IN2014MN00974A - - Google Patents
Info
- Publication number
- IN2014MN00974A IN2014MN00974A IN974MUN2014A IN2014MN00974A IN 2014MN00974 A IN2014MN00974 A IN 2014MN00974A IN 974MUN2014 A IN974MUN2014 A IN 974MUN2014A IN 2014MN00974 A IN2014MN00974 A IN 2014MN00974A
- Authority
- IN
- India
- Prior art keywords
- nucleic acid
- acid sequence
- modifying
- target
- target nucleic
- Prior art date
Links
- 150000007523 nucleic acids Chemical group 0.000 abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 102000011931 Nucleoproteins Human genes 0.000 abstract 2
- 108010061100 Nucleoproteins Proteins 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161576423P | 2011-12-16 | 2011-12-16 | |
PCT/IL2012/050528 WO2013088446A1 (en) | 2011-12-16 | 2012-12-16 | Compositions and methods for modifying a predetermined target nucleic acid sequence |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014MN00974A true IN2014MN00974A (de) | 2015-04-24 |
Family
ID=48611953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN974MUN2014 IN2014MN00974A (de) | 2011-12-16 | 2012-12-16 |
Country Status (15)
Country | Link |
---|---|
US (5) | US11458157B2 (de) |
EP (1) | EP2790708A4 (de) |
JP (1) | JP2015500648A (de) |
CN (1) | CN104080462B (de) |
AU (2) | AU2012354062B2 (de) |
BR (1) | BR112014014105B1 (de) |
CA (2) | CA3226329A1 (de) |
HK (1) | HK1203362A1 (de) |
IL (2) | IL253373A0 (de) |
IN (1) | IN2014MN00974A (de) |
PH (1) | PH12014501360A1 (de) |
RU (1) | RU2663354C2 (de) |
UA (1) | UA115772C2 (de) |
WO (1) | WO2013088446A1 (de) |
ZA (1) | ZA201403785B (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3078753B1 (de) | 2010-05-10 | 2018-04-18 | The Regents of The University of California | Verfahren unter verwendung von endoribonukleasezusammensetzungen |
US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
UA116097C2 (uk) | 2011-12-11 | 2018-02-12 | Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре | Спосіб модуляції провідності устячка рослини |
GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
US10415024B2 (en) | 2012-11-16 | 2019-09-17 | Poseida Therapeutics, Inc. | Site-specific enzymes and methods of use |
ES2901396T3 (es) | 2013-03-14 | 2022-03-22 | Caribou Biosciences Inc | Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico |
US9902973B2 (en) | 2013-04-11 | 2018-02-27 | Caribou Biosciences, Inc. | Methods of modifying a target nucleic acid with an argonaute |
GB201311057D0 (en) | 2013-06-21 | 2013-08-07 | Univ Greenwich | Antisense oligonucleotide compositions |
US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
US10538570B2 (en) * | 2013-09-30 | 2020-01-21 | Northwestern University | Targeted and modular exosome loading system |
ES2962492T3 (es) | 2013-10-25 | 2024-03-19 | Livestock Improvement Corporation Ltd | Marcadores genéticos y usos de los mismos |
US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
CN111705365A (zh) | 2014-02-11 | 2020-09-25 | 科罗拉多州立大学董事会(法人团体) | Crispr支持的多路基因组工程化 |
CN106459884A (zh) * | 2014-05-16 | 2017-02-22 | 株式会社钟化 | 土壤杆菌及使用土壤杆菌的转化植物的制造方法 |
EP3157328B1 (de) * | 2014-06-17 | 2021-08-04 | Poseida Therapeutics, Inc. | Verfahren zum lenken von proteinen zu spezifischen loci im genom und verwendungen davon |
WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
EP3175023A4 (de) | 2014-07-30 | 2018-03-07 | President and Fellows of Harvard College | Systeme und verfahren zur bestimmung von nukleinsäuren |
JP6830437B2 (ja) | 2014-12-10 | 2021-02-17 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 疾患を処置するための遺伝子改変された細胞、組織および臓器 |
EP3286322A1 (de) | 2015-04-21 | 2018-02-28 | Novartis AG | System zur rna-geführten genänderung und verwendungen davon |
DK3310909T3 (da) | 2015-06-17 | 2021-09-13 | Poseida Therapeutics Inc | Sammensætninger og fremgangsmåder til at føre proteiner til specifikke loci i genomet |
CN108472314A (zh) | 2015-07-31 | 2018-08-31 | 明尼苏达大学董事会 | 修饰的细胞和治疗方法 |
AU2016341041A1 (en) | 2015-10-20 | 2018-03-15 | Pioneer Hi-Bred International, Inc. | Methods and compositions for marker-free genome modification |
IL258821B (en) | 2015-10-23 | 2022-07-01 | Harvard College | Nucleobase editors and their uses |
US11098304B2 (en) * | 2015-11-04 | 2021-08-24 | Atreca, Inc. | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
SG10202112024PA (en) | 2016-01-11 | 2021-12-30 | Univ Leland Stanford Junior | Chimeric proteins and methods of immunotherapy |
IL260532B2 (en) | 2016-01-11 | 2023-12-01 | Univ Leland Stanford Junior | Systems containing chaperone proteins and their uses for controlling gene expression |
US9896696B2 (en) * | 2016-02-15 | 2018-02-20 | Benson Hill Biosystems, Inc. | Compositions and methods for modifying genomes |
EP3417065A4 (de) * | 2016-02-18 | 2019-07-17 | President and Fellows of Harvard College | Verfahren und systeme zur molekularen aufzeichnung durch crispr-cas-system |
EP3426780A1 (de) | 2016-03-11 | 2019-01-16 | Pioneer Hi-Bred International, Inc. | Neuartige cas9-systeme und verfahren zur verwendung |
CN105779609A (zh) * | 2016-04-15 | 2016-07-20 | 上海伊丽萨生物科技有限公司 | 一种超敏免疫检测方法 |
EP3474669B1 (de) | 2016-06-24 | 2022-04-06 | The Regents of The University of Colorado, A Body Corporate | Verfahren zur erzeugung von kombinatorischen barcodierten bibliotheken |
SG11201900907YA (en) | 2016-08-03 | 2019-02-27 | Harvard College | Adenosine nucleobase editors and uses thereof |
US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
US20190225974A1 (en) | 2016-09-23 | 2019-07-25 | BASF Agricultural Solutions Seed US LLC | Targeted genome optimization in plants |
CN107880132B (zh) * | 2016-09-30 | 2022-06-17 | 北京大学 | 一种融合蛋白及使用其进行同源重组的方法 |
GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
EP4338799A3 (de) | 2016-10-18 | 2024-06-05 | Regents of the University of Minnesota | Tumorinfiltrierende lymphozyten und therapieverfahren |
US20190276881A1 (en) * | 2016-11-08 | 2019-09-12 | President And Fellows Of Harvard College | Multiplexed imaging using merfish, expansion microscopy, and related technologies |
WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
EP3592853A1 (de) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Unterdrückung von schmerzen durch geneditierung |
WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
CA3056650A1 (en) | 2017-03-30 | 2018-10-04 | Pioneer Hi-Bred International, Inc. | Methods of identifying and characterizing gene editing variations in nucleic acids |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
EP3625340A4 (de) * | 2017-05-18 | 2021-02-24 | Cargill, Incorporated | Genomeditiersystem |
WO2018218150A1 (en) | 2017-05-26 | 2018-11-29 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
WO2019006418A2 (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物 |
CN111263810A (zh) * | 2017-08-22 | 2020-06-09 | 纳匹基因公司 | 使用多核苷酸指导的核酸内切酶的细胞器基因组修饰 |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
CN107759673B (zh) * | 2017-09-27 | 2021-06-04 | 复旦大学 | 可对hbv的dna进行表观甲基化修饰的蛋白分子及其应用 |
US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
CN111566121A (zh) | 2018-01-12 | 2020-08-21 | 巴斯夫欧洲公司 | 小麦7a染色体上决定每穗小穗数QTL的基因 |
CN112292138A (zh) | 2018-01-22 | 2021-01-29 | 西雅图儿童医院(Dba西雅图儿童研究所) | Car t细胞的使用方法 |
CA3096859A1 (en) | 2018-05-25 | 2019-11-28 | Pioneer Hi-Bred International, Inc. | Systems and methods for improved breeding by modulating recombination rates |
CN109355246B (zh) * | 2018-11-21 | 2022-02-11 | 河南农业大学 | 一种拟南芥叶肉细胞原生质体及其制备方法和应用 |
RU2712497C1 (ru) * | 2018-11-26 | 2020-01-29 | Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий | Средство разрезания ДНК на основе Cas9 белка из биотехнологически значимой бактерии Clostridium cellulolyticum |
RU2712492C1 (ru) * | 2018-11-26 | 2020-01-29 | Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий | Средство разрезания днк на основе cas9 белка из defluviimonas sp. |
WO2020163379A1 (en) | 2019-02-05 | 2020-08-13 | Emendobio Inc. | Crispr compositions and methods for promoting gene editing of ribosomal protein s19 (rps19) gene |
WO2020191153A2 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
WO2021178569A2 (en) * | 2020-03-04 | 2021-09-10 | Regents Of The University Of Minnesota | Anti-dr5 polypeptides and methods of use thereof |
CN111514949B (zh) * | 2020-04-27 | 2020-12-01 | 四川大学 | 一种微流控芯片及其制备方法 |
KR20230019843A (ko) | 2020-05-08 | 2023-02-09 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적 이중 가닥 뉴클레오티드 서열의 두 가닥의 동시 편집을 위한 방법 및 조성물 |
WO2022170058A1 (en) * | 2021-02-05 | 2022-08-11 | University Of Massachusetts | Prime editor system for in vivo genome editing |
EP4095243A1 (de) * | 2021-05-25 | 2022-11-30 | European Molecular Biology Laboratory | System zur hybridisierungsbasierten präzisionsgenomspaltung und -editierung und verwendungen davon |
CA3234338A1 (en) | 2021-10-08 | 2023-04-13 | Pencil Biosciences Limited | Synthetic genome editing system |
AU2022386792A1 (en) * | 2021-11-12 | 2024-05-09 | Targetgene Biotechnologies Ltd. | Systems and methods for trans-modulation of immune cells by genetic manipulation of immune regulatory genes |
CN114717259B (zh) * | 2022-05-26 | 2023-06-20 | 山西大学 | 一种温控诱导型基因编辑系统及其应用 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
US4935357A (en) | 1986-02-05 | 1990-06-19 | New England Biolabs, Inc. | Universal restriction endonuclease |
DE69031172T2 (de) | 1989-12-22 | 1998-03-12 | Applied Research Systems | Modifikation der endogenen genexpression mit hilfe eines regulatorischen elements mittels homologe rekombination |
US6544780B1 (en) | 2000-06-02 | 2003-04-08 | Genphar, Inc. | Adenovirus vector with multiple expression cassettes |
CA2425917A1 (en) * | 2000-10-13 | 2002-04-18 | Crosslink Genetics Corporation | Artificial transcriptional factors and methods of use |
CA2482481A1 (en) * | 2002-04-16 | 2003-10-30 | Promega Corporation | Method to enhance homologous recombination |
US9447434B2 (en) * | 2002-09-05 | 2016-09-20 | California Institute Of Technology | Use of chimeric nucleases to stimulate gene targeting |
ES2808687T3 (es) * | 2003-08-08 | 2021-03-01 | Sangamo Therapeutics Inc | Métodos y composiciones para escisión dirigida y recombinación |
DE102004043155A1 (de) | 2004-09-03 | 2006-03-23 | TransMIT Gesellschaft für Technologietransfer mbH | Hochspezifisch mit DNA interagierende Enzym-Konjugate mit programmierbarer Spezifität |
US20070042404A1 (en) * | 2005-08-19 | 2007-02-22 | Huimin Zhao | Compositions and method for detecting endonuclease activity |
DK2341149T3 (en) | 2005-08-26 | 2017-02-27 | Dupont Nutrition Biosci Aps | Use of CRISPR-associated genes (Cas) |
WO2008130629A2 (en) * | 2007-04-19 | 2008-10-30 | Codon Devices, Inc. | Engineered nucleases and their uses for nucleic acid assembly |
EP2215252A4 (de) | 2007-12-07 | 2011-01-26 | Prec Biosciences Inc | Rational entworfene meganukleasen mit erkennungssequenzen aus dnase-hypersensitiven regionen des menschlichen genoms |
US20100076057A1 (en) | 2008-09-23 | 2010-03-25 | Northwestern University | TARGET DNA INTERFERENCE WITH crRNA |
US9404098B2 (en) | 2008-11-06 | 2016-08-02 | University Of Georgia Research Foundation, Inc. | Method for cleaving a target RNA using a Cas6 polypeptide |
NZ598457A (en) | 2009-08-03 | 2014-06-27 | Recombinetics Inc | Methods and compositions for targeted gene modification |
CA2781835A1 (en) * | 2009-11-27 | 2011-06-03 | Basf Plant Science Company Gmbh | Chimeric endonucleases and uses thereof |
EP2510096B2 (de) | 2009-12-10 | 2018-02-07 | Regents of the University of Minnesota | Tal-effektorvermittelte dna-modifizierung |
CA2798988C (en) * | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Tal-effector (tale) dna-binding polypeptides and uses thereof |
EP2392208B1 (de) | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusionsproteine, die eine DNA-Bindungsdomäne eines TAL-Effektorproteins und eine unspezifische Spaltungsdomäne einer Restriktionsnuklease umfassen, und deren Verwendung |
JP5725864B2 (ja) | 2010-08-06 | 2015-05-27 | 株式会社 資生堂 | エラスターゼ阻害剤 |
CN103842511A (zh) | 2011-03-23 | 2014-06-04 | 先锋国际良种公司 | 产生复合转基因性状基因座的方法 |
GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
PE20150336A1 (es) * | 2012-05-25 | 2015-03-25 | Univ California | Metodos y composiciones para la modificacion de adn objetivo dirigida por arn y para la modulacion de la transcripcion dirigida por arn |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
US9340800B2 (en) * | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
-
2012
- 2012-12-16 IN IN974MUN2014 patent/IN2014MN00974A/en unknown
- 2012-12-16 WO PCT/IL2012/050528 patent/WO2013088446A1/en active Application Filing
- 2012-12-16 RU RU2014129015A patent/RU2663354C2/ru active
- 2012-12-16 EP EP12857977.8A patent/EP2790708A4/de active Pending
- 2012-12-16 CA CA3226329A patent/CA3226329A1/en active Pending
- 2012-12-16 US US14/364,216 patent/US11458157B2/en active Active
- 2012-12-16 BR BR112014014105-3A patent/BR112014014105B1/pt active IP Right Grant
- 2012-12-16 AU AU2012354062A patent/AU2012354062B2/en active Active
- 2012-12-16 UA UAA201408005A patent/UA115772C2/uk unknown
- 2012-12-16 CA CA2858801A patent/CA2858801C/en active Active
- 2012-12-16 CN CN201280062262.XA patent/CN104080462B/zh active Active
- 2012-12-16 JP JP2014546733A patent/JP2015500648A/ja active Pending
-
2014
- 2014-05-23 ZA ZA2014/03785A patent/ZA201403785B/en unknown
- 2014-06-16 PH PH12014501360A patent/PH12014501360A1/en unknown
-
2015
- 2015-04-21 HK HK15103852.4A patent/HK1203362A1/xx unknown
-
2017
- 2017-03-03 US US15/449,468 patent/US11690866B2/en active Active
- 2017-03-03 US US15/449,492 patent/US11278560B2/en active Active
- 2017-04-28 US US15/582,384 patent/US10220052B2/en active Active
- 2017-07-09 IL IL253373A patent/IL253373A0/en active IP Right Grant
- 2017-07-09 IL IL253372A patent/IL253372B/en active IP Right Grant
- 2017-11-28 AU AU2017268502A patent/AU2017268502B2/en active Active
-
2023
- 2023-05-15 US US18/317,447 patent/US20240148771A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2014MN00974A (de) | ||
IL274204B (en) | Preparations Containing, Methods Involving, and Uses of Unnatural Amino Acids Related to Dolastatin History | |
HK1247254A1 (zh) | 核酸測序的方法和組合物 | |
AU2017248555B2 (en) | Closed nucleic acid structures | |
EA201390145A1 (ru) | Конъюгаты, частицы, композиции и связанные с ними способы | |
HK1246360A1 (zh) | 用於蛋白質和核酸的超高靈敏度測量的方法和試劑盒以及新型酶底物 | |
HRP20190484T1 (hr) | Pripravci stanične kulture i postupci proizvodnje polipeptida | |
GB2487632B (en) | Methods,compositions,and kits for determining the presence/absence of a variant nucleic acid sequence | |
SG11201403450VA (en) | Artificial nucleic acid molecules for improved protein or peptide expression | |
EA201590488A1 (ru) | Способы модификации клеток-хозяев | |
ZA201309652B (en) | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives | |
IN2014CN02527A (de) | ||
MX2013003681A (es) | Ácidos nucleicos manipulados y métodos de uso de los mismos. | |
AU2011356210A8 (en) | Novel fucosyltransferases and their applications | |
WO2013170170A3 (en) | Compositions and methods for gene therapy | |
MX2015007875A (es) | Productos para el cuidado oral que contienen un complejo de zinc tetrabasico-aminaocido-halogenuro. | |
EA201690529A1 (ru) | Способы модификации клетки-хозяина | |
BR112014019901A8 (pt) | Proteínas de fator viii recombinante | |
EP2576836A4 (de) | Zusammensetzungen und verfahren zur sequenzierung von nukleinsäuren | |
IL222200A0 (en) | Plant peptide gamma-zein for delivery of biomolecules into plant cells | |
EP2414385A4 (de) | Zusammensetzungen und verfahren zur modulation der wirkung komplementärer regulatorproteine auf zielzellen | |
MX361434B (es) | Proteínas de fusión npp1. | |
WO2012135575A3 (en) | Compositions and methods for introduction of macromolecules into cells | |
IN2014DN04600A (de) | ||
FI20105629A0 (fi) | Menetelmä lipidiaktivoituvien entsyymien peptidi-inhibiittoreiden valmistamiseksi ja menetelmällä valmistettuja peptidejä |