IT1182150B - Composti eterociclici tetraidrocarbozolonici, procedimenti per preparli e composizioni farmaceutiche che li contengono - Google Patents

Composti eterociclici tetraidrocarbozolonici, procedimenti per preparli e composizioni farmaceutiche che li contengono

Info

Publication number
IT1182150B
IT1182150B IT47600/85A IT4760085A IT1182150B IT 1182150 B IT1182150 B IT 1182150B IT 47600/85 A IT47600/85 A IT 47600/85A IT 4760085 A IT4760085 A IT 4760085A IT 1182150 B IT1182150 B IT 1182150B
Authority
IT
Italy
Prior art keywords
tetraidrocarbozolonici
procedures
preparing
pharmaceutical compositions
compositions containing
Prior art date
Application number
IT47600/85A
Other languages
English (en)
Italian (it)
Other versions
IT8547600A0 (it
Inventor
Jan Harold Coates
James Angus Bell
David Cedric Humber
Ewan George Blanch
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IT8547600A0 publication Critical patent/IT8547600A0/it
Application granted granted Critical
Publication of IT1182150B publication Critical patent/IT1182150B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT47600/85A 1984-01-25 1985-01-25 Composti eterociclici tetraidrocarbozolonici, procedimenti per preparli e composizioni farmaceutiche che li contengono IT1182150B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
IT8547600A0 IT8547600A0 (it) 1985-01-25
IT1182150B true IT1182150B (it) 1987-09-30

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47600/85A IT1182150B (it) 1984-01-25 1985-01-25 Composti eterociclici tetraidrocarbozolonici, procedimenti per preparli e composizioni farmaceutiche che li contengono

Country Status (29)

Country Link
KR (1) KR920003064B1 (el)
AT (1) AT392276B (el)
AU (1) AU579132B2 (el)
BE (1) BE901576A (el)
CA (1) CA1252793A (el)
CH (1) CH664152A5 (el)
CY (1) CY1479A (el)
CZ (1) CZ404391A3 (el)
DE (2) DE3502508A1 (el)
DK (1) DK169521B1 (el)
ES (3) ES8609309A1 (el)
FI (1) FI84349C (el)
FR (1) FR2561244B1 (el)
GB (1) GB2153821B (el)
GR (1) GR850219B (el)
HK (1) HK33189A (el)
HU (1) HU193592B (el)
IE (1) IE57809B1 (el)
IL (1) IL74165A (el)
IT (1) IT1182150B (el)
LU (2) LU85743A1 (el)
NL (2) NL190373C (el)
NO (2) NO164025C (el)
NZ (1) NZ210940A (el)
PH (1) PH22672A (el)
PT (1) PT79890B (el)
SE (1) SE460359B (el)
SG (1) SG7089G (el)
SK (1) SK404391A3 (el)

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JPH0249772A (ja) * 1988-04-07 1990-02-20 Glaxo Group Ltd イミダゾール誘導体
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JPH0256485A (ja) * 1988-04-27 1990-02-26 Glaxo Group Ltd ラクタム誘導体
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
DK0422154T3 (da) * 1989-04-21 1994-03-07 Sandoz Ag Terapeutisk anvendelse af 5-HT3-receptorantagonister
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
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US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
EP1022025A3 (en) * 1991-06-26 2002-06-05 Sepracor, Inc. Method and compositions for treating emesis nausea and other disorders using optically pure R(+) ondansetron
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
ES2043535B1 (es) * 1992-03-13 1994-08-01 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
KR960700711A (ko) * 1993-03-08 1996-02-24 후지야마 아키라 뇌혈관성 질환의 치료 또는 예방용 약제(Medicament for treating or preventing cerebrovascular diseases)
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325408B (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Chewing gum formulation comprising ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
CA2371822A1 (en) 1999-03-01 2000-09-08 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
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FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (es) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
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Also Published As

Publication number Publication date
FI850323A0 (fi) 1985-01-25
ES8801247A1 (es) 1987-12-16
IT8547600A0 (it) 1985-01-25
IE57809B1 (en) 1993-04-21
ES539852A0 (es) 1986-07-16
ES556101A0 (es) 1987-12-16
NL190373B (nl) 1993-09-01
GB2153821B (en) 1988-01-20
CY1479A (en) 1989-07-21
HUT37784A (en) 1986-02-28
SK277923B6 (en) 1995-08-09
DE3502508C2 (el) 1990-05-03
LU85743A1 (fr) 1986-08-04
GR850219B (el) 1985-05-23
SE460359B (sv) 1989-10-02
NL940009I2 (nl) 1999-05-03
SE8500368L (sv) 1985-07-26
NL190373C (nl) 1994-02-01
ATA20485A (de) 1990-08-15
AU579132B2 (en) 1988-11-17
CH664152A5 (fr) 1988-02-15
SE8500368D0 (sv) 1985-01-25
ES8708224A1 (es) 1987-10-01
NZ210940A (en) 1989-08-29
DE19375046I2 (de) 2002-10-10
GB2153821A (en) 1985-08-29
DE3502508A1 (de) 1985-08-14
IL74165A (en) 1988-11-15
AU3809785A (en) 1985-08-01
PT79890A (en) 1985-02-01
NO164025C (no) 1990-08-22
FI84349C (fi) 1991-11-25
NL8500202A (nl) 1985-08-16
SK404391A3 (en) 1995-08-09
DK35785A (da) 1985-07-26
NO164025B (no) 1990-05-14
KR920003064B1 (ko) 1992-04-13
DK35785D0 (da) 1985-01-25
FI84349B (fi) 1991-08-15
NO1994022I1 (no) 1994-11-09
NL940009I1 (nl) 1994-07-18
ES548430A0 (es) 1987-10-01
PH22672A (en) 1988-11-14
HU193592B (en) 1987-11-30
GB8501889D0 (en) 1985-02-27
BE901576A (fr) 1985-07-25
FI850323L (fi) 1985-07-26
KR850005439A (ko) 1985-08-26
NO850300L (no) 1985-07-26
DK169521B1 (da) 1994-11-21
FR2561244B1 (fr) 1988-03-04
HK33189A (en) 1989-04-28
FR2561244A1 (fr) 1985-09-20
AT392276B (de) 1991-02-25
CA1252793A (en) 1989-04-18
SG7089G (en) 1989-06-09
LU88268I2 (el) 1994-02-03
IE850187L (en) 1985-07-25
ES8609309A1 (es) 1986-07-16
CZ404391A3 (en) 1993-04-14
PT79890B (en) 1987-02-03

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Legal Events

Date Code Title Description
ITCP Complementary protection certificate

Free format text: CCP 221

MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 221, 19920504; GLAXO GROUP LIMITED

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960129