IT1178455B - Soluzioni di insulina stabilizzate e metodi per la loro produzione - Google Patents

Soluzioni di insulina stabilizzate e metodi per la loro produzione

Info

Publication number
IT1178455B
IT1178455B IT19420/83A IT1942083A IT1178455B IT 1178455 B IT1178455 B IT 1178455B IT 19420/83 A IT19420/83 A IT 19420/83A IT 1942083 A IT1942083 A IT 1942083A IT 1178455 B IT1178455 B IT 1178455B
Authority
IT
Italy
Prior art keywords
production
methods
insulin solutions
stabilized insulin
stabilized
Prior art date
Application number
IT19420/83A
Other languages
English (en)
Italian (it)
Other versions
IT8319420A0 (it
Inventor
Jens Jorgen Vejlgaard Brange
Svend Havelund
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of IT8319420A0 publication Critical patent/IT8319420A0/it
Application granted granted Critical
Publication of IT1178455B publication Critical patent/IT1178455B/it

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
IT19420/83A 1982-02-05 1983-02-04 Soluzioni di insulina stabilizzate e metodi per la loro produzione IT1178455B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (2)

Publication Number Publication Date
IT8319420A0 IT8319420A0 (it) 1983-02-04
IT1178455B true IT1178455B (it) 1987-09-09

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19420/83A IT1178455B (it) 1982-02-05 1983-02-04 Soluzioni di insulina stabilizzate e metodi per la loro produzione

Country Status (22)

Country Link
US (1) US4476118A (forum.php)
JP (1) JPS58192818A (forum.php)
AT (1) AT382780B (forum.php)
AU (1) AU549981B2 (forum.php)
BE (1) BE895832A (forum.php)
CA (1) CA1203476A (forum.php)
CH (1) CH657530A5 (forum.php)
DE (1) DE3303860A1 (forum.php)
ES (1) ES8500060A1 (forum.php)
FI (1) FI78616C (forum.php)
FR (1) FR2521009B1 (forum.php)
GB (1) GB2114573B (forum.php)
GR (1) GR77388B (forum.php)
IE (1) IE54548B1 (forum.php)
IT (1) IT1178455B (forum.php)
LU (1) LU84632A1 (forum.php)
NL (1) NL187269C (forum.php)
NO (1) NO161204C (forum.php)
NZ (1) NZ203189A (forum.php)
PT (1) PT76195B (forum.php)
SE (1) SE460948B (forum.php)
ZA (1) ZA83742B (forum.php)

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ATE50502T1 (de) * 1984-06-09 1990-03-15 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
EP0861089B1 (en) * 1995-11-13 2002-07-17 Medtronic MiniMed, Inc. Methods and compositions for the delivery of monomeric proteins
WO1997033978A1 (en) * 1996-03-12 1997-09-18 Life Technologies, Inc. Hematopoietic cell culture nutrient supplement
ATE264871T1 (de) * 1996-07-26 2004-05-15 Aventis Pharma Gmbh Insulinderivate mit erhöhter zinkbindung
ZA984697B (en) * 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
EP1283051B1 (en) * 1997-06-13 2006-06-14 Eli Lilly And Company Stable insulin formulations
CN1278737A (zh) * 1997-11-12 2001-01-03 阿尔萨公司 减少多肽自结合的方法
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
UA65636C2 (uk) * 1998-10-16 2004-04-15 Ново Нордіск А/С Стабільні концентровані препарати інсуліну для доставки через легені
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
AU4935701A (en) * 2000-03-24 2001-10-08 Genentech Inc Use of insulin for the treatment of cartilagenous disorders
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
EP1506230B1 (en) 2002-05-07 2011-01-19 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
WO2004056347A2 (en) * 2002-12-20 2004-07-08 Novo Nordisk A/S Pharmaceutical compositions comprising insulin and legends of insulin hexamer
WO2004096266A1 (en) * 2003-05-02 2004-11-11 Novo Nordisk A/S Improved physical stability of insulin formulations
KR101159559B1 (ko) * 2003-08-05 2012-06-26 노보 노르디스크 에이/에스 신규의 인슐린 유도체
RU2393168C2 (ru) * 2004-07-19 2010-06-27 Биокон Лимитед Инсулин-олигомерные конъюгаты, их препараты и применения
JP4808785B2 (ja) * 2005-12-28 2011-11-02 ノボ・ノルデイスク・エー／エス インスリン組成物および組成物の製造方法
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
PL3050568T3 (pl) 2007-03-13 2021-06-14 Jds Therapeutics, Llc Sposoby i kompozycje do przedłużonego uwalniania chromu
JP5552046B2 (ja) * 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
PL2597103T3 (pl) * 2007-11-16 2017-04-28 Novo Nordisk A/S Stabilne kompozycje farmaceutyczne zawierające liraglutyd i degludec
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
EP2341940A1 (en) * 2008-07-16 2011-07-13 Arecor Limited The stabilisation of proteins
CN102202683A (zh) * 2008-10-30 2011-09-28 诺沃-诺迪斯克有限公司 用少于每日一次的注射频率注射胰岛素来治疗糖尿病
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
WO2012119007A1 (en) 2011-03-01 2012-09-07 N21 Acquisition Holding, Llc Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
WO2014076423A1 (fr) 2012-11-13 2014-05-22 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
JP6111475B2 (ja) * 2012-12-19 2017-04-12 ウォックハート リミテッド ヒトインスリン又はその類似体もしくは誘導体を含む安定な水性組成物
RU2015130613A (ru) 2012-12-26 2017-01-31 Вокхардт Лимитед Фармацевтическая композиция
TWI780236B (zh) * 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
US9822158B2 (en) * 2013-12-04 2017-11-21 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
EP3413900A1 (en) 2016-02-11 2018-12-19 Nutrition 21, LLC Chromium containing compositions for improving health and fitness
ES2954180T3 (es) * 2016-09-29 2023-11-20 Arecor Ltd Formulación farmacéutica que comprende un compuesto de insulina
EA201992351A1 (ru) 2017-06-01 2020-03-26 Эли Лилли Энд Компани Быстродействующие композиции инсулина
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
WO2021009027A1 (en) 2019-07-12 2021-01-21 Novo Nordisk A/S High concentration insulin formulation
CN120142500A (zh) * 2025-02-28 2025-06-13 中国计量科学研究院 一种具有互换性的活性人胰岛素溶液标准物质及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
DE2459515C3 (de) * 1974-12-17 1982-02-11 Hoechst Ag, 6000 Frankfurt Arzneimittelzubereitungen mit antidiabetischer Wirkung
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
EP0102976A1 (en) * 1982-03-03 1984-03-21 Nordisk Insulinlaboratorium A process for producing an insulin preparation

Also Published As

Publication number Publication date
NL187269C (nl) 1991-08-01
NZ203189A (en) 1985-07-31
IT8319420A0 (it) 1983-02-04
PT76195A (en) 1983-03-01
ES519533A0 (es) 1984-10-16
JPH0367056B2 (forum.php) 1991-10-21
ES8500060A1 (es) 1984-10-16
FR2521009A1 (fr) 1983-08-12
FI78616B (fi) 1989-05-31
FI830375A0 (fi) 1983-02-03
SE460948B (sv) 1989-12-11
ZA83742B (en) 1983-11-30
DE3303860C2 (forum.php) 1989-12-28
FI830375L (fi) 1983-08-06
GB2114573B (en) 1985-05-01
LU84632A1 (fr) 1983-09-08
AT382780B (de) 1987-04-10
AU549981B2 (en) 1986-02-20
SE8300598D0 (sv) 1983-02-04
NO830385L (no) 1983-08-08
NO161204B (no) 1989-04-10
GR77388B (forum.php) 1984-09-11
NL8300440A (nl) 1983-09-01
CA1203476A (en) 1986-04-22
CH657530A5 (de) 1986-09-15
ATA38983A (de) 1986-09-15
SE8300598L (sv) 1983-08-06
JPS58192818A (ja) 1983-11-10
DE3303860A1 (de) 1983-08-18
NO161204C (no) 1989-07-19
GB2114573A (en) 1983-08-24
BE895832A (fr) 1983-08-04
NL187269B (nl) 1991-03-01
AU1113683A (en) 1983-08-11
IE830220L (en) 1983-08-05
US4476118A (en) 1984-10-09
GB8303133D0 (en) 1983-03-09
PT76195B (en) 1986-01-27
FI78616C (fi) 1989-09-11
IE54548B1 (en) 1989-11-08
FR2521009B1 (fr) 1987-07-17

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970226