branched chain keto acids

Info

Publication number
AU517505B2
AU517505B2 AU45154/79A AU4515479A AU517505B2 AU 517505 B2 AU517505 B2 AU 517505B2 AU 45154/79 A AU45154/79 A AU 45154/79A AU 4515479 A AU4515479 A AU 4515479A AU 517505 B2 AU517505 B2 AU 517505B2
Authority
AU
Australia
Prior art keywords
ornithine
branched chain
keto acids
arginine salts
chain keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU45154/79A
Other languages
English (en)
Other versions
AU4515479A (en
Inventor
Mackenzie Walser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MADDREY WILLIS C
Original Assignee
MADDREY WILLIS C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MADDREY WILLIS C filed Critical MADDREY WILLIS C
Publication of AU4515479A publication Critical patent/AU4515479A/en
Application granted granted Critical
Publication of AU517505B2 publication Critical patent/AU517505B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU45154/79A 1978-03-17 1979-03-15 Ornithine and arginine salts of branched chain keto acids Expired AU517505B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US887570 1978-03-17
US05/887,570 US4228099A (en) 1978-03-17 1978-03-17 Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders

Publications (2)

Publication Number Publication Date
AU4515479A AU4515479A (en) 1979-09-20
AU517505B2 true AU517505B2 (en) 1981-08-06

Family

ID=25391422

Family Applications (1)

Application Number Title Priority Date Filing Date
AU45154/79A Expired AU517505B2 (en) 1978-03-17 1979-03-15 Ornithine and arginine salts of branched chain keto acids

Country Status (17)

Country Link
US (1) US4228099A (enExample)
JP (1) JPS5838421B2 (enExample)
AU (1) AU517505B2 (enExample)
BE (1) BE874900A (enExample)
CA (1) CA1115729A (enExample)
DE (1) DE2910221A1 (enExample)
DK (1) DK153542C (enExample)
ES (1) ES478710A1 (enExample)
FI (1) FI72118C (enExample)
FR (1) FR2419723A1 (enExample)
GB (1) GB2017094B (enExample)
IE (1) IE48336B1 (enExample)
IT (1) IT1202904B (enExample)
LU (1) LU81057A1 (enExample)
NL (1) NL7902136A (enExample)
NO (1) NO151119C (enExample)
SE (1) SE446724B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296127A (en) * 1979-04-18 1981-10-20 The Johns Hopkins University Mixed salts of essential or semi-essential amino acids and nitrogen-free analogs thereof
DE3438455A1 (de) * 1984-10-19 1986-06-26 Institut Dr. Ziegler, Bettingen L-lysin- und l-histidinpyruvat
US4677121A (en) * 1985-01-22 1987-06-30 The Johns Hopkins University Method of inhibiting muscle protein degradation
US4752619A (en) * 1985-12-23 1988-06-21 The Johns Hopkins University Nutritional supplement for treatment of uremia
US4744990A (en) * 1986-09-25 1988-05-17 W. R. Grace & Co. Hydantoins as animal food supplements
US4871552A (en) * 1986-09-25 1989-10-03 W. R. Grace & Co.-Conn. Hydantoins as animal food supplements
US5639731A (en) * 1987-05-22 1997-06-17 Pripps Bryggerier Ab Amino acids for the preparation of a beverage
FR2615734B1 (fr) * 1987-05-27 1989-12-01 Synthelabo Compositions pharmaceutiques contenant un melange de sels de cetoacides et d'amino-acides utiles pour le traitement de l'uremie
FR2618331B1 (fr) * 1987-07-23 1991-10-04 Synthelabo Compositions pharmaceutiques utiles pour le traitement de l'uremie
AT393080B (de) * 1988-11-25 1991-08-12 Lubec Gert Pharmazeutische verwendung von arginin (salzen)
AT393079B (de) * 1989-03-06 1991-08-12 Lubec Gert Pharmazeutische verwendung von agmatin
SE462463B (sv) * 1988-12-02 1990-07-02 Decken Alexandra V D Livs- och fodermedel innehaallande ketosyror
JP2522034B2 (ja) * 1988-12-27 1996-08-07 味の素株式会社 α−ケト酸・アミノ酸塩化合物及びその製造方法
US5210098A (en) * 1990-09-21 1993-05-11 Regents Of The University Of Minnesota Use of pyruvate to treat acute renal failure
US5234696A (en) * 1991-12-27 1993-08-10 Abbott Laboratories Method of producing tablets, tablets produced thereby, and method of treatment using same
ATE235166T1 (de) 1994-10-07 2003-04-15 Firmenich & Cie Aromazusammensetzungen und aromatisierungsverfahren
US5591736A (en) * 1995-07-03 1997-01-07 The Johns Hopkins University Method of retarding the progression of chronic renal failure
EP1377339A4 (en) * 2001-04-04 2006-05-31 Critical Therapeutics Inc PROCEDURE FOR PREVENTING AKUTER NIERENINSUFFIZIENZ
JP4778913B2 (ja) * 2004-11-15 2011-09-21 協和発酵バイオ株式会社 Ｌ−オルニチン結晶およびその製造方法
ES2448549T3 (es) * 2004-11-26 2014-03-14 Ucl Business Plc Composiciones que comprenden ornitina y fenilacetato o fenilbutirato para tratar encefalopatía hepática
GB0426141D0 (en) * 2004-11-26 2004-12-29 Ucl Biomedica Plc Treatment
ES2652187T3 (es) 2009-04-03 2018-01-31 Ocera Therapeutics, Inc. Fenilacetato de l-ornitina y métodos para elaborar el mismo
EP2440200B8 (en) 2009-06-08 2014-10-15 UCL Business PLC Treatment of portal hypertension using l-ornithine phenylacetate
EP2625162B1 (en) 2010-10-06 2019-03-13 Ocera Therapeutics, Inc. Methods of making l-ornithine phenyl acetate
KR102487376B1 (ko) 2014-11-24 2023-01-10 유씨엘 비즈니스 리미티드 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료
JP6990170B2 (ja) 2015-08-18 2022-01-12 オセラ セラピューティクス， インコーポレイテッド Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防
CN106674057A (zh) * 2015-11-09 2017-05-17 江西乐维生物药业有限公司 L-精氨酸a-酮基异己酸盐的制备方法
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
WO2017090007A1 (en) * 2015-11-29 2017-06-01 Rao M Surya Compositions and methods for the treatment of urea cycle disorders and hepatic diseases
CN110740988A (zh) 2017-05-11 2020-01-31 欧塞拉治疗有限公司 制备l-鸟氨酸苯乙酸盐的方法
US11484579B2 (en) 2017-11-29 2022-11-01 Edgar L Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients
EP3716966A4 (en) 2017-11-29 2021-08-18 Hull, Edgar, L., Jr. ALPHA-KETO ACID COMPOSITIONS FOR THE TREATMENT OF HYPOALBUMINEMIA
US12109254B2 (en) 2017-11-29 2024-10-08 Edgar Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA814483A (en) * 1969-06-03 Abe Kyuji L-ornithine-l-aspartate
GB1034358A (en) 1963-05-01 1966-06-29 Chugai Pharmaceutical Co Ltd Body-protein-biosynthesis promoting composition
FR1432756A (fr) 1965-02-11 1966-03-25 D Opochimiotherapie Lab Pyruvates d'amino-acides et leur procédé de préparation
US3441650A (en) * 1965-07-23 1969-04-29 Lab Jacques Logeais Sa Therapy of ammonical intoxications by di-l-ornithine alpha-ketoglutarate
DE2335215B2 (de) * 1972-07-13 1979-04-05 The Johns Hopkins University, Baltimore, Md. (V.St.A.) Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen
US4100293A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Treatment of hepatic disorders with therapeutic compositions comprising keto analogs of essential amino acids
US3950529A (en) * 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same

Also Published As

Publication number Publication date
FR2419723A1 (fr) 1979-10-12
DE2910221C2 (enExample) 1988-04-28
FR2419723B1 (enExample) 1982-10-29
US4228099A (en) 1980-10-14
JPS5838421B2 (ja) 1983-08-23
BE874900A (fr) 1979-07-16
AU4515479A (en) 1979-09-20
FI790901A7 (fi) 1979-09-18
CA1115729A (en) 1982-01-05
IE48336B1 (en) 1984-12-12
NO790903L (no) 1979-09-18
FI72118B (fi) 1986-12-31
NO151119C (no) 1985-02-13
LU81057A1 (fr) 1979-09-07
DK153542C (da) 1988-12-05
DK153542B (da) 1988-07-25
SE7902401L (sv) 1979-10-16
SE446724B (sv) 1986-10-06
NL7902136A (nl) 1979-09-19
DK110879A (da) 1979-09-18
ES478710A1 (es) 1980-01-16
NO151119B (no) 1984-11-05
IT7921071A0 (it) 1979-03-16
IT1202904B (it) 1989-02-15
GB2017094B (en) 1982-07-07
GB2017094A (en) 1979-10-03
JPS54163518A (en) 1979-12-26
IE790993L (en) 1979-09-17
DE2910221A1 (de) 1979-09-20
FI72118C (fi) 1987-04-13

Similar Documents

Publication Publication Date Title
AU4515479A (en) Ornithine and arginine salts of branched chain keto acids
GB2014573B (en) Derivatives of dehydrocyclicimino acids
GB2016460B (en) 2-(m-benzoylphenoxy)-propionic acid and derivatives
AU579569B2 (en) Enantiomers of pyridyloxyphenoxyalkanoic acids and their derivatives
AU5417979A (en) Isoquinoline derivatives and their use as anti-inflammatory and analgesic agents
NO791012L (no) Kontinuerlig fremgangsmaate for fremstilling av karboksylpersyrer
IL58869A0 (en) Preparation of glyoxylic acids and derivatives thereof
PH22340A (en) Phenylalkanoic acid derivatives and their compositions
DE2965361D1 (en) Process for the preparation of optically active alpha-amino acids and their derivatives
AU3725178A (en) 4-hydroxy-2-quinolinone-3-carboxylic acids and their salts
JPS5531083A (en) Monocarboxylate of phenylguanidinesulfonic acid ester
AU3832378A (en) Aminoalkylenephosphonic acids and salts thereof
JPS54145663A (en) N*nndimethylloopyrazolyllcarbamic acid ester* its preparation and use as incecticide
AU521516B2 (en) Derivatives of thiazolidinecarboxylic acids and related acids
GR65627B (en) Method for the preparation of derivatives of spectinomisine and salts thereof with acids
AU525876B2 (en) Ester derivatives of quinolopyran-4-one-2-carboxylic acids and antiallergic antasthmatics
AU520791B2 (en) Salts of aminoalkylesters of carbothioic acids
AU529638B2 (en) 9-n-isobutylaminodeoxyclavulanic acid and ester
AU5301279A (en) Dicarboxylic acids + their salts and their use to improve soil structure
AU510456B2 (en) Preparation of esters of thiolcarbamic acids
GB2032429B (en) Paraterpenylbenzoic acid and salts esters and anhydrides thereof
GB1549368A (en) Cyclopropanecarboxylic acid derivatives and hexenoic acid ester derivatives
AU522977B2 (en) Copolymer of acrylic acid derivatives
GB2020284B (en) Preparation of a cycloporopylacetic acid and its derivatives
IL65978A (en) Methyl esters of 15-deoxy-16-hydroxy-prostaglandin derivatives and their preparation