US2515483A
(en)
|
1946-08-10 |
1950-07-18 |
Merck & Co Inc |
Diacylated pteroic acid and process for preparing same
|
US2816110A
(en)
|
1956-11-23 |
1957-12-10 |
Merck & Co Inc |
Methods for the production of substituted pteridines
|
US3392173A
(en)
|
1964-03-09 |
1968-07-09 |
Lilly Co Eli |
Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
|
US3387001A
(en)
|
1964-10-19 |
1968-06-04 |
Lilly Co Eli |
Novel aminoacyl esters of desacetyl vincaleukoblastine
|
US3641109A
(en)
|
1968-09-04 |
1972-02-08 |
Carl D Emerson |
Alkyl and aryl esters of polyhalo-dithio alcohols
|
US3632622A
(en)
|
1969-04-01 |
1972-01-04 |
Chevron Res |
Polyhaloalkylpolythioalkyl sulfite esters
|
US4203898A
(en)
|
1977-08-29 |
1980-05-20 |
Eli Lilly And Company |
Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
|
US4166810A
(en)
|
1978-04-20 |
1979-09-04 |
Eli Lilly And Company |
Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
|
US4337339A
(en)
|
1979-04-30 |
1982-06-29 |
Baker Instruments Corp. |
Process for preparation of folic acid derivatives
|
US4639456A
(en)
|
1980-06-10 |
1987-01-27 |
Omnichem S.A. |
Vinblastin-23-oyl amino acid derivatives
|
US4316885A
(en)
|
1980-08-25 |
1982-02-23 |
Ayerst, Mckenna And Harrison, Inc. |
Acyl derivatives of rapamycin
|
US4713249A
(en)
|
1981-11-12 |
1987-12-15 |
Schroeder Ulf |
Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
|
US5140104A
(en)
|
1982-03-09 |
1992-08-18 |
Cytogen Corporation |
Amine derivatives of folic acid analogs
|
JPS59175493A
(ja)
|
1983-03-25 |
1984-10-04 |
Kyowa Hakko Kogyo Co Ltd |
マイトマイシン誘導体
|
EP0116208B1
(en)
|
1982-12-07 |
1988-03-30 |
Kyowa Hakko Kogyo Co., Ltd. |
Mitomycin analogues
|
GR81790B
(he)
|
1983-04-29 |
1984-12-12 |
Omnichem Sa |
|
US4866180A
(en)
|
1984-02-24 |
1989-09-12 |
Bristol-Myers Company |
Amino disulfide thiol exchange products
|
GB8413849D0
(en)
|
1984-05-31 |
1984-07-04 |
Amersham Int Plc |
Nmr contrast agents
|
JPS60255789A
(ja)
|
1984-06-01 |
1985-12-17 |
Kyowa Hakko Kogyo Co Ltd |
マイトマイシン誘導体,その製造法および抗腫瘍剤
|
US5266333A
(en)
|
1985-03-06 |
1993-11-30 |
American Cyanamid Company |
Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone
|
US4650803A
(en)
|
1985-12-06 |
1987-03-17 |
University Of Kansas |
Prodrugs of rapamycin
|
US4801688A
(en)
|
1986-05-27 |
1989-01-31 |
Eli Lilly And Company |
Hydrazone immunoglobulin conjugates
|
IL82579A0
(en)
|
1986-05-27 |
1987-11-30 |
Lilly Co Eli |
Immunoglobulin conjugates
|
DE3750846T2
(de)
|
1986-08-29 |
1995-05-11 |
Kyowa Hakko Kogyo Kk |
Mitomycin-derivate.
|
US5006652A
(en)
|
1988-08-08 |
1991-04-09 |
Eli Lilly And Company |
Intermediates for antibody-vinca drug conjugates
|
US5094849A
(en)
|
1988-08-08 |
1992-03-10 |
Eli Lilly And Company |
Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers
|
US5688488A
(en)
|
1989-04-03 |
1997-11-18 |
Purdue Research Foundation |
Composition and method for tumor imaging
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
JPH03206886A
(ja)
|
1989-11-13 |
1991-09-10 |
Green Cross Corp:The |
ヒト腫瘍細胞抗原に対し特異性を持つマウス―ヒトキメラa10抗体
|
US5627165A
(en)
|
1990-06-13 |
1997-05-06 |
Drug Innovation & Design, Inc. |
Phosphorous prodrugs and therapeutic delivery systems using same
|
US5998603A
(en)
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
ES2171392T3
(es)
|
1990-08-29 |
2002-09-16 |
Ct Hospitalier Regional De Nan |
Poliligandos de proteina unidos a un nucleo de proteina estable.
|
US5130307A
(en)
|
1990-09-28 |
1992-07-14 |
American Home Products Corporation |
Aminoesters of rapamycin
|
US5221670A
(en)
|
1990-09-19 |
1993-06-22 |
American Home Products Corporation |
Rapamycin esters
|
US5378696A
(en)
|
1990-09-19 |
1995-01-03 |
American Home Products Corporation |
Rapamycin esters
|
US5233036A
(en)
|
1990-10-16 |
1993-08-03 |
American Home Products Corporation |
Rapamycin alkoxyesters
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5194447A
(en)
|
1992-02-18 |
1993-03-16 |
American Home Products Corporation |
Sulfonylcarbamates of rapamycin
|
US5138051A
(en)
|
1991-08-07 |
1992-08-11 |
American Home Products Corporation |
Rapamycin analogs as immunosuppressants and antifungals
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
US5169851A
(en)
|
1991-08-07 |
1992-12-08 |
American Home Products Corporation |
Rapamycin analog as immunosuppressants and antifungals
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
US5159079A
(en)
|
1991-12-20 |
1992-10-27 |
Eli Lilly And Company |
2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids
|
US6004555A
(en)
|
1992-03-05 |
1999-12-21 |
Board Of Regents, The University Of Texas System |
Methods for the specific coagulation of vasculature
|
US6022966A
(en)
|
1993-11-22 |
2000-02-08 |
Neorx Corporation |
Pretargeting methods and compounds
|
US5302584A
(en)
|
1992-10-13 |
1994-04-12 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
US5260300A
(en)
|
1992-11-19 |
1993-11-09 |
American Home Products Corporation |
Rapamycin carbonate esters as immuno-suppressant agents
|
US5583020A
(en)
|
1992-11-24 |
1996-12-10 |
Ribozyme Pharmaceuticals, Inc. |
Permeability enhancers for negatively charged polynucleotides
|
US7279561B1
(en)
|
1993-04-23 |
2007-10-09 |
Wyeth |
Anti-rapamycin monoclonal antibodies
|
AU686629B2
(en)
|
1993-04-23 |
1998-02-12 |
Wyeth |
Rapamycin Conjugates and Antibodies
|
US5562907A
(en)
|
1993-05-14 |
1996-10-08 |
Arnon; Stephen S. |
Method to prevent side-effects and insensitivity to the therapeutic uses of toxins
|
US5391730A
(en)
|
1993-10-08 |
1995-02-21 |
American Home Products Corporation |
Phosphorylcarbamates of rapamycin and oxime derivatives thereof
|
US5385908A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Hindered esters of rapamycin
|
US5385909A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Heterocyclic esters of rapamycin
|
US5385910A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Gem-distributed esters of rapamycin
|
US5389639A
(en)
|
1993-12-29 |
1995-02-14 |
American Home Products Company |
Amino alkanoic esters of rapamycin
|
US5417982A
(en)
|
1994-02-17 |
1995-05-23 |
Modi; Pankaj |
Controlled release of drugs or hormones in biodegradable polymer microspheres
|
IL112873A
(en)
|
1994-03-08 |
2005-03-20 |
Wyeth Corp |
Rapamycin-fkbp12 binding proteins, their isolation and their use
|
US6171859B1
(en)
|
1994-03-30 |
2001-01-09 |
Mitokor |
Method of targeting conjugate molecules to mitochondria
|
US5362718A
(en)
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
US5463048A
(en)
|
1994-06-14 |
1995-10-31 |
American Home Products Corporation |
Rapamycin amidino carbamates
|
US5491231A
(en)
|
1994-11-28 |
1996-02-13 |
American Home Products Corporation |
Hindered N-oxide esters of rapamycin
|
US5547668A
(en)
|
1995-05-05 |
1996-08-20 |
The Board Of Trustees Of The University Of Illinois |
Conjugates of folate anti-effector cell antibodies
|
AUPN449295A0
(en)
|
1995-07-28 |
1995-08-24 |
Inner And Eastern Health Care Network, The |
Radioprotectors
|
US6207157B1
(en)
|
1996-04-23 |
2001-03-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Conjugate vaccine for nontypeable Haemophilus influenzae
|
US6030941A
(en)
|
1996-05-01 |
2000-02-29 |
Avi Biopharma, Inc. |
Polymer composition for delivering substances in living organisms
|
DE69737867T2
(de)
|
1996-05-03 |
2007-10-18 |
Immunomedics, Inc. |
Zielgerichtete kombinations-immuntherapie für krebs
|
DE19621133A1
(de)
|
1996-05-24 |
1997-11-27 |
Boehringer Mannheim Gmbh |
Bestimmungsverfahren mit oligomerisierten Rezeptoren
|
JP2001501596A
(ja)
|
1996-08-27 |
2001-02-06 |
ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション |
バイオコンジュゲートおよび生物学的活性剤の送達
|
AU4163197A
(en)
*
|
1996-08-30 |
1998-03-19 |
Eli Lilly And Company |
Nonclassical pyrrolo{2,3-d}pyrimidine antifolates
|
CA2265476A1
(en)
|
1996-09-12 |
1998-03-19 |
Merck & Co., Inc. |
Conjugates useful in the treatment of prostate cancer
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
US6177404B1
(en)
|
1996-10-15 |
2001-01-23 |
Merck & Co., Inc. |
Conjugates useful in the treatment of benign prostatic hyperplasia
|
US6071532A
(en)
|
1996-10-15 |
2000-06-06 |
Emory University |
Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
|
WO1999020626A1
(en)
|
1997-10-17 |
1999-04-29 |
Purdue Research Foundation |
Folic acid derivatives
|
GB9723669D0
(en)
|
1997-11-07 |
1998-01-07 |
Univ Aberdeen |
Skin penetration enhancing components
|
US6399638B1
(en)
|
1998-04-21 |
2002-06-04 |
Bristol-Myers Squibb Company |
12,13-modified epothilone derivatives
|
US6093382A
(en)
|
1998-05-16 |
2000-07-25 |
Bracco Research Usa Inc. |
Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
|
DE69942578D1
(de)
|
1998-05-22 |
2010-08-26 |
Univ R |
Bifunktionelle moleküle sowie darauf basierende therapien.
|
US6589503B1
(en)
*
|
1998-06-20 |
2003-07-08 |
Washington University |
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
|
WO2000035422A2
(en)
|
1998-12-18 |
2000-06-22 |
Hadasit Medical Research Services & Development Ltd. |
Method of administering a compound to multi-drug resistant cells
|
US6291684B1
(en)
|
1999-03-29 |
2001-09-18 |
Bristol-Myers Squibb Company |
Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
|
US7238368B2
(en)
|
1999-04-23 |
2007-07-03 |
Alza Corporation |
Releasable linkage and compositions containing same
|
AU769425B2
(en)
|
1999-04-23 |
2004-01-29 |
Alza Corporation |
Conjugate having a cleavable linkage for use in a liposome
|
AUPQ014799A0
(en)
|
1999-05-04 |
1999-05-27 |
Access Pharmaceuticals Australia Pty Limited |
Amplification of folate-mediated targeting to tumor cells using polymers
|
AUPQ071299A0
(en)
|
1999-06-02 |
1999-06-24 |
Access Pharmaceuticals Australia Pty Limited |
Vitamin directed dual targeting therapy
|
US6822086B1
(en)
|
1999-08-09 |
2004-11-23 |
The General Hospital Corporation |
Drug-carrier complexes and methods of use thereof
|
AU769315B2
(en)
|
1999-08-24 |
2004-01-22 |
Cellgate, Inc. |
Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
|
US6669951B2
(en)
*
|
1999-08-24 |
2003-12-30 |
Cellgate, Inc. |
Compositions and methods for enhancing drug delivery across and into epithelial tissues
|
EP1231942A1
(en)
|
1999-10-15 |
2002-08-21 |
Mayo Foundation For Medical Education And Research |
Cobalamin conjugates useful as imaging agents and as antitumor agents
|
US7067111B1
(en)
|
1999-10-25 |
2006-06-27 |
Board Of Regents, University Of Texas System |
Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
|
NZ517772A
(en)
|
1999-11-24 |
2004-03-26 |
Immunogen Inc |
Cytotoxic agents comprising taxanes and their therapeutic use
|
AU5697001A
(en)
|
2000-03-31 |
2001-10-15 |
Purdue Research Foundation |
Method of treatment using ligand-immunogen conjugates
|
US6670355B2
(en)
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
US6290929B1
(en)
|
2000-07-28 |
2001-09-18 |
The Procter & Gamble Company |
Cancer treatment
|
EP1318837B1
(en)
|
2000-08-11 |
2004-10-06 |
Wyeth |
Method of treating estrogen receptor positive carcinoma
|
DE60136200D1
(de)
|
2000-09-19 |
2008-11-27 |
Wyeth Corp |
Wasserlösliche rapamycin-ester
|
US6399625B1
(en)
|
2000-09-27 |
2002-06-04 |
Wyeth |
1-oxorapamycins
|
US6399626B1
(en)
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
US6440991B1
(en)
|
2000-10-02 |
2002-08-27 |
Wyeth |
Ethers of 7-desmethlrapamycin
|
US6821731B2
(en)
|
2000-11-28 |
2004-11-23 |
Wyeth |
Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis of prostate cancer
|
US20020168737A1
(en)
|
2001-01-24 |
2002-11-14 |
Cornish Virginia W. |
Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
JP2004533226A
(ja)
|
2001-04-02 |
2004-11-04 |
ワイス |
B7−4に対するpd−1、aレセプター、およびその使用
|
ATE427948T1
(de)
|
2001-04-24 |
2009-04-15 |
Purdue Research Foundation |
Folat-mimetika und deren folatrezeptorbindende konjugate
|
PL367102A1
(en)
|
2001-05-02 |
2005-02-21 |
Purdue Research Foundation |
Treatment and diagnosis of macrophage mediated disease
|
US7109165B2
(en)
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
JP2004532888A
(ja)
|
2001-06-01 |
2004-10-28 |
ブリストル−マイヤーズ スクイブ カンパニー |
エポチロン誘導体
|
US20040018203A1
(en)
|
2001-06-08 |
2004-01-29 |
Ira Pastan |
Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates
|
UA77200C2
(en)
|
2001-08-07 |
2006-11-15 |
Wyeth Corp |
Antineoplastic combination of cci-779 and bkb-569
|
DE60206512T2
(de)
|
2001-08-22 |
2006-06-22 |
Wyeth |
Rapamycin 29-enole
|
US6680330B2
(en)
|
2001-08-22 |
2004-01-20 |
Wyeth |
Rapamycin dialdehydes
|
ATE451935T1
(de)
|
2001-09-28 |
2010-01-15 |
Purdue Research Foundation |
Behandlungsverfahren mit liganden- immunogenkonjugaten
|
GR1004163B
(el)
|
2001-11-01 |
2003-02-21 |
|
Πολυκυκλικα παραγωγα τροποποιησης των οπτικων ιδιοτητων και των ιδιοτητων αντοχης στο πλασμα των πολυμερων λιθογραφιας
|
US20050074457A1
(en)
|
2001-12-12 |
2005-04-07 |
Adeela Kamal |
Assays and implements for determining and modulating hsp90 binding activity
|
US20030194409A1
(en)
|
2002-01-17 |
2003-10-16 |
Rothman James E. |
Conjugate heat shock protein-binding peptides
|
US8043602B2
(en)
|
2002-02-07 |
2011-10-25 |
Endocyte, Inc. |
Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
|
US7000695B2
(en)
|
2002-05-02 |
2006-02-21 |
Halliburton Energy Services, Inc. |
Expanding wellbore junction
|
EP1501551B1
(en)
|
2002-05-06 |
2009-11-18 |
Endocyte, Inc. |
Folate-receptor targeted imaging agents
|
US6596757B1
(en)
|
2002-05-14 |
2003-07-22 |
Immunogen Inc. |
Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
|
CA2484640C
(en)
|
2002-05-15 |
2012-01-17 |
Endocyte, Inc. |
Vitamin-mitomycin conjugates
|
EP1521769B1
(de)
|
2002-07-09 |
2015-09-09 |
Dömling, Alexander |
Tubulysinkonjugate
|
AU2003266233A1
(en)
|
2002-07-09 |
2004-01-23 |
Morphochem Aktiengesellschaft Fur Kombinatorische Chemie |
Novel tubulysin analogues
|
PL374528A1
(en)
|
2002-07-31 |
2005-10-31 |
Schering Aktiengesellschaft |
New effector conjugates, process for their production and their pharmaceutical use
|
PT1545613E
(pt)
*
|
2002-07-31 |
2011-09-27 |
Seattle Genetics Inc |
Conjugados de auristatina e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infecciosa
|
DE10241152A1
(de)
|
2002-09-05 |
2004-03-18 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Tubulysin-Biosynthese-Gene
|
PT1534340E
(pt)
|
2002-09-06 |
2012-03-13 |
Cerulean Pharma Inc |
Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente
|
US20040047917A1
(en)
|
2002-09-06 |
2004-03-11 |
Stephen Wilson |
Drug delivery and targeting with vitamin B12 conjugates
|
CA2501752A1
(en)
|
2002-10-10 |
2004-04-22 |
Wyeth |
Compositions, organisms and methodologies employing a novel human kinase
|
AU2003286705A1
(en)
|
2002-10-24 |
2004-05-13 |
Research Corporation Technologies |
Functional mri agents for cancer imaging
|
MXPA05005385A
(es)
|
2002-11-21 |
2005-08-03 |
Wyeth Corp |
Composicion y metodo para tratar lupus nefritico.
|
DE10254439A1
(de)
|
2002-11-21 |
2004-06-03 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Tubulysine, Herstellungsverfahren und Tubulysin-Mittel
|
EP1572242B1
(en)
|
2002-12-13 |
2014-04-16 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
WO2004069159A2
(en)
|
2003-01-27 |
2004-08-19 |
Endocyte, Inc. |
Vitamin receptor binding drug delivery conjugates
|
AR042938A1
(es)
|
2003-02-06 |
2005-07-06 |
Wyeth Corp |
Uso del cci-779 en el tratamiento de la fibrosis hepatica
|
EP2664672A1
(en)
|
2003-04-17 |
2013-11-20 |
Alnylam Pharmaceuticals Inc. |
Modified iRNA agents
|
EP1622646B1
(en)
|
2003-05-06 |
2012-08-08 |
Purdue Research Foundation |
Treatment of lupus targeting the macrophages or the folate receptor
|
WO2004101803A2
(en)
|
2003-05-12 |
2004-11-25 |
Wyeth Holdings Corporation |
Process for producing anticancer agent ll-d45042
|
WO2005010010A1
(en)
|
2003-07-16 |
2005-02-03 |
Wyeth |
Cci-779 isomer c
|
KR20060057605A
(ko)
|
2003-08-07 |
2006-05-26 |
와이어쓰 |
Cci-779의 위치선택적 합성 방법
|
DE602005003453T2
(de)
|
2004-01-30 |
2008-09-25 |
Bayer Schering Pharma Aktiengesellschaft |
Neue effektor-konjugate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
|
WO2005111238A2
(en)
|
2004-04-19 |
2005-11-24 |
Archemix Corporation |
Aptamer-mediated intracellular delivery of therapeutic oligonucleotides
|
NZ550934A
(en)
|
2004-05-19 |
2010-05-28 |
Medarex Inc |
Chemical linkers and conjugates thereof
|
WO2005115912A1
(ja)
|
2004-05-25 |
2005-12-08 |
Matsushita Electric Industrial Co., Ltd. |
水素生成装置及びそれを用いた燃料電池システム
|
WO2006012527A1
(en)
|
2004-07-23 |
2006-02-02 |
Endocyte, Inc. |
Bivalent linkers and conjugates thereof
|
WO2006020768A2
(en)
|
2004-08-10 |
2006-02-23 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides
|
TW200616604A
(en)
|
2004-08-26 |
2006-06-01 |
Nicholas Piramal India Ltd |
Nitric oxide releasing prodrugs containing bio-cleavable linker
|
AU2005294214A1
(en)
|
2004-10-07 |
2006-04-20 |
Emory University |
Multifunctional nanoparticles conjugates and their use
|
US20060222653A1
(en)
|
2004-11-12 |
2006-10-05 |
Xencor, Inc. |
Antibodies operably linked to selected chemoattractants
|
US20110166319A1
(en)
|
2005-02-11 |
2011-07-07 |
Immunogen, Inc. |
Process for preparing purified drug conjugates
|
TW200640493A
(en)
|
2005-02-16 |
2006-12-01 |
Insert Therapeutics Inc |
Cyclodextrin-based polymers for therapeutics delivery
|
US7312217B2
(en)
|
2005-03-11 |
2007-12-25 |
Syntrix Biosystems, Inc. |
Aminopterin dosage forms and methods for inflammatory disorders
|
JP5289935B2
(ja)
|
2005-03-16 |
2013-09-11 |
エンドサイト,インコーポレイテッド |
プテロイン酸およびその結合体の合成と精製
|
CN101203759A
(zh)
|
2005-03-30 |
2008-06-18 |
普渡研究基金会 |
使用细胞叶酸维生素受体定量法而用于癌症预后的方法
|
AU2006262231B2
(en)
|
2005-06-20 |
2013-01-24 |
Psma Development Company, Llc |
PSMA antibody-drug conjugates
|
WO2007006041A2
(en)
|
2005-07-05 |
2007-01-11 |
Purdue Research Foundation |
Imaging and therapeutic method using monocytes
|
JP2009515508A
(ja)
|
2005-08-19 |
2009-04-16 |
ネオス テクノロジーズ インコーポレイテッド |
グリコpeg化因子viiおよび因子viia
|
ES2468240T3
(es)
*
|
2005-08-19 |
2014-06-16 |
Endocyte, Inc. |
Conjugados de ligando de múltiples fármacos
|
US20080280937A1
(en)
|
2005-08-19 |
2008-11-13 |
Christopher Paul Leamon |
Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives
|
IL305084A
(he)
|
2005-08-24 |
2023-10-01 |
Immunogen Inc |
תהליך להכנת תצריפי תרופה מטוהרים
|
EP1957113A4
(en)
|
2005-11-21 |
2011-11-09 |
Medivas Llc |
POLYMER PARTICLES FOR THE OUTPUT OF MACROMOLECULES AND METHOD OF APPLICATION THEREFOR
|
PE20080102A1
(es)
|
2006-05-25 |
2008-02-11 |
Bristol Myers Squibb Co |
Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos
|
EP2087337A4
(en)
|
2006-11-03 |
2010-09-08 |
Purdue Research Foundation |
METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY
|
JP2010516625A
(ja)
|
2007-01-24 |
2010-05-20 |
インサート セラピューティクス, インコーポレイテッド |
制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
|
WO2008101231A2
(en)
|
2007-02-16 |
2008-08-21 |
Endocyte, Inc. |
Methods and compositions for treating and diagnosing kidney disease
|
US8664181B2
(en)
*
|
2007-02-16 |
2014-03-04 |
Ktb Tumorforschungsgesellschaft Mbh |
Dual acting prodrugs
|
CN101678124A
(zh)
*
|
2007-03-14 |
2010-03-24 |
恩多塞特公司 |
结合配体连接的微管溶素递药缀合物
|
US8980833B2
(en)
|
2007-05-10 |
2015-03-17 |
R&D-Biopharmaceuticals Gmbh |
Tubulysine derivatives
|
US9877965B2
(en)
|
2007-06-25 |
2018-01-30 |
Endocyte, Inc. |
Vitamin receptor drug delivery conjugates for treating inflammation
|
EP3569251A1
(en)
|
2007-06-25 |
2019-11-20 |
Endocyte, Inc. |
Conjugates containing hydrophilic spacer linkers
|
US8476451B2
(en)
|
2007-07-20 |
2013-07-02 |
The Regents Of The University Of California |
Tubulysin D analogues
|
EP3656403B1
(en)
|
2007-08-17 |
2022-05-11 |
Purdue Research Foundation |
Preparation process of psma binding ligand-linker conjugates
|
CA2703491C
(en)
|
2007-10-25 |
2017-06-13 |
Endocyte, Inc. |
Tubulysins and processes for preparing
|
US8507455B2
(en)
|
2007-12-04 |
2013-08-13 |
Alnylam Pharmaceuticals, Inc. |
Folate conjugates
|
US8609105B2
(en)
*
|
2008-03-18 |
2013-12-17 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
BRPI0911442A2
(pt)
|
2008-04-30 |
2019-03-12 |
Immunogen, Inc. |
conjugados potentes e ligantes hidrofílicos
|
US20100040669A1
(en)
|
2008-08-12 |
2010-02-18 |
Higuchi John W |
Non-Invasive Ocular Delivery of Rapamycin
|
US20100074863A1
(en)
|
2008-09-17 |
2010-03-25 |
Yat Sun Or |
Anti-infective pyrrolidine derivatives and analogs
|
EP2349274A4
(en)
|
2008-09-17 |
2014-12-17 |
Endocyte Inc |
CONJUGATES OF ANTIFOLATES BINDING THE FOLATE RECEPTOR
|
EP2174947A1
(en)
|
2008-09-25 |
2010-04-14 |
Universität des Saarlandes |
Bioactive pre-tubulysins and use thereof
|
US20110288152A1
(en)
|
2008-10-17 |
2011-11-24 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
IT1394860B1
(it)
|
2009-07-22 |
2012-07-20 |
Kemotech S R L |
Composti farmaceutici
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
WO2011057805A1
(en)
|
2009-11-12 |
2011-05-19 |
R&D Biopharmaceuticals Gmbh |
Tubulin inhibitors
|
EP2322537A1
(en)
|
2009-11-12 |
2011-05-18 |
R & D Biopharmaceuticals Gmbh |
Tubulin inhibitors
|
WO2011069116A1
(en)
|
2009-12-04 |
2011-06-09 |
Endocyte, Inc. |
Binding ligand linked drug delivery conjugates of tubulysins
|
EP2515651A4
(en)
*
|
2009-12-23 |
2016-01-13 |
Endocyte Inc |
VITAMIN RECEPTOR-ACTIVE EXTRACTION CONJUGATES FOR THE TREATMENT OF INFLAMMATION
|
WO2011106639A1
(en)
*
|
2010-02-25 |
2011-09-01 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
CA2807511A1
(en)
|
2010-08-06 |
2012-02-09 |
Endocyte, Inc. |
Processes for preparing tubulysins
|
WO2012047525A2
(en)
|
2010-09-27 |
2012-04-12 |
Endocyte, Inc. |
Folate conjugates for treating inflammation of the eye
|
US20140243282A1
(en)
|
2010-12-31 |
2014-08-28 |
Satish Reddy Kallam |
Methods and compositions for designing novel conjugate therapeutics
|
BR112013025228A2
(pt)
|
2011-03-29 |
2018-09-25 |
Immunogen Inc |
processo para fabricar conjugados de homogeneidade aperfeçoada
|
KR20220009505A
(ko)
|
2011-03-29 |
2022-01-24 |
이뮤노젠 아이엔씨 |
일-단계 방법에 의한 메이탄시노이드 항체 접합체의 제조
|
JP6209159B2
(ja)
|
2011-06-21 |
2017-10-04 |
イミュノジェン・インコーポレーテッド |
ペプチドリンカーを有する新規メイタンシノイド誘導体およびその結合体
|
BR112014013526A8
(pt)
|
2011-12-05 |
2017-06-13 |
Igenica Biotherapeutics Inc |
conjugados de anticorpo-fármaco e compostos, composições e métodos relacionados
|
US10080805B2
(en)
|
2012-02-24 |
2018-09-25 |
Purdue Research Foundation |
Cholecystokinin B receptor targeting for imaging and therapy
|
EP2822386B1
(en)
|
2012-02-29 |
2021-05-05 |
Purdue Research Foundation |
Folate receptor alpha binding ligands
|
US20140080175A1
(en)
|
2012-03-29 |
2014-03-20 |
Endocyte, Inc. |
Processes for preparing tubulysin derivatives and conjugates thereof
|
WO2013170272A2
(en)
|
2012-05-11 |
2013-11-14 |
Alexander Krantz |
Site-specific labeling and targeted delivery of proteins for the treatment of cancer
|
US9884127B2
(en)
|
2012-05-15 |
2018-02-06 |
Concortis Biosystems, Corp. |
Drug-conjugates, conjugation methods, and uses thereof
|
PL2872157T3
(pl)
|
2012-07-12 |
2020-07-13 |
Hangzhou Dac Biotech Co., Ltd |
Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi
|
EP2708243A1
(en)
|
2012-09-17 |
2014-03-19 |
OntoChem GmbH |
Receptor ligand linked cytotoxic molecules
|
AU2013331440A1
(en)
|
2012-10-16 |
2015-04-30 |
Endocyte, Inc. |
Drug delivery conjugates containing unnatural amino acids and methods for using
|
US20140107316A1
(en)
|
2012-10-16 |
2014-04-17 |
Endocyte, Inc. |
Drug delivery conjugates containing unnatural amino acids and methods for using
|
JP6892218B2
(ja)
|
2012-11-15 |
2021-06-23 |
エンドサイト・インコーポレイテッドEndocyte, Inc. |
薬物送達結合体およびpsma発現細胞によって引き起こされる疾患の治療方法
|
CA2891280C
(en)
|
2012-11-24 |
2018-03-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
US20140154702A1
(en)
|
2012-11-30 |
2014-06-05 |
Endocyte, Inc. |
Methods For Treating Cancer Using Combination Therapies
|
RU2019105549A
(ru)
|
2012-12-21 |
2019-03-28 |
Биоэллаенс К. В. |
Гидрофильные саморазрушающиеся линкеры и их конъюгаты
|
KR102215954B1
(ko)
|
2013-02-14 |
2021-02-15 |
브리스톨-마이어스 스큅 컴퍼니 |
튜부리신 화합물, 그의 제조 및 사용 방법
|
US20140249315A1
(en)
|
2013-03-01 |
2014-09-04 |
Endocyte, Inc. |
Processes for preparing tubulysins
|