IN2013MU03577A - - Google Patents

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Publication number
IN2013MU03577A
IN2013MU03577A IN3577MU2013A IN2013MU03577A IN 2013MU03577 A IN2013MU03577 A IN 2013MU03577A IN 3577MU2013 A IN3577MU2013 A IN 3577MU2013A IN 2013MU03577 A IN2013MU03577 A IN 2013MU03577A
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IN
India
Prior art keywords
preparation
novel
compounds
stereoisomers
agonists
Prior art date
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English (en)
Inventor
Ranjit C Desai
Brijeshkumar Srivastava
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to MX2016006337A priority Critical patent/MX2016006337A/es
Priority to KR1020167015760A priority patent/KR20160077213A/ko
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Priority to JP2016530884A priority patent/JP6352415B2/ja
Priority to US15/034,661 priority patent/US10011609B2/en
Priority to CN201480061963.0A priority patent/CN105722841A/zh
Priority to IN3577MU2013 priority patent/IN2013MU03577A/en
Priority to PCT/IN2014/000704 priority patent/WO2015097713A1/en
Priority to AU2014372114A priority patent/AU2014372114A1/en
Priority to CA2928097A priority patent/CA2928097A1/en
Priority to EA201690888A priority patent/EA201690888A1/ru
Priority to AP2016009176A priority patent/AP2016009176A0/en
Priority to EP14851420.1A priority patent/EP3068788A1/en
Priority to TW103138358A priority patent/TW201531459A/zh
Priority to ARP140104297A priority patent/AR098432A1/es
Publication of IN2013MU03577A publication Critical patent/IN2013MU03577A/en
Priority to IL245301A priority patent/IL245301A0/he
Priority to MA38999A priority patent/MA38999A1/fr
Priority to PH12016500885A priority patent/PH12016500885A1/en
Priority to HK16109584.5A priority patent/HK1221465A1/zh
Priority to US16/002,007 priority patent/US10246470B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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AU2014372114A AU2014372114A1 (en) 2013-11-14 2014-11-03 Novel heterocyclic compounds
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US15/034,661 US10011609B2 (en) 2013-11-14 2014-11-03 Heterocyclic compounds
JP2016530884A JP6352415B2 (ja) 2013-11-14 2014-11-03 新規なヘテロ環化合物
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101569522B1 (ko) * 2013-04-18 2015-11-17 현대약품 주식회사 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
CN111423408A (zh) 2014-10-17 2020-07-17 现代药品株式会社 代谢性疾病的预防或治疗用复合制剂
CN107208906A (zh) * 2015-02-17 2017-09-26 三菱电机株式会社 室外机
US10208030B2 (en) * 2016-04-08 2019-02-19 Mankind Pharma Ltd. GPR119 agonist compounds
EP3551176A4 (en) * 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. ANTIDIABETIC HETEROCYCLIC COMPOUNDS
PE20210640A1 (es) 2018-02-13 2021-03-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
TWI712412B (zh) 2018-04-19 2020-12-11 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
ES2962674T3 (es) 2018-07-13 2024-03-20 Gilead Sciences Inc Inhibidores PD-1/PD-L1
CN112955435B (zh) 2018-10-24 2024-09-06 吉利德科学公司 Pd-1/pd-l1抑制剂
AU2020363377A1 (en) 2019-10-07 2022-04-21 Kallyope, Inc. GPR119 agonists
CA3178994A1 (en) 2020-05-19 2021-11-25 Iyassu Sebhat Ampk activators
AU2021297323A1 (en) 2020-06-26 2023-02-16 Kallyope, Inc. AMPK activators

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011446A1 (en) 2002-07-26 2004-02-05 Bayer Pharmaceuticals Corporation Indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives and their use as antidiabetics
US7820837B2 (en) 2003-05-30 2010-10-26 Takeda Pharmaceutical Company Limited Condensed ring compound
US7456218B2 (en) 2003-12-25 2008-11-25 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl) propanoic acid derivatives
EP1737809B1 (en) 2004-02-27 2013-09-18 Amgen, Inc Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
JP4859665B2 (ja) 2004-03-30 2012-01-25 武田薬品工業株式会社 アルコキシフェニルプロパン酸誘導体
WO2006038738A1 (ja) 2004-10-08 2006-04-13 Takeda Pharmaceutical Company Limited 受容体機能調節剤
CA2593788A1 (en) 2005-01-28 2006-08-10 Merck And Co., Inc. Antidiabetic bicyclic compounds
JP2008528628A (ja) 2005-01-31 2008-07-31 メルク エンド カムパニー インコーポレーテッド 抗糖尿病性二環式化合物
EP1912065B1 (en) 2005-07-27 2015-02-18 Ajinomoto Co., Inc. Method for analysis of albumin in sample solution
WO2007049050A2 (en) 2005-10-27 2007-05-03 Heptahelix Ab Modulators of gpr40 for the treatment of diabetes
TW200815377A (en) 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
CA2651153C (en) 2006-05-15 2014-04-29 Merck & Co., Inc. Antidiabetic bicyclic compounds
US20070297620A1 (en) 2006-06-27 2007-12-27 Choy Daniel S J Methods and Systems for Producing a Zone of Reduced Background Noise
UA95296C2 (uk) 2006-06-27 2011-07-25 Такеда Фармасьютікал Компані Лімітед Конденсовані циклічні сполуки
CA2662305C (en) 2006-09-07 2012-04-17 Amgen Inc. Heterocyclic gpr40 modulators
AU2007314405A1 (en) 2006-10-31 2008-05-08 Merck & Co., Inc. Antidiabetic bicyclic compounds
WO2008054674A2 (en) 2006-10-31 2008-05-08 Merck & Co., Inc. Antidiabetic bicyclic compounds
JP2010524932A (ja) 2007-04-16 2010-07-22 アムジエン・インコーポレーテツド 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸ｇｐｒ４０調節物質
US8318781B2 (en) 2007-04-26 2012-11-27 Japan Science And Technology Agency G-protein-conjugated receptor agonist
WO2009038204A1 (ja) 2007-09-17 2009-03-26 Pharma Frontier Co., Ltd. 新規長鎖脂肪酸誘導体化合物及びそれら化合物を有効成分とするｇタンパク質共役型レセプター作動剤
WO2009048527A1 (en) 2007-10-10 2009-04-16 Amgen Inc. Substituted biphenyl gpr40 modulators
TW200932219A (en) 2007-10-24 2009-08-01 Astellas Pharma Inc Oxadiazolidinedione compound
US8399507B2 (en) 2007-10-29 2013-03-19 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2010012650A1 (en) 2008-07-28 2010-02-04 Syddansk Universitet Compounds for the treatment of metabolic diseases
US8748462B2 (en) 2008-10-15 2014-06-10 Amgen Inc. Spirocyclic GPR40 modulators
US20110312995A1 (en) 2009-01-23 2011-12-22 Schering Corporation Bridged and fused heterocyclic antidiabetic compounds
US20110313008A1 (en) 2009-01-23 2011-12-22 Schering Corporation Pentafluorosulpholane-containing antidiabetic compounds
US20110312967A1 (en) 2009-01-23 2011-12-22 Schering Corporation Bridged and fused antidiabetic compounds
US8575166B2 (en) 2009-02-05 2013-11-05 Merck Sharp & Dohme Corp. Phthalazine-containing antidiabetic compounds
JPWO2010123016A1 (ja) 2009-04-22 2012-10-25 アステラス製薬株式会社 カルボン酸化合物
MX2012003389A (es) 2009-10-06 2012-04-10 Bristol Myers Squibb Co Moduladores de gpr40 de pirrolidina.
AR078522A1 (es) * 2009-10-15 2011-11-16 Lilly Co Eli Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
JPWO2011052756A1 (ja) 2009-10-30 2013-03-21 持田製薬株式会社 新規３−ヒドロキシ−５−アリールイソキサゾール誘導体
AR078948A1 (es) 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
EP2332427A1 (en) 2009-12-07 2011-06-15 Nestec S.A. low caloric fat replacers
US8476287B2 (en) 2009-12-25 2013-07-02 Mochida Pharmaceutical Co., Ltd. 3-hydroxy-5-arylisothiazole derivative
WO2011083752A1 (ja) 2010-01-05 2011-07-14 国立大学法人金沢大学 Gpr40陽性骨髄幹細胞
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
EP2404753A1 (en) 2010-07-06 2012-01-11 La Seda de Barcelona S.A. Seal capable of generating molecular hydrogen and suitable for closing a container and for scavenging oxygen
SG187176A1 (en) 2010-07-23 2013-02-28 Connexios Life Sciences Pvt Ltd Agonists of gpr40
WO2012020738A1 (ja) 2010-08-09 2012-02-16 武田薬品工業株式会社 複素環化合物およびその用途
TW201242951A (en) 2010-11-30 2012-11-01 Takeda Pharmaceutical Bicyclic compound
WO2012108478A1 (ja) 2011-02-09 2012-08-16 武田薬品工業株式会社 単環化合物
EP2675774A1 (en) 2011-02-17 2013-12-25 Takeda Pharmaceutical Company Limited Production method of optically active dihydrobenzofuran derivative
US9499467B2 (en) 2011-04-08 2016-11-22 Caldan Therapeutics Limited Ortho-fluoro substituted compounds for the treatment of metabolic diseases
US9072758B2 (en) 2011-04-28 2015-07-07 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
TWI537262B (zh) 2011-08-17 2016-06-11 美國禮來大藥廠 供治療糖尿病使用之新穎１，２，３，４－四氫喹啉衍生物
EP2776407A1 (en) 2011-11-08 2014-09-17 Arena Pharmaceuticals, Inc. Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
CN104144920A (zh) 2012-02-28 2014-11-12 皮拉马尔企业有限公司 作为gpr促效剂的苯基烷酸衍生物
US8642585B2 (en) 2012-03-26 2014-02-04 Boehringer Ingelheim International Gmbh Indanyloxydihydrobenzofuranylacetic acids
WO2013147443A1 (ko) 2012-03-27 2013-10-03 주식회사 동진쎄미켐 사다리형 실세스퀴옥산 고분자를 포함하는 광학필름용 수지 조성물
US8809376B2 (en) 2012-04-30 2014-08-19 Boehringer Ingelheim International Gmbh Indanyloxydihydrobenzofuranylacetic acids
MX2015001500A (es) 2012-08-02 2015-04-08 Merck Sharp & Dohme Compuestos antidiabeticos triciclicos.
US20140128333A1 (en) 2012-11-02 2014-05-08 Maqui New Life S.A. Compounds, Compositions, and Methods for Decreasing Intestinal Glucose Uptake and Inducing Incretin Release
TWI692469B (zh) 2012-11-09 2020-05-01 南韓商Ｌｇ化學股份有限公司 Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物
HUE032401T2 (en) 2012-11-16 2017-09-28 Bristol Myers Squibb Co Dihydropyrazole GPR40 modulators
CN104918935B (zh) 2012-11-16 2017-07-28 百时美施贵宝公司 二氢吡唑gpr40调节剂
AU2013344602A1 (en) 2012-11-16 2015-07-02 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
AU2013344603B2 (en) 2012-11-16 2017-07-06 Bristol-Myers Squibb Company Pyrrolidine GPR40 modulators
CN104822675A (zh) 2012-11-28 2015-08-05 勃林格殷格翰国际有限公司 新的茚满基氧基二氢苯并呋喃乙酸
WO2014086712A1 (en) 2012-12-07 2014-06-12 Boehringer Ingelheim International Gmbh New indanyloxydihydrobenzofuranylacetic acids
WO2014122067A1 (en) 2013-02-06 2014-08-14 Boehringer Ingelheim International Gmbh New indanyloxydihydrobenzofuranylacetic acids
AU2014219020A1 (en) 2013-02-22 2015-07-23 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
KR101735787B1 (ko) 2013-02-28 2017-05-16 주식회사 티움바이오 삼환식 화합물 및 이의 용도
US9763905B2 (en) 2013-03-15 2017-09-19 The Children's Medical Center Corporation Therapeutic target for the treatment of cancers and related therapies and methods
CN104059039B (zh) 2013-03-22 2017-03-15 正大天晴药业集团股份有限公司 具有gpr40受体功能调节作用的稠环化合物
KR101569522B1 (ko) * 2013-04-18 2015-11-17 현대약품 주식회사 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
WO2015028960A1 (en) * 2013-08-28 2015-03-05 Piramal Enterprises Limited Substituted heterocyclic derivatives as gpr agonists and uses thereof

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US20180346486A1 (en) 2018-12-06
US20160257701A1 (en) 2016-09-08
PH12016500885A1 (en) 2016-06-20
MA38999A1 (fr) 2018-01-31
IL245301A0 (he) 2016-06-30
JP2016537361A (ja) 2016-12-01
AU2014372114A1 (en) 2016-06-09
JP6352415B2 (ja) 2018-07-04
CA2928097A1 (en) 2015-07-02
CN105722841A (zh) 2016-06-29
EP3068788A1 (en) 2016-09-21
TW201531459A (zh) 2015-08-16
MX2016006337A (es) 2016-09-06
US10011609B2 (en) 2018-07-03
EA201690888A1 (ru) 2016-10-31
WO2015097713A1 (en) 2015-07-02
US10246470B2 (en) 2019-04-02
AR098432A1 (es) 2016-05-26
AP2016009176A0 (en) 2016-04-30

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