IN2013MU02145A - - Google Patents
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- Publication number
- IN2013MU02145A IN2013MU02145A IN2145MU2013A IN2013MU02145A IN 2013MU02145 A IN2013MU02145 A IN 2013MU02145A IN 2145MU2013 A IN2145MU2013 A IN 2145MU2013A IN 2013MU02145 A IN2013MU02145 A IN 2013MU02145A
- Authority
- IN
- India
- Prior art keywords
- monoclonal antibody
- purification
- provides
- desired monoclonal
- purity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW103121726A TWI596107B (zh) | 2013-06-25 | 2014-06-24 | 單株抗體之新穎純化方法 |
ARP140102380A AR096713A1 (es) | 2013-06-25 | 2014-06-24 | Proceso de purificación para anticuerpos monoclonales |
EA201592192A EA201592192A1 (ru) | 2013-06-25 | 2014-06-25 | Способ очистки моноклональных антител |
IN2145MU2013 IN2013MU02145A (fr) | 2013-06-25 | 2014-06-25 | |
US14/895,432 US9708365B2 (en) | 2013-06-25 | 2014-06-25 | Purification process for monoclonal antibodies |
JP2015563045A JP6039828B2 (ja) | 2013-06-25 | 2014-06-25 | モノクローナル抗体の精製方法 |
EP14777867.4A EP3013849B1 (fr) | 2013-06-25 | 2014-06-25 | Procédé de purification pour anticorps monoclonaux |
CA2911874A CA2911874A1 (fr) | 2013-06-25 | 2014-06-25 | Procede de purification pour anticorps monoclonaux |
NZ714079A NZ714079A (en) | 2013-06-25 | 2014-06-25 | Purification process for monoclonal antibodies |
KR1020157035759A KR101683415B1 (ko) | 2013-06-25 | 2014-06-25 | 단일클론항체에 대한 정제 방법 |
AU2014300486A AU2014300486B2 (en) | 2013-06-25 | 2014-06-25 | Purification process for monoclonal antibodies |
SG11201509502XA SG11201509502XA (en) | 2013-06-25 | 2014-06-25 | Purification process for monoclonal antibodies |
BR112015031196A BR112015031196A2 (pt) | 2013-06-25 | 2014-06-25 | “processo de purificação de anticorpo monoclonal” |
PCT/IN2014/000421 WO2014207763A1 (fr) | 2013-06-25 | 2014-06-25 | Procédé de purification pour anticorps monoclonaux |
CN201480031532.XA CN105263947A (zh) | 2013-06-25 | 2014-06-25 | 单克隆抗体的纯化工艺 |
MX2015016586A MX350610B (es) | 2013-06-25 | 2014-06-25 | Proceso para la purificacion de anticuerpos monoclonales. |
ZA2015/08258A ZA201508258B (en) | 2013-06-25 | 2015-11-09 | Purification process for monoclonal antibodies |
IL242649A IL242649A (en) | 2013-06-25 | 2015-11-18 | Purification process of monoclonal antibody |
HK16105366.7A HK1217344A1 (zh) | 2013-06-25 | 2016-05-11 | 單克隆抗體的純化工序 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2145MU2013 IN2013MU02145A (fr) | 2013-06-25 | 2014-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013MU02145A true IN2013MU02145A (fr) | 2015-06-05 |
Family
ID=51655799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2145MU2013 IN2013MU02145A (fr) | 2013-06-25 | 2014-06-25 |
Country Status (19)
Country | Link |
---|---|
US (1) | US9708365B2 (fr) |
EP (1) | EP3013849B1 (fr) |
JP (1) | JP6039828B2 (fr) |
KR (1) | KR101683415B1 (fr) |
CN (1) | CN105263947A (fr) |
AR (1) | AR096713A1 (fr) |
AU (1) | AU2014300486B2 (fr) |
BR (1) | BR112015031196A2 (fr) |
CA (1) | CA2911874A1 (fr) |
EA (1) | EA201592192A1 (fr) |
HK (1) | HK1217344A1 (fr) |
IL (1) | IL242649A (fr) |
IN (1) | IN2013MU02145A (fr) |
MX (1) | MX350610B (fr) |
NZ (1) | NZ714079A (fr) |
SG (1) | SG11201509502XA (fr) |
TW (1) | TWI596107B (fr) |
WO (1) | WO2014207763A1 (fr) |
ZA (1) | ZA201508258B (fr) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI398554B (zh) * | 2010-07-29 | 2013-06-11 | Zhen Ding Technology Co Ltd | 電鍍裝置 |
EP2702077A2 (fr) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Procédé de contrôle du profil de galactosylation de protéines exprimées de manière recombinante |
WO2013158273A1 (fr) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Procédés de modulation de la distribution de variant de lysine c-terminal |
US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013176754A1 (fr) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Nouvelle purification d'anticorps au moyen de chromatographie à interaction hydrophobe |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
WO2014151878A2 (fr) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Procédés pour la modulation des profils de glycosylation de protéines de traitements à base de protéines recombinantes au moyen de monosaccharides et d'oligosaccharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
TWI596107B (zh) | 2013-06-25 | 2017-08-21 | 卡地拉保健有限公司 | 單株抗體之新穎純化方法 |
EP3052640A2 (fr) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Utilisation d'ions métaux pour la modulation des profils de glycosylation de protéines recombinantes |
CA2926588C (fr) | 2013-10-16 | 2020-07-21 | Oncobiologics, Inc. | Formulations de tampon pour stabilite d'anticorps amelioree |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
EP3247718B1 (fr) | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation de variants de charge dans une composition d'anticorps monoclonaux |
WO2016149088A1 (fr) * | 2015-03-13 | 2016-09-22 | Bristol-Myers Squibb Company | Utilisation de lavages alcalins durant une chromatographie pour éliminer les impuretés |
JP6968055B2 (ja) * | 2015-08-21 | 2021-11-17 | ジェネンテック, インコーポレイテッド | アフィニティークロマトグラフィーにおける宿主細胞タンパク質の低減方法 |
PL3337817T3 (pl) | 2015-08-21 | 2022-01-17 | F. Hoffmann-La Roche Ag | Sposób zmniejszania zawartości białek komórek gospodarza w chromatografii powinowactwa |
CN109563161A (zh) | 2016-02-03 | 2019-04-02 | 安口生物公司 | 用于提高抗体稳定性的缓冲制剂 |
MX2019000935A (es) | 2016-08-16 | 2019-07-04 | Regeneron Pharma | Metodos para cuantificar anticuerpos individuales de una mezcla. |
CN109923411B (zh) | 2016-10-25 | 2022-05-31 | 里珍纳龙药品有限公司 | 用于色谱数据分析的方法和系统 |
CN109963560A (zh) * | 2016-10-28 | 2019-07-02 | 默沙东公司 | 用于除去酪氨酸硫酸化抗体变体的纯化方法、经纯化的组合物 |
CA3047530A1 (fr) | 2016-12-23 | 2018-06-28 | Serum Institute Of India Private Limited | Procedes ameliores pour augmenter la productivite d'anticorps dans une culture de cellules de mammifere et minimiser l'agregation pendant des processus de formulation en aval, procedes de formulation et formulations d'anticorps stables obtenus a partir de ceux-ci |
KR102087823B1 (ko) * | 2017-05-16 | 2020-03-13 | 에이치케이이노엔 주식회사 | 친화성 크로마토그래피를 이용한 항체 또는 항체절편 정제 방법 |
EP3431168A1 (fr) * | 2017-07-19 | 2019-01-23 | Bayer Aktiengesellschaft | Élimination de médicament non lié après accouplement conjugué anticorps-médicament |
CN108101987A (zh) * | 2017-11-17 | 2018-06-01 | 安徽未名生物医药有限公司 | 一种重组抗TNF-α全人源单克隆抗体的纯化方法 |
CN110128538B (zh) * | 2018-02-09 | 2022-08-26 | 鲁南制药集团股份有限公司 | 一种纯化抗cd20人鼠嵌合单克隆抗体的方法 |
US11155575B2 (en) | 2018-03-21 | 2021-10-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbent, devices and methods |
TW202005694A (zh) | 2018-07-02 | 2020-02-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
EP3823594A1 (fr) | 2018-07-19 | 2021-05-26 | Ichnos Sciences S.A. | Formulation d'anticorps liquide |
KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
CN111072773A (zh) * | 2018-10-19 | 2020-04-28 | 菲鹏生物股份有限公司 | 抗体的纯化方法、抗体和应用 |
EP3643322A1 (fr) * | 2018-10-26 | 2020-04-29 | Mabion SA | Formulation de ligand anti cd20 à faible agrégat |
WO2020084503A1 (fr) | 2018-10-26 | 2020-04-30 | Cadila Healthcare Limited | Composition comprenant un anticorps ayant un niveau réduit de variants basiques de celui-ci |
CN109320611B (zh) * | 2018-10-31 | 2022-06-03 | 鼎康(武汉)生物医药有限公司 | 一种人鼠嵌合单克隆抗体生物类似药的纯化方法 |
CN109336969B (zh) * | 2018-11-09 | 2021-02-12 | 杭州奕安济世生物药业有限公司 | 一种抗体的纯化方法 |
CN114729003A (zh) | 2019-11-22 | 2022-07-08 | 莫佛塞斯公司 | 提高离子交换色谱过程中抗体产率的方法 |
WO2021139720A1 (fr) * | 2020-01-08 | 2021-07-15 | 信达生物制药(苏州)有限公司 | Procédé de purification d'adalimumab et composition stable associée |
KR102154952B1 (ko) * | 2020-02-21 | 2020-09-10 | 프레스티지바이오로직스 주식회사 | 아달리무맙의 Non-Protein A 정제방법 |
WO2022245306A1 (fr) * | 2021-05-20 | 2022-11-24 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Purification de protéines par chromatographie d'affinité |
CN114133446A (zh) * | 2021-12-31 | 2022-03-04 | 方坦思(上海)生物医药有限公司 | 单克隆抗体的纯化方法 |
CN115491328A (zh) * | 2022-08-31 | 2022-12-20 | 深圳市卫光生物制品股份有限公司 | 一种大肠杆菌表达蛋白及其表达纯化方法 |
EP4335869A1 (fr) | 2022-09-07 | 2024-03-13 | Bio T Biyoteknoloji Cozumleri Ve Uretim Anonim | Résine et colonne de chromatographie qui épure des anticorps avec de petits peptides résistant aux protéases |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5429746A (en) * | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
US5641870A (en) * | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
SI1308456T1 (sl) | 1998-05-06 | 2008-02-29 | Genentech Inc | Ciscenje protiteles z ionsko izmenjevalno kromatografijo |
PT1308455E (pt) | 1998-05-06 | 2006-08-31 | Genentech Inc | Composicao compreendendo anticorpos anti-her2 |
ATE274522T1 (de) * | 1998-06-01 | 2004-09-15 | Genentech Inc | Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie |
EP1614693A4 (fr) | 2003-03-31 | 2006-07-19 | Kirin Brewery | Purification d'un anticorps monoclonal humain et d'un anticorps polyclonal humain |
WO2005000898A2 (fr) | 2003-06-27 | 2005-01-06 | Biogen Idec Ma Inc. | Purification et synthese preferentielle de molecules de liaison |
SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Amersham Biosciences Ab | Antibody purification |
HUE049797T2 (hu) | 2005-03-11 | 2020-10-28 | Wyeth Llc | Gyenge megoszlási kromatográfiás eljárás |
CN101365722A (zh) | 2005-06-17 | 2009-02-11 | 艾兰制药国际有限公司 | 纯化抗Aβ抗体的方法 |
WO2007109163A2 (fr) | 2006-03-16 | 2007-09-27 | Amgen Inc | Tampon de lavage et procédé d'utilisation correspondant |
NZ611859A (en) | 2006-04-05 | 2014-12-24 | Abbvie Biotechnology Ltd | Antibody purification |
MX2009002576A (es) | 2006-09-08 | 2009-03-20 | Wyeth Corp | Lavado de arginina en purificacion de proteina utilizando cromatografia de afinidad. |
EP2212432A4 (fr) * | 2007-10-22 | 2011-10-19 | Schering Corp | Anticorps anti-vegf entièrement humains et leurs procédés d'utilisation |
WO2010030222A1 (fr) | 2008-09-12 | 2010-03-18 | Ge Healthcare Bio-Sciences Ab | Séparation protéine-agrégat améliorée avec des échangeurs d'anions multimodaux en présence de zwitterions exclus de la protéine |
US20100069617A1 (en) | 2008-09-12 | 2010-03-18 | Ge Healthcare Bio-Sciences Ab | Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions |
SG10201702922VA (en) | 2008-10-20 | 2017-06-29 | Abbvie Inc | Isolation and purification of antibodies using protein a affinity chromatography |
CN104744560A (zh) | 2009-10-20 | 2015-07-01 | Abbvie公司 | 使用蛋白a亲和色谱法分离和纯化抗-il-13抗体 |
EP2519536A4 (fr) * | 2009-12-29 | 2013-06-05 | Reddys Lab Ltd Dr | Purification des protéines par échange d'ions |
AU2011208659B2 (en) | 2010-01-22 | 2015-05-28 | Boehringer Ingelheim International Gmbh | Chromatographic method for purifying Fc-containing proteins |
CN102179237A (zh) * | 2010-04-26 | 2011-09-14 | 无锡加莱克色谱科技有限公司 | 一种用于分离、提纯单克隆抗体和抗体球蛋白的亲和色谱填料及其制备方法 |
JP6023715B2 (ja) * | 2010-10-11 | 2016-11-09 | アッヴィ・バハマズ・リミテッド | タンパク質の精製方法 |
EP2649016B1 (fr) | 2010-12-06 | 2020-06-10 | Pall Corporation | Procédés de traitement continu pour produits biologiques |
US20120238730A1 (en) | 2011-03-15 | 2012-09-20 | Abbott Laboratories | Integrated approach to the isolation and purification of antibodies |
EP2723759A4 (fr) * | 2011-06-24 | 2015-01-28 | Reddys Lab Ltd Dr | Purification de protéine chimérique |
WO2013066707A1 (fr) * | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Procédé de chromatographie permettant de décomposer des agrégats d'anticorps hétérogènes |
WO2013075740A1 (fr) | 2011-11-23 | 2013-05-30 | Sanofi | Procédé de purification d'anticorps |
EP4026596A1 (fr) * | 2013-03-14 | 2022-07-13 | Amgen, Inc | Élimination de ligand de purification par affinité de fuite |
WO2014209508A1 (fr) * | 2013-05-13 | 2014-12-31 | Medimmune, Llc | Séparation de multimères d'anticorps polyclonaux de recombinaison avec une séparation minimale des monomères |
TWI596107B (zh) | 2013-06-25 | 2017-08-21 | 卡地拉保健有限公司 | 單株抗體之新穎純化方法 |
-
2014
- 2014-06-24 TW TW103121726A patent/TWI596107B/zh not_active IP Right Cessation
- 2014-06-24 AR ARP140102380A patent/AR096713A1/es unknown
- 2014-06-25 CN CN201480031532.XA patent/CN105263947A/zh active Pending
- 2014-06-25 NZ NZ714079A patent/NZ714079A/en not_active IP Right Cessation
- 2014-06-25 JP JP2015563045A patent/JP6039828B2/ja active Active
- 2014-06-25 SG SG11201509502XA patent/SG11201509502XA/en unknown
- 2014-06-25 MX MX2015016586A patent/MX350610B/es active IP Right Grant
- 2014-06-25 AU AU2014300486A patent/AU2014300486B2/en not_active Ceased
- 2014-06-25 BR BR112015031196A patent/BR112015031196A2/pt not_active IP Right Cessation
- 2014-06-25 WO PCT/IN2014/000421 patent/WO2014207763A1/fr active Application Filing
- 2014-06-25 US US14/895,432 patent/US9708365B2/en active Active
- 2014-06-25 EP EP14777867.4A patent/EP3013849B1/fr not_active Revoked
- 2014-06-25 CA CA2911874A patent/CA2911874A1/fr not_active Abandoned
- 2014-06-25 KR KR1020157035759A patent/KR101683415B1/ko active IP Right Grant
- 2014-06-25 EA EA201592192A patent/EA201592192A1/ru unknown
- 2014-06-25 IN IN2145MU2013 patent/IN2013MU02145A/en unknown
-
2015
- 2015-11-09 ZA ZA2015/08258A patent/ZA201508258B/en unknown
- 2015-11-18 IL IL242649A patent/IL242649A/en not_active IP Right Cessation
-
2016
- 2016-05-11 HK HK16105366.7A patent/HK1217344A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2016525500A (ja) | 2016-08-25 |
MX2015016586A (es) | 2016-03-16 |
TW201512217A (zh) | 2015-04-01 |
NZ714079A (en) | 2017-05-26 |
US20160115195A1 (en) | 2016-04-28 |
KR20160003311A (ko) | 2016-01-08 |
WO2014207763A1 (fr) | 2014-12-31 |
AR096713A1 (es) | 2016-01-27 |
AU2014300486B2 (en) | 2016-06-30 |
MX350610B (es) | 2017-09-11 |
ZA201508258B (en) | 2017-03-29 |
TWI596107B (zh) | 2017-08-21 |
CN105263947A (zh) | 2016-01-20 |
SG11201509502XA (en) | 2015-12-30 |
HK1217344A1 (zh) | 2017-01-06 |
CA2911874A1 (fr) | 2014-12-31 |
IL242649A (en) | 2016-03-31 |
KR101683415B1 (ko) | 2016-12-06 |
US9708365B2 (en) | 2017-07-18 |
EP3013849A1 (fr) | 2016-05-04 |
EP3013849B1 (fr) | 2017-09-13 |
JP6039828B2 (ja) | 2016-12-07 |
EA201592192A1 (ru) | 2016-07-29 |
AU2014300486A1 (en) | 2015-11-26 |
BR112015031196A2 (pt) | 2017-07-25 |
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