MX2013010392A - Proteinas de fusion npp1. - Google Patents
Proteinas de fusion npp1.Info
- Publication number
- MX2013010392A MX2013010392A MX2013010392A MX2013010392A MX2013010392A MX 2013010392 A MX2013010392 A MX 2013010392A MX 2013010392 A MX2013010392 A MX 2013010392A MX 2013010392 A MX2013010392 A MX 2013010392A MX 2013010392 A MX2013010392 A MX 2013010392A
- Authority
- MX
- Mexico
- Prior art keywords
- fusion polypeptide
- fusion proteins
- vector
- npp1
- npp1 fusion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04001—Phosphodiesterase I (3.1.4.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Abstract
La presente invención proporciona un polipéptido de fusión novedoso que contiene un dominio catalítico de NPP1 fusionado a un resto de direccionamiento, ácidos nucleicos que codifican el polipéptido de fusión, un vector que contiene el ácido nucleico integrado en este, una célula hospedadora transformada con el vector y composiciones farmacéuticas que comprenden el polipéptido de fusión.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2011/028233 WO2011113027A2 (en) | 2010-03-12 | 2011-03-11 | Npp1 fusion proteins |
PCT/US2011/051858 WO2012125182A1 (en) | 2011-03-11 | 2011-09-15 | Npp1 fusion proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013010392A true MX2013010392A (es) | 2014-03-27 |
MX361434B MX361434B (es) | 2018-12-06 |
Family
ID=46831271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013010392A MX361434B (es) | 2011-03-11 | 2011-09-15 | Proteínas de fusión npp1. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP2683742B1 (es) |
KR (1) | KR101772366B1 (es) |
CN (1) | CN103443128B (es) |
AU (1) | AU2011362576B2 (es) |
CA (1) | CA2829767C (es) |
MX (1) | MX361434B (es) |
RU (1) | RU2601154C2 (es) |
SG (1) | SG193024A1 (es) |
WO (1) | WO2012125182A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014126965A2 (en) * | 2013-02-13 | 2014-08-21 | Yale University | Compositions and methods for treating pathological calcification and ossification |
EP3234116B1 (en) | 2014-12-19 | 2021-09-08 | Alexion Pharmaceuticals, Inc. | Methods of treating tissue calcification |
US10787523B2 (en) * | 2015-01-29 | 2020-09-29 | University Of Massachusetts | Nanoparticle-protein complex for intracellular protein delivery |
JP6995627B2 (ja) * | 2015-05-19 | 2022-02-04 | イエール ユニバーシティ | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
WO2017218786A1 (en) | 2016-06-16 | 2017-12-21 | Alexion Pharmaceuticals, Inc. | Methods of treating myointimal proliferation |
US11390859B2 (en) | 2016-08-05 | 2022-07-19 | Yale University | Compositions and methods for stroke prevention in pediatric sickle cell anemia patients |
US20220119782A1 (en) * | 2018-08-31 | 2022-04-21 | Yale University | ENPP1 Polypeptides and Methods of Using Same |
CA3181983A1 (en) | 2020-06-09 | 2021-12-16 | Zhiliang Cheng | Soluble enpp1 or enpp3 proteins and uses thereof |
CN113388625B (zh) * | 2021-06-03 | 2022-06-24 | 广西大学 | 一种甘蔗梢腐病效应因子Fs_00548基因及其应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US6825396B2 (en) | 1996-06-12 | 2004-11-30 | Board Of Trustees Operating Michigan State University | Methods for tissue specific synthesis of protein in eggs of transgenic hens |
KR20010031190A (ko) | 1997-10-16 | 2001-04-16 | 아비게닉스, 인코포레이티드 | 조류 트랜스제네시스용 매그넘-특이적 프로모터를함유하는 벡터 |
US20040019923A1 (en) | 1997-10-16 | 2004-01-29 | Ivarie Robert D. | Exogenous proteins expressed in avians and their eggs |
US5932465A (en) * | 1997-10-16 | 1999-08-03 | Icos Corporation | Phosphodiesterase 8A |
AU748587B2 (en) | 1997-11-07 | 2002-06-06 | Trillium Therapeutics Inc | Methods and compositions for immunomodulation |
DE20121960U1 (de) * | 2000-04-06 | 2004-01-15 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit Metastase assoziierten Krankheiten |
US20020108132A1 (en) | 2001-02-02 | 2002-08-08 | Avigenics Inc. | Production of a monoclonal antibody by a transgenic chicken |
US7294507B2 (en) | 2001-11-30 | 2007-11-13 | Avigenics, Inc. | Ovomucoid promoters and methods of use |
US6875588B2 (en) | 2001-11-30 | 2005-04-05 | Avigenics, Inc. | Ovomucoid promoter and methods of use |
US7858297B2 (en) | 2001-12-18 | 2010-12-28 | Centre National De La Recherche Scientifique Cnrs | Chemokine-binding protein and methods of use |
US7323542B2 (en) | 2002-02-21 | 2008-01-29 | University Of Virginia Patent Foundation | Bone targeting peptides |
US20050090001A1 (en) | 2003-10-07 | 2005-04-28 | Parker Stephen H. | Cell lines and methods for producing proteins |
ES2628841T3 (es) * | 2010-03-12 | 2017-08-04 | Alexion Pharmaceuticals, Inc. | Proteínas de fusión npp1 |
-
2011
- 2011-09-15 EP EP11861101.1A patent/EP2683742B1/en active Active
- 2011-09-15 SG SG2013067442A patent/SG193024A1/en unknown
- 2011-09-15 CN CN201180069050.XA patent/CN103443128B/zh not_active Expired - Fee Related
- 2011-09-15 AU AU2011362576A patent/AU2011362576B2/en not_active Ceased
- 2011-09-15 MX MX2013010392A patent/MX361434B/es active IP Right Grant
- 2011-09-15 WO PCT/US2011/051858 patent/WO2012125182A1/en active Application Filing
- 2011-09-15 KR KR1020177003612A patent/KR101772366B1/ko active IP Right Grant
- 2011-09-15 RU RU2013142583/10A patent/RU2601154C2/ru active IP Right Revival
- 2011-09-15 CA CA2829767A patent/CA2829767C/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2011362576A1 (en) | 2013-09-19 |
EP2683742A4 (en) | 2014-08-06 |
CA2829767C (en) | 2023-08-29 |
MX361434B (es) | 2018-12-06 |
RU2013142583A (ru) | 2015-04-20 |
CN103443128B (zh) | 2017-11-24 |
KR101772366B1 (ko) | 2017-08-28 |
EP2683742A1 (en) | 2014-01-15 |
EP2683742B1 (en) | 2018-12-19 |
SG193024A1 (en) | 2013-10-30 |
WO2012125182A1 (en) | 2012-09-20 |
AU2011362576B2 (en) | 2017-06-08 |
CN103443128A (zh) | 2013-12-11 |
CA2829767A1 (en) | 2012-09-20 |
RU2601154C2 (ru) | 2016-10-27 |
KR20170018473A (ko) | 2017-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: ALEXION PHARMACEUTICALS, INC. |