IN2012DN05187A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN05187A IN2012DN05187A IN5187DEN2012A IN2012DN05187A IN 2012DN05187 A IN2012DN05187 A IN 2012DN05187A IN 5187DEN2012 A IN5187DEN2012 A IN 5187DEN2012A IN 2012DN05187 A IN2012DN05187 A IN 2012DN05187A
- Authority
- IN
- India
- Prior art keywords
- isoprene
- gas
- purification
- fermentor
- solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C11/00—Aliphatic unsaturated hydrocarbons
- C07C11/12—Alkadienes
- C07C11/173—Alkadienes with five carbon atoms
- C07C11/18—Isoprene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0426—Counter-current multistage extraction towers in a vertical or sloping position
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C7/00—Purification; Separation; Use of additives
- C07C7/04—Purification; Separation; Use of additives by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C7/00—Purification; Separation; Use of additives
- C07C7/10—Purification; Separation; Use of additives by extraction, i.e. purification or separation of liquid hydrocarbons with the aid of liquids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Water Supply & Treatment (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28814209P | 2009-12-18 | 2009-12-18 | |
PCT/US2010/060552 WO2011075534A2 (en) | 2009-12-18 | 2010-12-15 | Purification of isoprene from renewable resources |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN05187A true IN2012DN05187A (ar) | 2015-10-23 |
Family
ID=44167932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN5187DEN2012 IN2012DN05187A (ar) | 2009-12-18 | 2010-12-15 |
Country Status (12)
Country | Link |
---|---|
US (3) | US8569562B2 (ar) |
EP (1) | EP2513021A2 (ar) |
JP (3) | JP5643838B2 (ar) |
CN (1) | CN102884028B (ar) |
AR (1) | AR079560A1 (ar) |
AU (1) | AU2010331946A1 (ar) |
BR (1) | BR112012014736B1 (ar) |
CA (1) | CA2783976A1 (ar) |
IN (1) | IN2012DN05187A (ar) |
SG (1) | SG181605A1 (ar) |
TW (1) | TWI481594B (ar) |
WO (1) | WO2011075534A2 (ar) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2716231T3 (es) | 2008-07-02 | 2019-06-11 | Danisco Us Inc | Procedimientos para producir isopreno |
US8324442B2 (en) | 2009-03-03 | 2012-12-04 | Amyris, Inc. | Microbial derived isoprene and methods for making the same |
TWI434921B (zh) * | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
TWI427149B (zh) * | 2009-06-17 | 2014-02-21 | Danisco Us Inc | 使用dxp及mva途徑之改良之異戊二烯製造 |
SG181605A1 (en) | 2009-12-18 | 2012-07-30 | Danisco Us Inc | Purification of isoprene from renewable resources |
CN102906269A (zh) * | 2009-12-22 | 2013-01-30 | 丹尼斯科美国公司 | 用于增加异戊二烯气体产量的膜生物反应器 |
US8933282B2 (en) | 2010-06-17 | 2015-01-13 | Danisco Us Inc. | Fuel compositions comprising isoprene derivatives |
WO2012019169A1 (en) | 2010-08-06 | 2012-02-09 | Danisco Us Inc. | Production of isoprene under neutral ph conditions |
CN103443271A (zh) | 2010-10-27 | 2013-12-11 | 丹尼斯科美国公司 | 用于增加异戊二烯产量的异戊二烯合酶变体 |
BR112013016264A2 (pt) | 2010-12-22 | 2018-06-19 | Danisco Us Inc | produção biológica de açúcares de pentose com o uso de células recombinantes |
SG191235A1 (en) | 2010-12-22 | 2013-07-31 | Danisco Us Inc | Compositions and methods for improved isoprene production using two types of ispg enzymes |
EP2702139A1 (en) | 2011-04-29 | 2014-03-05 | Danisco US Inc. | Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities |
AU2012249320A1 (en) | 2011-04-29 | 2013-11-14 | Danisco Us Inc. | Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids |
WO2013022799A1 (en) | 2011-08-05 | 2013-02-14 | Danisco Us Inc. | PRODUCTION OF ISOPRENOIDS UNDER NEUTRAL pH CONDITIONS |
BR112014008278A2 (pt) | 2011-10-07 | 2017-04-18 | Danisco Us Inc | utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno |
JP6101275B2 (ja) | 2011-10-27 | 2017-03-22 | ダニスコ・ユーエス・インク | イソプレン産生時の溶解度が向上されたイソプレン合成酵素変異体 |
EP2794863A1 (en) | 2011-12-23 | 2014-10-29 | Danisco US Inc. | Enhanced production of isoprene using host cells having decreased ispa activity |
US9315831B2 (en) | 2012-03-30 | 2016-04-19 | Danisco Us Inc. | Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids |
WO2013155053A1 (en) * | 2012-04-09 | 2013-10-17 | Michigan Biotechnology Institute | Process for reducing methyl butenol (2-methyl-3-buten-2-ol) |
US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
US8895277B2 (en) | 2012-05-02 | 2014-11-25 | Danisco Us Inc. | Legume isoprene synthase for production of isoprene |
JP6010342B2 (ja) * | 2012-05-21 | 2016-10-19 | 株式会社ブリヂストン | イソプレン−ブタジエン共重合体、イソプレン−ブタジエン共重合体の製造方法、ゴム組成物及びタイヤ |
JP6010343B2 (ja) * | 2012-05-21 | 2016-10-19 | 株式会社ブリヂストン | イソプレン−ブタジエン共重合体、イソプレン−ブタジエン共重合体の製造方法、ゴム組成物及びタイヤ |
JP6074161B2 (ja) * | 2012-05-22 | 2017-02-01 | 株式会社ブリヂストン | ゴム組成物およびタイヤの製造方法 |
JP6074160B2 (ja) * | 2012-05-22 | 2017-02-01 | 株式会社ブリヂストン | ゴム組成物およびタイヤの製造方法 |
WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
WO2014100726A2 (en) | 2012-12-21 | 2014-06-26 | Danisco Us Inc. | Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway |
WO2014121357A1 (en) * | 2013-02-07 | 2014-08-14 | Braskem S.A. | Method of separating and purifying a conjugated diolefin produced by fermentation under anaerobic conditions |
US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
CN105102624B (zh) | 2013-03-29 | 2019-11-01 | 味之素株式会社 | 用于收集发酵气体中含有的异戊二烯的方法及用于生产纯化的异戊二烯的方法 |
SG11201508186XA (en) | 2013-04-10 | 2015-11-27 | Danisco Us Inc | Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
WO2014205355A2 (en) | 2013-06-21 | 2014-12-24 | Danisco Us Inc. | Compositions and methods for clostridial transformation |
US10427996B2 (en) * | 2013-12-02 | 2019-10-01 | Braskem S.A. | Fermentation hydrocarbon gas products separation via membrane |
JP6744819B2 (ja) | 2014-02-20 | 2020-08-19 | ダニスコ・ユーエス・インク | メバロン酸、イソプレン、イソプレノイド前駆体、イソプレノイド、およびアセチルCoA由来産物の生産向上のための組換え微生物 |
WO2015127435A1 (en) * | 2014-02-24 | 2015-08-27 | Glycos Biotechnologies, Inc. | Recovery of isoprene from fermentation processes using mechanical compression and condensation |
US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
CN106866341B (zh) * | 2017-01-20 | 2019-08-06 | 中国科学院青岛生物能源与过程研究所 | 一种分离回收发酵尾气中低浓度异戊二烯的方法 |
CN110354644A (zh) * | 2018-04-10 | 2019-10-22 | 天津科技大学 | 一种高效的醋酸丁酯废气吸收与解吸装置 |
CN111454114B (zh) * | 2020-05-11 | 2023-07-14 | 长沙贝塔医药科技有限公司 | 一种用13c2-香叶醇合成高纯度13c2-月桂烯的方法 |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1344713A (en) | 1915-12-02 | 1920-06-29 | Westinghouse Electric & Mfg Co | Reactance-coil |
GB819188A (en) | 1956-05-03 | 1959-09-02 | Gulf Research Development Co | Purifying isoprene by distillation |
US3146278A (en) | 1958-04-29 | 1964-08-25 | British Hydrocarbon Chem Ltd | Production of conjugated diolefins |
GB1025432A (en) | 1963-05-13 | 1966-04-06 | Rikagaku Kenkyusho | Process for producing isoprene |
US3510405A (en) * | 1967-11-11 | 1970-05-05 | Nippon Zeon Co | Isoprene purification process |
US3621072A (en) * | 1967-12-23 | 1971-11-16 | Sumitomo Chemical Co | Process for producing isoprene |
DE1793254A1 (de) | 1968-08-23 | 1971-12-16 | Bayer Ag | Verfahren zur Gewinnung von Cyclopenten,Isopren und einem Diolefinstrom aus C?-Crackbenzinschnitten |
JPS493962B1 (ar) | 1969-08-02 | 1974-01-29 | ||
US3574780A (en) * | 1969-08-08 | 1971-04-13 | Sumitomo Chemical Co | Method for producing isoprene |
US3972955A (en) | 1973-09-22 | 1976-08-03 | Bayer Aktiengesellschaft | Process for preparation of isoprene |
NL7409855A (nl) * | 1974-07-22 | 1976-01-26 | Stamicarbon | Werkwijze voor de bereiding van isopreen. |
US4000209A (en) | 1975-11-05 | 1976-12-28 | Monsanto Company | Isoprene production and catalyst therefor |
US4067923A (en) * | 1976-01-21 | 1978-01-10 | Vladimir Alexandrovich Belyaev | Process for producing isoprene |
JPS6021125B2 (ja) * | 1976-12-20 | 1985-05-25 | ジェイエスアール株式会社 | イソプレンの精製法 |
JPS58222037A (ja) * | 1982-06-18 | 1983-12-23 | Japan Synthetic Rubber Co Ltd | 1,3−ブタジエンの回収方法 |
US4511751A (en) | 1982-10-14 | 1985-04-16 | Kuraray Company, Ltd. | Process for producing isoprene |
DE3338269A1 (de) | 1983-10-21 | 1985-05-02 | Basf Ag, 6700 Ludwigshafen | Verfahren zur gewinnung von isopren aus einem c(pfeil abwaerts)5(pfeil abwaerts)-kohlenwasserstoffgemisch |
GB8407828D0 (en) | 1984-03-27 | 1984-05-02 | Ontario Research Foundation | In situ preparation |
US4570029A (en) * | 1985-03-04 | 1986-02-11 | Uop Inc. | Process for separating isoprene |
US5035794A (en) * | 1985-12-27 | 1991-07-30 | Exxon Chemical Patents Inc. | Isoprene recovery in the butyl rubber process |
US5177290A (en) | 1991-01-10 | 1993-01-05 | Exxon Chemical Patents Inc. | Isoprene process |
US5849970A (en) * | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
TWI250210B (en) | 1998-05-06 | 2006-03-01 | Dsm Ip Assets Bv | An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate |
EP0955363A3 (en) | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | Dna sequences encoding enzymes involved in production of isoprenoids |
US6500970B1 (en) * | 2001-07-20 | 2002-12-31 | Eastman Chemical Company | Recovery and purification of 3,4-epoxy-1-butene using high-boiling solvents |
DE60335574D1 (de) | 2002-10-04 | 2011-02-10 | Du Pont | Verfahren zur biologischen herstellung von 1,3-propandiol mit hoher ausbeute |
FR2850101B1 (fr) | 2003-01-22 | 2007-03-02 | Michelin Soc Tech | Procede d'obtention d'une coupe c5 "fcc" enrichie en isoprene et polymerisation selective de l'isoprene a partir de cette coupe |
JP3917163B2 (ja) * | 2003-03-31 | 2007-05-23 | 株式会社クラレ | イソプレンの製造方法 |
US6987152B1 (en) * | 2005-01-11 | 2006-01-17 | Univation Technologies, Llc | Feed purification at ambient temperature |
US7442233B2 (en) * | 2005-07-06 | 2008-10-28 | Basf Catalysts Llc | Integrated heavy hydrocarbon removal, amine treating and dehydration |
CN100410230C (zh) | 2006-05-17 | 2008-08-13 | 绍兴文理学院 | 1-氯-2-甲基-4-烃酰氧基-2-丁烯制备方法 |
DK2024504T4 (da) | 2006-05-26 | 2023-02-27 | Amyris Inc | Fremstilling af isoprenoider |
US7947478B2 (en) | 2006-06-29 | 2011-05-24 | The Regents Of The University Of California | Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria |
CN101244976B (zh) * | 2007-02-15 | 2011-05-04 | 中国石油化工股份有限公司 | 一种制取聚合级异戊二烯的方法 |
CN101104573B (zh) * | 2007-07-19 | 2010-10-06 | 中国石油化工集团公司 | 组合精馏分离异戊二烯的方法 |
CN102027124B (zh) | 2007-12-13 | 2015-11-25 | 丹尼斯科美国公司 | 用于生产异戊二烯的组合物和方法 |
JP5624980B2 (ja) * | 2008-06-30 | 2014-11-12 | ザ・グッドイヤー・タイヤ・アンド・ラバー・カンパニーThe Goodyeartire & Rubber Company | 再生資源に由来するイソプレンの重合体 |
ES2716231T3 (es) | 2008-07-02 | 2019-06-11 | Danisco Us Inc | Procedimientos para producir isopreno |
CN102083990B (zh) | 2008-07-04 | 2016-05-04 | 财富科学家股份有限公司 | 通过3-羟基烷酸的酶促脱羧制备烯 |
US7909913B2 (en) | 2008-07-17 | 2011-03-22 | Air Products And Chemicals, Inc. | Gas purification by adsorption of hydrogen sulfide |
MY156562A (en) * | 2008-09-15 | 2016-02-26 | Danisco Us Inc | Increased isoprene production using the archaeal lower mevalonate pathway |
MY156588A (en) * | 2008-09-15 | 2016-03-15 | Danisco Us Inc | Systems using cell culture for production of isoprene |
EP2337844A1 (en) | 2008-09-15 | 2011-06-29 | Danisco US Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
US20100184178A1 (en) * | 2008-09-15 | 2010-07-22 | Zachary Quinn Beck | Increased isoprene production using mevalonate kinase and isoprene synthase |
ZA201102109B (en) * | 2008-09-15 | 2013-10-30 | Goodyear Tire & Rubber | Conversion of prenyl derivatives to isoprene |
US20100099932A1 (en) * | 2008-10-21 | 2010-04-22 | Ecoprene Llc | Isoprene Compositions and Methods of Use |
EP2382312A2 (en) * | 2008-12-30 | 2011-11-02 | Danisco US Inc. | Methods of producing isoprene and a co-product |
US20100216958A1 (en) * | 2009-02-24 | 2010-08-26 | Peters Matthew W | Methods of Preparing Renewable Butadiene and Renewable Isoprene |
US8324442B2 (en) | 2009-03-03 | 2012-12-04 | Amyris, Inc. | Microbial derived isoprene and methods for making the same |
TW201120213A (en) * | 2009-06-17 | 2011-06-16 | Danisco Us Inc | Polymerization of isoprene from renewable resources |
TWI427149B (zh) | 2009-06-17 | 2014-02-21 | Danisco Us Inc | 使用dxp及mva途徑之改良之異戊二烯製造 |
TWI434921B (zh) * | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
US8178736B2 (en) * | 2009-08-07 | 2012-05-15 | Lummus Technology Inc. | Process and system for the production of isoprene |
SG181605A1 (en) * | 2009-12-18 | 2012-07-30 | Danisco Us Inc | Purification of isoprene from renewable resources |
-
2010
- 2010-12-15 SG SG2012042511A patent/SG181605A1/en unknown
- 2010-12-15 JP JP2012544763A patent/JP5643838B2/ja not_active Expired - Fee Related
- 2010-12-15 EP EP10799184A patent/EP2513021A2/en not_active Withdrawn
- 2010-12-15 US US12/969,440 patent/US8569562B2/en active Active
- 2010-12-15 BR BR112012014736A patent/BR112012014736B1/pt not_active IP Right Cessation
- 2010-12-15 CA CA2783976A patent/CA2783976A1/en not_active Abandoned
- 2010-12-15 AU AU2010331946A patent/AU2010331946A1/en not_active Abandoned
- 2010-12-15 IN IN5187DEN2012 patent/IN2012DN05187A/en unknown
- 2010-12-15 CN CN201080064167.4A patent/CN102884028B/zh not_active Expired - Fee Related
- 2010-12-15 WO PCT/US2010/060552 patent/WO2011075534A2/en active Application Filing
- 2010-12-17 TW TW099144617A patent/TWI481594B/zh active
- 2010-12-20 AR ARP100104783A patent/AR079560A1/es unknown
-
2013
- 2013-09-24 US US14/035,746 patent/US20140187839A1/en not_active Abandoned
-
2014
- 2014-09-10 JP JP2014184058A patent/JP6378013B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-09 US US14/682,930 patent/US9751820B2/en active Active
-
2016
- 2016-11-18 JP JP2016225310A patent/JP2017081924A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2011075534A3 (en) | 2012-04-12 |
US20140187839A1 (en) | 2014-07-03 |
AU2010331946A2 (en) | 2012-07-19 |
CN102884028B (zh) | 2015-08-19 |
TWI481594B (zh) | 2015-04-21 |
JP6378013B2 (ja) | 2018-08-22 |
US20150274615A1 (en) | 2015-10-01 |
AR079560A1 (es) | 2012-02-01 |
TW201139367A (en) | 2011-11-16 |
JP5643838B2 (ja) | 2014-12-17 |
JP2017081924A (ja) | 2017-05-18 |
BR112012014736A2 (pt) | 2016-04-19 |
BR112012014736B1 (pt) | 2018-09-18 |
AU2010331946A1 (en) | 2012-06-28 |
US9751820B2 (en) | 2017-09-05 |
SG181605A1 (en) | 2012-07-30 |
CN102884028A (zh) | 2013-01-16 |
CA2783976A1 (en) | 2011-06-23 |
JP2013514375A (ja) | 2013-04-25 |
US8569562B2 (en) | 2013-10-29 |
EP2513021A2 (en) | 2012-10-24 |
US20110178261A1 (en) | 2011-07-21 |
WO2011075534A2 (en) | 2011-06-23 |
JP2015007119A (ja) | 2015-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2012DN05187A (ar) | ||
SG182608A1 (en) | Process for purifying ethanol | |
BR112012019406A2 (pt) | processo para purificacao de um produto de etanol bruto | |
MY159252A (en) | Process for the preparation of dopo-derived compounds and compositions thereof | |
IN2012DN02313A (ar) | ||
FI20115722L (fi) | Menetelmä biologista alkuperää olevan materiaalin puhdistamiseksi | |
BR112012028507A2 (pt) | processo para recuperação de etanol com extrações laterais para regular as concentrações de c3 + alcoóis | |
MX2007007682A (es) | Proceso para depurar polioles polimericos. | |
MX2009013747A (es) | Proceso continuo para preparar neral en forma pura o enriquecida. | |
NZ606720A (en) | A method of producing ingenol-3-angelate | |
MX2012013921A (es) | Sistema de recuperacion de acido debil para procedimientos de separacion de etanol. | |
TW200942512A (en) | Purification of acetic acid from wood acetylation process | |
MX2007010141A (es) | Procesos para la preparacion de intermedios de linezolid. | |
MX2012007907A (es) | Metodo para la eliminacion de compuestos organicos de los flujos de aguas residuales en un proceso para la produccion de acido (met) acrilico. | |
MX2009006615A (es) | Proceso para la preparacion y usos de novedosos compuestos de bis(dialquilamida). | |
IN2014DN02166A (ar) | ||
IN2015MN00013A (ar) | ||
SG182641A1 (en) | Processes for producing anhydrous ethanol compositions | |
MX2023004496A (es) | Procesos para purificar acido acetico e hidratar un anhidrido. | |
MX2012008928A (es) | Proceso de purificar etanol. | |
WO2012122451A3 (en) | Polymorphs of maxacalcitol and process for the preparation of maxacalcitol | |
IN2015DN03980A (ar) | ||
WO2012066569A8 (en) | A novel process for the purification of tissue plasminogen activator | |
MY180951A (en) | Process and apparatus for purification of acrylic acid | |
WO2009088255A3 (en) | Method for preparing antigen effective for preventing anthrax infection |